Search clinical trials for: PDE4 inhibition

Total 1273 results

NMP Medical Research Institute

Completed

Homeopathy as an Adjuvant to Chemotherapy Improves Clinical Outcome in Relapsed Pulmonary Tuberculosis

Pulmonary Tuberculosis

India
Assiut University

Unknown

Assessment of Early Outcomes of Roflumilast in Patients With Non Cystic Fibrosis Bronchiectasis

Bronchiectasis
Pfizer

Completed

A Study To Evaluate the Safety, Tolerability, And Pharmacokinetics Of PF-06266047 In Healthy Adult Subjects

Healthy Volunteers

Belgium
Tianjin Hemay Pharmaceutical Co., Ltd

Completed

Efficacy and Safety Study of Hemay005 in Subjects With Moderate to Severe Plaque Psoriasis

Psoriasis

China
GlaxoSmithKline

Completed

A Repeat Dose Study in Healthy Volunteers Investigating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of GSK356278

Huntington Disease

Netherlands
Chiesi Farmaceutici S.p.A.

Completed

A Study to Evaluate the Efficacy After Allergen Challenge, Safety and Tolerability of Inhaled CHF6001 DPI in Asthmatics (CHF6001_POC2)

Asthma

United Kingdom
Icahn School of Medicine at Mount Sinai
Pfizer

Recruiting

PDE4 Inhibition in Seborrheic Dermatitis and Papulopustular Rosacea

Seborrheic Dermatitis | Papulopustular Rosacea

United States
NHS Greater Glasgow and Clyde

Completed

Immune Metabolic Associations in Psoriatic Arthritis (IMAPA)

Psoriasis | Psoriatic Arthritis

United Kingdom
Chiesi Farmaceutici S.p.A.

Completed

A 24-wk Dose Ranging Study to Evaluate the Efficacy and Safety of 4 Doses of a New PDE4 Inhibitor in Patients With COPD (PIONEER)

Chronic Obstructive Pulmonary Disease
Amgen

Completed

Safety and Efficacy Study of Apremilast to Treat Psoriatic Arthritis

Psoriatic Arthritis

Spain, Canada, United States, Czechia, Russian Federation, Hungary, Australia, New Zealand, Estonia, Romania
GlaxoSmithKline

Completed

Topical GW842470X In Adults Patients With Moderate Atopic Dermatitis

Dermatitis, Atopic | Atopic Dermatitis

Germany, Netherlands
National Institute of Mental Health (NIMH)

Completed

Antidepressant Effects on cAMP Specific Phosphodiesterase (PDE4) in Depressed Patients

Healthy | Major Depressive Disorder

United States
Chiesi Farmaceutici S.p.A.

Recruiting

Efficacy and Safety of Tanimilast in Asthmatics uNcontrolled on ICS-containinG backgrOund Maintenance Therapy (TANGO)

Uncontrolled Asthma

Argentina, Bulgaria, Czechia, Georgia, Germany, Hungary, Italy, Korea, Republic of, Latvia, Lithuania, Poland, Romania, South Africa, Spain
Arcutis Biotherapeutics, Inc.

Completed

Trial of PDE4 Inhibition With Roflumilast for the Management of Plaque Psoriasis (DERMIS-1)

Chronic Plaque Psoriasis

United States, Canada
Arcutis Biotherapeutics, Inc.

Completed

Trial of PDE4 Inhibition With Roflumilast for the Management of Atopic Dermatitis (Integument-PED)

Atopic Dermatitis Eczema

United States, Canada
Arcutis Biotherapeutics, Inc.

Completed

Trial of PDE4 Inhibition With Roflumilast for the Management of Atopic Dermatitis (INTEGUMENT-I)

Atopic Dermatitis Eczema

United States, Canada
Arcutis Biotherapeutics, Inc.

Completed

Trial of PDE4 Inhibition With Roflumilast for the Management of Atopic Dermatitis (INTEGUMENT-II)

Atopic Dermatitis Eczema

United States, Canada
Chiesi Farmaceutici S.p.A.

Recruiting

A 52-week, Placebo-controlled Study to Evaluate the Efficacy and Safety of 2 Doses of CHF6001 DPI (Tanimilast), as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis (PILASTER) (PILASTER)

Chronic Obstructive Pulmonary Disease

Bulgaria, United States, Albania, Argentina, Australia, Austria, Bosnia and Herzegovina, Chile, China, Czechia, Georgia, Germany, Greece, Hungary, Israel, Italy, Mexico, Netherlands, New Zealand, North Macedonia, Poland, Romania, Russian... and more
Arcutis Biotherapeutics, Inc.

Completed

Twin Trial of PDE4 Inhibition With Roflumilast for the Management of Plaque Psoriasis (DERMIS-2)

Chronic Plaque Psoriasis

United States, Canada
Duke University
Pfizer

Completed

Pilot Study Evaluating the Efficacy of a Topical PDE4 Inhibitor for Morphea

Morphea

United States
Chiesi Farmaceutici S.p.A.

Recruiting

A 52-week, Placebo- and Active- Controlled (Roflumilast, Daliresp® 500µg) Study to Evaluate the Efficacy and Safety of Two Doses of CHF6001 DPI (Tanimilast) as add-on to Maintenance Triple Therapy in Subjects With COPD and Chronic Bronchitis. (PILLAR) (PILLAR)

Chronic Obstructive Pulmonary Disease

Bulgaria, United States, Argentina, Austria, Bosnia and Herzegovina, Chile, Croatia, Czechia, Estonia, Germany, Greece, Hungary, Israel, Latvia, Mexico, Netherlands, New Zealand, North Macedonia, Poland, Romania, Russian Federation and more
Tufts Medical Center
Celgene Corporation

Completed

Study of Apremilast in Atopic or Contact Dermatitis

Atopic Dermatitis | Allergic Contact Dermatitis

United States
Arcutis Biotherapeutics, Inc.

Completed

Trial of PDE4 Inhibition With Roflumilast (ARQ-154) Foam 0.3% for the Management of Seborrheic Dermatitis (STRATUM)

Seborrheic Dermatitis

United States, Canada
Arcutis Biotherapeutics, Inc.

Completed

Open-Label Extension Trial of PDE4 Inhibition With Roflumilast for the Management of Plaque Psoriasis (DERMIS-OLE)

Chronic Plaque Psoriasis

United States, Canada, Dominican Republic
Arcutis Biotherapeutics, Inc.

Active, not recruiting

Open Label Extension Trial of PDE4 Inhibition With Roflumilast for the Management of Atopic Dermatitis (INTEGUMENT-OLE)

Atopic Dermatitis Eczema

United States, Canada
Maastricht University
Netherlands Brain Foundation

Completed

Roflumilast to Treat Cognitive Sequela After Stroke (ROSTMEMA)

Cerebrovascular Disorders | Functional Recovery | Memory | Drug Intervention

Netherlands
Maastricht University Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development

Completed

Roflumilast and Cognition (EEGrofl)

Dementia

Netherlands
Maastricht University Medical Center

Recruiting

Cognitive Effects of Roflumilast in (a)MCI and Mild Dementia Patients (ROMEMA)

Mild Cognitive Impairment | Mild Dementia | Amnestic Mild Cognitive Disorder

Netherlands
Ganzhou Hemay Pharmaceutical Co., Ltd

Recruiting

A Study of Efficacy and Safety of Hemay005 Tablets in Patients With Behçet's Disease

Behçet's Disease

China
Tianjin Hemay Pharmaceutical Co., Ltd

Terminated

A Study to Evaluate the Efficacy and Safety of Hemay005 in the Treatment of Behçet Disease

Behçet Disease

China
National Institute of Mental Health (NIMH)

Completed

PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of McCune-Albright Syndrome

Nervous System Disease

United States
Assistance Publique - Hôpitaux de Paris
Société de Dermatologie Française

Completed

Assessing the Long Term Effectiveness and Safety of Systemic Treatments in Cutaneous Psoriasis (PSOBIOTEQ)

Psoriasis

France
GlaxoSmithKline

Completed

Healthy Volunteer Positron Emission Tomography (PET) Brain Occupancy Study of a Phosphodiesterase 4 (PDE4) Inhibitor in Huntington's Disease

Huntington Disease

United Kingdom
Astellas Pharma Inc

Completed

A Proof-of-principle Study of Oral Treatment of Non-alcoholic Steatohepatitis With a Novel PDE4 Inhibitor ASP9831 (ASTER)

Non-Alcoholic Steatohepatitis

United Kingdom, Belgium, Switzerland, Germany, France, Romania, Czech Republic
Vertex Pharmaceuticals Incorporated

Not yet recruiting

A Microneurography Study of NaV1.8 Inhibition in Healthy Adults

Pain
University of Reading
INNOPURE

Recruiting

The Effects of Vitamin B6 Supplementation on Pain Thresholds and Tolerance

Pain

United Kingdom
Riphah International University

Recruiting

Effect of Superficial Back Line Relaxation Technique on Hamstring Flexibility in Non Specific Low Back Pain Patients

Low Back Pain, Mechanical | Hamstring Flexibility

Pakistan
Riphah International University

Recruiting

Effects of Sub Occipital Muscle Inhibition Technique in Mechanical Low Back Pain

Mechanical Low Back Pain

Pakistan
Chulalongkorn University

Not yet recruiting

"Quick-starting" of a Quadriphasic Contraceptive Pills, 1 - 3 mg Estradiol Valerate/ 2 - 3 mg Dienogest VS 20 mcg Ethinylestradiol/75 mcg Gestodene Focusing on Ovulation Inhibition

Ultrasound Finding: Ovulation Inhibition, Ovarian Activities | Cervical Mucus | Serum Hormonal Profile
Chulalongkorn University

Not yet recruiting

"Quick-starting" of a New Combined Hormonal Contraceptive Pills, 15 mg Estetrol/3 mg Drospirenone VS 20 mcg Ethinylestradiol/75 mcg Gestodene Focusing on Ovulation Inhibition

Ultrasound Finding: Ovulation Inhibition, Ovarian Activities | Cervical Mucus | Serum Hormonal Profile
Fundació Sant Joan de Déu
Instituto de Salud Carlos III

Recruiting

Precursors of Binge Eating Disorder in a Clinical Sample of Adolescents With Obesity (PREC-BED)

Obesity | Binge-Eating Disorder | Emotion Regulation | Eating Disorders | Food Addiction | Other Specified Feeding or Eating Disorder | Eating Disorder Nos | BED

Spain
Amsterdam UMC, location VUmc
Maastricht University Medical Center; Erasmus Medical Center; St. Antonius Hospital

Not yet recruiting

Neoadjuvant Triple Treatment for Borderline Resectable Pancreatic Cancer (PREOPANC-5) (PREOPANC-5)

Borderline Resectable Pancreatic Cancer
University of Minnesota

Not yet recruiting

How Does Cerebellar tDCS Alter Intracortical Inhibition Over Time?

Stroke
Jord Vink

Not yet recruiting

Interaction Between the Brain Hemispheres - Key to Motor Recovery After Stroke (InterAct)

Stroke

Netherlands
Haaglanden Medical Centre
Takeda; Leiden University Medical Center

Not yet recruiting

Complement Inhibition: Attacking the Overshooting Inflammation @Fter Subarachnoid Hemorrhage (CIAO@SAH) (CIAO@SAH)

Subarachnoid Hemorrhage, Aneurysmal
Ann & Robert H Lurie Children's Hospital of Chicago

Not yet recruiting

Mechanisms of SGLT2 Inhibition in Pediatric Steatotic Liver Disease (SHIELD)

Non-Alcoholic Fatty Liver Disease
GRI Bio Operations, Inc.

Recruiting

Biomarker Modulation and the Inhibition of NKT1 Cells by Oral GRI-0621 in Patients With IPF

Idiopathic Pulmonary Fibrosis

United States
Children's Hospital Medical Center, Cincinnati

Not yet recruiting

ADHD PreSMA Response Inhibition Therapy

Attention Deficit Hyperactivity Disorder
University College, London
Novartis; Cancer Research UK; Janssen Pharmaceutica NV

Not yet recruiting

A Randomised Controlled Platform Trial Testing Treatments in Metastatic Hormone Sensitive Prostate Cancer (STAMPEDE2)

Prostate Cancer Metastatic
University of Washington
Washington State University

Not yet recruiting

Single-Dose Pharmacokinetics of Oral Testosterone Undecanoate With and Without Concomitant Inhibition of UGT2B17 (OralT12)

Hypogonadism, Male

Search clinical trials for: PDE4 inhibition

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