Search clinical trials for: Plasmodium mutants

Total 472 results

Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Recruiting

Phase IIa Proof of Concept Study of M5717-Pyronaridine in Adults and Adolescents With Acute Uncomplicated Plasmodium Falciparum Malaria (CAPTURE 1)

Acute Malaria

Burkina Faso, Gabon, Mozambique, Uganda
Bill & Melinda Gates Medical Research Institute

Not yet recruiting

Study To Evaluate Safety, Tolerability, and Pharmacokinetics of MAM01 in African Population

Healthy Volunteers

Kenya, Uganda
Merck Sharp & Dohme LLC

Recruiting

A Study to Evaluate Antimalarial Activity and Safety of MK-7602 in Healthy Adults (MK-7602-003)

Malaria

Australia
M.D. Anderson Cancer Center

Not yet recruiting

Phase I/II Study of a Combination of Decitabine and Cedazuridine (ASTX727) and ASTX029, an ERK Inhibitor, for Patients With RAS Pathway Mutant Myelodysplastic Syndromes and Myelodysplastic/Myeloproliferative Neoplasms

Myeloproliferative Neoplasm | Myelodysplastic Neoplasm | Pathway Mutant Myelodysplastic Syndromes

United States
MapKure, LLC

Recruiting

A Study to Investigate BGB-3245 (Brimarafenib) With Panitumumab in Participants With Advanced or Metastatic RAS Mutant Colorectal and Pancreatic Ductal Cancers

Colorectal Cancer | Pancreatic Ductal Cancer | Advanced or Metastatic RAS Mutant Colorectal and Pancreatic Ductal Cancers

United States
BioNTech SE

Recruiting

A Clinical Trial to Evaluate the Safety, Efficacy and Immune Responses After Vaccination With an Investigational RNA-based Vaccine Against Malaria

Malaria

United States
University of Oxford

Not yet recruiting

Mass Vaccine and Drug Administration, Bangladesh (MVDA)

Plasmodium Falciparum Malaria

Bangladesh
Institute of Tropical Medicine, Belgium
KU Leuven; Leiden University Medical Center; Barcelona Institute for Global Health and other collaborators

Recruiting

Host Immune and Metabolic Determinants of Sexual Conversion in Plasmodium Parasites IMMETASEX (IMMETASEX)

Uncomplicated Malaria | Severe Malaria | Asyptomatic Plasmodium Infection

Mozambique, Belgium, Burkina Faso
Jiangsu Pacific Meinuoke Bio Pharmaceutical Co Ltd

Not yet recruiting

Open-Label Study to Assess Meplazumab in Adult Patients Diagnosed With Plasmodium Falciparum

Malaria
Merck Healthcare KGaA, Darmstadt, Germany, an affiliate...

Recruiting

Efficacy, Safety, and PK of M5717 in Combination With Pyronaridine as Chemoprevention in Adults and Adolescents With Asymptomatic Plasmodium Falciparum Infection (CAPTURE-2)

Malaria Infection

Kenya, Burkina Faso, Gambia, Zambia
University of Oxford

Not yet recruiting

A Study to Find Out if a Combination of 3 Medicines for the Treatment of Malaria Works as Well and is as Safe and Tolerable as Combinations of 2 Medicines (FD-TACT)

Uncomplicated Plasmodium Falciparum Malaria
CAS Lamvac (Guangzhou) Biomedical Technology Co...
The Third Affiliated Hospital of Southern Medical University

Not yet recruiting

Plasmodium Immunotherapy for Advanced Ovarian Cancer

Advanced Ovarian Cancer

China
Zydus Lifesciences Limited

Not yet recruiting

A Study to Determine Safety, Tolerability, and Pharmacokinetics of Different Orally Administered Regimens of the Combination ZY19489-Ferroquine in Adult Asymptomatic Plasmodium Falciparum Carriers

Asymptomatic Condition | Falciparum Malaria | Uncomplicated Malaria
National Institute of Allergy and Infectious Diseases...

Recruiting

Study of the Plasmodium Vivax Transmission-blocking Vaccine Pvs230D1-EPA/Matrix-M to Assess Safety, Immunogenicity, and Transmission-blocking Activity in Healthy Malaria-naive Adults

Malaria

United States
London School of Hygiene and Tropical Medicine
Radboud University Medical Center; Groupe de Recherche Action en Sante

Recruiting

Understanding and Maximizing the Community Impact of Antimalarial Treatment (INDIE-SMC) (INDIE-SMC)

Malaria | Malaria,Falciparum

Burkina Faso
Novartis Pharmaceuticals
MMV, EDCTP, WANECAM

Recruiting

Efficacy, Safety and Tolerability of KLU156 in Adults and Children ≥ 5 kg Body Weight With Uncomplicated P. Falciparum Malaria (KALUMA)

Uncomplicated Plasmodium Falciparum Malaria

Congo, The Democratic Republic of the
King Faisal Hospital Rwanda

Not yet recruiting

Addressing Asymptomatic Plasmodium Reservoirs to Accelerate Malaria Elimination and Eradication in Rwanda.

Malaria,Falciparum
Shoklo Malaria Research Unit
Mahidol Oxford Tropical Medicine Research Unit

Recruiting

ACT vs CQ With Tafenoquine for P. Vivax Mono-infection (ACTQ)

Malaria | Malaria, Vivax | Plasmodium Vivax Malaria

Thailand
Muhimbili University of Health and Allied Sciences
Uppsala University; The Swedish Research Council

Not yet recruiting

Triple Artemisinin-based Combination Therapy for Delaying Drug Resistance Development - a Randomized Clinical Trial (3ACT)

Uncomplicated Plasmodium Falciparum Malaria

Tanzania
Novartis Pharmaceuticals

Recruiting

Platform Study to Evaluate the Efficacy and Safety of Anti-malarial Agents in Patients With Uncomplicated Plasmodium Falciparum Malaria (PLATINUM)

Uncomplicated Plasmodium Falciparum Malaria

Côte D'Ivoire, Kenya, Ghana, Uganda
National Institute of Allergy and Infectious Diseases...
University of Maryland, Baltimore; Makerere University

Recruiting

Pharmacokinetic Study of IV Artesunate to Treat Children With Severe Malaria

Plasmodium Falciparum Infection

Uganda
Johns Hopkins Bloomberg School of Public Health
Johns Hopkins University; University of Maryland; University of California, San... and other collaborators

Recruiting

Platelet-Directed Whole Blood Transfusion Strategy for Malaria (PLATFORM)

Thrombocytopenia | Severe Malaria

United States, Zambia
Nahda University

Recruiting

Evaluation of New Different Herbal Mouthwashes Against Caries Forming Bacteria, RCT

Dental Caries in Children

Egypt
Douglas Postels, MD, MS
National Institute of Allergy and Infectious Diseases (NIAID)

Recruiting

DON in Pediatric Cerebral Malaria

Malaria, Cerebral

Malawi
Université Catholique de Louvain

Not yet recruiting

Emptying Malaria Reservoirs to Accelerate Malaria Elimination in High Transmission Settings

Asymptomatic Malaria
University of Oxford

Recruiting

A Study of the Plasmodium Falciparum Malaria Vaccine Candidate Pfs48/45 in Matrix-M Adjuvant in the UK

Malaria | Plasmodium Falciparum

United Kingdom
National Institute of Allergy and Infectious Diseases...
National Institutes of Health (NIH); Centers for Disease Control and Prevention and other collaborators

Recruiting

Anti-malaria MAb in Kenyan Children

Malaria | Plasmodium Falciparum Infection

Kenya
University of North Carolina, Chapel Hill
Doris Duke Charitable Foundation

Recruiting

Permethrin-treated Baby-wraps for the Prevention of Malaria in Children

Malaria | P. Falciparum

Uganda
University of Oxford
Mahidol University

Not yet recruiting

A Safety, Immunogenicity and Efficacy Study of PvRII/Matrix-M in Healthy Thai Adults Living in Thailand ( MIST3 ) (MIST3)

Plasmodium Vivax Infection | Malaria Vaccine

Thailand
University of Oxford
European and Developing Countries Clinical Trials Partnership (EDCTP); Medical...

Recruiting

A Study to Assess the Experimental Malaria Vaccines RH5.2-VLP and R21

Malaria, Plasmodium Falciparum

Gambia
University of Yaounde 1
Biotechnology Center (BTC), University of Yaounde I, Cameroon; National Malaria... and other collaborators

Not yet recruiting

Efficacy and Safety of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine in Cameroon

Malaria
Centro de Investigação em Saúde de Manhiça
University of California, San Francisco; Barcelona Institute for Global Health and other collaborators

Recruiting

Plasmodium Falciparum Genomic Intelligence in Mozambique (GenMoz)

Malaria | Malaria in Pregnancy | Malaria,Falciparum

Mozambique
Macfarlane Burnet Institute for Medical Research...
National Centre for Parasitology, Entomology and Malaria Control, Cambodia; Health Poverty Action and other collaborators

Not yet recruiting

Reducing Malaria Transmission in Forest-going Mobile and Migrant Populations in Lao PDR and Cambodia

Plasmodium Infection
University of Oxford
Wellcome Trust

Recruiting

A Controlled Human Vivax Malaria Infection Study Through Inoculation of Infected Erythrocytes (MIST2)

Plasmodium Vivax Infection

Thailand
University of Dschang
Barcelona Institute for Global Health; University of Yaounde 1

Recruiting

Plasmodium Vivax Among Duffy Negative Population in Cameroon. (VIBRANT)

Malaria | Malaria, Vivax | Malaria,Falciparum

Cameroon
University of California, San Francisco
Centers for Disease Control and Prevention; University of Massachusetts, Amherst and other collaborators

Recruiting

Targeting High Risk Populations With Enhanced Reactive Focal Mass Drug Administration in Thailand (COMBAT)

Plasmodium Falciparum Malaria | Plasmodium Vivax Malaria

Thailand
Fundação de Medicina Tropical Dr. Heitor Vieira...
Bill and Melinda Gates Foundation; Conselho Nacional de Desenvolvimento Científico...

Recruiting

Study to Evaluate Primaquine for Radical Cure of Uncomplicated Plasmodium Vivax Malaria in Children (CHILDPRIM)

Malaria, Vivax

Brazil
Macfarlane Burnet Institute for Medical Research...
National Malaria Control Program, Myanmar; Health Poverty Action

Not yet recruiting

Reducing Malaria Transmission in Forest-going Mobile and Migrant Populations in Myanmar

Plasmodium Falciparum Infection
University of Yaounde 1
Biotechnology Center (BTC), University of Yaounde I, Cameroon; National Malaria... and other collaborators

Not yet recruiting

Efficacy and Safety of Artesunate-amodiaquine and Artemether-lumefantrine for the Treatment of Malaria in Cameroon

Falciparum Malaria
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors

Prognostic Stage IIIC Breast Cancer AJCC v8 | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Anatomic Stage IV Breast Cancer AJCC v8 | Prognostic Stage IV Breast Cancer AJCC v8 | Metastatic Melanoma | Stage IV Lung Cancer AJCC v8 | Locally Advanced Malignant Solid Neoplasm | Locally... and other conditions

United States
Malaria Vaccine and Drug Development Center

Not yet recruiting

Efficacy of a Synthetic Vaccine Derived From Plasmodium Vivax Circumsporozoite Protein (PvCS) in naïve and Semi-immune Volunteers

Malaria, Vivax

Colombia
University of Oxford
PATH

Not yet recruiting

Southeast Asia Dose Optimization of Tafenoquine (SEADOT)

Plasmodium Vivax Malaria

Cambodia, Lao People's Democratic Republic, Thailand, Vietnam
Novartis Pharmaceuticals
Wellcome Trust; European and Developing Countries Clinical Trials Partnership...

Recruiting

To Evaluate Efficacy, Safety, Tolerability and PK of Intravenous Cipargamin in Participants With Severe Plasmodium Falciparum Malaria

Severe Malaria

Burkina Faso, India, Rwanda, Congo, The Democratic Republic of the, Gabon, Nigeria, Côte D'Ivoire, Kenya
Novartis Pharmaceuticals
European and Developing Countries Clinical Trials Partnership (EDCTP)

Recruiting

Efficacy, Safety and Tolerability of KAF156 in Combination With Lumefantrine Solid Dispersion Formulation (LUM-SDF) in Pediatric Population With Uncomplicated Plasmodium Falciparum Malaria (KALUMI)

Uncomplicated Plasmodium Falciparum Malaria

Burkina Faso, Mali, Gabon
Centre de Recherche Médicale de Lambaréné
Leiden University Medical Center

Recruiting

Validation of INSPiRED Innovative Smart Diagnostic Devices for the Detection of Parasites Infections. (INSPiRED-WP3)

Performance | Sensitivity | Specificity | Testing

Gabon
University of California, San Francisco
Centers for Disease Control and Prevention; University of Massachusetts, Amherst and other collaborators

Recruiting

Targeting High Risk Populations With Enhanced Reactive Case Detection in Southern Lao Peoples Democratic Republic (COMBAT)

Plasmodium Falciparum Malaria | Plasmodium Vivax Malaria

Lao People's Democratic Republic
Menzies School of Health Research
Aga Khan University; University of Melbourne; Universitas Sumatera Utara; Ethiopian... and other collaborators

Recruiting

Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and Primaquine (EFFORT)

Vivax Malaria | Malaria, Vivax | Plasmodium Vivax | Malaria Relapse

Cambodia, Ethiopia, Indonesia, Pakistan
Memorial Sloan Kettering Cancer Center
AstraZeneca; Guardant Health, Inc.

Recruiting

Osimertinib Alone or With Chemotherapy for EGFR-Mutant Lung Cancers

Metastatic Non-small Cell Lung Cancer

United States
U.S. Army Medical Research and Development Command
Walter Reed Army Institute of Research (WRAIR)

Recruiting

A Trial For The Study of Falciparum Malaria Protein 014 Administered Via Intramuscular Injection in Healthy Adults

Vaccine Reaction

United States
U.S. Army Medical Research and Development Command
Walter Reed Army Institute of Research (WRAIR)

Recruiting

A Trial For The Study of Falciparum Malaria Protein 013 Administered Via Intramuscular Injection in Healthy Adults

Vaccine Reaction

United States

Search clinical trials for: Plasmodium mutants

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Malaysia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations