Search clinical trials for: Osteoclastogenesis inhibitor

Total 68019 results

Modern Biosciences Ltd
Covance

Completed

Safety and Tolerability Study of MBS2320 in Healthy Subjects and Subjects With Rheumatoid Arthritis

Arthritis, Rheumatoid

United Kingdom
Gruppo Oncologico Italiano di Ricerca Clinica

Recruiting

AGNOSTIC THERAPY IN A PHASE II SINGLE-ARM STUDY IN FIRST-LINE TREATMENT OF DURVALUMAB IN ASSOCIATION WITH CARBOPLATIN OR CISPLATIN AND ETOPOSIDE IN PATIENTS AFFECTED BY EXTENSIVE STAGE - EXTRAPULMONARY SMALL CELL CARCINOMA (DURVASCC)

Extrapulmonary Small Cell Carcinoma

Italy
Milton S. Hershey Medical Center
Aminex Therapeutics, Inc.

Not yet recruiting

Difluoromethylornithine (DFMO) and AMXT-1501 for Neuroblastoma, CNS Tumors, and Sarcomas

Ewing Sarcoma | Embryonal Tumor With Multilayered Rosettes | Osteosarcoma Recurrent | Atypical Teratoid/Rhabdoid Tumor | DIPG Brain Tumor | Neuroblastoma Recurrent
Wuhan University

Not yet recruiting

A Real-World Study of Neoadjuvant/Conversion Therapy for Locally Advanced or Metastatic Gastric Cancer

Gastric Cancer

China
Nanjing IASO Biotechnology Co., Ltd.

Recruiting

A Phase III Study of Eque-cel in Subjects With Len-refractory RRMM (FUMANBA-03) (FUMANBA-03)

Multiple Myeloma

China
Pfizer

Not yet recruiting

A Study to Learn About the Study Medicine PF-07220060 Together With Letrozole Compared to Letrozole Alone in Women Post Menopause

Breast Cancer
Wen-huo Chen

Recruiting

Endovascular Treatment for Mild Ischemic Stroke Due to Acute Large Vessel Occlusion in the Anterior Circulation (Mild-MT)

Mild Stroke | Endovascular Treatment

China
Yunpeng Liu
CSPC Ouyi Pharmaceutical Co., Ltd.

Not yet recruiting

Irinotecan Hydrochloride Liposome Combined With Capecitabine and Lenvatinib in Patients With Biliary Tract Carcinoma

Biliary Tract Carcinoma

China
Genelux Corporation
Newsoara Biopharma Co., Ltd.

Not yet recruiting

Efficacy & Safety of Olvimulogene Nanivacirepvec and Platinum-doublet + Physician's of Choice Immune Checkpoint Inhibitor Compared With Docetaxel in NSCL Cancer (VIRO-25) ((VIRO-25))

Non-small Cell Lung Cancer Stage III | Non-small Cell Lung Cancer | Advanced Non-squamous Non-small-cell Lung Cancer | Non-small Cell Lung Cancer Stage IV | Metastatic Squamous Non-Small Cell Lung Carcinoma | Non-small Cell Lung Cancer Recurrent | Metastatic Non-squamous Non Small Cell Lung Cancer and other conditions
The First Affiliated Hospital of Henan University...

Not yet recruiting

Adebrelimab in Combination With Apatinib and Chemotherapy/Chemoradiotherapy in Immuno-experienced Second-line ESCC.

Esophageal Cancer

China
University of Sao Paulo
University of Campinas, Brazil; Faculdade de Medicina do ABC

Recruiting

Use of Botulinum Toxin A in Direct Eyebrow Lift Scar

Skin Scarring | Eyebrow Ptosis

Brazil
Tianjin Medical University Cancer Institute and...

Not yet recruiting

Sonrotoclax, Zanubrutinib and CD20mab in Untreated MCL Patients

MCL
University Hospital, Strasbourg, France

Recruiting

Optimizing the Management of Sickle Cell Patients on Hydroxyurea: The Value of Therapeutic Pharmacological Monitoring (OPTIMDREP)

Sickle Cell Disease

France
Guangzhou Medical University

Not yet recruiting

Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid Tumors

Leptomeningeal Metastasis

China
Genentech, Inc.

Recruiting

A Study to Evaluate the Effect of Injection Site on PK of Astegolimab in Healthy Subjects

Healthy Volunteers

United States
Faeth Therapeutics
GOG Foundation

Not yet recruiting

Sapanisertib and Serabelisib (PIKTOR) With Paclitaxel, Serabelisib With Paclitaxel, and Paclitaxel Alone in Patients With Advanced/Recurrent Endometrial Cancer

Endometrial Cancer
AbbVie

Not yet recruiting

A Study to Assess Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Children From 2 to Less Than 12 Years of Age With Moderate to Severe Atopic Dermatitis (Start Up)

Atopic Dermatitis
Zhou Chengzhi
Guangdong Provincial Hospital of Traditional Chinese Medicine; Sun Yat-sen... and other collaborators

Not yet recruiting

Liposomal Irinotecan Combination Regimen for First-line Treatment of Small Cell Lung Cancer

Small Cell Lung Cancer
University of Melbourne
Monash University; University of Adelaide; University of Sydney; The University... and other collaborators

Not yet recruiting

PLatform for Adaptive Trials In Perinatal UnitS - [Core Protocol] (PLATIPUS)

Preterm Birth
Chengdu Baiyu Pharmaceutical Co., Ltd.

Recruiting

A Phase l Study of By101298, an Oral DNA-PK Inhibitor, in Patients With Advanced Solid Tumors

Solid Tumor, Adult

China
CytomX Therapeutics
Merck Sharp & Dohme LLC

Not yet recruiting

First In Human Study of CX-801 in Advanced Solid Tumors

Solid Tumor, Adult

United States
Guangzhou University of Traditional Chinese Medicine
Jiangsu Province Hospital of Traditional Chinese Medicine; The First Affiliated...

Not yet recruiting

Acupuncture for Enhancing Immunotherapy in Advanced NSCLC：a Pilot Study

Non-small Cell Lung Cancer | Non-Small-Cell Lung Carcinoma

China
Chen Xiaoping

Recruiting

Precision Treatment of Unresectable HCC Guided by Multi-omics Deep Learning Models

HCC | Precision Therapy

China
Guangzhou Medical University

Not yet recruiting

Sacituzumab Govitecan and Intrathecal Chemotherapy for Treating Leptomeningeal Metastases From Her2-negative Breast Cancer

Leptomeningeal Metastases
Stanford University
Janssen, LP

Not yet recruiting

Talquetamab & Lenalidomide as Post Stem Cell Transplant Maintenance in Multiple Myeloma

Multiple Myeloma | Post Stem Cell Transplant

United States
Zai Lab (Hong Kong), Ltd.

Recruiting

A Study to Compare the Effect of Omadacycline Versus Moxifloxacin in Healthy Adult Volunteers

Healthy Volunteer

China
Shanghai Yueyang Integrated Medicine Hospital

Not yet recruiting

Clinical Study of Trilinolein Cream for Prevention of Relapse in Remission of Moderate-to-severe Atopic Dermatitis.

Atopic Dermatitis
Merck Sharp & Dohme LLC
GOG Foundation; European Network of Gynaecological Oncological Trial Groups...

Not yet recruiting

A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)

Cervical Cancer
Assiut University

Not yet recruiting

Serum Cystatin C for Early Detection of Acute Kidney Injury After Primary Percutaneous Coronary Intervention

Acute Kidney Injury
Merck Sharp & Dohme LLC

Not yet recruiting

A Study of MK-6837 as a Monotherapy and Combination Therapy in Participants With Advanced/Metastatic Solid Tumors (MK-6837-001)

Neoplasm Metastasis
Lee's Pharmaceutical Limited

Not yet recruiting

Phase III Study of Socazolimab as First-Line Treatment in Persistent, Recurrent, or Metastatic Cervical Cancer

Cervical Cancer
Merck Sharp & Dohme LLC

Not yet recruiting

Bomedemstat vs Hydroxyurea for Essential Thrombocythemia (MK-3543-007)

Essential Thrombocythemia
Shanghai Chest Hospital
Novartis; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; BeiGene

Not yet recruiting

Trametinib Plus Anlotinib Combined With Tislelizumab in KRAS-mutant NSCLC

KRAS Mutation-Related Tumors | Advanced Lung Cancer | Refractory Tumor

China
Memorial Sloan Kettering Cancer Center
TransThera Sciences

Recruiting

A Study of Tinengotinib (TT-00420) in Combination With Standard Treatments in People With Prostate Cancer

Prostate Cancer

United States
Coherus Biosciences, Inc.

Not yet recruiting

A Study of Toripalimab in Combination With Cisplatin and Gemcitabine in Participants With Recurrent Metastatic Nasopharyngeal Cancer (TRANSPARENT)

Nasopharyngeal Cancer Recurrent
Kocaeli City Hospital
Health Institutes of Türkiye (TUSEB)

Not yet recruiting

Effect of Sevoflurane and Desflurane on Heme Oxygenase-1 Expression in Elective Cholecystectomy

Cholecystitis, Chronic

Turkey
Alexandria University
Tanta University

Recruiting

Impact of Curcumin and Pentoxiphylline on Chronic Kidney Disease Patients (CKD)

Chronic Kidney Disease

Egypt
Stemline Therapeutics, Inc.

Not yet recruiting

A Study of Tagraxofusp in Combination With Venetoclax and Azacitidine in Adults With Untreated CD123+ Acute Myeloid Leukemia Who Cannot Undergo Intensive Chemotherapy

Acute Myeloid Leukemia

United States
Ningbo No. 1 Hospital

Recruiting

First-line Treatment of PCNSL With the Combination of Orelabrutinib, Rituximab, and Methotrexate (ORM Regimen)

Primary Central Nervous System Lymphoma

China
Yongyong MA

Recruiting

Daratumumab/Daratumumab and Hyaluronidase-fihj in Combination With Pomalidomide and Dexamethasone for the Treatment of Patients With Newly Diagnosed AL Amyloidosis: a Prospective, Multicenter, Single-arm Study

Amyloid Light-chain Amyloidosis

China
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

Markers of Favorable Response to Complement Inhibitors Therapy (OPTIMISE)

Myasthenia Gravis, Generalized

Italy
Jilin University

Not yet recruiting

Efficacy of Upadacitinib After NECS in Vitiligo

Vitiligo
Peking Union Medical College Hospital

Recruiting

Orelabrutinib Combined With Obinutuzumab and Lenalidomide (OGL Regimen) as First-line Treatment for Marginal Zone Lymphoma.

Marginal Zone Lymphoma

China
Fujian Cancer Hospital
Zhangzhou Municipal Hospital of Fujian Province

Recruiting

Nituzumab Plus Serplulimab Combined With SBRT in Cervical Cancer

Cervical Cancer

China
Fudan University

Recruiting

Short-course Radiotherapy Combined With CapeOx and PD-1 Inhibitor After Local Excision for High-risk Early Rectal Cancer (TORCH-LE)

Rectal Cancer

China
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Gemcitabine and Leflunomide in Patients With Advanced Unresectable Pancreatic Cancer

Stage III Pancreatic Cancer AJCC v8 | Stage IV Pancreatic Cancer AJCC v8 | Advanced Pancreatic Adenocarcinoma | Unresectable Pancreatic Ductal Adenocarcinoma

United States
CARE ARTHRITIS LTD.

Not yet recruiting

A Study to Evaluate the Impact of Upadacitinib on Spondyloarthritis Outcomes in Patients With Active Psoriatic Arthritis (UP-SPOUT)

Psoriatic Arthritis | Spondyloarthritis, Axial
Tianjin Medical University Cancer Institute and...

Not yet recruiting

Phase Ib/II Clinical Study of Adebrelimab in Combination With Decitabine, Albumin-bound Paclitaxel, and Gemcitabine for the First-line Treatment of Metastatic Pancreatic Cancer

Metastatic Pancreatic Cancer | Decitabine | Adebrelimab (SHR-1316)

China
City of Hope Medical Center
National Cancer Institute (NCI)

Not yet recruiting

Regorafenib in Combination With Venetoclax and Azacitidine for the Treatment of Patients With Relapsed or Refractory Acute Myeloid Leukemia

Recurrent Acute Myeloid Leukemia | Recurrent Myelodysplastic Syndrome | Refractory Acute Myeloid Leukemia | Refractory Myelodysplastic Syndrome | Myelodysplastic Syndrome/Acute Myeloid Leukemia

United States
Qilu Hospital of Shandong University

Recruiting

Adjuvant Adebrelimab Plus Apatinib for Participants With HCC at High-risk of Recurrence After Curative Resection

Carcinoma, Hepatocellular

China

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