Search clinical trials for: asparagine depletion

Total 305 results

ERYtech Pharma

Completed

Study of Eryaspase in Combination With Chemotherapy Versus Chemotherapy Alone as 2nd-Line Treatment in PAC (Trybeca-1)

Pancreatic Adenocarcinoma

United States, United Kingdom, France
Liangjing Lu
Shanghai Ming Ju Biotechnology Co., Ltd.

Not yet recruiting

Relmacabtagene Autoleucel for the Treatment of Systemic Sclerosis

Systemic Sclerosis

China
Novartis Pharmaceuticals

Not yet recruiting

Pharmacokinetics Study of Ianalumab in Chinese Participants With Autoimmune Diseases

Systemic Lupus Erythematosus | Sjogren Disease
Novartis Pharmaceuticals

Not yet recruiting

Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL PFS with1mL Pre-filled Syringe in Adult Participants With Autoimmune Disease

Rheumatoid Arthritis | Systemic Lupus Erythematosus | Sjögrens Disease
Rigshospitalet, Denmark
Canadian Institutes of Health Research (CIHR); Diabetesforeningen; Region Hovedstadens...

Not yet recruiting

Depletion of Liver Fat in Type 2 Diabetes (DepLiv)

Obesity | Type2diabetes
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Allogeneic Immunotherapy of Hematological Malignancies Using Regulatory T-cell Selective Depletion (ILDTreg2)

Hematological Malignancies | Relapse | Regulatory T Cell Depletion
Novartis Pharmaceuticals

Recruiting

Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension). (SIRIUS-SLE LTE)

Systemic Lupus Erythematosus

Spain
Nationwide Children's Hospital

Recruiting

αβT Cell/CD19+ B Cell Depletion for Alternative Donor Allogeneic Hematopoietic Cell Transplantation (HSCT) (TB19DHCT)

Hematologic Malignancy | Hematopoietic Stem Cell Transplantation

United States
Neena Kapoor, M.D.

Not yet recruiting

TCRαβ/CD19 Depletion of Stem Cell Grafts for Transplant

Acute Myeloid Leukemia | Acute Lymphoblastic Leukemia | Hematologic Malignancy | Graft Vs Host Disease | Graft-versus-host-disease | Non-hematologic Malignancy
Jinnah Postgraduate Medical Centre

Not yet recruiting

Efficacy of L-Ornithine L-Aspartate and Polyethylene Glycol in Cirrhotic Patients With Overt Hepatic Encephalopathy

Hepatic Encephalopathy Stage 2 | Hepatic Encephalopathy Stage 3 | Hepatic Encephalopathy Stage 4

Pakistan
Novartis Pharmaceuticals

Recruiting

A Study of Ianalumab (VAY736) in Patients With Primary Immune Thrombocytopenia (ITP) Previously Treated With at Least Two Lines of Therapies

Primary Immune Thrombocytopenia (ITP)

Spain, Italy, France, Germany, China, Korea, Republic of, Czechia, Turkey, Malaysia, United States, Argentina, Australia, United Kingdom, Poland
Nanjing University School of Medicine

Recruiting

Trial of Belimumab Combined With Multi-target Induction Therapy in Lupus Nephritis (BEAM)

Lupus Nephritis | Safety Issues | Remission

China
Guy's and St Thomas' NHS Foundation Trust
King's College London

Recruiting

Beyond the Eosinophil: Understanding the Impact of Eosinophil Depletion on T2 Inflammation. (BEUTI) (BEUTI)

Asthma

United Kingdom
University of Florida
Florida Department of Health

Recruiting

Alpha/Beta T Cell and CD19+ B Cell Depletion in Allogeneic Stem Cell Transplantation in Patients With Malignant Diseases

Lymphoma, Non-Hodgkin | Acute Myeloid Leukemia | Myelodysplastic Syndromes | Juvenile Myelomonocytic Leukemia | Acute Lymphoblastic Leukemia | Chronic Myeloid Leukemia | Lymphoma, Hodgkin

United States
Medical College of Wisconsin

Recruiting

MCW Alpha/Beta T-Cell and B-Cell Depletion With Targeted ATG Dosing

Leukemia | Burkitt Lymphoma | Lymphoblastic Lymphoma | Myelodysplasia | Acute Myeloid Leukemia in Remission | Acute Lymphoblastic Leukemia in Remission | Chronic Myelogenous Leukemia - Chronic Phase | Chronic Myelogenous Leukemia, Accelerated Phase | Biphenotypic Acute Leukemia | Burkitt Leukemia | Chronic... and other conditions

United States
University of Pittsburgh

Recruiting

Buoy Electrolyte Study on Hydration Status of Active Men and Women

Dehydration | Fluid and Electrolyte Imbalance | Electrolyte Imbalance | Electrolyte Depletion

United States
Masonic Cancer Center, University of Minnesota

Recruiting

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Acute Lymphoblastic Leukemia | AML | Acute Leukemia | Neurofibromatosis 1 | Hematologic Malignancy | Myelodysplasia | Minimal Residual Disease | Chromosome Abnormality | Monosomy 7 | Remission | Somatic Mutation | Cytogenetic Abnormality | TP53 | Fetal Hemoglobin | Intrachromosomal Amplification of Chromosome... and other conditions

United States
Universitätsklinikum Köln

Not yet recruiting

S-ICD Electrode Registry

Sudden Cardiac Death | ICD Malfunction

Germany
Hospices Civils de Lyon

Recruiting

Hypovitaminosis C Prevalence and Risk Factors in an Acute Geriatric Unit (HYPO-VIT-C)

Deficiency, Vitamin C

France
Novartis Pharmaceuticals

Recruiting

A Study of Efficacy and Safety of Ianalumab Versus Placebo in Addition to Eltrombopag in Primary Immune Thrombocytopenia Patients Who Failed Steroids (VAYHIT2)

Primary Immune Thrombocytopenia

United States, China, Germany, Spain, Singapore, Japan, Taiwan, Belgium, Italy, Czechia, Hungary, Malaysia, Korea, Republic of, Turkey, Argentina, Thailand, India, United Kingdom, France, Australia, Romania, Austria, Norway, Netherlands, Philippin...
Novartis Pharmaceuticals

Recruiting

Study of Ianalumab Versus Placebo in Addition to First-line Corticosteroids in Primary Immune Thrombocytopenia (ITP) (VAYHIT1)

Primary Immune Thrombocytopenia (ITP)

China, United States, Spain, Singapore, Austria, Germany, Belgium, Italy, Japan, Czechia, Hong Kong, Hungary, Malaysia, Argentina, Bulgaria, Turkey, Vietnam, Australia, Thailand, Mexico, United Kingdom, France, Romania, Norway, India
Novartis Pharmaceuticals

Recruiting

A Study of Efficacy and Safety of Ianalumab in Previously Treated Patients With Warm Autoimmune Hemolytic Anemia (VAYHIA)

Warm Autoimmune Hemolytic Anemia (wAIHA)

China, Japan, Spain, Singapore, France, Germany, Taiwan, United States, Italy, India, Malaysia, Argentina, Hungary, Israel, Australia, Thailand, United Kingdom, Romania
Novartis Pharmaceuticals

Recruiting

Phase 3 Study to Evaluate Two Regimens of Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 1) (SIRIUS-SLE 1)

Systemic Lupus Erythematosus

China, Japan, United States, Spain, Thailand, Brazil, Singapore, Turkey, Israel, Hungary, Portugal, Slovakia, Guatemala, Poland, Czechia, Bulgaria, South Africa, Canada
Novartis Pharmaceuticals

Recruiting

Phase 3 Study to Evaluate Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 2) (SIRIUS-SLE 2)

Systemic Lupus Erythematosus

United States, Germany, France, Taiwan, Italy, India, Argentina, Korea, Republic of, Mexico, Malaysia, Chile, Colombia, Romania, Australia, United Kingdom
Children's Oncology Group

Recruiting

Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome

Acute Myeloid Leukemia | Acute Lymphoblastic Leukemia | Myelodysplastic Syndrome | Mixed Phenotype Acute Leukemia

United States, Australia, Canada
Novartis Pharmaceuticals

Recruiting

Three-arm Study to Assess Efficacy and Safety of Ianalumab (VAY736) in Patients With Active Sjogren's Syndrome (NEPTUNUS-2)

Sjogren Syndrome

Spain, Hungary, Germany, Canada, Greece, United Kingdom, Bulgaria, Japan, Colombia, United States, South Africa, Australia, China, Mexico, Israel, Lebanon, Taiwan, Argentina, Italy, France, Chile, Romania, India, Brazil, Poland, Slovakia, S...
Nanjing Medical University
Beijing Anzhen Hospital; Second Affiliated Hospital of Nanchang University

Recruiting

Additive Anti-inflammatory Action for Aortopathy & Arteriopathy (Thymosin α1) V

Acute Aortic Syndrome | Aortic Dissectio

China
Novartis Pharmaceuticals

Recruiting

Long-term Follow-up of Patients With Spinal Muscular Atrophy Treated With OAV101 in Clinical Trials (SPECTRUM)

Spinal Muscular Atrophy (SMA)

Spain, Canada, Taiwan, Belgium, Malaysia, China, Japan, Italy, Singapore, United Kingdom, France, Australia, Thailand, Denmark, United States
Beijing Friendship Hospital

Not yet recruiting

L-DEP/DEP Regimen and PD-1 Antibody as a Treatment for Relapse/Refractory EBV-HLH

Hemophagocytic Lymphohistiocytosis

China
Baylor College of Medicine
The Methodist Hospital Research Institute; Center for Cell and Gene Therapy...

Recruiting

Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 Depletion (HAPLOTAB)

Myelodysplastic Syndromes | Primary Immunodeficiency Diseases | Hemoglobinopathies | Chronic Myeloid Leukemia | Cytopenia | Severe Aplastic Anemia | Bone Marrow Failure Syndrome | Acute Myeloid Leukemia in Remission | Hemophagocytic Lymphohistiocytoses | Acute Lymphoblastic Leukemia in Remission | Severe...

United States
Haider Mahdi
Dr. Reddys Laboratories, SA

Recruiting

T-regulatory Cell Depletion With E7777 Combined With Pembrolizumab in Recurrent or Metastatic Solid Tumors

Epithelial Ovarian Cancer

United States
Novartis Pharmaceuticals

Recruiting

Safety, Efficacy and Tolerability of Ianalumab Versus Placebo, Combination With SoC Therapy, in Participants With Active Lupus Nephritis (SIRIUS-LN)

Lupus Nephritis

China, United States, Spain, Germany, Korea, Republic of, Italy, Thailand, Hungary, Argentina, Brazil, Singapore, Taiwan, France, Vietnam, Malaysia, Lithuania, Canada, India, Colombia, Romania, United Kingdom, Czechia, Guatemala, Mexico, Eston... and more
Federal Research Institute of Pediatric Hematology...

Recruiting

Ex-vivo Primed Memory Donor Lymphocyte Infusion to Boost Anti-viral Immunity After T-cell Depleted HSCT

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Acute Lymphoblastic Leukemia, in Relapse | Non-hodgkin Lymphoma | High Risk Acute Myeloid Leukemia | High Risk Acute Lymphoblastic Leukemia | Acute Biphenotypic Leukemia in Relapse

Russian Federation
Stephan Grupp MD PhD

Recruiting

Autologous Stem Cell Transplant (ASCT) for Autoimmune Diseases

Systemic Lupus Erythematosus | Systemic Sclerosis

United States
Washington University School of Medicine

Recruiting

Haploidentical Hematopoietic Stem Cell Transplantation With Ex Vivo TCR Alpha/Beta and CD19 Depletion in Pediatric Hematologic Malignancies

Pediatric Hematologic Malignancies

United States
Aspa Therapeutics

Recruiting

A Study of AAV9 Gene Therapy in Participants With Canavan Disease (CANaspire)

Canavan Disease

United States
University of Birmingham
IMPACT (funded by NHS Blood & Transplant, Anthony Nolan and Leukaemia UK)

Recruiting

Methods of T Cell Depletion Trial (MoTD) (MoTD)

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Multiple Myeloma | Hodgkin Lymphoma | Myelofibrosis | Chronic Myelomonocytic Leukemia | Acute Lymphoblastic Leukemia | Non Hodgkin Lymphoma | Chronic Myelogenous Leukemia

United Kingdom
Universitätsklinikum Hamburg-Eppendorf

Recruiting

The Influence of Ego-depletion on Implicit Aggression and Cognitive Performance

Aggression

Germany
McGill University Health Centre/Research Institute...

Recruiting

Deoxynucleosides Pyrimidines as Treatment for Mitochondrial Depletion Syndrome (dC-dT-MDS)

Mitochondrial Diseases | Mitochondrial Encephalomyopathy | Mitochondrial Encephalopathy | Mitochondrial DNA Depletion | Mitochondrial Metabolism Disorders

Canada
Adipeau Inc.
Romo Plastic Surgery

Recruiting

A Clinical Trial Evaluating the Efficacy of a Skin Cream in Improving Facial Appearance and Skin Elasticity

Photoaging | Atrophy, Hemifacial | Elastosis

United States
Porteus, Matthew, MD
California Institute for Regenerative Medicine (CIRM)

Recruiting

Stem Cell Transplant From Donors After Alpha Beta Cell Depletion in Children and Adults With T-allo10 Cells Addback

Hematologic Diseases

United States
Pontificia Universidad Catolica de Chile

Recruiting

Fluid unLoading On Weaning (FLOW) (FLOW)

Fluid Overload | Weaning Failure | Cardiac Failure Acute

Chile
Christopher Dvorak

Recruiting

A Feasibility Study Using CLINIMACS® for Alpha/Beta T-Cell Depletion in Stem Cell Transplant

Graft Vs Host Disease | Graft-versus-host-disease

United States
Institut Cancerologie de l'Ouest

Recruiting

Impact of Bladder Depletion on Mesorectal Movements During Radiotherapy in Rectal Cancer (MESORECT-VV)

Rectal Cancer

France
Alice Bertaina

Recruiting

Stem Cell Transplant From Donors After Alpha Beta Cell Depletion in Children and Young Adults

Hematologic Diseases

United States
University of Chicago

Recruiting

Haploidentical Hematopoietic Stem Cell Transplantation (HSCT) for Patients With Severe Sickle Cell Disease

Sickle Cell Disease

United States
Aspa Therapeutics

Recruiting

Natural History Study of Patients With Canavan Disease

Canavan Disease

United States, Germany
Mitchell Cairo

Recruiting

AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion

Hodgkin Lymphoma | Sickle Cell Disease | Acute Leukemia | Beta-Thalassemia | Non-hodgkin Lymphoma | Severe Aplastic Anemia | Diamond Blackfan Anemia | Amegakaryocytic Thrombocytopenia | Kostmann

United States
Shanghai Children's Medical Center
Chinese University of Hong Kong; Nanfang Hospital of Southern Medical University and other collaborators

Recruiting

TCDαβ/CD45RA Haploidentical Transplantation in Children With Leukemia

Relapsed Pediatric AML | Relapsed Pediatric ALL | Acute Graft-Versus-Host Disease (Gvhd) Grade IV (Diagnosis)

China
Wuerzburg University Hospital

Recruiting

Autologous Dendritic Cells, Metronomic Cyclophosphamide and Checkpoint Blockade in Children With Relapsed HGG

Childhood Glioblastoma

Germany

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