Search clinical trials for: Sporadic Chordoma

Total 159 results

National Cancer Institute (NCI)

Recruiting

Genetic Clues to Chordoma Etiology: A Protocol to Identify Sporadic Chordoma Patients for Studies of Cancer-Susceptibility Genes

Genes | Sporadic Chordoma

United States
National Cancer Institute (NCI)

Completed

Genetic Aspects of Chordoma: A Collaboration With SEER Registries to Identify Chordoma Families

Chordoma

United States
Verge Genomics

Recruiting

A Study of VRG50635 in Participants With Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic Lateral Sclerosis

Canada, Netherlands
Xuanwu Hospital, Beijing

Recruiting

Apatinib Combined With Camrelizumab in Treating Participants With Advanced Chordoma

Chordoma | Chemotherapy Effect

China
Centre Antoine Lacassagne

Recruiting

Analysis of the Toxicity and Efficacy of Daily 1 vs 2 Beam Proton Therapy (P1V2)

Osteosarcoma | Ewing Sarcoma | Chondrosarcoma | Chordoma

France
ZIWIG
Monitoring Force Group

Recruiting

ALS Diagnosis From a Saliva Sample: a Non-coding RNA Analysis Approach (RNALS)

Amyotrophic Lateral Sclerosis | Amyotrophic Lateral Sclerosis, Sporadic

France
Peking University Third Hospital

Recruiting

Clinical Study to Evaluate the Efficacy and Safety of FB1006 in the Treatment of ALS Patients (FB1006)

Sporadic and Familial Amyotrophic Lateral Sclerosis

China
CNAO National Center of Oncological Hadrontherapy
Dept. of Electronics, Informatics, Bioengineering, Politecnico di Milano,...

Recruiting

Multi-parametric Imaging in Personalized Radiotherapy

Skull Base Chordoma

Italy
Quironsalud

Recruiting

Hypofractionated Protontherapy in Chordomas and Chondrosarcomas of the Skull Base

Chondrosarcoma | Chordoma

Spain
Xuanwu Hospital, Beijing

Recruiting

A Prospective Study of Surgical Treatment Strategies for Chordoma

Surgery | Chordoma of Spine

China
University Hospital, Lille
Groupement Interrégional de Recherche Clinique et d'Innovation

Not yet recruiting

Methylome Study in Sporadic Limb Malformations (METHYLIMB)

Amelia | Femur Fibula Ulna Syndrome
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Not yet recruiting

Camrelizumab Plus Anlotinib in Patients With Recurrent Sporadic MMRd Endometrial Cancer (CAN-RESPOND)

Endometrial Cancer
Huashan Hospital
Boehringer Ingelheim

Not yet recruiting

Study to Evaluate the Efficacy of Afatinib in Skull Base Chordoma

Chordoma of Clivus

China
Susan Chi, MD
Bristol-Myers Squibb; Epizyme, Inc.

Recruiting

Tazemetostat+Nivo/Ipi in INI1-Neg/SMARCA4-Def Tumors

Chordoma | Epithelioid Sarcoma | Atypical Teratoid Rhabdoid Tumor | INI1 (SMARCB1)-Deficient Primary CNS Malignant Tumors | SMARCA4-deficient Primary CNS Malignant Tumors | Malignant Rhabdoid Tumor (MRT) | Rhabdoid Tumor of the Kidney (RTK)

United States
Hospices Civils de Lyon

Not yet recruiting

The Aim is to Identify Recurrent Genomic Mutations and/or Predisposing Polymorphisms in Patients With Sporadic Cases of Multiple Myeloma (MMSPORADGEN)

Multiple Myeloma

France
National Cancer Institute (NCI)

Recruiting

Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors

Malignant Solid Neoplasm | Rhabdoid Tumor | Refractory Malignant Solid Neoplasm | Recurrent Malignant Solid Neoplasm | Recurrent Rhabdoid Tumor | Refractory Rhabdoid Tumor | Epithelioid Sarcoma | Kidney Medullary Carcinoma | Atypical Teratoid/Rhabdoid Tumor | Poorly Differentiated Chordoma | Recurrent Atypical... and other conditions

United States, Australia, Canada
M.D. Anderson Cancer Center

Recruiting

Cetuximab for the Treatment of Advanced Unresectable or Metastatic Chordoma

Chordoma | Metastatic Chordoma | Unresectable Chordoma

United States
AL-S Pharma

Recruiting

A Study to Evaluate, Safety, Tolerability, Pharmacodynamic (PD) Markers and Pharmacokinetics (PK) of AP-101 in Participants With Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic Lateral Sclerosis

Korea, Republic of, United States, Canada, Germany, Sweden, Belgium
Mayo Clinic

Recruiting

Comparing Carbon Ion Therapy, Surgery, and Proton Therapy for Management of Pelvic Sarcomas Involving the Bone

Ewing Sarcoma of Bone | Chondrosarcoma | Chordoma | Bone Sarcoma | Pelvic Rhabdomyosarcoma

United States
National Cancer Institute (NCI)

Recruiting

Testing of Bevacizumab, Erlotinib, and Atezolizumab in Combination for Advanced-Stage Kidney Cancer

Renal Cell Carcinoma | Stage III Renal Cell Cancer AJCC v8 | Stage IV Renal Cell Cancer AJCC v8 | Papillary Renal Cell Carcinoma | Hereditary Leiomyomatosis and Renal Cell Carcinoma | Sporadic Papillary Renal Cell Carcinoma

United States
Leiden University Medical Center
HollandPTC; Varian Medical Systems

Recruiting

Image Assisted Optimization of Proton Radiation Therapy in Chordomas and Chondrosarcomas (CHIPT)

Magnetic Resonance Imaging | Chondrosarcoma | Chordoma | Proton Therapy | Bone Neoplasm of Vertebral Column | PET-CT

Netherlands
Mayo Clinic

Recruiting

Retina is a Marker for Cerebrovascular Heath

Cerebral Small Vessel Diseases | Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy | Cerebral Microbleeding | Sporadic White Matter Disease

United States
Kyoto University
Pfizer; Kitasato University; Tokushima University; Tottori University

Recruiting

iPSC-based Drug Repurposing for ALS Medicine (iDReAM) Study

Amyotrophic Lateral Sclerosis

Japan
University of Texas Southwestern Medical Center

Recruiting

POCUS: Hemostatic Potential and Joint Health in Patients With Severe Hemophilia A on Novel Replacement Therapies

Hemophilia A | Factor VIII

United States
Dana-Farber Cancer Institute
Gateway for Cancer Research

Recruiting

Study of Nivolumab and Ipilimumab in Children and Young Adults With INI1-Negative Cancers

Epithelioid Sarcoma | Atypical Teratoid/Rhabdoid Tumor | Malignant Rhabdoid Tumor | Rhabdoid Tumor of the Kidney | Chordoma (Poorly Differentiated or De-differentiated) | Other INI1 Negative Tumors (With PI Approval) | Other SMARCA4-deficient Malignant Tumors (With PI Approval)

United States
Centre Georges Francois Leclerc

Recruiting

EXOME Analysis Position in the Strategy of Genetic Predisposition Factors Identification in Early-onset Cancer (EX²TRICAN)

Cancer | Genetic Predisposition

France
Ohio State University

Recruiting

Long-Term Longitudinal QoL in Patients Undergoing EEA

Chondrosarcoma | Chordoma | Meningioma | Craniopharyngioma | Encephalocele | Esthesioneuroblastoma | Pituitary Tumor | Rathke Cleft Cysts

United States
National Cancer Institute (NCI)

Recruiting

Children and Adults With Chordoma

Chordoma

United States
University of Texas Southwestern Medical Center
Massachusetts General Hospital

Recruiting

Dystonia Genotype-Phenotype Correlation

Dystonia | Dystonia; Idiopathic | Dystonia, Primary | Dystonia, Secondary | Dystonia, Familial | Dystonia Disorder | Dystonias, Sporadic | Dystonia; Orofacial | Dystonia Lenticularis | Dystonia, Paroxysmal | Dystonia 6 | Dystonia 5 | Dystonia 8 | Dystonia 9 | Dystonia 19 | Dystonia 10 | Dystonia 11 | Dystonia 20 | Dystonia 12 | Dystonia... and other conditions

United States
Grupo Espanol de Investigacion en Sarcomas

Recruiting

Trial of Palbociclib in Second Line of Advanced Sarcomas With CDK4 Overexpression. (PalboSarc)

Osteosarcoma | Chordoma | Soft-tissue Sarcoma

Spain
Italian Sarcoma Group

Recruiting

Sacral Chordoma: Surgery Versus Definitive Radiation Therapy in Primary Localized Disease (SACRO)

Chordoma

Italy, Spain, Netherlands, Austria, Germany, Hungary, Japan, Norway, Poland, United Kingdom
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Decision Making Tool in Supporting Decision Making in Contralateral Prophylactic Mastectomy in Patients With Newly Diagnosed Breast Cancer

Anatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage IA Breast Cancer AJCC v8 | Anatomic Stage IB Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage IIA Breast Cancer AJCC v8 | Anatomic Stage IIB Breast Cancer AJCC v8 | Anatomic Stage III Breast Cancer AJCC v8 | Anatomic... and other conditions

United States
Hospices Civils de Lyon

Recruiting

Randomized Carbon Ions vs Standard Radiotherapy for Radioresistant Tumors (ETOILE)

Malignant Tumors as Chordoma, Adenoid Cystic Carcinoma and Sarcoma

France
Ataxia Study Group
German Center for Neurodegenerative Diseases (DZNE)

Recruiting

Sporadic Degenerative Ataxia With Adult Onset: Natural History Study (SPORTAX-NHS)

Late Onset Sporadic Cerebellar Ataxia

Norway, Austria, Germany, Netherlands, Italy
Sanford Health
National Ataxia Foundation; Beyond Batten Disease Foundation; Pitt Hopkins Research... and other collaborators

Recruiting

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford (CoRDS)

Mitochondrial Diseases | Retinitis Pigmentosa | Myasthenia Gravis | Eosinophilic Gastroenteritis | Multiple System Atrophy | Leiomyosarcoma | Leukodystrophy | Anal Fistula | Spinocerebellar Ataxia Type 3 | Friedreich Ataxia | Kennedy Disease | Lyme Disease | Hemophagocytic Lymphohistiocytosis | Spinocerebellar Ataxia... and other conditions

United States, Australia
Heidelberg University

Recruiting

Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Chordoma of the Skull Base (HIT-1)

Chordoma | Tumor | Treatment

Germany
National Human Genome Research Institute (NHGRI)
Children's National Research Institute; Uniformed Services University of the...

Recruiting

Study of Proteus Syndrome and Related Congenital Disorders

Proteus Syndrome | PIK3CA Related Overgrowth Spectrum

United States
Aveni Foundation

Available

BLESSED: Expanded Access for DeltaRex-G for Advanced Pancreatic Cancer, Sarcoma and Carcinoma of Breast

Sarcoma | Soft Tissue Sarcoma | Pancreatic Cancer | Osteosarcoma | Chondrosarcoma | Chordoma | Carcinoma of Breast | MPNST (Malignant Peripheral Nerve Sheath Tumor)

United States
Epizyme, Inc.

Completed

A Study of Tazemetostat in Adult Participants With Soft Tissue Sarcoma

Synovial Sarcoma | Epithelioid Sarcoma | Renal Medullary Carcinoma | Malignant Rhabdoid Tumors (MRT) | Rhabdoid Tumors of the Kidney (RTK) | Atypical Teratoid Rhabdoid Tumors (ATRT) | Selected Tumors With Rhabdoid Features | INI1-negative Tumors | Malignant Rhabdoid Tumor of Ovary | Poorly Differentiated... and other conditions

France, United States, Australia, Taiwan, Belgium, United Kingdom, Canada, Germany, Italy
National Cancer Institute (NCI)

Active, not recruiting

Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

Malignant Solid Neoplasm | Nasopharyngeal Carcinoma | Adenoid Cystic Carcinoma | Transitional Cell Carcinoma | Cholangiocarcinoma | Intrahepatic Cholangiocarcinoma | Chordoma | Gestational Trophoblastic Tumor | Pseudomyxoma Peritonei | Cervical Adenocarcinoma | Vaginal Adenocarcinoma | Vaginal Squamous Cell... and other conditions

United States, Guam
Foghorn Therapeutics Inc.

Terminated

FHD-609 in Subjects With Advanced Synovial Sarcoma or Advanced SMARCB1-Loss Tumors

Advanced Synovial Sarcoma

United States, Spain, France, Italy
Peking University First Hospital

Completed

Optimization of Management for Sporadic Bilateral Renal Cell Carcinoma

Kidney Cancer

China
Jonsson Comprehensive Cancer Center
Bristol-Myers Squibb

Completed

Nivolumab and Relatlimab in Treating Participants With Advanced Chordoma

Chordoma | Metastatic Chordoma | Unresectable Chordoma | Locally Advanced Chordoma

United States
University of California, Irvine
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Active, not recruiting

Sporadic Inclusion Body Myositis Natural History Study (INSPIRE-IBM)

Inclusion Body Myositis | Sporadic Inclusion Body Myositis

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...
Bristol-Myers Squibb; National Cancer Institute (NCI); Chordoma Foundation

Active, not recruiting

Nivolumab With or Without Stereotactic Radiosurgery in Treating Patients With Recurrent, Advanced, or Metastatic Chordoma

Chordoma

United States
Epizyme, Inc.

No longer available

Tazemetostat Expanded Access Program for Adults With Solid Tumors

Renal Cell Carcinoma | Malignant Mesothelioma | Chondrosarcoma | Synovial Sarcoma | Renal Medullary Carcinoma | Malignant Rhabdoid Tumor | Poorly Differentiated Chordoma | Malignant Rhabdoid Tumor of Ovary | Epithelioid Malignant Peripheral Nerve Sheath Tumor | Sinonasal Carcinoma | Spindle Cell Sarcoma | Epithelioid... and other conditions
Novartis Pharmaceuticals

Active, not recruiting

A Study of FAZ053 Single Agent and in Combination With PDR001 in Patients With Advanced Malignancies.

Advanced Solid Tumors | Triple Negative Breast Cancer | Chordoma and Alveolar Soft Part Sarcoma

United States, Taiwan, Spain, Canada, Singapore, Italy, Japan, Israel, France
Massachusetts General Hospital

Active, not recruiting

Nilotinib With Radiation for High Risk Chordoma

Chordoma

United States
Institut Curie

Active, not recruiting

Improvement of Local Control in Skull Base, Spine and Sacral Chordomas Treated by Surgery and Protontherapy Targeting Hypoxic Cells Revealed by [18F]FAZA) PET/CT Tracers (PROTONCHORDE01)

Skull Base Chordoma | Vertebral Chordoma

France
National Cancer Institute (NCI)

Completed

Sorafenib Tosylate in Treating Patients With Metastatic, Locally Advanced, or Recurrent Medullary Thyroid Cancer

Multiple Endocrine Neoplasia Type 2A | Multiple Endocrine Neoplasia Type 2B | Recurrent Thyroid Gland Medullary Carcinoma | Hereditary Thyroid Gland Medullary Carcinoma | Locally Advanced Thyroid Gland Medullary Carcinoma | Sporadic Thyroid Gland Medullary Carcinoma | Stage III Thyroid Gland Medullary... and other conditions

United States

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