Search clinical trials for: Sodium channels

Total 10128 results

Medical University of Vienna

Completed

Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8

Pain

Austria
Tata Memorial Hospital
All India Institute of Medical Sciences, New Delhi; Shri Siddhivinayak Ganpati... and other collaborators

Active, not recruiting

Randomized Controlled Trial to Assess Blockade of Voltage Gated Sodium Channels During Surgery in Operable Breast Cancer

Operable Breast Cancer

India
Danish Headache Center
Maastricht University Medical Center

Completed

Classical Trigeminal Neuralgia and Sodium Channel Mutations

Trigeminal Neuralgia
University of Oxford
Multiple Sclerosis Society of Great Britain and Northern Ireland

Completed

Amiloride Clinical Trial In Optic Neuritis (ACTION)

Multiple Sclerosis | Optic Neuritis

United Kingdom
GlaxoSmithKline

Completed

A Study to Investigate the Safety, Tolerability and Pharmacokinetics of GSK2339345.

Cough

United Kingdom
GlaxoSmithKline
North West Lung Centre

Completed

GSK2339345 Hypertussive Challenge Study

Cough

United Kingdom
Fondazione I.R.C.C.S. Istituto Neurologico Carlo...
Yale University; University of Manchester; Maastricht University; Ospedale San... and other collaborators

Unknown

Probing the Role of Sodium Channels in Painful Neuropathies

Painful Peripheral Neuropathy | Painless Peripheral Neuropathy
Regional Hospital Holstebro

Completed

Effect of Hypertonic Sodium Chloride on Urinary Biomarkers in Healthy Subjects and Patients With Chronic Kidney Disease (CASE)

Nephropathy

Denmark
Regional Hospital Holstebro

Completed

The Effect of Thiazide, Amiloride and Hypertonic Saline on Urinary Biomarkers in Healthy Subjects (THAM)

Nephropathy

Denmark
University of Southern Denmark
Odense University Hospital; The Ministry of Science, Technology and Innovation... and other collaborators

Unknown

Increased Activity of a Renal Salt Transporter (ENaC) in Diabetic Kidney Disease

Hypertension | Diabetic Nephropathies

Denmark
Regional Hospital Holstebro

Completed

The Effects of Isotonic and Hypertonic Saline Infusion on Renal Biomarkers in Healthy Young Subjects (NARA)

Nephropathy

Denmark
University of North Carolina, Chapel Hill

Completed

Do Acid Sensing Ion Channels Contribute to Heartburn?

Gastroesophageal Reflux Disease | Heartburn

United States
Kolding Sygehus
Odense University Hospital; Regionshospitalet Holstebro, Holstebro, Denmark

Unknown

Water- and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung Disease

Heart Failure | Aortic Stenosis | Healthy Volunteers | Ischemic Heart Disease | Pulmonary Hypertension

Denmark
National Institute of Neurological Disorders and...

Completed

Mexiletine for the Treatment of Focal Dystonia

Dystonia | Spasm | Blepharospasm

United States
Boehringer Ingelheim

Not yet recruiting

A Study to Test Whether BI 690517 in Combination With Empagliflozin Helps People With Heart Failure

Heart Failure
Afyonkarahisar Health Sciences University

Recruiting

Postoperative Pain Control Following Hysteroscopy

Postoperative Pain | Analgesia | Postoperative Nausea

Turkey
Ain Shams University

Recruiting

Renoprotective Effects of Dapagliflozin Versus Pentoxiphylline in Chronic Kidney Disease Patients

Chronic Kidney Diseases

Egypt
E-DA Hospital

Recruiting

2% Lidocaine Gel in Reducing Postoperative Pain Following Haemorrhoidectomy

Pain, Postoperative | Surgery

Taiwan
Jeffrey Zonder

Not yet recruiting

DapagliFLOzin in Renal AL Amyloidosis (FLORAL) (FLORAL)

Renal AL Amyloidosis

United States
Gødstrup Hospital

Not yet recruiting

Effects of Exogenous Ketosis on Renal Function, Renal Perfusion, and Sodium Excretory Capacity ((KETO-HT))

Essential Hypertension | Ketosis
Cairo University
National Heart Institute, Egypt

Not yet recruiting

Efficacy and Safety of Combination Diuretic Therapy in Patients With Acute Decompensated Heart Failure and Volume Overload

Edema | Acute Decompensated Heart Failure | Volume Overload

Egypt
Mansoura University

Recruiting

Effect of Sodium-glucose Cotransporter-2 Inhibitors (SGLT-2i) on Proteinuria in Nephrotic Children Older Than 10 Years

Nephrotic Syndrome in Children

Egypt
HighTide Biopharma Pty Ltd
Shenzhen HighTide Biopharmaceutical Ltd.

Recruiting

Effects of Berberine Ursodeoxycholate (HTD1801) Versus Dapagliflozin in Patients With Type 2 Diabetes Inadequately Controlled With Metformin

T2DM (Type 2 Diabetes Mellitus)

China
University Medical Center, Kazakhstan
Nazarbayev University; Astana Medical University; Ministry of Science and Higher... and other collaborators

Recruiting

Effectiveness of Weight Loss Methods on Lifespan for Metabolic Syndrome

Metabolic Syndrome

Kazakhstan
Sidney Kimmel Comprehensive Cancer Center at Johns...
Agenus Inc.; Private Philanthropic Funds

Not yet recruiting

KRAS-Targeted Vaccine Combined With Balstilimab and Botensilimab for Patients With Stage IV MMR-p Colorectal Cancer and Pancreatic Ductal Cancer

Colorectal Cancer | Pancreatic Cancer

United States
University of Cologne

Recruiting

Regulation of Extracellular Sodium in End Stage Renal Disease Upon Volume and Electrolyte Challenges (RESERVE)

Hyponatremia

Germany
European Organisation for Research and Treatment...

Not yet recruiting

Improvement of Quality of Life Through Supportive Treatments for Hormone Therapy - Related Symptoms in Women With Early Breast Cancer; A Pragmatic Randomized Controlled Trial

Musculoskeletal Pain | Drug-Related Side Effects and Adverse Reactions | Breast Cancer Stage I | Breast Cancer Stage II | Breast Cancer Stage III | HER2-negative Breast Cancer | ER+ Breast Cancer
West China Hospital

Recruiting

Effect of Lidocaine on Postoperative Pain and Long-term Survival in Elderly Patients Undergoing Colorectal Surgery

Colorectal Cancer

China
University of Ioannina

Recruiting

Opioid-free Anaesthesia in Breast Cancer Surgery

Pain, Postoperative | Breast Cancer | Anesthesia | Pain, Chronic | Cancer Recurrence | Opioid Free Anaesthesia

Greece
Beni-Suef University

Not yet recruiting

Adjuvant Therapy With Letrozole in Induction of Ovulation With Polycystic Ovarian Syndrome

Polycystic Ovary

Egypt
Semmelweis University

Recruiting

The Effect of an Additional Pre-extubational Loading Dose of Caffeine-citrate (NEOKOFF22)

Premature Birth | Respiratory Failure | Apnea of Prematurity

Hungary
China National Center for Cardiovascular Diseases

Recruiting

Use of SGLT2i in noHCM With HFpEF

Hypertrophic Cardiomyopathy | Heart Failure With Preserved Ejection Fraction

China
Sichuan Academy of Medical Sciences

Recruiting

Dapagliflozin Delays the Loss of Renal Function in Peritoneal Dialysis Patients

Peritoneal Dialysis Complication | Renal Function Aggravated | Sodium-glucose Co-transporter-2 Inhibitors

China
University of Pavia

Not yet recruiting

Clinical Efficacy of Calcium and Sodium Phosphosilicate (Novamin) in the Treatment of MIH (Molar Incisor Hypolimineralization) in Pediatric Patients

Molar Incisor Hypomineralization

Italy
Ain Shams University

Recruiting

Effect of Topical Airway Block on Hemodynamic Stability Post Induction of Anaesthesia in Cardiac Surgeries (hemodynamics)

Cardiac Surgery

Egypt
Eyestem Research Pvt. Ltd.

Not yet recruiting

Safety & Efficacy of Eyecyte-RPE™ in Patients With Geographic Atrophy Secondary to Dry Age-related Macular Degeneration.

Eye Diseases | Age-Related Macular Degeneration | Macular Degeneration | Geographic Atrophy | Retinal Disease
Sinclair Pharmaceuticals Limited

Recruiting

A Study to Evaluate the Safety and Effectiveness of Injectable Gel for Correction of Infraorbital Hollowing in Chinese Population

Infraorbital Hollowing

China
Poznan University of Medical Sciences

Not yet recruiting

Erector Spinae Plane Block for Cervical Spine Surgery

Spine Fusion | Spine Disease | Spinal Disease

Poland
Hannover Medical School
Boehringer Ingelheim

Not yet recruiting

Study of Empagliflozin in Patients With Autosomal Dominant Polycystic Kidney Disease (EMPA-PKD) (EMPA-PKD)

Autosomal Dominant Polycystic Kidney
Washington University School of Medicine

Not yet recruiting

LIMIT Trial - Lidocaine With Intramuscular Injection of Benzathine Penicillin G for Treponema Pallidum Treatment (LIMIT)

Syphilis Infection | Benzathine Penicillin Adverse Reaction
Tianjin Medical University General Hospital

Not yet recruiting

The Effect of Esketamine on Sleep Disturbance

Sleep Disturbance

China
Peking Union Medical College Hospital
Peking University; Shanghai Huilun Pharmaceutical Co., Ltd.

Recruiting

Efficacy and Safety of Sivelestat Sodium and Dexamethasone in the Treatment of ARDS (STAR)

Acute Respiratory Distress Syndrome

China
TC Erciyes University

Recruiting

Effect of Different Irrigation Solutions on Postoperative Pain and Lesion Healing

Endodontic Disease

Turkey
Tongji Hospital

Not yet recruiting

Effect of Amobarbital Sodium Combined With Low-dose Propofol on Hemodynamics During Induction and Perioperative Adverse Reactions

Hemodynamics Instability | Amobarbital Sodium
Novartis Pharmaceuticals

Not yet recruiting

A Clinical Study to Evaluate the Safety and Effectiveness of Inclisiran Sodium in Indian Patients With Primary Hypercholesterolemia or Mixed Dyslipidemia

Mixed Dyslipidemia | Primary Hypercholesterolemia
Nordsjaellands Hospital

Recruiting

Combining Lidocaine and Ropivacaine for an Infraclavicular Brachial Plexus Nerve Block

Anesthesia, Local | Surgery | Brachial Plexus Block | Nerve Block | Forearm Fracture

Denmark
Nordsjaellands Hospital

Recruiting

Ultrasound-guided Infraclavicular Block With Lidocaine or Ropivacaine for Closed Reduction of Distal Radius Fractures

Colles' Fracture | Fracture Dislocation | Distal Radius Fractures | Lidocaine | Ropivacaine | Closed Reduction of Fracture and Application of Plaster Cast

Denmark
Wilfrid Laurier University
Natural Sciences and Engineering Research Council, Canada

Not yet recruiting

Effect of Oral Lactate Ingestion on Appetite Regulation

Appetitive Behavior
Modern Biosciences Ltd

Recruiting

Drug-Drug Interaction (DDI) Study of Leramistat in Healthy Adult Subjects

Pharmacokinetics

United Kingdom
HALEON

Recruiting

A Real-World Evidence Study to Evaluate the Effects of Voltaren Use on Mobility and Quality of Life in Participants With Knee Osteoarthritis Pain

Pain

United States, Poland

Search clinical trials for: Sodium channels

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