Search clinical trials for: bronchial epithelial lining fluid

Total 76212 results

Southeast University, China

Recruiting

Comparison of Epithelial Lining Fluid and Blood Pharmacokinetics and Pharmacodynamics of Intravenous and Intravenous Plus Nebulized Polymyxin B in Multidrug Resistant Bacteria Ventilator-associated Pneumonia Patients

Ventilator-associated Pneumonia | Multidrug Resistant Bacterial Infection | Polymyxin B | Pharmacogenomic Drug Interaction

China
The University of Queensland
Chinese University of Hong Kong; University of Malaya; The Alfred; Centre Hospitalier... and other collaborators

Recruiting

PNEUmonia DOSing in Critically Ill Patients (PNEUDOS) (PNEUDOS)

Pneumonia

Hong Kong, France, Belgium, Australia, Malaysia
University of Jena
Medical University Innsbruck

Completed

Effects of Kalydeco on Upper Airway and Paranasal Sinus Inflammation Measured by Nasal Lavage and on Symptoms (KPNSI)

Inflammatory Changes in Epithelial Lining Fluid Sampled Non-invasively by Nasal Lavage in CF Patients With G551D Receiving Kalydeco

Germany
Baxalta now part of Shire
Arriva Pharmaceuticals, Inc.

Completed

Study of the Effect of Aerosolized, Recombinant Alpha 1-Antitrypsin on Epithelial Lining Fluid Analytes in Subjects With Alpha 1-Antitrypsin Deficiency

Alpha1-antitrypsin Deficiency

United States
Allecra

Completed

Lung Pharmacokinetics (PK) in Epithelial Lining Fluid (ELF)

Healthy Subjects

United Kingdom
Fraunhofer-Institute of Toxicology and Experimental...
AstraZeneca

Completed

Lung Pharmacokinetics (PK) in Epithelial Lining Fluid (ELF)

Healthy

Germany
University of Aarhus
Aarhus University Hospital

Terminated

Concentrations of Voriconazole in Blood and BAL-fluid After Inhalation and Oral Administration

Invasive Aspergillosis

Denmark
University Hospital Tuebingen

Terminated

Steady State Serum and Epithelial Lining Fluid (ELF) Antibiotics Concentrations Under Continous Infusion

Pneumonia | Bacteremia

Germany
Ohio State University Comprehensive Cancer Center

Recruiting

Evaluating the Impact of Synthetic Cooling Agents in Combustible Cigarettes on Smoking Perceptions and Use

Cigarette Smoking-Related Carcinoma

United States
Franciscus Gasthuis
Erasmus Medical Center; TNO

Recruiting

Phenotyping and Classifying Asthma Exacerbations (ExCluSieF)

Asthma Attack

Netherlands
National Cancer Institute (NCI)

Recruiting

Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining

Malignant Pleural Mesotheliomas NOS | Esophageal Cancers NOS | Lung Cancer NOS | Thoracic Cancers | Cancers of Non Thoracic Origin With Metastases to the Lungs or Pleura

United States
Memorial Sloan Kettering Cancer Center
GlaxoSmithKline

Completed

A Phase 1/2 Trial of Trametinib and Erlotinib in Patients With EGFR-Mutant Lung Adenocarcinomas and Acquired Resistance to Erlotinib

Lung Cancer | Lung Cancer Metastatic | Lung Adenocarcinoma | Lung Cancer Stage IV | Recurrent Lung Adenocarcinoma | Recurrent Lung Cancer

United States
Spero Therapeutics

Completed

A Study to Assess the Intrapulmonary Pharmacokinetics (PK) of SPR719 by Comparing the Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations Following the Oral Administration of Multiple Doses of SPR720 in Healthy Volunteers.

Healthy Volunteer

United States
University of Chicago

Completed

A Study of Immunotherapy Drugs Nivolumab and Ipilimumab in Patients w/Resectable Malignant Peritoneal Mesothelioma

Mesothelioma | Peritoneal Mesothelioma

United States
Rempex Pharmaceuticals (a wholly owned subsidiary...
Innovative Medicines Initiative; Universitätsklinikum Köln

Withdrawn

Safety and PK Trial Evaluating the Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations of Minocin IV

Normal Healthy Volunteers

Austria
Spero Therapeutics
United States Department of Defense

Completed

Study to Assess the Intrapulmonary Pharmacokinetics of SPR206 in Healthy Volunteers

Healthy Volunteers

United Kingdom
Imperial College London

Completed

Development of Human Nasal Challenge Models With Microbial Constituents and Grass Pollen

Asthma | Latent Tuberculosis | Allergic Rhinitis

United Kingdom
Endo Pharmaceuticals

Completed

Safety and Pharmacokinetics of Vasopressin in Healthy Volunteers

Healthy Volunteer Safety Study

United States
Spero Therapeutics
Clinartis

Completed

Study to Assess the Intrapulmonary Pharmacokinetics of SPR859 by Comparing the Plasma, Epithelial Lining Fluid (ELF), and Alveolar Macrophages (AM) Concentrations Following the Oral Administration of Five Doses of SPR994 in Healthy, Nonsmoking Volunteers

Healthy Volunteers

United States
Radboud University Medical Center

Completed

Mucosal Immunity Against SARS-CoV-2 Infection in COVID-19 Patients (MuCo)

SARS-CoV-2 Infection

Netherlands
Ludwig-Maximilians - University of Munich

Completed

Development a Method to Extract Antibiotic Concentration From Interstitial Lung and Epithelial Lining Fluid. (ALF)

Lung Transplantation

Germany
Venatorx Pharmaceuticals, Inc.
National Institutes of Health (NIH)

Completed

Safety and Pharmacokinetics of VNRX-5133 in the Epithelial Lining Fluid of Healthy Adult Subjects

Healthy Subjects

United States
Novartis Pharmaceuticals

Terminated

Study of Safety and Efficacy of INC280 and Cetuximab, in Adult c-MET Positive mCRC and HNSCC Patients After Progression on Cetuximab or Panitumumab Therapy

Metastatic Colorectal Cancer | Squamous Cell Carcinoma of Head and Neck (SCCHN)

France, Belgium, Spain, Germany, Italy, Canada, United States
Entasis Therapeutics
Clinartis

Completed

Study to Determine and Compare Plasma and Intrapulmonary Concentrations of ETX2514 and Sulbactam in Healthy Subjects

Healthy

United States
Pfizer

Completed

Study to Assess the Concentration of Avibactam and Ceftazidime in Epithelial Lining Fluid and Plasma

Healthy

United Kingdom
Imperial College Healthcare NHS Trust

Unknown

Nasal, Tracheal and Bronchial Mucosal Lining Fluid(MLF) Sampling From Patients With Respiratory Diseases (RESPI-SAM)

Healthy | Asthma | Tuberculosis | COPD | Sarcoidosis | IPF

United Kingdom
MerLion Pharmaceuticals GmbH

Completed

Pharmacokinetic Profile in Plasma and Epithelial Lining Fluid of Finafloxacin

Safety and Tolerability

United States
University Hospital, Clermont-Ferrand
Université d'Auvergne; R2D2 Retinoids, Reproduction Developmental Diseases

Unknown

Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) (IROCA)

Pulmonary Edema | Hypovolemia | Acute Respiratory Distress Syndrome (ARDS)

France
Sture Andersson

Unknown

Inhaled Salbutamol in Elective Caesarean Section (SAISTY)

Cesarean Section | Postnatal Pulmonary Adaptation

Finland
Keith A. Rodvold
Pulmonary Associates, PA

Completed

Doripenem Intrapulmonary Pharmacokinetics in Healthy Adult Subjects

Healthy

United States
Eli Lilly and Company

Completed

Study of Pemetrexed in Mesothelioma and Lung Cancer Patients With Fluid Around the Lungs or Abdomen

Lung Neoplasms | Mesothelioma | Non-small Cell Lung Cancer

Spain, Germany, Denmark
Henan University of Traditional Chinese Medicine

Recruiting

Lifei Xiaoji Wan Treatment's of Early-stage NSCLC and Its Impact on the Tumor Microenvironment

Early Stage Lung Adenocarcinoma

China
The First Affiliated Hospital of Guangzhou Medical...

Recruiting

Osimertinib as Neoadjuvant Therapy in Patients With Resectable Stage II-IIIB EGFR-mutated Lung Squamous Cell Carcinoma (GALAXY-02)

Carcinoma, Squamous Cell | Lung Cancer

China
Shanghai Simnova Biotechnology Co.,Ltd.
Shanghai Chest Hospital

Recruiting

SNC115 Injections in Patients With Recurrent/Refractory Small Cell Lung Cancer and Lung Large Cell Neuroendocrine Carcinoma

Recurrent/Refractory Small Cell Lung Cancer Lung Large Cell Neuroendocrine Carcinoma

China
AIO-Studien-gGmbH
Merck Sharp & Dohme LLC

Not yet recruiting

Head and Neck Carcinoma Clinical Research Platform for Molecular and Blood-based Biomarkers, Treatment and Outcome (HEAT)

Squamous Cell Carcinoma of the Larynx | Squamous Cell Carcinoma of the Oral Cavity | Squamous Cell Carcinoma of the Oropharynx | Squamous Cell Carcinoma of the Hypopharynx

Germany
Cancer Research UK
UCB Biopharma SRL

Not yet recruiting

A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer

Uterine Cervical Neoplasms | Carcinoma, Non-Small-Cell Lung | Colorectal Neoplasms | Pancreatic Neoplasms | Esophageal Neoplasms | Ovarian Neoplasms | Squamous Cell Carcinoma of Head and Neck | Triple Negative Breast Neoplasms | Advanced Solid Tumours | Carcinoma, Renal Cell (Clear Cell Only) | Stomach Neoplasms...

United Kingdom
Sun Yat-sen University

Recruiting

BAI-BACE for Advanced Lung Squamous Cell Carcinoma

Squamous Cell Carcinoma

China
AstraZeneca

Not yet recruiting

Osimertinib With Chemotherapy as First-line Therapy for EGFR Mutation-positive NSCLC (FOREFRONT)

Neoplasms | Respiratory Tract Diseases | Lung Diseases | Neoplasms by Site | Carcinoma, Non-Small-Cell Lung | Lung Neoplasms | Respiratory Tract Neoplasms | Thoracic Neoplasms | Carcinoma, Bronchogenic | Bronchial Neoplasms

China
University Hospital, Basel, Switzerland

Not yet recruiting

Abundance of a Natural Odour in Human Cerebrospinal Fluid After Olfactory Exposure (OLFO-Brain)

Overweight and Obesity

Switzerland
Fudan University

Recruiting

Neuroendocrine Transformation in RB1/TP53 Inactivated NSCLC

Non-small Cell Lung Cancer | Neuroendocrine Carcinoma | Histology Transformation

China
7 Hills Pharma, LLC

Not yet recruiting

A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy

Melanoma | Kidney Cancer | Renal Cell Carcinoma | Hepatocellular Carcinoma | Colorectal Cancer | NSCLC | Non Small Cell Lung Cancer | Skin Cancer | Metastasis | Advanced Solid Tumor | Advanced Cancer | Renal Cell Cancer | Hepatocellular Cancer | Mismatch Repair Deficiency | Pleural Mesothelioma | MSI-High | Anaplastic Lymphoma... and other conditions

United States
Beijing Friendship Hospital

Recruiting

Plasma Metabolic Biomarkers for Multi-Cancer Diagnosis

Renal Cell Carcinoma | Cervical Cancer | Breast Cancer | Gastric Cancer | Colorectal Cancer | Pancreatic Cancer | Esophageal Cancer | Ovarian Cancer | Lung Cancer | Prostate Cancer | Cholangiocarcinoma | Thyroid Cancer | Liver Cancer

China
China Medical University, China

Recruiting

Effects of Different Inhaled Oxygen Concentrations on Lung Function in Older Patients After Laparoscopic Gastrointestinal Surgery Under General Anesthesia

Oxygenation Index

China
Mayo Clinic

Recruiting

Predicting Response to Immune Checkpoint Inhibitors Across Solid Tumors Using a Live Tumor Diagnostic Platform (CYBRID-04)

Metastatic Lung Non-Small Cell Carcinoma | Metastatic Clear Cell Renal Cell Carcinoma | Resectable Lung Non-Small Cell Carcinoma | Metastatic Malignant Solid Neoplasm | Metastatic Bladder Urothelial Carcinoma | Metastatic Colorectal Carcinoma | Metastatic Triple-Negative Breast Carcinoma | Locally... and other conditions

United States
Atatürk Chest Diseases and Chest Surgery Training...

Not yet recruiting

Risk Factors for AKI in Patients Undergoing VATS for Pulmonary Resection

Lung Cancer | Surgery | Acute Kidney Injury

Turkey
Peking University Third Hospital

Recruiting

The Optimal Number of Fiducial Marker for Stereotactic Body Radiotherapy (ONFM-SBRT)

Renal Cell Carcinoma | Pancreatic Cancer | Lung Cancer | Liver Cancer

China
Insel Gruppe AG, University Hospital Bern

Not yet recruiting

CT-guided Lung Biopsy Risk Optimization Method (BROM-I)

Pneumothorax | Risk Factors | Biopsy, Needle | Radiology, Interventional

Switzerland
LG Chem

Not yet recruiting

Study to Evaluate LB-LR1109 for the Treatment of Solid Tumors (LB-LR1109)

Urothelial Carcinoma | Malignant Melanoma | Non-small Cell Lung Cancer(NSCLC) | Head and Neck Squamous Cell Carcinoma(HNSCC) | Renal Cell Carcinoma(RCC)
Unity Health Toronto
Canadian Institutes of Health Research (CIHR)

Not yet recruiting

Role of Active Deresuscitation After Resuscitation: (RADAR-Canada)

Sepsis | Critical Illness | Trauma | ARDS | Fluid Overload

Canada
University Hospital Regensburg

Not yet recruiting

Integrated Analysis of Therapy Response and Resistence in Embryonal Tumors and Gliomas (BZKF-AYA)

Ependymoma | Medulloblastoma | Glioma, Malignant | Embryonal Tumor

Search clinical trials for: bronchial epithelial lining fluid

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