Search clinical trials for: failed approved standard therapies

Total 17914 results

Haim Bio Co., Ltd.

Unknown

MTD, Safety and Efficacy of NYH817G and NYH100P in Monotherapy and Combination in Patients With Advanced Solid Tumors

Advanced Solid Tumors

Korea, Republic of
RemeGen Co., Ltd.

Recruiting

A Study of RC48-ADC Combination With Zimberelimab Injection Therapies at Least First-line Platinum-containing Standard Therapy Failed With Recurrent or Metastatic Cervical Cancer

Cervical Cancer

China
New Mexico Cancer Care Alliance

Terminated

Comparison of Standard of Care or Treatment on Protocol

Stomach Cancer | Esophageal Cancer | Ovarian Cancer | Lung Cancer | Bladder Cancer | Skin Cancer | Uterine Cancer

United States
AlaMab Therapeutics (Shanghai) Inc.

Not yet recruiting

A Study to Evaluate the Efficacy of ALMB-0168 in Solid Tumor Patients With Bone Metastatic Whose Prior Standard Treatment Have Failed

Advanced Solid Tumors With Bone Only Metastasis
Lee's Pharmaceutical Limited

Recruiting

Study of AU409 Capsule in Advanced Hepatocellular Carcinoma Patients Who Failed Standard Treatment

Advanced Hepatocellular Carcinoma

China
Sun Yat-sen University
Kousai Bio Co., Ltd.

Not yet recruiting

KSD-101 Therapy for Standard Treatment Failed EBV-associated NPC: an Exploratory Clinical Trial

Nasopharyngeal Carcinoma

China
Amgen

Recruiting

AMG 193 Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol)

Non-small Cell Lung Cancer | Thoracic Tumors

United States
Nyamdavaa Tuul

Not yet recruiting

Phase I Study of Combined Immune Cell Therapy in Patients With Stage 4 Colorectal Cancer With Metastatic Lesion Who Failed Prior Standard of Care

Metastatic Colorectal Cancer | Colorectal Cancer Stage IV
Dizal Pharmaceuticals

Recruiting

A Phase II Clinical Trial of DZD9008 in Combination With AZD4205 in Standard Treatment Failed NSCLC Patients With EGFR Mutations (WU-KONG21)

Non-small Cell Lung Cancer

China
Peking University

Recruiting

Targeted Treatment Plus Tislelizumab and HAIC for Advanced CRCLM Failed From Standard Systemic Treatment

Liver Metastasis Colon Cancer | MSS | ctDNA Genotype | Failed From Standard Treatment

China
Institut Curie
Zionexa

Recruiting

ECLECTIC: EstroTEP and Circulating Biomarkers for ER-positive HER2-negative Metastatic Breast Cancer Patients (ECLECTIC)

Breast Carcinoma

France
AstraZeneca

Recruiting

Study of Non-Small Cell Lung Cancer Patients in the US Receiving Standard-of-Care and Initiating an Approved Therapy With Risk of Pneumonitis/ILD (LOOP)

Non-Small Cell Lung Cancer

United States
Soonchunhyang University Hospital

Not yet recruiting

A Single-center Clinical Study to Evaluate the Safety and Efficacy of Autologous Bone Marrow-derived DCs(CellgramDC-WT1) and Immune Checkpoint Inhibitors in Patients With Metastatic Pancreatic Cancer Who Have Failed First-line or More Standard Chemotherapy (DICI_PC)

Pancreas Cancer
Johannes Grand

Not yet recruiting

Optimal Diuretic Therapies for Acute Heart Failure With Volume Overload (DRAIN-AHF)

Acute Heart Failure

Denmark
AbbVie

Recruiting

Study Assessing Activity of Intravenous (IV) ABBV-383 Monotherapy Versus Standard Available Therapies in Adult Participants With Relapsed or Refractory Multiple Myeloma

Multiple Myeloma

Israel, Taiwan
Shanghai Changzheng Hospital

Not yet recruiting

A Study of Surufatinib Combined With Serplulimab in the Treatment of Advanced Solid Tumors With Neuroendocrine Differentiation That Failed Standard Therapy

Advanced Solid Tumors With Neuroendocrine Differentiation
Hospital Israelita Albert Einstein

Recruiting

Impact of Yoga and Gentle Massage Practices on Symptom Management in Patients Undergoing HSCT (Yoga)

Bone Marrow Transplantation | Hematopoietic Stem Cell Transplantation

Brazil
Ottawa Hospital Research Institute

Not yet recruiting

Hyperbaric Oxygen Therapy for Perianal Fistulizing Crohn's Disease Not Responsive or Intolerant to Conventional Care: HYPNOTIC Pilot Study (HYPNOTIC)

Inflammatory Bowel Disease (IBD)
Evopoint Biosciences Inc.
Merck Sharp & Dohme LLC

Recruiting

Study of XNW5004 Tablet in Combination With KEYTRUDA® (Pembrolizumab) in Subjects With Advanced Solid Tumors Who Failed Standard Treatments (KEYNOTE F19)

Carcinoma | Cervical Cancer | Prostate Cancer | Squamous Cell Carcinoma of Head and Neck | Non-small Cell Lung Cancer | Small-cell Lung Cancer | Urothelial Carcinoma | Other Solid Tumors

China
Qurgen Inc.

Recruiting

A First-in-Human Study of SON-DP in Participants With Relapsed/Refractory Intolerant to Standard of Care Therapies for Advanced/Metastatic Solid Tumors

Breast Cancer | Colorectal Cancer | Pancreatic Cancer | Ovarian Cancer | Solid Tumor

United States
Andalusian Network for Design and Translation of...

Recruiting

Clinical Trial With Adipose Tissue Stem Cells on Biological Matrix for the Treatment of Venous Ulcer of the Lower Limbs

Venous Ulcer

Spain
University of Giessen

Recruiting

Monitoring of the Influence of Approved PH-therapies RV-PA Coupling

Pulmonary Hypertension

Germany
Second Affiliated Hospital, School of Medicine,...

Recruiting

Efficacy and Safety of Cadonilimab Plus Anlotinib in Advanced STS That Failed the Previous First-line Standard Treatment

Soft Tissue Sarcoma

China
American University of Beirut Medical Center

Recruiting

Standard Versus Hyperangulated Video Laryngoscopy Blades for Intubation in Neonates and Small Infants

Intubation; Difficult or Failed

Lebanon
Centro Cardiologico Monzino
IRCCS National Neurological Institute "C. Mondino" Foundation

Recruiting

Antiplatelet Therapies in Patients With Depression and Coronary Disease (ENHANCE)

Depression | Coronary Artery Disease

Italy
Eutilex

Recruiting

A Phase 1 Study to Evaluate the Safety, Tolerability and Preliminary Efficacy of EU103 in Advanced or Metastatic Solid Tumors That Have Failed Standard Therapy

Solid Tumor

Korea, Republic of
Princess Maxima Center for Pediatric Oncology
Innovative Therapies For Children with Cancer Consortium; IBFM; Fight Kids Cancer

Not yet recruiting

HEM-iSMART-C: Ruxolitinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies (HEM-iSMART C)

Acute Lymphoblastic Leukemia, in Relapse | Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent | Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent | Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory | Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Refractory

Netherlands
Associazione Ginco Ticino

Recruiting

Integration Between Learning, Body and Emotions (I-ACE) (I-ACE)

Quality of Life | Burnout, Professional | Dementia

Switzerland
Universität Duisburg-Essen

Not yet recruiting

Pranayama for Posttraumatic Stress Disorder (PRANAPTSD)

Post Traumatic Stress Disorder
Fudan University

Not yet recruiting

Camrelizumab Combined With Bevacizumab and HAIC in Patients With Metastatic Liver Cancer Who Failed Standard Therapy

Metastatic Liver Cancer

China
Tianjin Medical University Cancer Institute and...

Recruiting

Multi-cohort Study of Surufatinib Plus Sintilimab in Metastatic NEN and Pancreatic Carcinoma Who Failed Standard Chemotherapy

Pancreatic Carcinoma | Neuroendocrine Carcinoma | Neuroendocrine Tumor Grade 3

China
University Magna Graecia

Not yet recruiting

Psychological Evaluation After SCS Implantation

Quality of Life | Cognitive Impairment | Psychological Disability

Italy
Assiut University

Recruiting

High Voltage VS Standard Voltage Radiofrequency in a Patient With Failed Back Surgery Syndrome

Neuralgia | Failed Back Surgery Syndrome

Egypt
Zhejiang Cancer Hospital

Recruiting

A Single-Arm Phase II Exploratory Clinical Study of Pemigatinib in the Treatment of Advanced Gastrointestinal Cancer (Excluding Biliary Tract Cancer) Patients With FGFR Alterations Who Have Failed Standard Therapy

Gastrointestinal Cancer

China
ULURU Inc.
United States Department of Defense

Recruiting

Comparison of Transforming Powder Dressing to NPIAP Recommended Standard of Care Therapies in Stage 2, 3 and 4 Pressure Injuries

Pressure Ulcers Stage II | Pressure Ulcers Stage III | Pressure Ulcer, Stage IV

United States
BeiGene

Recruiting

Study Investigating BGB-24714 as Monotherapy and With Combination Therapies in Participants With Solid Tumors

Solid Tumor, Adult

United States, Australia, New Zealand, China, Korea, Republic of
The First Affiliated Hospital of Zhengzhou University
BeiGene; Jiangsu Hengrui Pharmaceutical Co., Ltd.; RemeGen Co., Ltd.

Not yet recruiting

Study of Tislelizumab Combined With DisitamabVedotin and Pyrotinib Maleate in HER2-positive or Mutated Advanced Colorectal Cancer Who Failed Standard Therapy

HER2-positive or Mutated Advanced Colorectal Cancer
Dr Anthony De Buys Roessingh

Not yet recruiting

Use of Progenitor Biological Bandages in Burn Care (Bru_PBB) (Bru_PBB)

Burn Injury
The First Affiliated Hospital of Xiamen University

Recruiting

A Single-Arm Phase II Clinical Study of Pemigatinib in the Treatment of Advanced Non-Small Cell Lung Cancer Patients With FGFR Alterations Who Have Failed Standard Therapy

Advanced Non-Small Cell Lung Cancer

China
ImmuneOncia Therapeutics Inc.

Recruiting

A Study of IMC-002 in Patients With Advanced Cancer Failed to Standard Therapy

Advanced Cancer

Korea, Republic of
Wuhan Union Hospital, China

Recruiting

A Single-Arm Phase II Exploratory Clinical Study of Pemigatinib in the Treatment of Advanced Gastric and Colorectal Cancer Patients With FGFR Alterations Who Have Failed Standard Therapy

Gastric and Colorectal Cancer

China
Tan Tock Seng Hospital
Melbourne Health; National University Hospital, Singapore; Samsung Medical Center and other collaborators

Recruiting

Early Oral Step-down Antibiotic Therapy for Uncomplicated Gram-negative Bacteraemia

Gram-negative Bacteraemia

Singapore
Icahn School of Medicine at Mount Sinai

Recruiting

Rapid Sequencing of Approved Therapies in Patients With Metastatic or Unresectable Clear Cell Renal Cell Carcinoma

Renal Cell Carcinoma

United States
National Health Research Institutes, Taiwan
National Taiwan University Hospital; Chang Gung Memorial Hospital; Kaohsiung... and other collaborators

Recruiting

Lenvatinib Plus Paclitaxel for Patients With Advanced Biliary Tract Cancer Who Failed to Gemcitabine-based Treatment (LenPac)

Advanced Biliary Tract Cancer

Taiwan
Abu Dhabi Stem Cells Center

Recruiting

Safety and Efficacy of Extracorporeal Photopheresis (ECP) in the Treatment of Multiple Sclerosis (PHOMS)

Multiple Sclerosis | Multiple Sclerosis, Relapsing-Remitting | Multiple Sclerosis, Secondary Progressive

United Arab Emirates
iTeos Belgium SA
GlaxoSmithKline; iTeos Therapeutics

Recruiting

Study of EOS-448 With Standard of Care and/or Investigational Therapies in Participants With Advanced Solid Tumors (TIG-006)

Melanoma | Head and Neck Cancer | Lung Cancer | Advanced Cancer

Spain, Italy, France, United States, United Kingdom, Belgium
Tarus Therapeutics, Inc.

Not yet recruiting

TT-4 as a Single Agent in Subjects With Advanced Selected Solid Tumors

Hepatocellular Carcinoma | Gastric Cancer | Colorectal Cancer | Pancreatic Cancer
Tianjin Medical University Cancer Institute and...

Not yet recruiting

Drug-eluting Beads Bronchial Arterial Chemoembolization in Stage II-III Non-small-cell Lung Cancer Patients Failed, Refused or Ineligible to Receive Standard Treatments

Carcinoma, Non-Small-Cell Lung
Makerere University
Mbarara University of Science and Technology; Ministry of Health, Uganda; Joint...

Not yet recruiting

Safety & Efficacy of Low Dose Aspirin / Ivermectin Combination Therapy for Treatment of Covid-19 Patients (IVCOM)

Covid19
Cardresearch
McMaster University; Eiger BioPharmaceuticals; Cytel Inc.; Fastgrants; RainWater...

Recruiting

Repurposed Approved and Under Development Therapies for Patients With Early-Onset COVID-19 and Mild Symptoms

Covid19 | SARS-Associated Coronavirus

Brazil

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