Search clinical trials for: Organic Anion Transporting Polypeptide 1B1 (OATP1B1)

Total 508 results

Seoul National University Hospital

Completed

Influence of Organic Anion Transporting Polypeptide1B1(OATP1B1) Genotype on Rosuvastatin PK, PD and Lipid Profiles (OATP)

Organic Anion Transporting Polypeptide1B1 (OATP1B1) | Rosuvastatin

Korea, Republic of
Bayer

Completed

Study to Learn the Effect of Drug BAY1817080 on the Way the Body Absorbs, Distributes and Excretes Another Drug Rosuvastatin in Healthy Adult Participants

Drug Interactions

United States
Seoul National University Hospital

Completed

Influence of OATP1B1 and BRCP Genotype on Rosuvastatin PK, PD and Lipidomics in Hyperlipidemic Patients

Hypercholesterolemia

Korea, Republic of
AstraZeneca
Parexel

Completed

A Study to Assess the Effect of AZD5462 on the Pharmacokinetics of Midazolam, Rosuvastatin and Digoxin

Healthy Participants

United States
University Medicine Greifswald

Completed

Influence of the OATP1B1 and OATP1B3 Genotype on the Hepatic Uptake of Primovist®

MRI | Pharmacokinetics | Liver | Drug Transporter | Gd-EOB-DTPA

Germany
Bayer

Completed

Drug-drug Interaction Study Using Rosuvastatin as a Breast Cancer Resistant Protein (Efflux Transporter), Organic Anion-transporting Polypeptide (OATP)1B1, and OATP1B3 (Uptake Transporters) Probe Substrate

Healthy Volunteers | Pharmacokinetics | Drug Interaction

Germany
Yi Han
Qianfoshan Hospital

Recruiting

Prospective Observational Association Between SLCO1B1 Gene Polymorphism and the Anti-factor Xa Activity of Edoxaban in Patients With Moderate to Severe Renal Insufficiency

Renal Insufficiency | Gene Polymorphism | Edoxaban

China
Kadmon, a Sanofi Company

Completed

A Study to Assess the Effect of Oral Belumosudil on Inhibition of Various Proteins in the Fed State in Healthy Male Subjects

Immune System Disorder (Healthy Volunteers)

United States
Millennium Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Effect of Single-Dose Intravenous Rifampin as a Prototypic Inhibitor of Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 on the Single-Dose Pharmacokinetics (PK) of Oral TAK-906 in Healthy Adult Participants

Healthy Volunteers

United States
Gerd Mikus

Completed

Influence of OATP1B1 and CYP2C9 Genotypes on the Pharmacokinetics of Bosentan Before and During Clarithromycin

Drug Interactions

Germany
Institut Curie

Completed

Biomarker Evaluation in Advanced Stage Cervical Cancer by an International Working Group. Tumor Stages (1B1 - 4) (BIO-RAIDs)

Cervical Cancer

France, Germany, Netherlands, Romania, Serbia
Instituto do Cancer do Estado de São Paulo
Instituto de Ciências Biomédicas da Universidade de São Paulo

Not yet recruiting

Determination of ALDH1b1 and ALDH2 Polymorphisms Frequency in the Brazilian Population (ALDH2020)

Oral Squamous Cell Carcinoma (OSCC)

Brazil
GlaxoSmithKline

Completed

A Study to Investigate the Effect of GSK1605786 on Hepatic Cytochrome P450, and BCRP and OATP1B1 Transport in Healthy Adult Subjects

Crohn's Disease

United States
VA Office of Research and Development

Completed

Integrating Pharmacogenetics In Clinical Care (I-PICC)

Cardiovascular Disease

United States
Novartis Pharmaceuticals
Medicines for Malaria Venture

Completed

Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Midazolam, Repaglinide, Dextromethorphan, Metformin, Rosuvastatin and Dolutegravir

Malaria

United Kingdom
Dizal Pharmaceuticals

Recruiting

Assessing the Effect of DZD9008 on the Pharmacokinetics of the Cocktail Probes Representative for CYP3A4, P-gp, BCRP and OATP1B1 in Patients With EGFR or HER2 Mutant Advanced Non-small Cell Lung Cancer (WU-KONG19)

Non-small Cell Lung Cancer

China
Barts & The London NHS Trust
Royal Marsden NHS Foundation Trust; Guy's and St Thomas' NHS Foundation Trust; Case Western Reserve University and other collaborators

Completed

Diagnostic Accuracy of MRI, DWI MRI, FDG-PET/CT and FEC PET/CT in the Detection of Lymph Node Metastases in Surgically Staged Endometrial and Cervical Carcinoma (MAPPING)

Endometrial Cancer | Surgically Staged Endometrial and Cervical Carcinoma | Cervical Cancer: Invasive Disease, FIGO Stage 1B1 or Higher | Stage 1A With Myometrial Invasion or Any Higher Stage and Grade 3 | Stage 1A With Myometrial Invasion or Any Other Higher Stage and Serous Papillary or... and other conditions

United Kingdom
Icahn School of Medicine at Mount Sinai
Mayo Clinic; Baylor College of Medicine; Children's Hospital of Philadelphia; University... and other collaborators

Recruiting

Clinical and Basic Investigations Into Congenital Disorders of Glycosylation

Congenital Disorders of Glycosylation

United States
AstraZeneca
Parexel

Completed

Pharmacokinetics of Verinurad and Allopurinol in Combination With Cyclosporine and Rifampicin in Healthy Volunteers

Chronic Kidney Disease

Germany
Gilead Sciences
Galapagos NV

Completed

Study to Evaluate Organic Anion Transporting Polypeptide (OATP) Transporter-Mediated Drug-Drug Interactions Between Filgotinib and Statins as Probe Drugs in Healthy Participants

Rheumatoid Arthritis

United States
Janssen-Cilag International NV

Completed

A Study to Evaluate the Effect of Cyclosporine, a P-Glycoprotein, Breast Cancer Resistance Protein, and Organic-Anion-Transporting Polypeptide Inhibitor, on Pimodivir in Healthy Adults

Healthy

Belgium
Boehringer Ingelheim

Completed

Drug-drug Interaction (DDI) With a P-gp Inhibitor, Organic Anion Transporting Polypeptide OATP-inhibitor, Food Effect

Healthy

Germany
University of California, San Francisco

Withdrawn

Interplay Between Organic Anion Transporting Polypeptide (OATP) Transporters Transporters and CYP2C9 in Glyburide Pharmacokinetics (PK)

Healthy
Alexion

Completed

Potential Drug Interaction Between ALXN2040 and Rosuvastatin

Healthy Participants

United States
Shen Ning

Recruiting

A Pharmacokinetics Study of Meropenem and Piperacillin in Patients With Sepsis (APSOMAPIPWS)

Sepsis | Acute Kidney Injury

China
Changi General Hospital

Completed

The Threshold of Serum Anion Gap as a Screening Tool for Organic Acidosis

Critical Illness | Metabolic Acidosis | Anion Gap Acidosis | Lactic Acidosis | Keto Acidosis | Acid Base Disorder

Singapore
Chonbuk National University Hospital

Completed

Efficacy and Safety of Heme-Iron Polypeptide on Improvement of Anemia

Anemia

Korea, Republic of
Janssen-Cilag International NV

Completed

A Phase 1 Study to Evaluate the Effect of the Organic Anion Transporter Inhibitor Probenecid on the Pharmacokinetics of JNJ-64041575 in Healthy Adults

Healthy

Germany
Idorsia Pharmaceuticals Ltd.

Completed

Study to Assess the Efficacy and Safety of ACT-541468 (Daridorexant) in Adult and Elderly Subjects Suffering From Difficulties to Sleep

Insomnia Disorder

United States, Korea, Republic of, Germany, Belgium, Bulgaria, Canada, Czechia, Finland, France, Hungary, Sweden
University Hospital, Gentofte, Copenhagen

Recruiting

The Glucagonotropic Effects of Glucose-dependent Insulinotropic Polypeptide and Alanine in Healthy Individuals (GIPALANIN)

Effect of iv Administration of GIP and Alanine

Denmark
Owlstone Ltd

Recruiting

Assessment of Volatile Organic Compounds (VOC) for the Diagnosis of Invasive Aspergillosis (IA) in Lung Transplant Recipients (UHN)

Invasive Aspergillosis

Canada
University Hospital, Antwerp

Not yet recruiting

The Role of VOCs, Airway Mucins and Airway Microbiome in Bronchopulmonary Dysplasia (INFANCY)

Bronchopulmonary Dysplasia
Second Affiliated Hospital of Wenzhou Medical University

Recruiting

Application of MRD Combined With Personalized Vaccine in the Treatment of Postoperative Recurrence Prevention of EOC

Epithelial Ovarian Cancer

China
Michele Tinazzi, MD, PhD
Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona; IRCCS Ospedale...

Recruiting

Study of Biomorkers and Rehabilitation Strategies in Functional Motor Disorders (FMD)

Functional Motor Disorders

Italy
University Hospital, Gentofte, Copenhagen

Recruiting

The Involvement of the Gut Hormone GIP in the Pathophysiology of Post Prandial Hypotension (GA-21)

PostPrandial Hypotension

Denmark
Second Affiliated Hospital of Guangzhou Medical...

Not yet recruiting

Anti-cancer Neoantigen Polypeptide Vaccine to Treat Solid Tumors

Solid Tumor, Adult
University of Rostock
Prof. Dr. Daniel A. Reuter, Head of Department, Department of Anesthesiology... and other collaborators

Recruiting

Prognostic Value of Exhaled Isoprene Levels for Morbidity and Functional Outcome in Cardiosurgical Patients (PREDICT)

Muscle Weakness | Frailty | Volatile Organic Compounds | Isoprene

Germany
Imperial College London
Imperial College Healthcare NHS Trust

Recruiting

Volatile Organic Compounds as Breath Biomarkers in Squamous Oesophageal Neoplasms (ViSON)

Oesophageal Squamous Cell Carcinoma | Oesophageal Cancer

United Kingdom
University Hospital, Gentofte, Copenhagen
The Novo Nordisk Foundation Center for Basic Metabolic Research

Recruiting

The Effect of Glucose-dependent Insulinotropic Polypeptide on the Alpha Cell Response to Hypoglycaemia in Patients With Type 1 Diabetes (GIPHYPO)

Hypoglycemia | Type1diabetes | Type 1 Diabetes

Denmark
Bursa City Hospital

Not yet recruiting

Enteral Feeding of Premature Babies and Olive Oil Supplementation

Enteral Feeding | Premature | Olive Oil
Memorial Sloan Kettering Cancer Center
UNIVERSITY CAMPUS BIO-MEDICO, ITALY

Recruiting

Using E-Nose Technology to Measure Response to Treatment in People With Malignant Pleural Mesothelioma

Malignant Pleural Mesothelioma

United States
Alexandria University

Recruiting

Assessment of Nerve Damage Biomarkers in Acute and Chronic Organophosphate Toxicity

Nerve Degeneration | Neurotoxicity | Nerve Injury | Genotoxicity | Neuroinflammatory Response | Nerve Damage

Egypt
Hopital Foch

Recruiting

Analysis of Volatile Organic Compounds in Expired Air in Healthy Volunteers: Comparison of Three Mass Spectrometry Techniques for the Characterization of Volatolome in Clinical Studies (VOC-COMPARE)

Respiratory Disease

France
Virginia Polytechnic Institute and State University
Shady Grove Fertility Reproductive Science Center

Recruiting

The Effect of a Mindset Management Approach on Stress Levels in Women With Infertility

Stress | Infertility, Female

United States
Societa Italiana di Dermatologia Medica, Chirurgica...

Recruiting

Real-world Experience on the Use of Upadacitinib in the Treatment of Moderate-severe Adult Atopic Dermatitis (ERUDA) (ERUDA)

Atopic Dermatitis

Italy
University of Bern
DCB Research AG; Insel Gruppe AG, University Hospital Bern

Recruiting

The Daytime Circadian Rhythm in Exhaled Volatile Organic Compounds in People Living Without and Diabetes (VOCircle)

Diabetes Mellitus

Switzerland
Rambam Health Care Campus

Recruiting

VOC in Breath Samples for the Diagnosis of IPA

Invasive Pulmonary Aspergillosis | Volatile Organic Compounds | Breath Samples

Israel
Orygen
University of Melbourne; Youth Support and Advocacy Service

Recruiting

Guanfacine Extended-release for Adolescents With Cannabis Use (GRACE)

Cannabis Use Disorder

Australia
Ryazan State Medical University

Recruiting

Efficacy and Safety of the Regulatory Polypeptides in Patients With Peripheral Atherosclerosis.

Peripheral Arterial Occlusive Disease

Russian Federation
University of Virginia
National Institutes of Health (NIH); National Institute on Aging (NIA)

Recruiting

Organic Compounds and Postoperative Delirum

Identify Postoperative Delirium Using Exhaled Gas Patterns

United States

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