Search clinical trials for: Bempedoic Acid

Total 23808 results

Otsuka Pharmaceutical Co., Ltd.

Completed

A Dose-finding Trial of ETC-1002(Bempedoic Acid) in Patients With Hypercholesterolemia

Hypercholesterolemia

Japan
Esperion Therapeutics, Inc.

Completed

A Study Evaluating the Safety and Efficacy of Bempedoic Acid Plus Ezetimibe Fixed-Dose Combination Compared to Bempedoic Acid, Ezetimibe, and Placebo in Patients Treated With Maximally Tolerated Statin Therapy

Hyperlipidemias

United States
Esperion Therapeutics, Inc.

Recruiting

Bempedoic Acid Pregnancy Surveillance Program

Pregnancy | Hyperlipidemias

United States
Esperion Therapeutics, Inc.

Recruiting

Milk-Only Lactation Study to Evaluate the Concentration of Bempedoic Acid and Bempedoic Acid/Ezetimibe Fixed Combination Drug Product (FCDP) in the Breast Milk of Healthy Lactating Women

Healthy Lactating Women

United States
Nestlé

Completed

Safety and Efficacy of Addition of Structured Lipids in Starter Formulas

Healthy Newborn Infants
Otsuka Pharmaceutical Co., Ltd.

Completed

A Confirmatory Trial of ETC-1002 in Patients With Hyper-LDL Cholesterolemia

Hyper-low-density Lipoprotein (LDL) Cholesterolemia

Japan
Medanta, The Medicity, India
Diabetes & Endocrinology Foundation

Recruiting

Effect of Bempedoic Acid on Liver Fat in Individuals With Nonalcoholic Fatty Liver Disease and Type 2 Diabetes (B-LIFT)

Type 2 Diabetes | Non Alcholic Fatty Liver Disease

India
Esperion Therapeutics, Inc.

Completed

Assessment of the Long-Term Safety and Efficacy of Bempedoic Acid (CLEAR Harmony OLE)

Hypercholesterolemia | Atherosclerotic Cardiovascular Disease

United States
Otsuka Pharmaceutical Co., Ltd.

Active, not recruiting

A Long-term Trial of ETC-1002 in Patients With Hyper-LDL Cholesterolemia

Hyper-low-density Lipoprotein (LDL) Cholesterolemia

Japan
Esperion Therapeutics, Inc.
The Cleveland Clinic

Completed

Evaluation of Major Cardiovascular Events in Participants With, or at High Risk for, Cardiovascular Disease Who Are Statin Intolerant Treated With Bempedoic Acid (ETC-1002) or Placebo (CLEAR Outcomes)

Cardiovascular Diseases | Statin Adverse Reaction

Belgium, Germany, United States, Austria, Estonia, Mexico, New Zealand, Spain, Russian Federation, Netherlands, Hungary, Australia, Denmark, South Africa, United Kingdom, Bulgaria, Argentina, Romania, Turkey, Croatia, Serbia, Canada, Lithuan... and more
Esperion Therapeutics, Inc.

Completed

Evaluation of Long-Term Safety and Tolerability of ETC-1002 in High-Risk Patients With Hyperlipidemia and High CV Risk (CLEAR Harmony)

Hypercholesterolemia | Atherosclerotic Cardiovascular Diseases

United States, United Kingdom, Germany, Poland, Netherlands, Canada
Esperion Therapeutics, Inc.

Completed

Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) in Patients With Hyperlipidemia and Statin Intolerant (CLEAR Serenity)

Hypercholesterolemia | Atherosclerotic Cardiovascular Disease | Statin Adverse Reaction

United States, Canada
University of Salerno

Not yet recruiting

Efficacy and Safety of Bempedoic Acid in Association With Anti-PCSK9 and Ezetimibe in Statin-intolerant Patients (BESAFE)

Cardiovascular Diseases | Dyslipidemias | Lipid Metabolism Disorders | Statin Adverse Reaction
Kaiser Permanente
Esperion Therapeutics, Inc.

Not yet recruiting

Cholesterol Lowering Via Bempedoic Acid/Ezetimibe, an ACL-Inhibiting Regimen in Acute Coronary Syndrome Study

Cardiovascular Diseases | STEMI | NSTEMI

United States
Esperion Therapeutics, Inc.

Completed

Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) as Add-on to Ezetimibe Therapy in Patients With Elevated LDL-C (CLEAR Tranquility)

Atherosclerosis | Hypercholesterolemia | Statin Adverse Reaction

United States
Esperion Therapeutics, Inc.

Completed

Evaluation of Long-Term Efficacy of Bempedoic Acid (ETC-1002) in Patients With Hyperlipidemia at High Cardiovascular Risk (CLEAR Wisdom)

Hypercholesterolemia | Atherosclerotic Cardiovascular Disease

United States
Esperion Therapeutics, Inc.

Completed

Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) 180mg When Added to PCSK9 Inhibitor Therapy

Hypercholesterolemia

United States
Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company

Recruiting

Treatment With Bempedoic Acid and/or Its Fixed-dose Combination With Ezetimibe in Primary Hypercholesterolemia or Mixed Dyslipidemia (MILOS)

Hypercholesterolemia | Mixed Dyslipidemia

Austria, United Kingdom, Italy, Germany, Belgium
Jena University Hospital

Not yet recruiting

Intensive Lipid-lowering in Patients With STEMI and NSTEMI (Germany on Target) (GoT)

ST Elevation Myocardial Infarction | Non-ST Elevation Myocardial Infarction | LDL-cholesterol

Germany
Esperion Therapeutics, Inc.

Recruiting

A Phase 2 Clinical Study in Children With HeFH Aged 6 to 17 Treated Once Daily With Bempedoic Acid Oral Dosing (CLEAR Path 1)

Hypercholesterolemia

United States, Spain, Denmark, Canada, Netherlands, Germany
Priscilla Hsue, MD
Massachusetts General Hospital; University of California, Los Angeles

Recruiting

Cholesterol and Inflammation Lowering Via Bempedoic Acid, an ACL-inhibiting Regimen in HIV Trial (CLEAR HIV Trial)

Cardiovascular Diseases | HIV Infections | Atherosclerosis | Dyslipidemias

United States
Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company

Withdrawn

Treatment With Bempedoic Acid And/Or Its Fixed-dose Combination With Ezetimibe in Routine Clinical Practice in Patients With Primary Hypercholesterolemia Or Mixed Dyslipidemia (MILOS-Spain)

Mixed Dyslipidemia | Primary Hypercholesterolemia
Esperion Therapeutics, Inc.

Completed

Bempedoic Acid + Ezetimibe Fixed-Dose Combination (FDC) Study in Patients With Type 2 Diabetes and Elevated LDL-C

Diabetes Mellitus, Type 2 | Diabetes | Cholesterolemia

United States
Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
Daiichi Sankyo Germany

Completed

SurveY Followed by a Retrospective Chart Review to Describe the Key Factors Leading to Physician's Decision to Treat Patients at High and Very High Cardiovascular Risk With hyperchOlesterolemia or Mixed Dyslipidemia With NUSTENDI®

Hypercholesterolemia | Mixed Dyslipidemia

Germany
Esperion Therapeutics, Inc.

Completed

Evaluation of the Efficacy and Safety of Bempedoic Acid (ETC-1002) 180mg, Ezetimibe 10mg, and Atorvastatin 20 mg Triplet Therapy in Patients With Elevated LDL-C

Hypercholesterolemia

United States
Esperion Therapeutics, Inc.

Completed

A Study Of Pharmacokinetics, Pharmacodynamics And Safety Of Adding ETC-1002 To Atorvastatin 80 mg

Hyperlipidemia

United States
Lindenwood University
NNB Nutrition

Completed

A Pilot Study to Determine the Bioavailability of Oral Beta-Aminoisobutyric Acid (BAIBA) Ingestion (BBA)

Absorption; Chemicals

United States
University of Toronto

Completed

Protein Requirements in Male and Female Endurance Athletes

Healthy | Increased Metabolic Requirement

Canada
Vedic Lifesciences Pvt. Ltd.

Completed

Clinical Study to Evaluate Safety and Efficacy of Amino Acid in Healthy Individuals

Safety and Efficacy

India
University of Toronto
Ajinomoto Co., Inc.

Completed

Protein Requirements In Active Female Populations

Healthy | Increased Metabolic Requirement
Galmed Medical Reserch

Completed

A Phase 1 Single and Multiple-Dose Study of Aramchol in Healthy Male Volunteers

Healthy

Israel
Mirum Pharmaceuticals, Inc.

Completed

Open Label, Continuation Study of Cholic Acid in Subjects With Inborn Errors of Bile Acid Synthesis

Bile Acid Synthesis Defect

United States
University of South Florida
National Cancer Institute (NCI); Children's Oncology Group

Completed

Glutamic Acid in Reducing Nerve Damage Caused by Vincristine in Young Patients With Cancer

Sarcoma | Lymphoma | Kidney Cancer | Leukemia | Neurotoxicity | Peripheral Neuropathy

United States
Institut de Médecine et d'Epidémiologie Appliquée...

Completed

Pharmacokinetic Study of the Association of Amoxicillin / Clavulanic Acid to Obese Adults (PHACO)

Obesity

France
University of British Columbia
Canadian Institutes of Health Research (CIHR)

Unknown

Lysine Metabolic Availability in Children

Children

Canada
Mirum Pharmaceuticals, Inc.
Children's Hospital Medical Center, Cincinnati

Completed

Compassionate Treatment of Patients With Inborn Errors of Bile Acid Metabolism With Cholic Acid

Cholestasis | Peroxisomal Disorders | Adrenoleukodystrophy | Zellweger Syndrome | Infantile Refsum's Disease

United States
University of Cincinnati
Children's Hospital Medical Center, Cincinnati

Terminated

Study of Bile Acids in Patients With Peroxisomal Disorders

Adrenoleukodystrophy | Zellweger Syndrome | Infantile Refsum's Disease | Bifunctional Enzyme Deficiency
Ohio State University Comprehensive Cancer Center
National Cancer Institute (NCI)

Completed

Omega-3 Supplementation in Prevention of Aromatase Inhibitor-Induced Toxicity in Patients With Stage I-III Breast Cancer

Breast Neoplasms | Arthralgia

United States
The Hospital for Sick Children

Terminated

A Physiological Study to Determine the Enteral Threonine Requirements in Infants Aged 1 to 6 Months (INFORALTHR)

Tracheoesophageal Fistula | Diaphragmatic Hernia | Surgical Infants on NG/NJ/J/G-tube Feeds | Pierre-Robin Syndrome

Canada
Mahidol University

Recruiting

Oral Branched-chain Amino Acid Supplementation for Decompensated Cirrhotic Patients

Decompensated Cirrhosis and Ascites

Thailand
Mendel Tuchman
Children's Hospital of Philadelphia; University of California, Los Angeles; Icahn... and other collaborators

Completed

Short-Term Outcome of N-Carbamylglutamate in the Treatment of Acute Hyperammonemia (STO)

Methylmalonic Acidemia | Carbamoyl-Phosphate Synthase I Deficiency Disease | Propionic Acidemia, Type I and/or Type II | Ornithine Carbamoyltransferase Deficiency

United States
The University of Texas Health Science Center at...
National Center for Advancing Translational Sciences (NCATS); IIMS-UT Health...

Not yet recruiting

Oral Intradialytic Amino Acid Supplementation to Vitalize End-stage Kidney Disease Patients on Hemodialysis (OASIS)

End Stage Renal Disease
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

Omega 3 Fatty Acids and ERPR(-)HER2(+/-) Breast Cancer Prevention

Breast Cancer

United States
Retina Foundation of the Southwest
DSM Nutritional Products, Inc.

Completed

Effect of Long-Chain Polyunsaturated Fatty Acid Supplementation on Toddler Cognition

Infant Development

United States
University Hospital, Basel, Switzerland

Completed

Effect of Bile Acids on the Secretion of Satiation Peptides in Humans

Echolocation

Switzerland
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Effect of Fish Oil Enriched In Omega-11 Fatty Acid On Lipoprotein Metabolism In Adults

Proteomics | Lipoprotein Metabolism | PCSK9

United States
University Hospital, Gentofte, Copenhagen
Novo Nordisk Foundation Center for Basic Metabolic Research, University of...

Not yet recruiting

The Glucagonotropic Effect of Amino Acids in Humans (STAMINA)

Healthy
University of British Columbia
Canadian Institutes of Health Research (CIHR)

Completed

Determining Total Aromatic Amino Acid Requirements in Pregnant Women

Pregnancy Related

Canada
The Cleveland Clinic

Recruiting

Study of HMB-enriched Amino Acid Supplementation in Patients With Alcoholic Liver Disease and COVID-19

Alcoholic Liver Disease | COVID 19 Pneumonia

United States
The Cleveland Clinic

Recruiting

Leucine Enriched Essential Amino Acid Mixture to Reverse Muscle Loss in Cirrhosis

Cirrhosis, Liver

United States

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