Search clinical trials for: dose exploration

Total 21428 results

GlaxoSmithKline

Recruiting

Dose Exploration Study of GSK4532990 in Participants With NASH or Suspected NASH (SKYLINE)

Non-alcoholic Fatty Liver Disease

United States
Jiangsu Hansoh Pharmaceutical Co., Ltd.

Recruiting

Study of HS-10517 in Chinese Adult Participants

COVID-19

China
IlDong Pharmaceutical Co Ltd
Parexel; YUNOVIA CO.,LTD.

Recruiting

Safety, Tolerability, and Pharmacokinetics of ID119031166M With the Exploration of Pharmacodynamic Effects

Healthy Participants

United States
Beijing 302 Hospital

Not yet recruiting

Exploration of Dalpiciclib + Chidamide in HR+/HER2- Advanced Breast Cancer After Failure of CDK4/6 Inhibitor: a Phase Ⅰb Study

HR+/HER2- Advanced Breast Cancer

China
RenJi Hospital

Recruiting

Dose Exploration of Ciprofol for Sedation in Gastrointestinal Endoscopic Diagnosis and Treatment of Obese Patients.

Gastric Cancer | Intestinal Polyps | Gastric Ulcer | Intestinal Cancer

China
Centre Hospitalier Universitaire de Nice

Not yet recruiting

Diagnosis of Toxoplasma Gondii Infection by Exploration of Cellular Immunity (TOXCELL) (TOXCELL)

Toxoplasmosis | Toxoplasmosis, Congenital | Toxoplasma Infections | Toxoplasmosis Recurrent

France
Henan Cancer Hospital

Recruiting

A Dose Exploration Study of Almonertinib for EGFRm NSCLC Patients With Brain/Leptomeningeal Metastasis (ARTISTRY)

NSCLC | Brain Metastases | Leptomeningeal Metastasis

China
The First Affiliated Hospital of Soochow University

Recruiting

Dose Exploration Study OF JWCAR129, BCMA-Targeted CART for RRMM

Safety and Efficacy

China
AstraZeneca

Active, not recruiting

Dose Exploration Intramuscular/Intravenous Prophylaxis Pharmacokinetic Exposure Response Study

COVID-19

United States
Sanofi Pasteur, a Sanofi Company
GlaxoSmithKline

Completed

Study of Recombinant Protein Vaccines With Adjuvant as a Primary Series and as a Booster Dose Against COVID-19 in Adults 18 Years of Age and Older (VAT00002)

COVID-19

Honduras, United States, Australia, France, New Zealand, Spain, United Kingdom
University of Saskatchewan
Government of Canada; Vaccine Formulation Institute (VFI); Government of Saskatchewan and other collaborators

Completed

Clinical Trial to Study the COVAC-2 Booster Dose (for COVID-19) in Generally Healthy Adults.

Double Vaccinated for COVID-19 (For Phase 1 of the Study) | Acute Respiratory Syndrome Coronavirus 2 (For Phase 2 Exploratory Group)

Canada
Larimar Therapeutics, Inc.

Completed

A Double-Blind, Placebo-Controlled, Dose Exploration Study of CTI-1601 in Adult Subjects With Friedreich's Ataxia

Friedreich Ataxia

United States
Centre Hospitalier Régional d'Orléans

Withdrawn

Thoracic Kyphosis and Osteoporosis: Study of Their Relationship With Respiratory Functions in Chronic Obstructive Pulmonary Disease. (CYPHOS)

Osteoporosis | COPD | Kyphosis

France
Merck Sharp & Dohme LLC

Terminated

A Dose Exploration Study With Birabresib (MK-8628) in Participants With Selected Hematologic Malignancies (MK-8628-005)

DLBCL | AML Including AML de Novo and AML Secondary to MDS
Aurinia Pharmaceuticals Inc.

Terminated

Dose-Exploration Evaluating the Efficacy and Safety of Voclosporin in Subjects With Focal Segmental Glomerulosclerosis (AURONA™)

Focal Segmental Glomerulosclerosis

United States, Dominican Republic
Merck Sharp & Dohme LLC

Terminated

A Dose Exploration Study With Birabresib (MK-8628) in Participants With Selected Advanced Solid Tumors (MK-8628-006)

Non-small Cell Lung Cancer (NSCLC) | Triple Negative Breast Cancer (TNBC) | NUT Midline Carcinoma (NMC) | Castration-resistant Prostate Cancer (CRPC)
Genzyme, a Sanofi Company

Terminated

A Randomised, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Sevelamer Carbonate Tablets Dosed Three Times a Day in Hyperphosphataemic Chronic Kidney Disease Patients Not on Dialysis (ASPIRE)

Chronic Kidney Disease | Hyperphosphatemia

Germany, Greece, Portugal, Austria, France, Hungary, Italy, Spain, Sweden
Jiangsu Simcere Pharmaceutical Co., Ltd.

Unknown

The Comparative Study on Rh-Endostatin (Endostar®) Continuous Intravenous Infusion and Routine i.v in Combination With GP Regimens for Phase III B/IV Squamous Cell Lung Cancer and Biological Markers Exploration.

Lung Cancer

China
Chiesi Farmaceutici S.p.A.

Completed

Evaluation of Safety & Tolerability of Multiple Dose Regimens of CHF 5074 and Exploration of Effects on Potential Markers of Clinical Efficacy in Patients With Mild Cognitive Impairment - Prolonged Open Label Extension Phase (CT04 POLEP)

Alzheimer's Disease

United States, Italy
Chiesi Farmaceutici S.p.A.

Completed

Evaluation of Safety & Tolerability of Multiple Dose Regimens of CHF 5074 and Exploration of Effects on Potential Markers of Clinical Efficacy in Patients With Mild Cognitive Impairment - Open Label Extension (CT04 OLEP)

Alzheimer's Disease

United States, Italy
Hospices Civils de Lyon

Completed

Conventional Repetitive Transcranial Magnetic Stimulation for Tinnitus Treatment (MagTIN)

Chronic Tinnitus

France
Pfizer
AbbVie

Not yet recruiting

A Study to Learn About the Study Medicine Aztreonam-Avibactam (ATM-AVI) in Infants and Newborns Admitted in Hospitals With Bacterial Infection (CHERISH) (CHERISH)

Gram-negative Bacterial Infection
University of Melbourne
Monash University; University of Adelaide; University of Sydney; The University... and other collaborators

Not yet recruiting

PLatform for Adaptive Trials In Perinatal UnitS - [Core Protocol] (PLATIPUS)

Preterm Birth
First Affiliated Hospital Bengbu Medical College

Recruiting

Clinical Exploration Trial of YOLT-101 in the Treatment of Familial Hypercholesterolemia (FH)

Familial Hypercholesterolemia

China
Sidney Kimmel Comprehensive Cancer Center at Johns...
Canon Medical Systems, USA

Not yet recruiting

Exploration of Personalized Biomarkers During Neoadjuvant Radiation Therapy for Spinal and Sacral Chordoma (Canon)

Chordoma of Sacrum | Chordoma of Spine | Chordoma of Skull Base
Samsung Medical Center

Recruiting

Safety of Dose Escalation in Definitive Hypofractionated Radiation Therapy and Hormone Therapy With SpaceOAR TM for Patients With High - Risk Localized Prostate Cancer (DESAR-H) (DESAR-H)

High Risk Prostate Carcinoma

Korea, Republic of
Samsung Medical Center

Recruiting

Safety of Dose Escalation in Definitive Hypofractionated Radiation Therapy With SPACEOAR TM for Patients With Low-to-intermediate Risk Localized Prostate Cancer (DESAR-L) (DESAR-L)

Low-to-intermediate-risk Prostate Carcinoma

Korea, Republic of
Institute of Medical Biology, Chinese Academy of...

Not yet recruiting

Phase IV Study of Concomitant Administration of the sIPV and HepA

Hepatitis A | Polio

China
ProDa BioTech, LLC
Emory University; Georgia State University

Not yet recruiting

ProAgio in Combination With Gemcitabine in Patients With Metastatic Triple Negative Breast Cancer

Triple Negative Breast Cancer

United States
Ruijin Hospital

Not yet recruiting

The Efficacy of Allo-HSCT in ND HR-CBF-AML

Acute Myeloid Leukemia

China
RenJi Hospital

Recruiting

Clinical Exploration Trial of YOLT-101 in the Treatment of Familial Hypercholesterolemia (FH)

Familial Hypercholesterolemia

China
University Hospital of North Norway
SINTEF Health Research; Helse Nord; Helseapps; Norinnova

Not yet recruiting

Patient-centered Dosage of Levothyroxine

Hypothyroidism | Thyroid | Thyroid Cancer
University Hospital, Basel, Switzerland

Not yet recruiting

TIL Therapy in Non-small-cell Lung Cancer (NSCLC) Patients (BaseTIL-02)

Non-Small Cell Lung Cancer

Switzerland
Turku University Hospital

Recruiting

Sleep Quality and Sleep-disordered Breathing in Bypass Surgery Patients (UNI-CABG)

Coronary Artery Disease | Sleep Disorder

Finland
SNLD, Ltd.

Recruiting

A Phase I Study of TRN501 in Healthy Volunteers

Parkinson Disease

Japan
University Health Network, Toronto

Not yet recruiting

A Study of High Dose Radiation Therapy for Locally Advanced Pancreatic Cancer That Responded to Initial Chemotherapy Treatment (ABLATE)

Locally Advanced Pancreatic Adenocarcinoma
Regeneron Pharmaceuticals

Not yet recruiting

A First In Human (FIH) Study to Learn if Different Doses of ALN-ANG3 Are Safe and Well Tolerated in Healthy Adults

Healthy Volunteers
Technical University of Munich
Universitaire Ziekenhuizen KU Leuven; Helmholtz Zentrum München; Skane University... and other collaborators

Recruiting

Anti-viral Action Against Type 1 Diabetes Autoimmunity

Diabetes Mellitus, Type 1

Belgium, Germany, Sweden
CSPC Ouyi Pharmaceutical Co., Ltd.

Not yet recruiting

Safety and Efficacy Study of Pilocarpine HCl Ophthalmic Solution in Participants With Presbyopia

Presbyopia
Claris Biotherapeutics, Inc.

Recruiting

Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Subjects With Limbal Stem Cell Deficiency

Limbal Stem Cell Deficiency

United States
Tonghua Dongbao Pharmaceutical Co.,Ltd

Recruiting

A Trial to Investigate the Single Dose Pharmacokinetics of Insulin Degludec/Liraglutide in Healthy Chinese Subjects

Healthy

China
SURGE Therapeutics

Not yet recruiting

Study of STM-416p Administered to Patients Undergoing Radical Prostatectomy

Prostate Cancer
NEXBIOME THERAPEUTICS

Not yet recruiting

Efficacy, Safety, and Dose-response of a Live Biotherapeutic Product in Women With Acute Vaginal Infection (ELINA)

Bacterial Vaginosis | Vulvovaginal Candidiasis
University of North Carolina, Chapel Hill
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Not yet recruiting

Dose Optimization of Caffeine for HIE

Hypoxic-Ischemic Encephalopathy

United States
BioNTech SE

Not yet recruiting

Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With Small-cell Lung Cancer in Combination With Chemotherapy

Small-cell Lung Cancer | Extensive-stage Small-cell Lung Cancer
BioNTech SE

Not yet recruiting

Safety and Preliminary Effectiveness of BNT327, an Investigational Therapy for Breast Cancer, When Given in Combination With Chemotherapy

Triple Negative Breast Cancer | Locally Advanced Breast Cancer
University Medical Center Groningen

Not yet recruiting

PIRATES Phase I Trial (PIRATES)

Head and Neck Cancer | Oropharyngeal Cancer

Netherlands
Sichuan University

Not yet recruiting

Low-dose Radiation Combined With Neoadjuvant Immunochemotherapy for Esophageal Squamous Cell Carcinoma

Esophageal Squamous Cell Carcinoma
University of Alberta

Not yet recruiting

LoW Dose-Intensity vs. Standard Dose-Intensity COntinuous Renal ReplaceMent Therapy in Critically Ill Patients (WISDOM) (WISDOM)

Acute Kidney Injury | Dialysis; Complications
University Hospital, Clermont-Ferrand
Grünenthal GmbH

Not yet recruiting

Capsaicin in Digital Osteoarthritis Versus Control (CADOR)

Neuropathic Pain | Osteoarthritis Hand

France

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