Search clinical trials for: Severe refractory asthma

Total 25136 results

Istituti Clinici Scientifici Maugeri SpA

Recruiting

Treatment With Mepolizumab on Patients With Severe Refractory Eosinophilic Asthma With or Without CRSwNP.

Asthma | Nasal Polyps | Sinusitis Chronic

Italy
Queen's University, Belfast
The Leeds Teaching Hospitals NHS Trust; Cambridge University Hospitals NHS... and other collaborators

Recruiting

Co-morbidity and Refractory Asthma - UK Severe Asthma Registry (UKSAR)

Asthma

United Kingdom
GlaxoSmithKline

Completed

MEA112997 Open-label Long Term Extension Safety Study of Mepolizumab in Asthmatic Subjects

Asthma

United States, Argentina, Australia, France, Germany, Poland, Romania, Russian Federation, Canada, Chile, Korea, Republic of, Ukraine, United Kingdom
Nuvaira, Inc.

Terminated

Evaluating the Safety and Feasibility of TLD for the Treatment of Severe Asthma (RELIEF-1)

Asthma

Netherlands, France, United Kingdom, Germany
Boston Scientific Corporation

Completed

RISA Extension Study - Long Term Safety

Asthma

Canada, Brazil, United Kingdom
Washington University School of Medicine
University of Alabama at Birmingham; University of Chicago; The Cleveland Clinic and other collaborators

Completed

A Prospective Observational Study of Biopredictors of Bronchial Thermoplasty Response in Patients With Severe Refractory Asthma (BTR Study) (BTR)

Asthma

United States
Centre Hospitalier Universitaire de Besancon
Novartis

Completed

Omalizumab in Severe and Refractory Solar Urticaria (XOLUS)

Solar Urticaria

France
GlaxoSmithKline

Completed

A Study to Determine Long-term Safety of Mepolizumab in Asthmatic Subjects

Asthma

United States, Argentina, Australia, Canada, France, Germany, Japan, Netherlands, Poland, Russian Federation, Spain, Ukraine, Belgium, Chile, Korea, Republic of, United Kingdom, Czechia, Mexico, Italy
GlaxoSmithKline

Completed

Efficacy and Safety Study of Mepolizumab Adjunctive Therapy in Subjects With Severe Uncontrolled Refractory Asthma

Asthma

United States, Argentina, Australia, Canada, France, Germany, Japan, Russian Federation, Spain, Ukraine, Belgium, Chile, Korea, Republic of, Mexico, Italy, United Kingdom
GlaxoSmithKline

Completed

Dose Ranging Efficacy And Safety With Mepolizumab in Severe Asthma (DREAM)

Asthma

United States, Argentina, Australia, Germany, Poland, Romania, Russian Federation, Ukraine, Canada, Chile, France, Korea, Republic of, United Kingdom
National Heart, Lung, and Blood Institute (NHLBI)

Completed

A Randomized, Placebo-Controlled, Double-Blind Pilot Study of Pioglitazone Hydrochloride in Severe, Refractory Asthma

Airway Inflammation | Severe, Refractory Asthma | Airflow Obstruction

United States
Brigham and Women's Hospital
National Heart, Lung, and Blood Institute (NHLBI); Baim Institute for Clinical...

Completed

Effects of cKit Inhibition by Imatinib in Patients With Severe Refractory Asthma (KIA) (KIA)

Asthma

United States
GlaxoSmithKline

Completed

Mepolizumab Steroid-Sparing Study in Subjects With Severe Refractory Asthma

Asthma

United States, Australia, Canada, France, Germany, Netherlands, Poland, Mexico, United Kingdom, Czech Republic
Nantes University Hospital

Terminated

Predictive Factors for Exacerbation Outcome in Severe Refractory Asthmatics (EXPRESA)

Asthma | Chronic Inflammatory Diseases

France
AstraZeneca

Recruiting

A Study To Evaluate The Treatment Pattern Of Moderate-to-Severe Asthma Patients In China (PRESENT)

Moderate-to-Severe Asthma

China
AstraZeneca

Not yet recruiting

A Non-interventional, Prospective Study With Benralizumab (AIR POWER)

Asthma, Bronchial
University of California, San Diego
Mayo Clinic; National Heart, Lung, and Blood Institute (NHLBI); Yale University; Brigham and Women's Hospital and other collaborators

Recruiting

Leveraging Pharmacogenomics in Asthma for Predication, Mechanism and Endotyping (EPIPHANY)

Moderate to Severe Asthma

United States
Amgen

Not yet recruiting

A Phase 2, Dose Ranging Study Assessing Rocatinlimab in Moderate-to-severe Asthma

Asthma
University Medical Center Groningen
Trudell Medical International

Not yet recruiting

Inhaler Adherence and Inhalation Technique Assessed by a Smart Spacer in Patients With Severe Asthma on Biologics (OUTERSPACE-3)

Asthma

Netherlands
Sanofi

Not yet recruiting

A Study to Investigate Subcutaneous Isatuximab in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma (SubQSA)

Plasma Cell Myeloma Refractory
Wuhan Union Hospital, China

Not yet recruiting

CD19/BCMA HLA-independent TCR-T Cell Therapy for Refractory/Moderate-to-severe Systemic Lupus Erythematosus

Systemic Lupus Erythematosus
The First Affiliated Hospital with Nanjing Medical...

Recruiting

A Clinical Study of Omalizumab in the Treatment of Allergic Asthma(ESSENCE) (ESSENCE)

Moderate to Severe Allergic Asthma

China
Autolus Limited

Recruiting

A Study of CD19 Targeted CAR T Cell Therapy in Patients With Severe, Refractory Systemic Lupus Erythematosus (SLE) (CARLYSE)

Systemic Lupus Erythematosus

United Kingdom
Sunshine Guojian Pharmaceutical (Shanghai) Co.,...

Not yet recruiting

Efficacy and Safety Study of 610 in Patients With Severe Asthma

Asthma
Hospital Clinic of Barcelona

Not yet recruiting

Effect of CPAP Treatment in Patients With Severe Uncontrolled Asthma: The ASTHMA-SLEEP Trial

Asthma | Obstructive Sleep Apnea
Medical University of Graz

Not yet recruiting

Clock Proteins as Prognostic Markers (CLOCK-PM)

Severe Eosinophilic Asthma
University of Wisconsin, Madison
National Institute on Aging (NIA)

Recruiting

Comparison of Microglial Activation in Severe Asthma and Healthy Controls (MAIA-SC)

Asthma

United States
AstraZeneca

Recruiting

REACT - REAl Care for AsThma - A Disease Study to Identify Patients With Severe Uncontrolled Asthma (REACT-Asthma)

Asthma, Bronchial

Germany
Aristotle University Of Thessaloniki
University Hospital of Crete; University Hospital of Patras; Pulmonary Clinic... and other collaborators

Recruiting

BenRalizumab Effect on Airway Remodeling in Severe asTHma (BREATH)

Airway Remodeling | Asthma; Eosinophilic

Greece
AstraZeneca

Recruiting

PROPE Severe Asthma Study in Egypt

Severe Asthma

Egypt
Innovaderm Research Inc.

Not yet recruiting

Efficacy, Safety, and Tolerability of Abrocitinib in Subjects With Moderate to Severe Chronic Hand Eczema Refractory to Corticosteroid Therapy

Chronic Hand Eczema

Canada
AstraZeneca

Recruiting

A Retrospective Chart Review to Investigate Clinical Remission in Patients With Severe Asthma Treated With Biologics in the United Kingdom National Health Service (REMISSION UK)

Asthma

United Kingdom
Upstream Bio Inc.

Recruiting

A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALIANT)

Severe Asthma

United States, Canada
Sanofi

Recruiting

A Study to Evaluate the Efficacy and Safety of Subcutaneous Amlitelimab Monotherapy Compared With Placebo in Participants Aged 12 Years and Older With Moderate-to-severe Atopic Dermatitis (COAST 2)

Dermatitis Atopic

Japan, China, Spain, United States, Argentina, United Kingdom, Denmark, Sweden, Turkey
University of Saskatchewan

Not yet recruiting

Examining the Effects of a Remote Pulmonary Rehabilitation Program in the Severe Asthma Population. (STAPLE)

Asthma
St. Joseph's Healthcare Hamilton
Trudell Medical International

Not yet recruiting

Effect of OPEP on Mucus Plugging and Airflow Obstruction in Patients With Moderate-to-severe Asthma (AeroMUC)

Asthma

Canada
Nektar Therapeutics

Recruiting

A Phase 2b Study to Evaluate Rezpegaldesleukin (Rezpeg) in the Treatment of Adult Patients With Moderate-to-Severe Atopic Dermatitis (REZOLVE-AD)

Moderate to Severe Atopic Dermatitis

United States, Australia, Canada
AltruBio Inc.

Recruiting

Efficacy/Safety of ALTB-268 in Subjects w/Moderately to Severely Active UC Refractory to Biologics

Ulcerative Colitis

United States, Canada
Wuhan Union Hospital, China
Guangzhou Bio-gene Technology Co., Ltd

Not yet recruiting

A Clinical Study of CD19 CAR-T in Refractory/Moderate-to-severe Systemic Lupus Erythematosus

Systemic Lupus Erythematosus
Sanofi

Recruiting

Dose Ranging Study of Lunsekimig Compared With Placebo-control in Adult Participants With Moderate-to-severe Asthma (AIRCULES)

Asthma

Turkey, Argentina, India, Israel, Korea, Republic of, United States, Chile, Japan
IGM Biosciences, Inc.

Recruiting

A Phase 1b Study of Imvotamab in Moderate to Severe Rheumatoid Arthritis

Arthritis | Arthritis, Rheumatoid | Rheumatoid Arthritis

United States, Poland
National and Kapodistrian University of Athens

Recruiting

Mepolizumab Effectiveness in Patients With Chronic Rhinosinusitis, Nasal Polyps and Comorbid Severe Eosinophilic Asthma (MepoRiNaPAs)

Chronic Rhinosinusitis With Nasal Polyps | Chronic Rhinosinusitis Without Nasal Polyps | Severe Eosinophilic Asthma

Greece
University Hospital, Rouen

Recruiting

Dynamics of the Upper and Lower Airway Respiratory Microbiomes Associated With Severe Infant Asthma (Microbiosthme)

Asthma | Asthma in Children

France
GlaxoSmithKline

Not yet recruiting

REIMAGINE - Real World EvaluatIon of Mepolizumab in Severe Asthma achievinG on Treatment clinIcal remissioN, a prospEctive Study (REIMAGINE)

Asthma
German Asthma Net e.V.
Sanofi; GlaxoSmithKline; AstraZeneca; Chiesi Farmaceutici S.p.A.

Recruiting

Register Schweres Asthma - German Asthma Net e.V.

Severe Asthma

Germany
Sanofi

Recruiting

Long-term Safety and Efficacy Evaluation of Subcutaneous Amlitelimab in Adult Participants With Moderate-to-severe Asthma Who Completed Treatment Period of Previous Amlitelimab Asthma Clinical Study (RIVER-ASTHMA)

Asthma

Korea, Republic of, Argentina, Chile, South Africa, United States, Hungary, Poland, Turkey, United Kingdom, Canada, Japan
AstraZeneca
Amgen

Recruiting

A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma (HORIZON)

Asthma

United States, Poland, Korea, Republic of, Spain, France, China, United Kingdom, Canada, Netherlands, Argentina, Mexico, Brazil, Hungary, Japan, Philippines, South Africa, Colombia
AstraZeneca

Recruiting

Phase 2a Study to Assess the Efficacy and Safety of AZD4604 in Adult Patients With Moderate-to-Severe Asthma Uncontrolled on Medium-High Dose ICS-LABA (AJAX)

Asthma

Denmark, United States, South Africa, United Kingdom, Argentina, Vietnam, Brazil, Malaysia, Taiwan, France, Germany, Spain, Thailand, Bulgaria, Philippines, Sweden
Sanofi

Recruiting

A Study to Evaluate the Quality of Life in Male and Female Adult Participants With Severe Asthma Treated With Dupilumab in a Real-world Setting (PROVERB)

Asthma

France
Institut National de la Santé Et de la Recherche...

Recruiting

Characterization of Natural Killer Cells in Severe Asthma Patients in Comparison With Control Subjects (NKAS)

Asthma Acute

France

Search clinical trials for: Severe refractory asthma

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