Search clinical trials for: SEVERE

Total 8585 results

Istituti Clinici Scientifici Maugeri SpA

Not yet recruiting

Effects of L-arginine and Liposomial Vitamin C on Severe Copd Patients Undergoing Pulmonary Rehabilitation.

Chronic Obstructive Pulmonary Disease | Respiratory Failure

Italy
Regina Elena Cancer Institute

Recruiting

Analysis and Evaluation of Smoking Treatment With Cytisine

Moderate or Severe Tobacco Use Disorder

Italy
Asan Medical Center

Not yet recruiting

Tezepelumab Treatment in Korean Severe Asthma Patients

Asthma
Wuhan Union Hospital, China

Recruiting

Efficacy and Safety of Ganciclovir Capsules in the Treatment of Refractory Moderate-to-severe Allergic Rhinitis

Rhinitis, Allergic

China
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Shenzhen Hospital of Southern Medical University

Not yet recruiting

Immediate Angioplasty For Acute Ischemic Stroke With Severe Intracranial Atherosclerotic Stenosis (MAGIC)

Stroke, Acute Ischemic

China
University Hospital, Brest

Not yet recruiting

Efficacy and Tolerance of Cannabidiol in Patients With Severe Pruritus: a Multicenter, Double-blind, Randomized, Placebo-controlled Study (CANNABITCH)

Pruritus
Apollo Therapeutics Ltd

Recruiting

A Study of the Effects of Camoteskimab in Adults With Moderate to Severe Atopic Dermatitis

Dermatitis | Eczema | Atopic Dermatitis | Atopic | Eczema, Atopic | Dermatologic Disease | Eczema Atopic Dermatitis

United States, Canada
Hadassah Medical Organization
London North West Healthcare NHS Trust

Not yet recruiting

Severe COVID-19 Infection in Children Presenting to EDs in Israel and England (SPICE)

COVID-19 | Inflammatory Response
Shanghai Vitalgen BioPharma Co., Ltd.

Not yet recruiting

A Trial to Evaluate Safety and Efficacy of a Product Named VGN-R09b in Severe AADC Deficiency

Aromatic L-amino Acid Decarboxylase Deficiency
Yi Han
Qianfoshan Hospital

Recruiting

Prospective Observational Association Between SLCO1B1 Gene Polymorphism and the Anti-factor Xa Activity of Edoxaban in Patients With Moderate to Severe Renal Insufficiency

Renal Insufficiency | Gene Polymorphism | Edoxaban

China
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Study of Fecal Microbiota Transplantation (FMT) in Severe IBS Patients (ICEBOAT)

Irritable Bowel Syndrome

France
China National Center for Cardiovascular Diseases

Recruiting

Potts-shunt for the Treatment of Pediatric Patients With Severe Pulmonary Hypertension

Pulmonary Artery Hypertension

China
Henry M. Jackson Foundation for the Advancement...
Uniformed Services University of the Health Sciences; Brooke Army Medical Center

Not yet recruiting

Ketamine for Sedation in Severe Traumatic Brain Injury (Ketamine)

Intracranial Hypertension | Severe Traumatic Brain Injury | Intracranial Hemorrhage, Hypertensive
Merck Sharp & Dohme LLC

Not yet recruiting

A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)

Crohn's Disease
Assistance Publique - Hôpitaux de Paris
BPIfrance; Withings

Not yet recruiting

Monitoring Patients With Severe Obesity Treated With Wegovy® Using Connected Device: Real-world Data (TELE-SEMA)

Obesity

France
Centre Hospitalier de Moulins Yzeure

Recruiting

Prediction of Response to Bariatric Surgery in Patients With Severe Obesity (PREDI-CHIRBA)

Body Weight Changes

France
Peking Union Medical College Hospital

Not yet recruiting

A Prospective Study on the Treatment of Recurrent/Refractory/Intolerable NSAA With Lusutrombopag

Aplastic Anemia

China
UCB Biopharma SRL

Not yet recruiting

A Study to Evaluate the Efficacy and Safety of Bimekizumab Compared to Ustekinumab in Children and Adolescents From 6 Years to Less Than 18 Years of Age With Moderate to Severe Plaque Psoriasis (BE TOGETHER)

Moderate to Severe Plaque Psoriasis
Xie Kangjie

Recruiting

Study on Pharmacokinetics of Single Injection of Ciprofol in Patients With Moderate to Severe Hypoproteinemia

Pharmacokinetics | Hypoproteinemia | Ciprofol

China
Bristol-Myers Squibb

Not yet recruiting

Study to Assess Drug Levels and Safety of BMS-986278 in Healthy Participants and Participants With Different Degrees of Hepatic Impairment

Hepatic Impairment | Healthy Participants
AstraZeneca

Recruiting

A Study To Evaluate The Treatment Pattern Of Moderate-to-Severe Asthma Patients In China (PRESENT)

Moderate-to-Severe Asthma

China
AbbVie

Not yet recruiting

An Observational Study to Assess Real-World Use of Upadacitinib Tablets in Adolescent and Adult Participants With Moderate to Severe Atopic Dermatitis in China (REACH-AD)

Atopic Dermatitis
Haisco Pharmaceutical Group Co., Ltd.

Not yet recruiting

Efficacy and Safety of HSK16149 Capsule in the Treatment of Moderate and Severe Central Neuropathic Pain in China

Central Neuropathic Pain
AstraZeneca

Not yet recruiting

A Non-interventional, Prospective Study With Benralizumab (AIR POWER)

Asthma, Bronchial
Brigham and Women's Hospital

Not yet recruiting

Study of Novel Therapeutics for Acute Remedy of Colitis (SHARC)

Ulcerative Colitis | Ulcerative Colitis Chronic Moderate | Ulcerative Colitis Chronic Severe

United States
University Hospital, Brest

Not yet recruiting

Evolution of the Lymphocyte Phenotype in Patients With Infection in Intensive Care Unit (REAPHEN)

Patients Undergoing Esophagectomy | Patients With Severe Polytrauma | Patients With Severe Neurological Lesion | Patients With Abdominal Infection
InnovHeart
MAXIS, LLC

Recruiting

Reduction of Mitral Regurgitation With the SATURN Trans-Septal Transcatheter Mitral Valve Replacement (TMVR) System in Patients With Severe Symptomatic Mitral Regurgitation (CASSINI-EU)

Heart Failure

Lithuania, Poland
China National Center for Cardiovascular Diseases

Not yet recruiting

Exploring the Clinical Efficacy of Remote Management Applications Through Comprehensive Physical Therapy for Patients With Moderate to Severe Sleep Apnea

Aerobic Exercise | M-health | OSAHS | Oropharyngeal Muscle Training | Comprehensive Physical Therapy
Masonic Cancer Center, University of Minnesota

Not yet recruiting

MT2023-20: Hematopoietic Cell Transplant With Reduced Intensity Conditioning and Post-transplant Cyclophosphamide for Severe Aplastic Anemia and Other Forms of Acquired Bone Marrow Failure.

Acquired Pure Red Cell Aplasia | Paroxysmal Nocturnal Hemoglobinuria | Severe Aplastic Anemia | Acquired Amegakaryocytic Thrombocytopenia
GlaxoSmithKline

Not yet recruiting

A Study to Investigate the Safety and Pharmacological Effect of a Single Intravenous Infusion of Belantamab in Male and Female Participants Aged 18 to 75 With Moderate to Severe Systemic Lupus Erythematosus

Systemic Lupus Erythematosus

United States
MoonLake Immunotherapeutics AG

Recruiting

A Study to Evaluate the Efficacy and Safety of Subcutaneous Sonelokimab Compared With Placebo in Adult Participants With Moderate to Severe Hidradenitis Suppurativa

Hidradenitis Suppurativa

United States
MoonLake Immunotherapeutics AG

Recruiting

Study to Evaluate the Efficacy and Safety of Subcutaneous Sonelokimab Compared With Placebo in Adult Participants With Moderate to Severe Hidradenitis Suppurativa

Hidradenitis Suppurativa

United States
Novavax

Not yet recruiting

Phase 3 Strain Change Study for SARS-CoV-2 rS Vaccines (COVID-19)

Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Sanofi

Recruiting

A Study to Evaluate the Treatment Response and Safety of Two Dose Regimens of Subcutaneous Amlitelimab Monotherapy Compared With Treatment Withdrawal in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis (ESTUARY)

Dermatitis Atopic

United States
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Not yet recruiting

External Mastalgia-oil Versus Oral Tamoxifen in Premenopausal Women With Severe Mastalgia

Mastalgia

China
Maastricht University Medical Center
Cargill

Not yet recruiting

Plant Protein Blend and Milk Protein Supplements in Older Individuals (Blend-D2O)

Sarcopenia | Skeletal Muscle Atrophy | Protein Malnutrition
Dalhousie University
Alzheimer Society of Canada

Not yet recruiting

Dementia Moves: Protocol for a Feasibility Study

Moderate to Severe Dementia
Chinese Medical Association

Recruiting

Study on the Feasibility of Continuous Glucose Monitoring(CGM) for Improving Blood Glucose Control in Severe Patients

Continuous Glucose Monitoring

China
Pfizer

Not yet recruiting

An Observational Study of Etrasimod in Adult Patients With Moderate to Severe Ulcerative Colitis (ENDEAVOUR-UC)

Colitis, Ulcerative
Taizhou Mabtech Pharmaceutical Co.,Ltd

Not yet recruiting

Comparative Study of CMAB015 and Secukinumab for Patients With Moderate to Severe Plaque Psoriasis

Psoriasis
Oneness Biotech Co., Ltd.

Not yet recruiting

Evaluate Efficacy, Pharmacokinetics, and Safety of Repeat Subcutaneous Doses of FB825 in Adults With Moderate-to-Severe Atopic Dermatitis

Atopic Dermatitis
Max-Planck-Institute of Psychiatry

Recruiting

Deep Phenotyping for Clinical Inferring Response in Treatment Resistant Depression (DECIDE)

Depressive; Disorder, Major, Single Episode, Major, With Psychotic Symptoms | Depressive; Disorder, Major, Single Episode, Major (Without Psychotic Symptoms) | Depressive Disorder, Major, Recurrent, With Psychotic Symptoms | Depressive Disorder, Major, Recurrent, Without Psychotic Symptoms and other conditions

Germany
Pfizer

Not yet recruiting

A Study on 2 Different Combination Tablets of Nirmatrelvir Plus Ritonavir to Compare Them With Marketed Paxlovid in Healthy Participants

Healthy Participants | Biological Availability
Rigshospitalet, Denmark

Not yet recruiting

Microdialysis and Jugular Bulb Glucose Profiles During Hyperglycaemic Clamping in Patients With Severe Acute Brain Injury (CLAMP)

Acute Brain Injury

Denmark
Sanofi
Regeneron Pharmaceuticals

Recruiting

Study in Adults With Severe Chronic Rhinosinusitis With Nasal Polyposis Treated With Dupilumab in France (OPALE)

Chronic Rhinosinusitis With Nasal Polyposis

France, Réunion
AbbVie

Not yet recruiting

A Study to Assess the Effect of Upadacitinib in Atopic Dermatitis-induced Sleep Disturbance in Adults With Moderate to Severe Atopic Dermatitis (Sleep Up)

Sleep Disturbance | Atopic Dermatitis
VA Office of Research and Development

Not yet recruiting

Diagnosis and Treatment of CAD in Severe PAD After Lower Extremity Revascularization (CAD in sPAD)

Coronary Artery Disease | Peripheral Artery Disease

United States
AbbVie

Recruiting

A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab (Switch-Up)

Atopic Dermatitis

United States
Diabetes Foundation, India
National Diabetes Obesity and Cholesterol Foundation

Recruiting

Comparison of Micro- and Macrovascular Disease(s) in People With T2D, Who Have Moderate to Severe Acanthosis Nigricans vs. Those Who do Not Have Acanthosis Nigricans

Type 2 Diabetes Mellitus With Complication

India
University of California, San Diego
Mayo Clinic; National Heart, Lung, and Blood Institute (NHLBI); Yale University; Brigham and Women's Hospital and other collaborators

Recruiting

Leveraging Pharmacogenomics in Asthma for Predication, Mechanism and Endotyping (EPIPHANY)

Moderate to Severe Asthma

United States

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