- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04757714
Thoracic Kyphosis and Osteoporosis: Study of Their Relationship With Respiratory Functions in Chronic Obstructive Pulmonary Disease. (CYPHOS)
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Osteoporosis, characterized by bone quality disorders and low bone mineral density (BMD) leading to a high risk of fractures, is common in COPD patients. For example, studies have reported OP rates ranging from 9% to 69% in COPD patients. The explanatory factors for this low BMD are clearly multiple, involving to varying degrees of importance, vitamin D deficiency, depression, sedentary lifestyle, smoking, corticosteroids, low lean body mass and body mass index, chronic inflammation, low nutritional status, chronic hypoxia and hypercapnia. This is why patients with COPD have a high prevalence of fractures, particularly vertebral fractures (VF) ranging from 30 to 63% depending on the studies. In these patients the existence of thoracic VF is of crucial importance, as each VF is associated with a 9% decrease in the forced vital capacity of COPD patients.
For these reasons the latest HAS recommendations for COPD management indicate that the risk of osteoporosis should be systematically investigated and treated (HAS, 2014).
However, the relationship between densitometric variations and the presence of thoracic VF and the prognosis and severity of the disease is not yet very clear, as studies of these relationships have produced mixed results.
On the other hand, it is well established that patients with a recent diagnosis of COPD have a high prevalence of densitometric OPs and fractures.
Thoracic kyphosis is one of the determinants of the incidence of vertebral fractures. Increased thoracic kyphosis is associated with decreased physical capacity, increased risk of falls and abnormal respiratory function.
In addition, measurement of thoracic kyphosis was previously carried out either indirectly using point coordinates recorded in a database (patients were assessed in the supine position) or more directly using a ruler applied against the back.
Study Type
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Elodie POUGOUE TOUKO
- Phone Number: +33238744086
- Email: elodie.pougoue-touko@chr-orleans.fr
Study Locations
-
-
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Orleans, France, 45067
- CHR d'Orléans
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Contact:
- Eric LESPESSAILLES, Ph
- Email: eric.lespessailles@chr-orleans.fr
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Principal Investigator:
- Eric LESPESSAILLES, Ph
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Man or woman age > 40
- FEV1/CVF ratio < 0.7 as defined by the Global Initiative for Chronic Obstruction Lung Disease (GOLD).
- Moderate to severe COPD as defined by GOLD (grade C and D)
Exclusion Criteria:
- Presence of metal or plastic parts in the field of examination
- Pregnancy
- Patients who are not affiliated with or do not benefit from a social security system
- Person under guardianship or curatorship
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: COPD Patients
Patients agreeing to participate in the study and meeting the inclusion and non-inclusion criteria will have:
|
The high-resolution peripheral scanner (HRpQCT) of the tibia and radius
a low-dose imaging system exploration of their thoraco-lumbar spine (EOS system)
A search for sarcopenia by studying the strength of the grip (dynamometer)
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The thoracic kyphosis index
Time Frame: Day 0
|
The kyphosis index will be used to assess thoracic kyphosis at the beginning of the study.
This index is a percentage.
|
Day 0
|
Forced vital capacity
Time Frame: Day 0
|
Day 0
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Presence of densitometric osteoporosis
Time Frame: Day 0
|
Day 0
|
|
Presence of intermediate bone density
Time Frame: Day 0
|
Day 0
|
|
Percentage of maximum expiratory volume per second (FEV1), percentage predicted value
Time Frame: Day 0
|
Day 0
|
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predicted value FEV1/Forced Vital Capacity
Time Frame: Day 0
|
Day 0
|
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Quality of life score (St George Hospital questionnaire)
Time Frame: Day 0
|
Day 0
|
|
Severity index of Osteoporosis
Time Frame: Day 0
|
raw BMD values
|
Day 0
|
Severity index of Osteoporosis
Time Frame: Day 0
|
FRAX score
|
Day 0
|
Severity index of Osteoporosis
Time Frame: Day 0
|
number of VFs
|
Day 0
|
Chronic Obstructive Pulmonary Disease (COPD) severity index
Time Frame: Day 0
|
maximum expiratory volume per second (FEV1)
|
Day 0
|
Chronic Obstructive Pulmonary Disease (COPD) severity index
Time Frame: Day 0
|
severity stage by the Global Initiative for Chronic Obstruction Lung Disease (GOLD)
|
Day 0
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Chronic Obstructive Pulmonary Disease (COPD) severity index
Time Frame: Day 0
|
prognosis stage according to BODE index
|
Day 0
|
Parameters measured by HRpQCT
Time Frame: Day 0
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volume density and microarchitecture
|
Day 0
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Densitometric osteoporosis status
Time Frame: Day 0
|
The status will be determine between: Osteoporosis , intermediate bone density and normal
|
Day 0
|
Collaborators and Investigators
Investigators
- Principal Investigator: Eric LESPESSSAILLES, Ph.D., CHR Orléans
Publications and helpful links
General Publications
- Celli BR, Cote CG, Marin JM, Casanova C, Montes de Oca M, Mendez RA, Pinto Plata V, Cabral HJ. The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med. 2004 Mar 4;350(10):1005-12. doi: 10.1056/NEJMoa021322.
- Cielen N, Maes K, Gayan-Ramirez G. Musculoskeletal disorders in chronic obstructive pulmonary disease. Biomed Res Int. 2014;2014:965764. doi: 10.1155/2014/965764. Epub 2014 Mar 25.
- Decramer M, Janssens W, Miravitlles M. Chronic obstructive pulmonary disease. Lancet. 2012 Apr 7;379(9823):1341-51. doi: 10.1016/S0140-6736(11)60968-9. Epub 2012 Feb 6.
- Eagan TM, Aukrust P, Ueland T, Hardie JA, Johannessen A, Mollnes TE, Damas JK, Bakke PS, Wagner PD. Body composition and plasma levels of inflammatory biomarkers in COPD. Eur Respir J. 2010 Nov;36(5):1027-33. doi: 10.1183/09031936.00194209. Epub 2010 Apr 22.
- Ekblom O, Ekblom-Bak E, Bolam KA, Ekblom B, Schmidt C, Soderberg S, Bergstrom G, Borjesson M. Concurrent and predictive validity of physical activity measurement items commonly used in clinical settings--data from SCAPIS pilot study. BMC Public Health. 2015 Sep 28;15:978. doi: 10.1186/s12889-015-2316-y.
Study record dates
Study Major Dates
Study Start (Estimated)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Pathologic Processes
- Metabolic Diseases
- Respiratory Tract Diseases
- Lung Diseases
- Disease Attributes
- Musculoskeletal Diseases
- Spinal Diseases
- Bone Diseases
- Spinal Curvatures
- Bone Diseases, Metabolic
- Chronic Disease
- Lung Diseases, Obstructive
- Pulmonary Disease, Chronic Obstructive
- Osteoporosis
- Kyphosis
Other Study ID Numbers
- CHRO-2020-05
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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