Search clinical trials for: Proof of mechanism study

Total 437633 results

Universiteit Antwerpen
McGill University; Aragon Institute of Health Sciences

Not yet recruiting

Comparative Study of the Mechanism of Action of Dry Needling and Botulinum Toxin Type A as a Treatment for Lower Limb Post-stroke Spasticity: a Proof of Concept Controlled Trial (STROKEPOC)

Stroke | Spasticity as Sequela of Stroke
National Taiwan University Hospital

Recruiting

A Proof-of-concept Study Evaluating the Microbiota-gut-brain Axis

Parkinson Disease

Taiwan
Novartis Pharmaceuticals

Recruiting

A Proof of Concept and Dose-finding Study of XXB750 in Patients With Heart Failure

Heart Failure

Italy, Spain, United States, Japan, Germany, Taiwan, Bulgaria, France, Portugal
AstraZeneca

Recruiting

A Study to Evaluate the Effect of Budesonide, Glycopyrronium, Formoterol Fumarate (BGF) Metered Dose Inhaler (MDI), Budesonide and Formoterol Fumarate (BFF) MDI and Placebo MDI on Exercise Parameters in Participants With Chronic Obstructive Pulmonary Disease (COPD). (ATHLOS)

Chronic Obstructive Pulmonary Disease

Germany, Spain, United States, China, Korea, Republic of, Argentina, United Kingdom, Canada
University of Calgary

Not yet recruiting

A Proof of Principle Study of Ondansetron for the Prevention of Vasovagal Syncope: The Eleventh Prevention of Syncope Trial (POST11) (POST 11)

Syncope | Vasovagal Syncope (VVS)

Canada
Austin Institute for Clinical Research

Recruiting

Proof of Concept Study to Access Superficial Basal Cell Carcinoma in Adults

Superficial Basal Cell Carcinoma

United States
Hoffmann-La Roche

Recruiting

Study to Investigate the Pharmacokinetics and Safety and to Provide Proof of Mechanism of Alogabat in Children and Adolescents Aged 5-17 Years With Angelman Syndrome (AS) With Deletion Genotype. (Aldebaran)

Angelman Syndrome

Australia, United States, Spain, Italy, France, Germany
Clinical Academic Center (2CA-Braga)

Not yet recruiting

Proof-of-concept Study to Evaluate the Safety and Efficacy of Tryptophan in Patients With BPH. (TryptoBPH)

BPH
Invicro

Recruiting

Proof of Mechanism Study to Evaluate Binding of Alfa-synuclein

Parkinson Disease | Healthy Volunteer | Multisystem Atrophy

United States
University Hospital, Toulouse

Recruiting

ASPirin in Immune thRombocytopenia Patients With Cardiovascular disEase (ASPIRE)

Purpura, Thrombocytopenic

France
Institut Bergonié
Bristol-Myers Squibb

Recruiting

Combination of Nivolumab Plus Relatlimab in Patients With Advanced or Metastatic Soft-tissue Sarcoma: a Proof-of-concept Randomized Phase II Study (CONGRATS)

Advanced Cancer | Soft Tissue Sarcoma Adult

France
National Institute of Allergy and Infectious Diseases...

Recruiting

An Open-Label, Proof of Consent Study of Vorinostat for the Treatment of Mdoerate-to-Severe Crohn s Disease and Maintenance Therapy With Ustekinumab

Crohn's Disease

United States
Massachusetts General Hospital
Brain & Behavior Research Foundation; J Willard and Alice S. Marriott Foundation

Recruiting

BezafibrateTreatment for Bipolar Depression: A Proof of Concept Study

Bipolar Disorder | Depressive Episode

United States
AstraZeneca

Active, not recruiting

Real-world, 52-week Prospective Study to Capture the Reasons for Switch to Triple Combination Therapy, Assess the Clinical and Patient Reported Outcomes in Adults With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) Treated With Trixeo Aerosphere™ in Routine Care Settings in Greece (TRIAENA)

Pulmonary Disease, Chronic Obstructive (COPD)

Greece
University Hospital, Clermont-Ferrand
Federation Francophone de Cancerologie Digestive

Completed

Donepezil for Oxaliplatin-induced Neuropathy Peripheral Neuropathy: Proof of Concept Study (DONEPEZOX)

Digestive Oncology | Supportive Care

France
Inventiva Pharma

Active, not recruiting

Placebo-controlled, Proof-of-concept Study to Evaluate the Safety and Efficacy of Lanifibranor Alone and in Combination With SGLT2 Inhibitor EmpaGliflozin in patiEnts With NASH and Type 2 Diabetes Mellitus (LEGEND)

Diabetes Mellitus, Type 2 | NASH - Nonalcoholic Steatohepatitis

United States, Belgium, France, Netherlands, United Kingdom
Yale University

Terminated

Vitamin D as a Therapeutic Adjunct in the Stimulant Treatment of ADHD: a Proof-of-concept Tele-health Study of Stimulant-induced Improvement in Neurocognitive Functioning.

ADHD

United States
Pacira Pharmaceuticals, Inc

Terminated

Proof of Concept Study Comparing FX006 to Kenalog®-40 in Patients With Post-Traumatic Osteoarthritis of the Knee

Post-traumatic Osteoarthritis of the Knee

United States
Shanghai Institute Of Biological Products
First Affiliated Hospital Bengbu Medical College

Completed

A Study Exploring Efficacy of Pegloticase in Subjects With Asymptomatic Hyperuricemia

Asymptomatic Hyperuricemia

China
Universitätsklinikum Hamburg-Eppendorf

Completed

Avoiding Postinduction Hypotension: the Clinical ZERO-HYPOTENSION Proof-of-concept Study

Hypotension | Anesthesia | Hypotension on Induction

Germany
University of California, Los Angeles
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Active, not recruiting

Proof of Mechanism Study for the Treatment of Social Anhedonia in ASD (ACEP4)

ASD

United States
Suven Life Sciences Limited

Completed

SUVN-502 With Donepezil and Memantine for the Treatment of Moderate Alzheimer's Disease- Phase 2a Study

Alzheimer's Disease

United States
Academisch Medisch Centrum - Universiteit van Amsterdam...

Terminated

Pre-operative Decitabine in Colon Cancer: a Proof of Principle Study (DECO)

Colon Cancer

Netherlands
Johnson & Johnson Consumer Inc., McNeil Consumer...

Completed

Naproxen Sodium/Acetaminophen Proof of Concept Dosing Study

Pain

United States
Sanofi
Regeneron Pharmaceuticals

Completed

Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of SAR440340 (Anti-IL-33 mAb) in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease

Ukraine, Argentina, Chile, Poland, Russian Federation, Turkey, United States, Australia, Canada, Germany
Gustave Roussy, Cancer Campus, Grand Paris
Innovative Therapies For Children with Cancer Consortium

Terminated

Study of Vinblastine in Combination With Nilotinib in Children, Adolescents, and Young Adults (VINILO)

Refractory Low-grade Gliomas | Recurrent Low-grade Gliomas

Austria, Italy, France, Denmark, Netherlands, Spain, Switzerland, United Kingdom
Kristian Kjær Petersen
Aalborg University Hospital; CCBR, Aalborg

Completed

A Mechanism Based Proof of Concept Study of the Effects of Duloxetine in the Treatment of Patients With Osteoarthritic Knee Pain

Osteoarthritis, Knee

Denmark
Chiesi Farmaceutici S.p.A.

Completed

Functional Respiratory Imaging Study (DARWiIN)

Chronic Obstructive Pulmonary Disease

Belgium, Hungary
Sunnybrook Health Sciences Centre

Completed

Nasal Photodisinfection COVID-19 Proof of Concept Study

COVID-19 | SARS-CoV 2 | Corona Virus Infection

Canada
Alexion Pharmaceuticals
Achillion, a wholly owned subsidiary of Alexion

Completed

A Proof-of-Mechanism Study to Determine the Effect of Danicopan on C3 Levels in Participants With C3G or IC-MPGN

C3 Glomerulopathy | C3 Glomerulonephritis | Dense Deposit Disease | Immune Complex Mediated Membranoproliferative Glomerulonephritis | Membranoproliferative Glomerulonephritis Types I, II, and III

Netherlands, Australia, Belgium
Azevan Pharmaceuticals
United States Department of Defense; Weill Medical College of Cornell University and other collaborators

Terminated

Proof-of-concept Study to Assess the Efficacy and Safety of SRX246 in Adults With PTSD

PTSD

United States
Novartis Pharmaceuticals

Completed

Proof of Concept Study Evaluating the Efficacy and Safety of MIJ821 in Patients With Treatment-resistant Depression

Depressive Disorder, Treatment-Resistant

Spain, United States
Novartis Pharmaceuticals

Terminated

A Proof-of-mechanism Study of Multiple, Oral Doses of Fevipiprant (QAW039) in COPD Patients With Eosinophilia

Chronic Obstructive Pulmonary Disease

Germany, United Kingdom
Phoenicis Therapeutics

Terminated

A Double-blind, Randomized, Intra-subject Placebo-controlled, Multicenter, Multiple Dose Study, Evaluating Safety, Proof of Mechanism, Preliminary Efficacy and Systemic Exposure in Subjects With Confirmed DDEB or RDEB Diagnosis With One or More Pathogenic Mutations in Exon 73 in the COL7A1 Gene

Epidermolysis Bullosa Dystrophica, Recessive | Epidermolysis Bullosa Dystrophica, Dominant

United States, Spain, France
GlaxoSmithKline

Completed

Proof of Mechanism Study of GSK2330811 in Diffuse Cutaneous Systemic Sclerosis

Scleroderma, Systemic

United States, United Kingdom, Netherlands, Canada
Baxalta now part of Shire

Terminated

First-in-Human and Proof-of-Mechanism Study of ARC19499 Administered to Hemophilia Patients

Hemophilia

United Kingdom
Thomas Jefferson University
Astellas Pharma Inc

Terminated

Mirabegron in Achalasia: A Clinical and Manometric Proof of Concept Pilot Study

Achalasia

United States
EmeraMed
NBMI Science AB

Completed

Pilot Proof of Concept Study of NBMI Treatment of Mercury Intoxication (NBMI)

Mercury Poisoning

Ecuador
Novartis Pharmaceuticals

Completed

Proof of Concept Study to Determine the Safety and Antiviral Effect of BZF961 With or Without Ritonavir Boosting in Hepatitis C Virus Infected Patients (CBZF961X2201)

Hepatitis C

United States
Unity Health Toronto
University of Toronto; Li Ka Shing Knowledge Institute

Unknown

Proof-of-Concept: A Pilot, Randomized, Double-Blind Study of Oseltamivir Versus Placebo for Immune Thrombocytopenia

Immune Thrombocytopenia

Canada
NYU Langone Health

Terminated

A Proof of Concept Study of the Prevention of Mild Cognitive Impairment and Eventual Alzheimer's Disease Using F18 Flutemetamol

Alzheimer Disease

United States
Cairo University

Unknown

Intravenous Tranexamic Acid Versus IV Carbetocin in Abdominal Myomectomy

Myomectomy
GlaxoSmithKline

Completed

A Proof of Mechanism Study With GSK2126458 in Patients With Idiopathic Pulmonary Fibrosis (IPF)

Idiopathic Pulmonary Fibrosis

United Kingdom
Gregory Jicha, 323-5550
University of Kentucky; Kentucky Alzheimer's Center

Completed

Valproic Acid in Subjects With Intact Cognition - Proof of Concept Study (VPA)

Alzheimer's Disease

United States
Centre Hospitalier Universitaire de Nice

Unknown

Acid-Sensing Ion Channel and Migraine Disease Proof of Concept Study on the Efficacy of Amiloride in the Prophylaxis of Migraine Aura (APAM)

Migraine With Aura

France
HaEmek Medical Center, Israel
AbbVie

Completed

Proof of Concept Study To Evaluate the Efficacy and Justification Of OBV/PTV/r and DSV In Adults With Chronic Hepatitis C Virus Genotype 2K/1B

HCV Coinfection

Israel
University of California, San Francisco
Novartis

Completed

Phase I Dose Finding and Proof-of-concept Study of Panobinostat With Standard Dose Cytarabine and Daunorubicin for Untreated Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome

Acute Myeloid Leukemia | Advanced Myelodysplastic Syndrome

United States
Boehringer Ingelheim

Completed

Alzheimer Disease Proof of Concept Study With BI 409306 Versus Placebo

Alzheimer Disease

United States, Spain, Canada, United Kingdom, Germany, Italy, Netherlands, Portugal, Austria, Belgium, France, Poland
Massachusetts General Hospital
Stanley Medical Research Institute

Completed

A Proof of Concept Study of Intravenous Sodium Nitroprusside in Adults With Symptomatic Schizophrenia

Schizophrenia

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...
National Cancer Institute (NCI)

Completed

Phase 2 Study of Rituximab-ABVD in Classical Hodgkin Lymphoma

Lymphoma

United States

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