Search clinical trials for: autophagy

Total 88 results

Affiliated Hospital of Nantong University

Not yet recruiting

Pretreatment With HCQ Before Radiotherapy and Chemotherapy in Advanced NPC Patients

Nasopharyngeal Carcinoma

China
Hospices Civils de Lyon
Centre International de Recherche en Infectiologie (CIRI)

Not yet recruiting

TOward a Better Understanding of the autoPhagy Machinery for the Identification of Potential Novel Biomarkers and Therapeutic Targets in Crohn's Disease - TOPIC Study (TOPIC)

Crohn's Disease

France
Southern Medical University, China

Not yet recruiting

The Effectiveness of HP and TMZ Synergism on Adult Recurrence GBM

Glioblastoma Multiforme
University of Aarhus
Danish Cardiovascular Academy (DCA); Danish Diabetes Academy; Sygesikringen Danmark and other collaborators

Recruiting

Polyamine Treatment in Elderly Patients With Coronary Artery Disease (PolyCAD)

Myocardial Infarction | Cardiovascular Diseases | Quality of Life | Inflammation | Hypertension | Obesity | Diabetes Mellitus, Type 2 | Cognitive Impairment | Metabolic Syndrome | Ischemic Heart Disease | Dietary Habits | Diastolic Dysfunction | Cognition Disorder | Hypertensive Heart Disease

Denmark
McMaster University

Not yet recruiting

Nutritional Therapy in Late-onset Pompe Disease (PDT-MIS)

Obesity | Lysosomal Storage Diseases | Muscle Loss | Glycogen Storage Disease Type II | Pompe Disease | Nutrition Poor | Glycogen Storage Disease Type II, Adult | Glycogen Storage Disease Type II Late Onset
Mostafa Bahaa

Recruiting

Activation of Autophagy and Suppression of Apoptosis by Dapagliflozin Attenuates Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Egypt
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Recruiting

A Phase Ib/II Study Confirmed Inhibition of Autophagy Synergizes Anti-tumor Effect of High Dose CDK4/6i

Inhibition of Autophagy Synergizes Anti-tumor Effect

China
IMDEA Food
Ministerio de Ciencia e Innovación, Spain; CIBER Fisiopatología de la Obesidad...

Recruiting

Healthy Aging Through Time- Restricted Eating in Adults With Overweight/Obesity and Incipient Liver Disease: ENSATI (ENSATI)

Biological Aging

Spain
Ospedale San Raffaele

Recruiting

Study of the Expression of Autophagy Markers in the Myocardium in Patients With Persistent or Permanent Atrial Fibrillation (MIPAR-02)

Atrial Fibrillation

Italy
Hospices Civils de Lyon

Not yet recruiting

Autophagy in Paediatric Crohn's Disease (P-IBDphagy)

Crohn Disease | Pediatric Crohns Disease

France
VA Office of Research and Development

Not yet recruiting

Targeting Ischemia-Induced Autophagy Dependence in Hepatocellular Carcinoma (TAQE)

Hepatocellular Carcinoma

United States
Assiut University

Not yet recruiting

Hypoxia-induced Autophagy in the Pathogenesis of MAP

Hypoxia | Morbidly Adherent Placenta | Autophagy | Placenta
Association pour la Recherche Clinique et Immunologique

Not yet recruiting

Autophagy Dysfunction in Hidradenitis Suppurativa (AUTOPH-HS)

Hidradenitis Suppurativa (HS)
Medical College of Wisconsin

Recruiting

Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction

Type 2 Diabetes | Healthy Aging

United States
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Not yet recruiting

Regulatory Network and Diagnostic Value of Key Autophagy-related Genes in Sepsis

Sepsis | Autophagy
Paracelsus Medical University
Department of Psychiatry University of Bonn

Recruiting

Multi-level Molecular Profiling of Peak Performance in Endurance Sports (MSSA)

Healthy | Exercise | Physical Fitness | Exercise Test

Austria
Sohag University

Recruiting

ATG5 as a Serum Marker of Autophagy in Psoriatic Patient

Psoriasis Vulgaris | Autophagy

Egypt
Abramson Cancer Center at Penn Medicine
Johns Hopkins University; Pfizer; Translational Breast Cancer Research Consortium and other collaborators

Recruiting

Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer (PALAVY)

Breast Cancer

United States
Charite University, Berlin, Germany
Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum...

Recruiting

An Exploratory Clinical Study on Autophagy During Fasting

Healthy | Arthritis, Rheumatoid | Syndrome, Metabolic

Germany
Centre Hospitalier Universitaire de Nīmes

Recruiting

Autophagy/Apoptosis Balance During Pregnancy (GROSSAUTOP)

Pregnancy Related

France
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI); American Lebanese Syrian Associated Charities...

Recruiting

A Trial of Dabrafenib, Trametinib and Hydroxychloroquine for Patients With Recurrent LGG or HGG With a BRAF Aberration

Low Grade Glioma (LGG) of Brain With BRAF Aberration | High Grade Glioma (HGG) of the Brain With BRAF Aberration | Low Grade Glioma of Brain With Neurofibromatosis Type 1

United States
Centre Hospitalier Régional d'Orléans

Recruiting

Study of Autophagy and the Effects of GALIG Gene Products in HIV-1 Infected Patients Who Are Under Antiretroviral Therapy Since Primary-infection, Chronic Phase, or Never Treated. (ATGALIG-HIV)

HIV Infections | Autophagy | Galectins | Highly Active Antiretroviral Therapy

France
Neuromed IRCCS

Recruiting

Potential Impact of Neuroimmune and Autophagic Alterations on the Progression and Severity of Human Atherosclerotic Process

Carotid Atherosclerosis

Italy
University Hospital of Ferrara
AUSL Romagna Rimini

Recruiting

Use of Melatonin for Neuroprotection in Asphyxiated Newborns (MELPRO)

Hypoxic-Ischemic Encephalopathy | Cell Damage | Asphyxia Perinatal

Italy, Holy See (Vatican City State)
Universitair Ziekenhuis Brussel
University Hospital, Ghent

Recruiting

Dabrafenib/Trametinib/Hydroxychloroquine for Advanced Pretreated BRAF V600 Mutant Melanoma (COMBI-R2)

Melanoma

Belgium
The Cleveland Clinic

Recruiting

Ethanol Induces Skeletal Muscle Autophagy

Alcoholic Liver Disease

United States
The University of Texas Health Science Center at...

Recruiting

Sorafenib Induced Autophagy Using Hydroxychloroquine in Hepatocellular Cancer

Hepatocellular Cancer

United States
Far Eastern Memorial Hospital
Ministry of Science and Technology, Taiwan

Recruiting

The Influence of Autophagy on Fatty Liver

Obesity | Non-alcoholic Fatty Liver Disease

Taiwan
University of Oxford

Completed

Improving Vaccination in Older Adults by Inducing Autophagy With Spermidine

COVID-19 | Vaccine Reaction

United Kingdom
University Hospital, Grenoble
Genoscience Pharma

Terminated

Ezurpimtrostat Autophagy Inhibitor in Association With Atezolizumab-Bevacizumab in First Line Treatment of Unresectable Hepatocellular Carcinoma (ABE-LIVER)

Hepatocellular Carcinoma

France
Esraa Hassan,MD
South Egypt Cancer Institute

Active, not recruiting

Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population

Colo-rectal Cancer

Egypt
Radboud University Medical Center

Completed

Digoxin for the Reinduction of Radioiodine Uptake in Metastatic or Locally Advanced Non-medullary Thyroid Carcinoma (DIGUP-TC)

Non-Medullary Thyroid Carcinoma

Netherlands
L-Nutra Inc
The University of Texas Health Science Center at San Antonio

Active, not recruiting

Fasting Mimicking Diet and Autophagy

Diet | Autophagy

United States
British Columbia Cancer Agency
University of Victoria; BC Cancer Foundation

Completed

A Case Crossover Study of Intermittent Fasting in CLL/SLL

Chronic Lymphocytic Leukemia (CLL) | Small Lymphocytic Lymphoma (SLL)

Canada
Columbia University
Genentech, Inc.

Active, not recruiting

Study of Combination Therapy With the MEK Inhibitor, Cobimetinib, Immune Checkpoint Blockade, Atezolizumab, and the AUTOphagy Inhibitor, Hydroxychloroquine in KRAS-mutated Advanced Malignancies (MEKiAUTO)

Gastrointestinal Cancer

United States
University of New Mexico

Completed

A Double-Blind, Placebo-Controlled Trial of Anti-Aging, Pro-Autophagy Effects of Metformin in Adults With Prediabetes

PreDiabetes | Aging

United States
Muğla Sıtkı Koçman University

Completed

Autophagy Markers in Endometrial Polyps

Endometrial Polyp | Autophagy

Turkey
Maastricht Radiation Oncology

Withdrawn

The Addition of Chloroquine to Chemoradiation for Glioblastoma,

Glioblastoma | Astrocytoma, Grade IV
Centre Hospitalier Universitaire de Nice

Completed

Autophagy and Pathological Aging (AVP)

Osteoporosis

France
National Cancer Institute (NCI)

Terminated

Combination of Trametinib (MEK Inhibitor) and Hydroxychloroquine (HCQ) (Autophagy Inhibitor) in Patients With KRAS Mutation Refractory Bile Tract Carcinoma (BTC).

Cholangiocarcinoma | Bile Duct Cancer | Biliary Tract Neoplasms | Biliary Cancer

United States
Mayo Clinic
National Cancer Institute (NCI)

Withdrawn

Autophagy Activation for the Alleviation of Cardiomyopathy Symptoms After Anthracycline Treatment, ATACAR Trial

Hematopoietic and Lymphoid Cell Neoplasm | Sarcoma | Lymphoma | Breast Carcinoma

United States
University of New Mexico

Completed

mTORC1 and Autophagy in Human Brown Adipocytes (mTORHBFC)

Obesity | Metabolic Disease

United States
RedHill Biopharma Limited

Completed

A Study of ABC294640 (Yeliva ®) Alone and in Combination With Hydroxychloroquine Sulfate in Treatment of Patients With Advanced Cholangiocarcinoma

Cholangiocarcinoma | Cholangiocarcinoma Non-resectable | Cholangiocarcinoma, Perihilar | Cholangiocarcinoma, Extrahepatic | Cholangiocarcinoma, Intrahepatic

United States
Centre Hospitalier Régional d'Orléans

Completed

Effects of Cannabidiol (CBD) on the Activation of Autophagy and Inflammation Genes, Functional Consequences in Virologically Controlled HIV-infected Patients (GALIG-CBD)

HIV Seropositivity

France
Neuromed IRCCS
Principal investigator: Giacomo Frati; Co-investigator: Francesco Pompeo

Active, not recruiting

Autophagy and Venous Endothelial Function

Venous Disease

Italy
Washington University School of Medicine

Active, not recruiting

Dietary Protein and Monocyte/Macrophage Mammalian Target of Rapamycin (mTOR) Signaling (mTOR)

Dietary Protein

United States
Autophagy Sciences, Inc.

Completed

A Study of A4368 in Healthy Subjects (A4368)

Health Subjects

Korea, Republic of
Rutgers, The State University of New Jersey
National Cancer Institute (NCI); Rutgers Cancer Institute of New Jersey

Completed

Modulation of Autophagy in Patients With Advanced/Recurrent Non-small Cell Lung Cancer - Phase II

Non-small Cell Lung Cancer | Advanced Non-small Cell Lung Cancer | Recurrent Non-small Cell Lung Cancer

United States
University Hospital, Bonn

Active, not recruiting

An Exploratory Clinical Study on Autophagy and Multi-level Molecular Profiling During Spermidine Supplementation

Depression | Healthy

Germany
University Hospital, Bonn

Active, not recruiting

Multi-level Molecular Profiling of High Acute Stress: a Clinical Study

Healthy

Germany

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