Search clinical trials for: Single Ascending Dose (SAD)

Total 26605 results

Theravance Biopharma

Completed

SAD and MAD Study to Evaluate Safety, Tolerability, and Pharmacokinetics (PK) of TD-1473 in Healthy Subjects

Healthy

United States
Hoffmann-La Roche

Completed

A Single Ascending And Multiple Ascending Dose Study of RO5271983 in Healthy Volunteers

Healthy Volunteer

New Zealand
Dongguan HEC TaiGen Biopharmaceuticals Co., Ltd.
R&G Pharma Studies Co.,Ltd.

Completed

To Evaluate the Safety, Tolerability, and Pharmacokinetics Profile in Healthy Chinese Volunteers of TG-2349

Healthy Chinese Volunteers

China
University Hospital Schleswig-Holstein

Recruiting

Evaluation of Safety and Pharmacokinetics of Oral Controlled-ileal-release Nicotinic Acid (CIR-NA) Compared to Immediate-release Nicotinic Acid and Placebo in Healthy Subjects and Subjects With Prediabetes

Safety Issues | Pharmacokinetic

Germany
Shanghai Jiatan Pharmatech Co., Ltd

Completed

Sudapyridine (WX-081) in Healthy Volunteers

Healthy

China
Nanjing RegeneCore Biotech Co., Ltd.

Recruiting

A Phase I Study of RC1416 Injection

Healthy Volunteers

China
Beijing Suncadia Pharmaceuticals Co., Ltd

Active, not recruiting

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Single-dose Injection of SHR-2004 in Healthy Subjects

Prevention of Arterial and Venous Thrombosis

China
Galapagos NV

Completed

A Study to Evaluate the Effects of a Single and Multiple Oral Doses of GLPG3121 in Adult, Healthy, Male Subjects

Healthy

Belgium
JMackem Co., Ltd
Seoul National University Hospital

Recruiting

A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics After Oral Administration of AJH-2947 in Healthy Korean and/or Caucasian Adult Male Subjects

Diabetic Neuropathies | Neuropathic Pain | Post Herpetic Neuralgia

Korea, Republic of
Idorsia Pharmaceuticals Ltd.

Completed

A Study to Examine the Safety, Tolerability, and Pharmacokinetics of Single- and Multiple-ascending Doses of ACT-1014-6470 in Healthy Subjects

Healthy

Netherlands
Idorsia Pharmaceuticals Ltd.

Completed

A Study to Examine the Safety, Tolerability, and Pharmacokinetics of Single- and Multiple-ascending Doses of ACT-777991 in Healthy Subjects

Healthy

Netherlands
GlaxoSmithKline

Completed

Long-term Study Of Paroxetine in Women and Men (SAD)

Social Phobia

Japan
Vigonvita Life Sciences

Recruiting

Study of the Safety, Tolerability, Pharmacokinetics and Food Effects of VV119 Capsules in Chinese Healthy Volunteers

Schizophrenia

China
Inmagene LLC

Completed

Study to Evaluate IMG-004 in Healthy Participants

Healthy Participants

United States
Chiesi Farmaceutici S.p.A.

Completed

A Study to Investigate Safety, Tolerability and Pharmacokinetics of Single and Repeat Doses of CHF6333 in Healthy Subjects (CHF6333 FIH)

Cystic Fibrosis | Non-Cystic Fibrosis Bronchiectasis

Belgium
Pfizer

Completed

Single Ascending Dose Study of Intravenous Infusion of PF 07304814 in Healthy Adult Participants

Healthy

United States
Chiesi Farmaceutici S.p.A.

Completed

A Study to Investigate the Safety, Tolerability and Pharmacokinetics of Inhaled CHF6001 (CHF6001Ext)

Chronic Obstructive Pulmonary Disease

United Kingdom
University of Vermont
University of Pittsburgh; University of Maryland School of Medicine

Active, not recruiting

Optimizing Long-Term Outcomes for Winter Depression With CBT-SAD and Light Therapy

Seasonal Affective Disorder

United States
AstraZeneca

Completed

Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD5055 in Japanese and Chinese Healthy Volunteers..

Healthy Participants

United States
Wyeth is now a wholly owned subsidiary of Pfizer
Solvay Pharmaceuticals

Terminated

Study Evaluating the Safety and Tolerability of Single Ascending Dose (SAD) SLV-351 in Healthy Subjects

Healthy
Novartis

Completed

Tolerability, Safety and Efficacy of SAD448 in Subjects With Ocular Hypertension

Ocular Hypertension

Australia
Panthera Dental Inc.
AXONAL

Recruiting

Long-term Efficacy, Tolerance and Compliance of Panthera D-SAD® Mandibular Advancement Orthosis in Sleep Apnea (PANTHERA)

Sleep Apnea, Obstructive

France
RCD Mallorca SAD

Active, not recruiting

Model-based Systems for Professional Football Teams, Aimed at Optimizing Health and Performance (AIPROFB)

Arrhythmias, Cardiac | Electrocardiogram

Spain
EnnovaBio Australia Pharmaceuticals Pty Ltd

Not yet recruiting

A First-in-Human SAD/MAD Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ENC1018 in Healthy Adult Subjects

Healthy
AstraZeneca

Terminated

Efficacy of Quetiapine in Generalised Social Anxiety Disorder

Social Anxiety Disorder

Netherlands
Syneos Health
SynerK Pharmatech (Suzhou) Limited

Recruiting

Dose Escalation of SNK-396 in Participants With Elevated Low-Density Lipoprotein Cholesterol

Elevated Low-Density Lipoprotein Cholesterol

Australia
University of Malaya

Unknown

The Accuracy of the Performance and Placement Test for Predicting Supraglottic Airway Device (SAD) Position in the Hypopharynx as Confirmed With Video Laryngoscopy

General Anesthesia | Supraglottic Airway Device | Laryngeal Mask Airway
Fondazione IRCCS Istituto Nazionale dei Tumori,...

Completed

Selective Axillary Lymph Node Dissection Vs Complete Axillary Dissection: A Randomised Clinical Trial to Assess the Prevention of Lymphedema in Breast Cancer Treatment

Breast Cancer

Italy
ZYUS Life Sciences Inc.
Novotech (Australia) Pty Limited; ZYUS Life Sciences Australia Pty Ltd

Completed

Trichomylin® Safety, Tolerability & Pharmacokinetics in Healthy Adults and First in Human Osteoarthritis Pain Evaluation (HOPE)

Healthy | Osteoarthritis

Australia
Innovent Biologics (Suzhou) Co. Ltd.

Recruiting

A Study to Investigate the Safety, Tolerability and Pharmacokinetics of IBI356 in Healthy Participants and in Atopic Dermatitis Patients

Healthy Participants | Atopic Dermatitis Patients

China
Allena Pharmaceuticals

Completed

ALLN-346 Single Ascending Dose (SAD) Study in Healthy Volunteers (SAD)

Hyperuricemia

United States
AbbVie

Completed

Safety, Tolerability and PK Study of Single Doses of ABT-450 With and Without Ritonavir to Treat Hepatitis C Virus (HCV) Genotype 1

HCV Infection

United States
Chinese University of Hong Kong

Not yet recruiting

CvC-SAD (Clinician vs Coach)Self-help Versions in a RCT

Social Anxiety Disorder
Massachusetts General Hospital
Koa Health B.V.

Withdrawn

Waitlist-Control Trial of Smartphone CBT for Social Anxiety Disorder (SAD)

Social Anxiety Disorder

United States
7 Hills Pharma, LLC
Frontage Clinical Services, Inc.

Completed

A Phase 1 SAD and MAD Study of the Safety, Tolerability and PK of 7HP349 in Normal Healthy Male Subjects

Solid Tumor

United States
Abbott

Completed

Bioavailability of ABT-333 Tablet Versus First in Human (FIH) Capsule Formulation and Safety, Tolerability and PK Study of Single Doses of ABT-333 in Healthy Volunteers

HCV Infection

United States
Spero Therapeutics
Simbec Research

Completed

A Study of the Safety, Tolerability, and Pharmacokinetics of SPR720 in Healthy Volunteers

Healthy Volunteers

United Kingdom
University of Regensburg

Unknown

Comparison of Various Supraglottic Airway Devices for Fiberoptical Guided Tracheal Intubation (supraview)

Intubation; Difficult

Germany
Komazawa University

Completed

A Pilot Study of Loving-Kindness Meditation for Social Anxiety Disorder

Compassion | Social Anxiety Disorder

Japan
Biogen

Completed

A Phase 1, Single-Ascending-Dose, Safety, Tolerability, Pharmacokinetic(PK), and Pharmacodynamic(PD) Study of BIIB068 in Healthy Participants

Systemic Lupos Erythematosus, SLE

United States
University of Novi Sad

Recruiting

Intraoperative Dexmedetomidine and Coronary Artery Bypass Graft Surgery

Acute Kidney Injury

Serbia
Assembly Biosciences

Not yet recruiting

A Study to Assess the Safety, Pharmacokinetics, and Antiviral Activity of ABI-5366 in Healthy Participants and Participants Seropositive for HSV-2 With Recurrent Genital Herpes

Recurrent Genital Herpes Simplex Type 2

New Zealand
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating the Pharmacokinetics of HCV-796 in Healthy Japanese Men

Healthy

Japan
University of Novi Sad
Merck Sharp & Dohme LLC

Completed

Pneumococcal Nasopharyngeal and Oropharyngeal Carriage in Adults

Preference, Patient

Serbia
Pharmacobio

Recruiting

A Phase I Study of DDN-A-0101 in Healthy Volunteers and Elder People

Alzheimer Disease

Korea, Republic of
Biogen

Completed

Safety, Tolerability and Pharmacokinetics of BIIB118 (PF-05251749)

Healthy

United States
University Hospital Schleswig-Holstein

Completed

Safety and Pharmacokinetics of Oral Controlled-ileocolonic-release Nicotinamide (CICR-NAM)

Safety Issues | Pharmacokinetic

Germany
AstraZeneca

Completed

AZD8529 Single Ascending Dose Study (SAD)

Healthy Volunteer

United States
AstraZeneca
Parexel

Recruiting

A Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4144 Following Single and Multiple Ascending Doses Via Oral Administration to Healthy Participants

Healthy Participants

United States
University of Palermo
University of Novi Sad, Faculty of Sport and Physical Education; Patrizia Proia... and other collaborators

Active, not recruiting

New Regenerative Approach for Dermal Renovation (Karisma) (Karisma)

Skin Manifestations

Italy, Serbia

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