Search clinical trials for: Study drug concentration in human tears

Total 472256 results

Santen Inc.

Completed

Ocular Availability in Human Tears After Topical Administration of 1.5% Levofloxacin Compared to Active Comparators

Healthy

United States
Dompé Farmaceutici S.p.A

Recruiting

A Study to Evaluate Safety and Efficacy of a New Formulation of Recombinant Human Nerve Growth Factor (rhNGF) Eye Drop Solution in Patients With Dry Eye Disease (REDUCO)

Dry Eye Disease

United States, Italy
Baylor College of Medicine
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Baylor Infant and Toddler Biomarker of Nutrition Study (BITBONS)

Healthy Diet | Healthy Nutrition

United States
University of Michigan
Food and Drug Administration (FDA)

Recruiting

Pharmacokinetic Study of Single-Dose Modified Release Glipizide in Healthy Volunteers

Human Gastrointestinal Physiology Data

United States
Steve N. Caritis, MD
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Terminated

Relationship Between Plasma Concentration of Hydroxyprogesterone Caproate (17-OHPC) and Preterm Birth (PRO)

Preterm Birth

United States
Eli Lilly and Company

Completed

A Study of Olaratumab (LY3012207) in Participants With Advanced Soft Tissue Sarcoma (ANNOUNCE 2)

Soft Tissue Sarcoma

United States, France, Spain, Australia, Germany, United Kingdom, Israel, Hungary, Italy, Poland
University of California, Davis
University of British Columbia; Khon Kaen University; USDA, Western Human Nutrition... and other collaborators

Completed

Lao Zinc Study: Effects of Two Forms of Daily Preventive Zinc Versus Therapeutic Zinc Supplementation

Diarrhea

Lao People's Democratic Republic
Shire

Completed

Study to Assess the Blood Concentrations and Actions of Recombinant Human Parathyroid Hormone (rhPTH [1-84]) When Given Once and Twice Daily to Participants With Hypoparathyroidism (PARALLAX)

Hypoparathyroidism

United States, Hungary, Canada, Denmark
Kuopio University Hospital
Business Finland; 4Pharma Ltd.; Finnsusp Ltd.

Completed

Piiloset Trehalose Emulsion Eye Drop Study in Moderate or Severe Dry Eye

Dry Eye Syndrome

Finland
Eli Lilly and Company

Completed

A Study of LY2605541 (Insulin Peglispro) and Human Insulin Concentrations in Fat Tissue

Diabetes Mellitus, Type 1

Austria
Pfizer

Completed

A Study To Understand Safety And Plasma Concentrations Of PF-06669571 During And Following The Oral Administration Of Single And Multiple Doses Of PF-06669571 In Healthy Volunteers Under Fasted And Fed Conditions

Healthy

United States
Merck Sharp & Dohme LLC

Completed

A Study to Evaluate the Pharmacokinetic Effect of SCH 503034 (Boceprevir) on Methadone or Buprenorphine/Naloxone Plasma Concentrations (P08123)

Hepatitis C Virus
Wockhardt
Clinartis

Completed

Study to Determine and Compare Plasma and Intrapulmonary Concentrations of WCK 4873 in Healthy Adult Human Subjects

Healthy

United States
Assistance Publique - Hôpitaux de Paris

Completed

Study of Analgesics Drug and Human Milk Transfer in Mature Milk, to Avoid Breastfeeding Cessation Without Scientific Probes (ANTALAIT)

Analgesics Use During Breastfeeding and Concentrations in Human Mature Milk

France
Tibotec, Inc
Tibotec Therapeutics, a Division of Ortho Biotech Products, L.P., USA

Completed

A Study to Evaluate the Pharmacokinetic Profile (How the Body Absorbs, Distributes, Metabolizes and Eliminates a Drug) of TMC125 Plus Tenofovir/Emtricitabine Once Daily With or Without Darunavir/r Once Daily in Antiretroviral (ARV) Naive HIV-1 Patients (Patients Have Never Received ARV Treatment).

HIV-1 Infection
TNO
Alloksys Life Sciences B.V.

Completed

Microdose and First-In-Human (FIH) Study of Recombinant Human Placental Alkaline Phosphatase (hRESCAP)

Healthy

Netherlands
Wockhardt

Completed

Comparative Glucose Clamp Study of Wockhardt's Insulin Human Regular for Injection and Actrapid, in Healthy Subjects.

Diabetes

United States
Pfizer

Completed

A First In Human Study In Healthy People To Evaluate Safety, Toleration And Time Course Of Plasma Concentration Of Single Oral Doses Of PF-06273340

PAIN

Belgium
University of Reading
Comvita UK

Completed

Absorption and Metabolism of Olive Leaf Extract and Its Effect on Vascular Reactivity and Cytokine Concentrations

Absorption and Metabolism | Effect on Vascular Function | Effect on Cytokine Concentrations

United Kingdom
BioLineRx, Ltd.

Completed

A Study of the Safety and Efficacy of Combination Therapy With Morphine, Phenylephrine and Sorbitol in Human Subjects

Acute Pain

Israel
BeiGene

Not yet recruiting

Phase 1 First-in-Human Study of BGB-C354 Alone and in Combination With Tislelizumab in Participants With Advanced Solid Tumors

Advanced Solid Tumor
Bostal Drug Delivery Co., Ltd

Not yet recruiting

A Study to Evaluate Safety, Tolerability and pK of Semaglutide ER Injectable Suspension in Healthy, Adult Human Subjects

Diabetes Mellitus, Type 2
Top Health S.A.P.I DE C.V.
CLINICAL RESEARCH PS MEXICO

Not yet recruiting

Study to Evaluate the Effectivity and Safety of BIOSCAFF®H Compared to DuraGen®, in Patients Undergoing Dural Repair

Cerebrospinal Fluid Leakage
Kite, A Gilead Company
Arcellx, Inc.

Not yet recruiting

A Study Comparing Anitocabtagene Autoleucel to Standard of Care Therapy in Participants With Relapsed/ Refractory Multiple Myeloma (iMMagine-3)

Multiple Myeloma
University of Edinburgh

Not yet recruiting

HPV Equity Study: Exploring Cervical Cancer Control in Scotland for Women With Experience of Priority Risks (HPV Equity)

Human Papilloma Virus
Serum Institute of India Pvt. Ltd.

Recruiting

Clinical Study to Assess the Immunogenicity and Safety of Hexavalent Vaccine Containing Reduced Dose IPV

Hepatitis B Immunization | Diptheria Immunization | Tetanus Immunization | Pertussis Immunization | Haemophilus Influenzae Type B Immunization | Polio Immunization

Bangladesh, India
Medinol Ltd.

Not yet recruiting

First In Human Study to Assess Safety and Efficacy of the ChampioNIR™ Drug Eluting Peripheral Stent in the Treatment of Patients With Superficial Femoral Artery Disease and/or Proximal Popliteal Artery Disease (CHAMPIONSHIP)

Popliteal Artery Stenosis | Superficial Femoral Artery Stenosis
M.D. Anderson Cancer Center

Not yet recruiting

Phase II Study of REPotrectinib With or Without Fulvestrant in Patients With Hormone Receptor-positive Human Epidermal Growth Factor 2-negative Metastatic Invasive LObular Carcinoma Who Received a Prior Endocrine Therapy in Combination With Cyclin-dependent Kinase 4 and 6 Inhibitor (REPLOT Trial)

Hormone Receptor-positive Human Epidermal Growth Factor 2-negative | Metastatic Invasive LObular Carcinoma

United States
Oregon Health and Science University

Not yet recruiting

DBS TaT in Peer-assisted Telemedicine for Hepatitis C

Hepatitis C
Kyverna Therapeutics

Not yet recruiting

A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in Subjects With Systemic Sclerosis

Systemic Sclerosis | Systemic Sclerosis - Diffuse Cutaneous | Systemic Sclerosis - 2013 ACR/EULAR Classification Criteria
Celgene
Bristol-Myers Squibb

Recruiting

A Study to Compare the Efficacy and Safety of Idecabtagene Vicleucel With Lenalidomide Maintenance Therapy Versus Lenalidomide Maintenance Therapy Alone in Adult Participants With Newly Diagnosed Multiple Myeloma Who Have Suboptimal Response After Autologous Stem Cell Transplantation (KarMMa-9)

Multiple Myeloma

Austria, United States, Spain, Australia, Japan, France, Israel, Italy, Canada, Greece, Belgium, Norway, Romania, Czechia, Denmark, Germany, Korea, Republic of, United Kingdom, Poland
Mayo Clinic
Universidade Federal de Goias; University of Wisconsin, Eau Claire

Recruiting

A Study of Melatonin Concentration During Lactation

Breastfeeding

United States
Assembly Biosciences

Not yet recruiting

A Study to Assess the Safety, Pharmacokinetics, and Antiviral Activity of ABI-4334 in Subjects With Chronic Hepatitis B Virus Infection

Chronic Hepatitis B
BioMarin Pharmaceutical

Not yet recruiting

A Phase 2 Study of Vosoritide in Children With Idiopathic Short Stature

Idiopathic Short Stature
GlaxoSmithKline

Recruiting

A Study to Find and Confirm the Dose and Assess Safety, Reactogenicity and Immune Response of a Vaccine Against Pandemic H5N1 Influenza Virus in Healthy Younger and Older Adults

Influenza, Human

United States
Adicet Bio, Inc

Not yet recruiting

A Phase 1 Study of ADI-001 in Lupus Nephritis

Autoimmune Diseases | Lupus Nephritis
King Chulalongkorn Memorial Hospital
Health Systems Research Institute,Thailand

Recruiting

Investigating Neurocognitive Disorders Epidemiology (INDE)

Dementia | Alzheimer Disease | Cognitive Decline

Thailand
G.ST Antivirals GmbH

Recruiting

A Controlled Human Rhinovirus Infection Study of 2-Deoxy-D-Glucose in Healthy Adults

Acute Nasopharyngitis

Netherlands
EdiGene Inc.
The First Affiliated Hospital of Henan University of Science and Technology; Changping Laboratory

Recruiting

A Study to Evaluate the Safety and Efficacy of ATHENA CAR-T in Subjects With Systemic Lupus Erythematosus

Lupus Erythematosus, Systemic

China
Wageningen University

Recruiting

The EXPLAIN Study: Exploring Plant-Based Meat Analogues for Their Impact on Health (EXPLAIN)

Blood Pressure | Cardiometabolic Health

Netherlands
bioLytical Laboratories

Not yet recruiting

A Study to Evaluate the Performance, Usability, and Result Interpretation of INSTI® HIV Self-Test

Human Immunodeficiency Virus I Infection | Human Immunodeficiency Virus II Infection
Puma Biotechnology, Inc.

Not yet recruiting

A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer (ALISCA-Breast1)

Metastatic Breast Cancer | Recurrent Breast Cancer | Hormone Receptor Positive HER-2 Negative Breast Cancer

United States
Centre Hospitalier Universitaire de Saint Etienne

Recruiting

Pharmacology of Mupirocin in Nasal Application in Healthy Volunteers: Monocentric Study (MUPIPHARM)

Healthy | Staphylococcus Aureus Infection

France
Chinese University of Hong Kong

Recruiting

SGLT2i to Prevent of Liver Complications in Patients With CHB and Diabetes Mellitus

Chronic Hepatitis B

Hong Kong
Octapharma

Recruiting

Study of IV Human Plasma-derived C1 Esterase Inhibitor Concentrate in Patients With Congenital C1-INH Deficiency for Treatment and Pre-procedure Preventing of Acute Hereditary Angioedema Attacks

Acute Hereditary Angio Edema

Romania
Sanofi Pasteur, a Sanofi Company

Recruiting

A Study to Investigate the Safety and Immunogenicity of the Quadrivalent Influenza mRNA Vaccines in Adults Aged 18 Years and Above

Influenza Immunization

United States, Puerto Rico
Johns Hopkins University
ON Foundation

Not yet recruiting

Varying Bone Marrow-Derived Mesenchymal Stem Cells Concentrations' Impact on Rotator Cuff Repair Outcomes

Rotator Cuff Tears

United States
M.D. Anderson Cancer Center
Bellicum Pharmaceuticals, Inc.

Not yet recruiting

Dose Escalation and Expansion Study of TROP2 CAR Engineered IL-15- Transduced Cord Blood-derived NK Cells in Combination With Cetuximab in Patient With Colorectal Cancer (CRC) With Minimal Residual Disease (MRD)

Colorectal Cancer | Minimal Residual Disease

United States
Pavol Jozef Safarik University
University of Roma La Sapienza; Western University; L Pasteur University Hospital and other collaborators

Not yet recruiting

Complex Exploratory Study of Alcohol-Associated Hepatitis (CESAH)

Alcoholic Hepatitis

Slovakia
Beijing Friendship Hospital

Not yet recruiting

A Study on Factors of Biochemical Response in Autoimmune Hepatitis

Autoimmune Hepatitis

China

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