Search clinical trials for: controlled release

Total 14730 results

University Hospital Schleswig-Holstein

Recruiting

Evaluation of Safety and Pharmacokinetics of Oral Controlled-ileal-release Nicotinic Acid (CIR-NA) Compared to Immediate-release Nicotinic Acid and Placebo in Healthy Subjects and Subjects With Prediabetes

Safety Issues | Pharmacokinetic

Germany
Universiteit Antwerpen
McGill University; Aragon Institute of Health Sciences

Not yet recruiting

Comparative Study of the Mechanism of Action of Dry Needling and Botulinum Toxin Type A as a Treatment for Lower Limb Post-stroke Spasticity: a Proof of Concept Controlled Trial (STROKEPOC)

Stroke | Spasticity as Sequela of Stroke
Sen-wei Lu

Recruiting

MNK Therapy in Releasing the Superficial Fascia for Patients With AAS: an Assessor-blinded, Randomised Controlled Trial

Acute Ankle Sprain

China
Marie Badalamente

Recruiting

Randomized Placebo Controlled Study of Triamcinolone Acetonide Extended Release Injection for Thumb (CMC) Osteoarthritis

Carpometacarpal (CMC) Osteoarthritis

United States
Drug Delivery Company, LLC DBA Akyso Pharmaceuticals
National Institute on Drug Abuse (NIDA); Laboratory Corporation of America; Cognitive...

Not yet recruiting

A Phase 1, Placebo-controlled, Single-Ascending-Dose, Study of BIOPIN 6 in Healthy Adults

Opioid Use Disorder
University Hospital Bispebjerg and Frederiksberg

Recruiting

Two Modes of Mechanical Ventilation for Intensive Care Patients With Low Blood Oxygen Due to Breathing Difficulties

Hypoxic Respiratory Failure | Ventilators, Mechanical

Denmark
Cardresearch

Recruiting

A Multicenter, Adaptive, Randomized, doublE-blinded, Placebo-controlled Study in Participants With Long COVID-19: The REVIVE Trial (REVIVE)

Chronic Fatigue Syndrome | Long COVID-19 Syndrome

Brazil
Wuhan Union Hospital, China

Recruiting

Effect of APRV vs. LTV on Right Heart Function in ARDS Patients: a Single-center Randomized Controlled Study

Acute Respiratory Distress Syndrome | Mechanical Ventilation | Right Heart Failure

China
University of Calgary
Ferring Pharmaceuticals

Not yet recruiting

Efficacy and Safety of Budesonide MMX® vs. Budesonide CR for Induction of Remission in Microscopic Colitis

Microscopic Colitis
NLS Pharmaceutics

Not yet recruiting

A Eight-Week Study of NLS-2 (Mazindol Extended Release) in Participants With Narcolepsy Type 1 (AMAZE)

Narcolepsy Type 1 | Narcolepsy With Cataplexy
Amasya University
Ataturk University

Not yet recruiting

The Effect of Warm Application to the Breast With the Aid of Thera Pearl on Milk Release and Breastfeeding Success

Breast Feeding
Hospital Universitario 12 de Octubre
Instituto de Salud Carlos III; Spanish Clinical Research Network - SCReN

Recruiting

Cook´s Balloon Versus Dinoprostone for Labor Induction of Term Pregnancies With Fetal Growth Restriction (COLIGROW)

Fetal Growth Retardation

Spain
Vastra Gotaland Region
Sahlgrenska University Hospital, Sweden; The Gothenburg Society of Medicine; Åke... and other collaborators

Not yet recruiting

Treatment Study in Patients Treated With Both Insulin & Hydrocortisone (INSCORT)

Diabetes Mellitus | Adrenal Insufficiency | Polyglandular Autoimmune Syndrome

Sweden
Sustained Therapeutics Inc.

Recruiting

A Randomized, Controlled Study of Repeat Dose Sustained Release Lidocaine for Treatment of Chronic Scrotal Pain

Chronic Pain

Canada
Overseas Pharmaceuticals, Ltd.
Guangzhou Health Start Pharmaceutical Techology Co.,Ltd

Not yet recruiting

An Comparative Pharmacokinetic Study of Amlodipine Besylate Controlled-release Tablets,China in Normal, Healthy, Adult, Human Subjects Under Fasting Conditions

Hypertension

China
Beijing Tiantan Hospital
CSPC Ouyi Pharmaceutical Co., Ltd.

Not yet recruiting

Efficacy of Pentoxifylline on Cerebrovascular Function in Patients With Cerebral Small Vessel Disease(PERFORM) (PERFORM)

Cerebral Small Vessel Diseases

China
Parnassia Addiction Research Centre
Radboud University Medical Center; Columbia University; Academisch Medisch Centrum... and other collaborators

Not yet recruiting

Efficacy and Safety of Sustained-release Dexamphetamine in Patients With Moderate to Severe Cocaine Use Disorder

Cocaine Use Disorder
Kuopio University Hospital
University of Eastern Finland

Recruiting

An Absorbable Suture Versus a Non-absorbable Suture in Carpal Tunnel Release, a Randomized Controlled Trial (SUPER)

Carpal Tunnel Syndrome | Median Nerve Entrapment

Finland
Jing Liu

Not yet recruiting

Effects and Safety of Clonidine Patch on Young and Middle-aged Smokers With Mild Hypertension (ECLIPSE)

Hypertension

China
Mahidol University

Not yet recruiting

The Study of Efficacy and Safety of Generic Methylphenidate Prolong-released Comparison With Original

Adhd
Diakonhjemmet Hospital
Oslo University Hospital; University Hospital, Akershus; South-Eastern Norway... and other collaborators

Recruiting

A Norwegian Trial Comparing Treatment Strategies for Carpal Tunnel Syndrome (NOR-CACTUS)

Carpal Tunnel Syndrome

Norway
Wake Forest University Health Sciences
Johns Hopkins University; The University of Texas Health Science Center, Houston and other collaborators

Recruiting

Long-term Effectiveness of the Antiobesity Medication Phentermine (LEAP)

Obesity | Lifestyle, Healthy | Obesity; Drug

United States
Augusta University

Not yet recruiting

Comparing Number of Injection Sites of In-office Intravesical Onabotulinumtoxin A Treatments for Overactive Bladder: A Randomized Controlled Trial

Overactive Bladder | Overactive Bladder Syndrome
Regeneron Pharmaceuticals

Recruiting

A C5 Inhibitor-controlled Study to Evaluate the Efficacy and Safety of Pozelimab and Cemdisiran Combination Therapy in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Are Complement Inhibitor Treatment-Naive or Have Not Recently Received Complement Inhibitor Therapy (ACCESS-1)

Paroxysmal Nocturnal Hemoglobinuria

Mexico, Korea, Republic of, Turkey, Italy, United Kingdom, Thailand, Poland, Singapore, Spain, Taiwan, Canada, Japan, United States, Malaysia, Greece, Romania, Hungary
Tri-Service General Hospital

Recruiting

PO Pain Management With Extended-release Dinalbuphine Sebacate in Patients Undergoing Arthroscopic Shoulder Surgery

Orthopedic | Anesthesiology

Taiwan
Second Affiliated Hospital, School of Medicine,...

Recruiting

Clinical Study of Stalevo in the Treatment of Early Parkinson's Disease

Parkinson Disease

China
Universitaire Ziekenhuizen KU Leuven
Belgian Health Care Knowledge Centre (KCE)

Recruiting

Follow-up and Outcome of Operative Treatment With Decompressive Release Of The Peroneal Nerve (FOOTDROP)

Peroneal Nerve Entrapment

Belgium, Netherlands
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Nicotine Replacement Therapy, Counseling, Varenicline, and Bupropion for Smoking Cessation, the PISCES I Trial

Cigarette Smoking-Related Carcinoma

United States
University of Rochester NCORP Research Base
National Cancer Institute (NCI)

Recruiting

Bupropion to Reduce Cancer Related Fatigue in Cancer Survivors

Be Diagnosed With Cancer and Have Completed Systemic Therapy

United States
Thomas Jefferson University

Active, not recruiting

Effectiveness of an Enhanced Tobacco Intervention Protocol Compared to Standard Treatment in Helping Head and Neck and Lung Cancer Patients Starting Treatment to Reduce Cigarette Use

Head and Neck Squamous Cell Carcinoma | Lung Non-Small Cell Carcinoma

United States
San Francisco Veterans Affairs Medical Center
United States Department of Defense; Northern California Institute of Research...

Active, not recruiting

A Randomized Controlled Trial of Doxazosin for Nightmares, Sleep Disturbance, and Non-Nightmare Clinical Symptoms in PTSD

Stress Disorders, Post-Traumatic

United States
Mylan Pharmaceuticals Inc

Completed

Fasting Study of Paroxetine Hydrochloride Controlled-Release Tablets 25 mg to Paxil CR™ Tablets 25 mg

Healthy

United States
Mylan Pharmaceuticals Inc

Completed

Food Study of Paroxetine Hydrochloride Controlled-Release Tablets 25 mg to Paxil CR™ Tablets 25 mg

Healthy

United States
Emalex Biosciences Inc.
Psyadon Pharma

Completed

Safety and Tolerability Comparison of Immediate and Controlled Release Formulations of Ecopipam

Healthy

United States
University at Buffalo
GlaxoSmithKline

Terminated

Vascular Benefits of Adding CarvedilolCR to Type2 Diabetic Patients on ACEI.

Hypertension | Diabetes Mellitus, Type 2

United States
Henry Ford Health System

Active, not recruiting

Randomized Controlled Trial Examining the Efficacy of Botulinum Toxin in Biopsy Scar Minimization

Scar | Hypertrophic Scar

United States
Janssen Scientific Affairs, LLC

Completed

A Study of JNJ-68284528 Out-of-Specification (OOS) for Commercial Release in Participants With Multiple Myeloma

Multiple Myeloma

United States
Novo Nordisk A/S

Active, not recruiting

A Research Study Comparing Wegovy to Other Weight Management Drugs in People Living With Obesity in America

Obesity

United States
McMaster University
Purdue Pharma, Canada

Completed

A 14 Week, Randomized, Placebo-Controlled Cross-Over Study of Methylphenidate Hydrochloride Controlled Release Capsules in Adult ADHD With and Without Anxiety Disorder Comorbidity

Generalized Anxiety Disorder | Attention Deficit Hyperactivity Disorder | Social Anxiety Disorder | Panic Disorder | Agoraphobia

Canada
Yuhan Corporation

Completed

A Randomized, Active-controlled, Parallel, Open-label, Multicenter, Phase 4 Study to Compare the Efficacy and Safety of Pregabalin Sustained Release Tablet and Pregabalin Immediate Release Capsule in Type II Diabetic Patients With Peripheral Neuropathic Pain

Diabetes Mellitus, Type 2 | Neuropathic Pain

Korea, Republic of
Istanbul Gelisim University

Completed

Immediate Effects of Myofascial Release Techniques on Balance in Young Adults With Pes Planus

Flat Foot

Turkey
Uludag University

Completed

The Effect of Dienogest vs. Norethindrone Acetate Treatment in Endometriosis (DINE)

Endometriosis

Turkey
Revelle Aesthetics, Inc

Completed

CONtrolled Focal Fibrous Band Release Method Study (CONFFIRM)

Cellulite

United States, Australia
Leiden University Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development

Active, not recruiting

REduction of LEvothyroxine in Adults; a SElf Controlled Study (RELEASE)

Hypothyroidism

Netherlands
CTI-1, LLC
GlaxoSmithKline; CTI Clinical Trial and Consulting Services

Completed

A Study to Compare the Effects of Coreg CR and Coreg IR on Heart Function in Subjects With Stable Chronic Heart Failure (COMPARE)

Congestive Heart Failure

United States
Zogenix, Inc.

Completed

Phase 3 Study of Hydrocodone Bitartrate Controlled-release Capsules in Subjects With Chronic Low Back Pain

Back Pain Lower Back Chronic

United States
Overseas Pharmaceuticals, Ltd.
Guangzhou Kangqi Medical Technology Co., LTD

Active, not recruiting

Felodipine Controlled Release Tablets and Felodipine Sustained Release Tablets in Healthy Subjects Under Fasting State Comparative Pharmacokinetic Study

Hypertension

China
Zogenix, Inc.

Completed

Pharmacokinetics and Metabolism of Hydrocodone Bitartrate Controlled-Release (HC-CR) in Subjects With Hepatic Impairment

Hepatic Impairment
Zogenix, Inc.

Completed

Long-Term Study of Hydrocodone Bitartrate Controlled-release Capsules in Subjects With Chronic Pain

Chronic Pain

United States
University Hospital Schleswig-Holstein

Completed

Safety and Pharmacokinetics of Oral Controlled-ileocolonic-release Nicotinamide (CICR-NAM)

Safety Issues | Pharmacokinetic

Germany

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