Search clinical trials for: Severe emphysema

Total 9056 results

Pulmonx Corporation

Recruiting

Zephyr Valve Japan Post-Marketing Surveillance

Emphysema | COPD | Severe Emphysema

Japan
University Hospital, Limoges

Recruiting

Trial Evaluating the Rate of Pneumothorax in Severe Emphysema Secondary to Endoscopic Volume Reduction With Two-stage ZEPHYR® Valves Versus Endoscopic Volume Reduction With One-stage ZEPHYR® Valves (REPEAT)

COPD

France
Shanghai Chest Hospital

Not yet recruiting

A Multi-center RCT to Evaluate Subsegmental BTVA Treatment for Severe Emphysema (BTVA)

Severe Emphysema
Pulmonx Corporation

Recruiting

An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients With Severe Emphysema (CONVERT_II)

Emphysema or COPD | Emphysema, Pulmonary

Spain, Germany, Italy, Australia
Apreo Health, Inc.

Recruiting

Study to Assess Safety, Feasibility, and Preliminary Efficacy of the Apreo Implant for Severe Emphysema (BREATHE-2)

Emphysema or COPD

United Kingdom, Austria, Netherlands
Apreo Health, Inc.

Recruiting

First in Human Study to Assess an Implant to Treat Severe Emphysema (BREATHE-1)

Emphysema or COPD

Australia
IHF GmbH - Institut für Herzinfarktforschung

Not yet recruiting

BENTO - Bronchoscopic Lung Volume Reduction in Severe Emphysema Using Thermoablation

Emphysema or Chronic Obstructive Pulmonary Disease

Germany
Centre Hospitalier Universitaire de Liege
Sanofi; Takeda; University of Liege; Orchard Therapeutics; Centre Hospitalier Régional... and other collaborators

Recruiting

Baby Detect : Genomic Newborn Screening

Congenital Adrenal Hyperplasia | Hemophilia A | Hemophilia B | Mucopolysaccharidosis I | Mucopolysaccharidosis II | Cystic Fibrosis | Alpha 1-Antitrypsin Deficiency | Sickle Cell Disease | Fanconi Anemia | Chronic Granulomatous Disease | Wilson Disease | Severe Congenital Neutropenia | Ornithine Transcarbamylase... and other conditions

Belgium
University Hospital, Basel, Switzerland

Recruiting

Comparison Between the Non-powered AEON™ Endostapler and Echelon FLEX™ Powered Plus Stapler With Regards to the Closure of Lung Tissue After Lung Resection in the Presence of Severe Lung Emphysema (Stapler)

Lung Resection | Postoperative Air Leak

Switzerland
Isabelle Opitz, Professor, MD

Recruiting

Surgical Compared to Bronchoscopic Lung Volume Reduction in Patients With Severe Emphysema (SINCERE)

Emphysema

Belgium, Switzerland, Denmark, Austria
Pulmonx Corporation

Active, not recruiting

Fissure Closure With the AeriSeal System for CONVERTing Collateral Ventilation Status (CONVERT) (CONVERT)

Emphysema | COPD | Severe Emphysema

United Kingdom, France, Netherlands, Germany, Australia, Italy, Switzerland
Sanofi
Regeneron Pharmaceuticals

Completed

Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab in Patients With Moderate-to-severe COPD With Type 2 Inflammation (BOREAS)

Chronic Obstructive Pulmonary Disease

Spain, Argentina, China, Mexico, Canada, Ukraine, Israel, Italy, Czechia, Korea, Republic of, Bulgaria, Chile, Denmark, Finland, Germany, Hungary, Japan, Poland, Romania, Russian Federation, Slovakia, Sweden, Turkey, United States
University Medical Center Groningen

Completed

Evaluation of the Free Flow Medical Lung Tensioning Device System for the Treatment of Severe Emphysema (EFFORT)

Emphysema or COPD

Netherlands, Germany
Stanford University
Varian, a Siemens Healthineers Company

Active, not recruiting

Lung Volume Reduction for Severe Emphysema by Stereotactic Ablative Radiation Therapy

Emphysema

United States
Boston Scientific Corporation
PneumRx, Inc.

Completed

Study of PneumRx Endobronchial Coil System in Treatment of Subjects With Severe Emphysema (ELEVATE)

Emphysema

United Kingdom, France, Germany, Netherlands, Italy, Austria
University Medical Center Groningen
Maastricht University Medical Center; Center of Expertise for Chronic Organ...

Completed

A Trial on the Effects of Bronchoscopic Lung Volume Reduction in Severe Emphysema. (SOLVE)

Emphysema

Netherlands
Grifols Therapeutics LLC

Terminated

Study to Evaluate the Safety and Efficacy of Liquid Alpha1-Proteinase Inhibitor (Human) in Hospitalized Participants With Coronavirus Disease (COVID-19)

COVID-19

United States, Brazil, Chile, Colombia, Mexico
Mayo Clinic

Completed

Feasibility of a Multi Component Intervention in Patients With Severe Dyspnea and Obesity

Lung Diseases | Emphysema | COPD

United States
Heidelberg University

Completed

Implantation of Endobronchial Valves Versus Intrabronchial Valves in Patients With Severe Heterogeneous Emphysema

Pulmonary Emphysema

Germany
Heidelberg University

Terminated

Prevention of Pneumothorax Following Endoscopic Valve Therapy in Patients With Severe Emphysema

Pneumothorax

Germany
Dr Fabrice BRUNEEL

Completed

Very Severe Malaria Treated by Intravenous Artesunate (Palustar)

Severe Malaria

France
Mesoblast, Inc.

Completed

PROCHYMAL™ (Human Adult Stem Cells) for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)

Pulmonary Disease, Chronic Obstructive | Pulmonary Emphysema | Chronic Bronchitis

United States
Washington University School of Medicine
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); N... and other collaborators

Terminated

Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency (CBZ)

Liver Cirrhosis | Alpha-1-antitrypsin Deficiency

United States
Lifetech Scientific (Shenzhen) Co., Ltd.

Active, not recruiting

Cinenses Lung Volume Reduction Reverser System First-in-man Study Treating Patients With Severe Emphysema

Emphysema

Germany
Baxalta now part of Shire
Baxter Healthcare, Ltd. (New Zealand), Baxter Healthcare Pty. Ltd. (Australia)

Completed

Pharmacokinetic Study of ARALAST (Human Alpha1- PI)

Alpha 1-Antitrypsin Deficiency

Australia, New Zealand
AstraZeneca
Parexel

Completed

A Single Inhalation Dose Study to Assess Efficacy, Pharmacokinetics (PK), Safety and Tolerability of AZD8871 in Patients With Long-term Lung Diseases.

Chronic Obstructive Pulmonary Disease

Germany, United Kingdom
Olympus Corporation

Terminated

A Prospective Multicenter Clinical Study to Evaluate the Safety and Effectiveness of the OL-BF-001 for Severe Emphysema

Emphysema

Japan
Royal Brompton & Harefield NHS Foundation Trust

Unknown

LVR in Severe Emphysema Using Bronchoscopic Autologous Blood Instillation in Combination With Intra-bronchial Valves (BLOOD-VALVES)

Chronic Obstructive Pulmonary Disease | Emphysema

United Kingdom
Instituto de Investigación Sanitaria de la Fundación...

Unknown

Clinical Study to Evaluate the Exercise Capacity in Patients With Severe Emphysema Treated With Coils (CYCLONE)

Pulmonary Emphysema

Spain
Spiration, Inc.

Completed

Clinical Trial to Evaluate the Safety and Effectiveness of the IBV® Valve System for the Treatment of Severe Emphysema (IBV®Valve)

Emphysema | COPD

United States
Spiration, Inc.
Tigermed Consulting Co., Ltd; Olympus Corporation

Completed

The Spiration Valve System for the Treatment of Severe Emphysema (REACH)

Pulmonary Disease, Chronic Obstructive | Empyhsema

China
Federal Research Clinical Center of Federal Medical...

Withdrawn

Clinical Study of the Efficacy and Safety of the Application of Allogeneic Mesenchymal (Stromal) Cells of Bone Marrow, Cultured Under the Hypoxia in the Treatment of Patients With Severe Pulmonary Emphysema

Pulmonary Emphysema

Russian Federation
University Medical Center Groningen

Completed

A Safety and Feasibility Study of Re-treating Patients With Severe Emphysema With the RePneu LVRC System. (RECOIL)

Emphysema | COPD

Netherlands
AstraZeneca

Completed

Safety and Tolerability of Aclidinium Bromide/Formoterol Fumarate Compared With Formoterol Fumarate in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

United States
AstraZeneca

Completed

Efficacy, Safety and Tolerability of Two Fixed Dose Combinations of Aclidinium Bromide/Formoterol Fumarate, Aclidinium Bromide, Formoterol Fumarate and Placebo for 28-Weeks Treatment in Patients With Moderate to Severe, Stable Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease

United States, Australia, Canada, New Zealand
AstraZeneca

Completed

Long-term Safety, Tolerability and Efficacy of Aclidinium Bromide in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) (LAS-MD-35) (LAS-MD-35)

Chronic Obstructive Pulmonary Disease

United States, Canada
AstraZeneca

Completed

Efficacy, Safety and Tolerability of Aclidinium Bromide/Formoterol Fumarate Compared With Aclidinium Bromide and Formoterol Fumarate in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease

United States, Australia, Canada, New Zealand
AstraZeneca

Completed

Pharmacokinetic, Safety and Tolerability Study of Aclidinium/Formoterol Fixed Dose Combination and Formoterol in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)

Chronic Obstructive Pulmonary Disease (COPD)

United States
AstraZeneca

Completed

Efficacy, Safety, and Tolerability of Aclidinium Bromide in the Treatment of Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD) (LAS-MD-38) (LAS-MD-38)

Chronic Obstructive Pulmonary Disease

United States, Canada
AstraZeneca

Completed

Efficacy and Safety of Aclidinium Bromide for Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) (LAS-MD-33)

Chronic Obstructive Pulmonary Disease

United States, Canada
AstraZeneca

Completed

A Study of Exercise Endurance and Lung Hyperinflation in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)

Pulmonary Disease, Chronic Obstructive

United States, Canada
AstraZeneca

Completed

Long-term Extension Study of the Safety, Tolerability, and Efficacy of Aclidinium Bromide in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) (LAS-MD-36)

Chronic Obstructive Pulmonary Disease

United States, Canada
Cairo University

Unknown

Pulmonary Hemodynamics in Patients With Severe Emphysema Pre and Post BLVR

Pulmonary Hypertension | Chronic Obstructive Lung Disease

Egypt
Alung Technologies

Withdrawn

Use of the Hattler Respiratory Assist Catheter in Severe Respiratory Failure

Chronic Obstructive Pulmonary Disease | Respiratory Insufficiency | Asthma | Emphysema | Acute Respiratory Distress Syndrome

United Kingdom
AstraZeneca

Completed

A 4 Week Study to Investigate the Safety and Tolerability of AZD5069 in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) (CIRRUS)

Scientific Terminology Chronic Obstructive Pulmonary Disease (COPD) | Laymen Terminology Chronic Bronchitis and Emphysema

Bulgaria, Germany, Hungary, Ukraine
Heidelberg University

Completed

ELVR in PH Patients With Severe Emphysema

Pulmonary Emphysema | COPD

Germany
Proto Pharma Ltd

Completed

Superiority of ArTiMist Versus Quinine in Children With Severe Malaria

Plasmodium Falciparum Malaria

Burkina Faso, Ghana, Rwanda
Shanghai Vitalgen BioPharma Co., Ltd.

Not yet recruiting

A Trial to Evaluate Safety and Efficacy of VGN-R09b in Severe AADC Deficiency

Aromatic L-amino Acid Decarboxylase Deficiency
Yi Han
Qianfoshan Hospital

Recruiting

Prospective Observational Association Between SLCO1B1 Gene Polymorphism and the Anti-factor Xa Activity of Edoxaban in Patients With Moderate to Severe Renal Insufficiency

Renal Insufficiency | Gene Polymorphism | Edoxaban

China
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Study of Fecal Microbiota Transplantation (FMT) in Severe IBS Patients (ICEBOAT)

Irritable Bowel Syndrome

France

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