Search clinical trials for: donor safety

Total 46624 results

Shanghai Zhongshan Hospital

Not yet recruiting

Evaluation of the Efficacy and Safety of Fecal Microbiota Transplantation for Constipation in Parkinson's Disease

Parkinson Disease

China
Beijing GoBroad Hospital

Not yet recruiting

Safety, Tolerability, and Pharmacokinetics of Donor-derived CD19 CAR Therapy Bridged Allo-HSCT and Sequential Donor-derived CD22 CAR Therapy for r/r B-ALL: a Clinical Trial

Acute Lymphoblastic Leukemia, in Relapse | B-cell Acute Lymphoblastic Leukemia
Ruijin Hospital

Recruiting

Safety and Efficacy of LPE in Clearing DSA in Patients Who Received Allo-HSCT

Leukemia

China
Hobart W. Harris
Vitruvian Medical Devices, Inc.

Not yet recruiting

Study to Assess the Safety and Efficacy of DERMASEAL for the Treatment of Split-Thickness Skin Graft Donor Site Wounds

Skin Graft Complications
Dr. Melody Smith, MD, MS
Orca Biosystems, Inc.

Recruiting

Safety of Myeloablative Conditioning, Orca-T, and Allogeneic, Donor-Derived CD19/CD22-CAR (Chimeric Antigen Receptor) T Cells in Adults With B-cell Acute Lymphoblastic Leukemia (ALL)

Lymphoid Leukemia

United States
Nationwide Children's Hospital

Recruiting

Safety and Efficacy of Expanded, Universal Donor Natural Killer Cells for Relapsed/Refractory AML (KARMA)

Acute Myeloid Leukemia

United States
Cedars-Sinai Medical Center

Recruiting

DCD IIT: Evaluating the Safety of Utilizing Donor Hearts From Donation After Circulatory Death (DCD) Donors

Organ Transplant

United States
Hansa Biopharma AB

Recruiting

Efficacy and Safety in Imlifidase Desensitized Kidney Tx Patients, Including Two Non-Comparative Reference Cohorts (PAES)

Kidney Transplantation in Highly Sensitized Patients

Germany, Spain, Italy, France, Netherlands, Belgium, Austria, Czechia, Sweden, United Kingdom, Slovenia
Chinese PLA General Hospital

Recruiting

Efficacy and Safety Study of 4-Day ATG Regimen for Prophylaxis of aGVHD in Matched Sibling Donor PBSCT

aGVHD | cGVHD

China
Norwegian University of Science and Technology
St. Olavs Hospital

Recruiting

Safety and Efficacy of Plasma Transfusion From Exercise-trained Donors in Patients With Early Alzheimer's Disease (ExPlas)

Alzheimer Disease

Norway
Chulalongkorn University

Not yet recruiting

Clinical Efficacy and Safety of Sericin Hydrogel Sheet Impregnated With Bird's Nest Extract

Wound | Skin Graft Scar | Donor Site Complication | Scar Conditions and Fibrosis of Skin

Thailand
Northwestern University
Georgetown University

Recruiting

APOL1 Genetic Testing Program for Living Donors

Chronic Kidney Diseases | Kidney Transplantation | Apolipoprotein L1

United States
Chong Kun Dang Pharmaceutical

Recruiting

Efficacy and Safety of CertiroBell® Tablet Plus Tacrolimus in Primary Living Donor Liver Transplant Recipients (STELLA)

Liver Transplant

Korea, Republic of
University Hospital, Toulouse

Recruiting

Evaluation of the Safety of Use of Anti-IL6 Receptor Antibodies to Reduce Allo-sensitization Post Allograft Nephrectomy (RAIPONS)

Kidney Transplantation | Graft Failure

France
Sidney Kimmel Comprehensive Cancer Center at Johns...
PapiVax Biotech, Inc.

Recruiting

Safety and Efficacy of Allogeneic HPV-specific T Cells in Adults With Recurrent or Metastatic HPV16+ Cancers

HPV 16+ Recurrent or Metastatic Cancer

United States
Beijing Boren Hospital

Recruiting

Multi-centers, Open-Label, Phase 2 Study to Evaluate the Efficacy and Safety of Donor-Derived CD7 CAR T Cells in Subjects With Relapsed or Refractory T-cell Leukemia/Lymphoma

Relapse/Recurrence | T-cell Leukemia/Lymphoma | Refractory T Lymphoblastic Leukemia/Lymphoma

China
Guang'anmen Hospital of China Academy of Chinese...
National Natural Science Foundation of China; Special Project of National Traditional...

Not yet recruiting

Efficacy and Safety of Wen Xin Granules for the Treatment of Unstable Angina Pectoris

Coronary Heart Disease | Unstable Angina | Chinese Herbal Medicine
Catherine Bollard

Recruiting

Evaluate the Safety, Immunologic, and Virologic Responses of Donor Derived (DD) HIV-Specific T-cells (HST) in HIV-infected Individuals Following Allogeneic Bone Marrow Transplantation (alloRESIST)

HIV-Infected Individuals

United States
Sumithira Vasu
Kiadis Pharma

Recruiting

Trial Testing Safety of IL-21 NK Cells for Induction of R/R AML

Recurrent Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia | Blasts 10 Percent or More of Bone Marrow Nucleated Cells | Allogeneic Stem Cell Transplant Recipient

United States
The Cleveland Clinic

Recruiting

Safety and Efficacy of ARNI After LVAD ImplanT (SEAL-IT) Study (SEAL-IT)

Stage D Heart Failure

United States
Tongji Hospital

Not yet recruiting

Safety and Efficacy of Heterologous FMT by SQIMC-md Capsule in Mild-moderate Ulcerative Colitis Patients (SQIMC-md)

Ulcerative Colitis
Jordan Feld
University Health Network, Toronto

Recruiting

Transplantation Using Hepatitis C Positive Donors, A Safety Trial

Hepatitis C | Kidney Transplant Infection | Heart Transplant Infection | Lung Transplant Infection | Kidney Pancreas Infection

Canada
Hopital Foch

Recruiting

Feasibility Study of Uterine Transplantation From Living Donors in Terms of Efficacy and Safety in Patients With Mayer-Rokitansky-Küster-Hauser Syndrome (MRKH)

Mayer Rokitansky Kuster Hauser Syndrome

France
Xia Zhang

Recruiting

The Efficacy and Safety of Lower Limb Nerve Blocks in Postoperative Analgesia for the Free Flap Donor Sites

Pain, Post Operative | Elective Reconstructive Surgery

China
University Hospital, Basel, Switzerland

Recruiting

A Study to Assess Safety and Feasibility of Direct Infusions of Donor-derived Virus-specific T-cells in Recipients of Hematopoietic Stem Cell Transplantation With Post-transplant Viral Infections Using the Cytokine Capture System® (CCS)

Cytomegalovirus Infections | EBV | Adenovirus Infection | Cytokine Capture System | Allogenic Disease

Switzerland
Sangamo Therapeutics

Active, not recruiting

Safety & Tolerability Study of Chimeric Antigen Receptor T-Reg Cell Therapy in Living Donor Renal Transplant Recipients (STEADFAST)

End Stage Renal Disease | Kidney Transplant Rejection

Belgium, Netherlands, United Kingdom
Bellicum Pharmaceuticals

Terminated

Safety Study of Gene Modified Donor T Cell Infusion After Stem Cell Transplant for Non-Malignant Diseases

Hemoglobinopathies | Hemophagocytic Lymphohistiocytosis | Metabolic Disorders | Primary Immune Deficiency Disorders | Inherited Bone Marrow Failure Syndrome

United States
ABO Holdings, Inc.

Active, not recruiting

Safety and Immunogenicity Study of Tdap Vaccinations for Plasma Donors

Tetanus, Diphtheria and Acellular Pertussis Vaccination

United States
CVRx, Inc.

Active, not recruiting

Verification of the Efficacy and Safety of the BAROSTIM NEO System in the Treatment of Drug Resistant Hypertension

High Blood Pressure

Canada, Germany, Netherlands
The Emmes Company, LLC
Duke University; Stanford University

Completed

Dose-response Study of Sodium Nitroprusside in Children Requiring Controlled Hypotension in the Operating Room

Hypotension

United States
Dipnarine Maharaj

Enrolling by invitation

Safety, Efficacy of FFP From Healthy Donors to AmeliorateFrailty and Enhance Immune Function in Older Individuals

Frailty

United States
Washington University School of Medicine
BioLineRx, Ltd.

Completed

Safety and Efficacy of BL-8040 for the Mobilization of Donor Hematopoietic Stem Cells and Allogeneic Transplantation in Patients With Advanced Hematological Malignancies

Multiple Myeloma | Hodgkin Disease | Non-Hodgkin's Lymphoma | Acute Lymphoblastic Leukemia | Non-Hodgkin Lymphoma | Myelodysplastic Syndrome | Acute Myelogenous Leukemia | Chronic Myelogenous Leukemia | Myeloproliferative Neoplasm | Hodgkin's Disease | Hodgkins Disease

United States
Tambi Jarmi

Withdrawn

Feasibility and Safety of Allogeneic Adipose Mesenchymal Stem Cells (aMSCs) Delivery Into Kidney Allografts Procured From Deceased Donors With High Kidney Donor Profile Index (KDPI)

Ischemia Reperfusion Injury

United States
Novartis Pharmaceuticals

Completed

Study of Efficacy, Safety, Tolerability, Pharmacokinetic (PK) and Pharmacodynamic (PD) of an Anti-CD40 Monoclonal Antibody, CFZ533, in Liver Transplant Recipients With Additional 12-month Follow-up and Long-term Extension (CONTRAIL I)

Liver Transplant Rejection

United States, Belgium, Germany, Spain, Argentina, Netherlands, Italy, Hungary, France, Czechia
Bellicum Pharmaceuticals

Terminated

Safety Study of Gene Modified Donor T-cells Following TCRαβ+ Depleted Stem Cell Transplant

Lymphoma, Non-Hodgkin | Acute Lymphoblastic Leukemia | Primary Immunodeficiency | Anemia, Sickle Cell | Hemoglobinopathies | Fanconi Anemia | Anemia, Aplastic | Myelodysplastic Syndrome | Thalassemia | Cytopenia | Diamond Blackfan Anemia | Osteopetrosis | Leukemia, Acute Myeloid (AML), Child

United Kingdom, Italy
Center for International Blood and Marrow Transplant...
Sanofi; Genzyme, a Sanofi Company

Completed

A Phase II Study Evaluating the Safety and Efficacy of Subcutaneous Plerixafor

Non-Hodgkin's Lymphoma | Acute Lymphoblastic Leukemia | Chronic Lymphocytic Leukemia | Myelodysplastic Syndrome | Acute Myelogenous Leukemia | Chronic Myelogenous Leukemia | Hodgkin's Disease | Related Donors Donating Peripheral Blood Stem Cells (PBSC) to a Family Member

United States
Molnlycke Health Care AB

Completed

Confirm Performance and Safety of Exufiber When Used as Intended on Donor Sites (ExuDS01)

Acute Wound | Donor Site | Split Skin Graft

Sweden
Seoul National University Hospital
GC Pharma

Completed

Effect of Ascites Replacement Strategy on Time to 1st Flatus After LDLT

Living Donor Liver Transplantation

Korea, Republic of
Sandoz
Hexal AG

Active, not recruiting

Non-interventional, Long-term Safety Data Collection of Zarzio® / Filgrastim HEXAL® in Stem Cell Donors (SMART)

Hematopoietic Stem Cell Mobilization

Germany
Talaris Therapeutics Inc.

Terminated

A Safety and Efficacy Study of FCR001 vs Standard of Care in de Novo Living Donor Kidney Transplantation (FREEDOM-1)

Transplanted Organ Rejection

United States
Talaris Therapeutics Inc.

Withdrawn

A Safety and Efficacy Study of FCR001 Cell Therapy in Previously Transplanted Living Donor Kidney Recipients (FREEDOM-2)

Kidney Transplantation

United States
Centre hospitalier de l'Université de Montréal...
Maisonneuve-Rosemont Hospital

Withdrawn

Open-label Prospective Clinical Trial Evaluating the Safety and Efficacy of Biosynthetic CLP-PEG-MPC Corneal Implants in Patients Undergoing High-risk Deep Anterior Lamellar Keratoplasty. (CLP-PEG-MPC)

High-risk Corneal Transplantation | Corneal Blindess | Corneal Inflammation | Deep Anterior Lamellar Keratoplasty
Medical College of Wisconsin
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute... and other collaborators

Completed

Evaluating the Safety and Effectiveness of an Umbilical Cord Blood Stem Cell Transplant (BMT CTN 0604)

Lymphoma, Follicular | Lymphoma, B-Cell | Lymphoma, Large B-Cell, Diffuse | Leukemia, Myeloid, Acute | Burkitt Lymphoma | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

United States
Medical College of Wisconsin
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute... and other collaborators

Completed

Evaluating the Safety and Effectiveness of Bone Marrow Transplants in Children With Sickle Cell Disease (BMT CTN 0601) (SCURT)

Sickle Cell Disease

United States
GCAM Inc.

Completed

Tdap Vaccine Safety for Plasma Donors

Tetanus

United States
Lawson Health Research Institute
Novartis; Canadian Institutes of Health Research (CIHR); Astellas Pharma Canada...

Completed

The Living Kidney Donor Safety Study (LKD)

Living Kidney Donation

Canada, Australia
Albert B. Sabin Vaccine Institute
ICON plc; Oklahoma Blood Institute

Completed

Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults

Ebola Virus Disease | Marburg Virus Disease

United States
PT. Daewoong Infion
Equilab International

Completed

Efficacy and Safety Evaluation of EASYEF® in Acute Wound (Split-thickness Skin Graft Donor Site)

Skin Graft Scar | Split-Thickness Skin Graft (STSG)

Indonesia
Bellicum Pharmaceuticals

Active, not recruiting

Safety Study of Gene Modified Donor T-cells Following Partially Mismatched Stem Cell Transplant

Lymphoma | Myelodysplastic Syndromes | Acute Lymphoblastic Leukemia | Acute Myelogenous Leukemia

United States
Bellicum Pharmaceuticals

Active, not recruiting

Safety/PK Study of Gene Modified Donor T Cell Infusion in Children With Recurrent Hem Malignancies After Allo Transplant

Hematologic Malignancy

Italy

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