Search clinical trials for: failing prior treatment

Total 64975 results

Reade Rheumatology Research Institute
ZonMw: The Netherlands Organisation for Health Research and Development; Sint...

Active, not recruiting

Using Adalimumab Serum Concentration to Choose a Subsequent Biological DMARD in Rheumatoid Arthritis Patients Failing Adalimumab Treatment (ADDORA-switch)

Rheumatoid Arthritis

Netherlands
GlaxoSmithKline

Active, not recruiting

An Open-label, Dose Escalation Study in Japanese Participants With Relapsed/Refractory Multiple Myeloma Who Have Failed Prior Anti Myeloma Treatments

Multiple Myeloma

Japan
Sun Pharma Advanced Research Company Limited

Active, not recruiting

Safety and Anti-leukemic Activity of Vodobatinib (K0706) for Treatment of Ph+ CML Resistant/Intolerant to ≥3 Prior CML Therapies

Healthy (For Part A) | Chronic Myeloid Leukemia (for Part B and C)

United States, Spain, Hungary, Italy, India, Belgium, France, Romania, Singapore, United Kingdom, Korea, Republic of, Turkey
Novartis Pharmaceuticals

Active, not recruiting

Study of Efficacy and Safety of CML-CP Patients Treated With Asciminib Versus Best Available Therapy, Previously Treated With 2 or More Tyrosine Kinase Inhibitors

Leukemia, Chronic Myelogenous

China
Abbott Medical Devices
Cardiovascular Research Foundation, New York

Active, not recruiting

Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The ECLIPSE Trial (ECLIPSE)

Coronary Artery Disease | Ischemic Heart Disease | Non ST Segment Elevation Myocardial Infarction

United States
Raija Silvennoinen
Bristol-Myers Squibb; Amgen; Hospital District of Helsinki and Uusimaa

Completed

Carfilzomib + Elotuzumab + Dexamethasone for Relapsed Multiple Myeloma After 1-3 Prior Treatment Lines (KEd)

Multiple Myeloma in Relapse

Finland, Sweden
Tanta University

Completed

Safety and Efficacy of Sofosbuvir-Based Regimens in the Treatment of Egyptian Patients With Hepatitis C Infection

Hepatitis C

Egypt
Novartis Pharmaceuticals

Completed

Study of Efficacy, Safety, and Quality of Life of Pazopanib in Patients With Advanced and/or Metastatic Renal Cell Carcinoma After Prior Checkpoint Inhibitor Treatment (IO-PAZ)

Metastatic Renal Cell Carcinoma | Advanced Renal Cell Carcinoma

Spain, Germany, United States, Austria, Czechia, United Kingdom, Argentina, Hungary, France, Canada, Chile
SWOG Cancer Research Network
National Cancer Institute (NCI)

Suspended

Testing the Addition of an Anti-Cancer Immunotherapy Drug, Avelumab, to Gemcitabine and Carboplatin Chemotherapy Prior to Surgery in Muscle Invasive Urinary Tract Cancer vs. Surgery Alone in Patients Who Are Not Able to Receive Cisplatin Therapy (SWOG GAP TRIAL)

Stage II Bladder Cancer AJCC v8 | Bladder Carcinoma Infiltrating the Muscle of the Bladder Wall | Infiltrating Renal Pelvis and Ureter Urothelial Carcinoma

United States
Olivia Newton-John Cancer Research Institute
Bristol-Myers Squibb

Active, not recruiting

A Phase II Trial of Ipilimumab and Nivolumab for the Treatment of Rare Cancers

Gastrointestinal Cancer | Malignant Female Reproductive System Neoplasm | Neuroendocrine Tumours

Australia
Medical College of Wisconsin
University of Cincinnati

Completed

Pancreas Cancer: Molecular Profiling as a Guide to Therapy Before and After Surgery ("Personalized Medicine")

Pancreatic Adenocarcinoma

United States
National Taiwan University Hospital

Completed

Transforming ED Throughput With AI-Driven Clinical Decision Support System (TEDAI)

Critical Care | Emergency Treatment | Triage | Readmission

Taiwan
Minoryx Therapeutics, S.L.

Active, not recruiting

A Clinical Study in Male Pediatric Patients With Cerebral X-linked Adrenoleukodystrophy (Cald) to Assess the Effects of MIN-102 Treatment on Disease Progression Prior to Human Stem Cell Transplant (HSCT) (NEXUS)

Cerebral Adrenoleukodystrophy

Spain, Germany, France, Argentina
Memorial Sloan Kettering Cancer Center

Active, not recruiting

ß-Thalassemia Major With Autologous CD34+ Hematopoietic Progenitor Cells Transduced With TNS9.3.55 a Lentiviral Vector Encoding the Normal Human ß-Globin Gene

Confirmed Diagnosis of ß-thalassemia Major

United States
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Completed

Chemotherapy Before Surgery in Treating Patients With High Grade Upper Urinary Tract Cancer

High Grade Upper Tract Urothelial Carcinoma

United States
AIO-Studien-gGmbH
Amgen; ClinAssess GmbH

Completed

Maintenance Therapy With 5-FU/FA Plus Panitumumab vs. 5-FU/FA Alone After Prior Induction and Re-induction After Progress for 1st-line Treatment of Metastatic Colorectal Cancer (PanaMa)

Metastatic Colorectal Cancer

Germany
Eastern Cooperative Oncology Group
National Cancer Institute (NCI)

Completed

High-Dose Methotrexate and Leucovorin in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Brain and Central Nervous System Tumors

United States
Bristol-Myers Squibb

Active, not recruiting

A Study of Participants With Advanced Non-Small Cell Lung Cancer Treated With Nivolumab in France After at Least One Prior Chemotherapy-based Treatment by Lung Initiative on Sequence Therapy (LIST)

Lung Cancer

France
Indiana University

Completed

Comparing Brief Relaxation Period to Virtual Reality Period in Reducing Dental Anxiety Prior to Root Canal Treatment

Dental Anxiety

United States
Novartis Pharmaceuticals

Completed

A Descriptive Study of Baseline Characteristics, Clinical Outcomes, and Treatment Patterns of HR+/HER2- Advanced or Metastatic Breast Cancer Patients Treated With Alpelisib Plus Fulvestrant Who Have Received Fulvestrant in Any Prior Line of Therapy

HR+/HER2- Advanced or Metastatic Breast Cancer

Ireland
Bristol-Myers Squibb

Completed

Continuing Treatment for Subjects Who Have Participated on a Prior Protocol Investigating Dasatinib

Multiple Indications Cancer

France, Poland
Kepler University Hospital

Completed

Optimization of Treatment Priority of the Manchester Triage System (OPTIMTS)

Triage

Austria
Genmab

Terminated

Trial With HuMax-CD4 in Participants With Rheumatoid Arthritis (RA) Failing Treatment With Methotrexate (MTX) and a TNF-alpha Blocker

Rheumatoid Arthritis

United States, Canada
Idorsia Pharmaceuticals Ltd.

Completed

Multicenter Study to Evaluate the Efficacy and Safety of Oral ACT-539313 in the Treatment of Adults With Moderate to Severe Binge Eating Disorder

Binge-Eating Disorder

United States
Bristol-Myers Squibb

Active, not recruiting

A Study of Nivolumab in Participants With Locally Advanced or Metastatic (Stage IIIB-IV) Non-Small Cell Lung Cancer (NSCLC) With Squamous and Non-Squamous Histology After Prior Chemotherapy Treated in Real World Settings in Greece and Cyprus (LUCENCE)

Non-Small Cell Lung Cancer

Greece
University of California, San Diego
Epimed International; Myoscience (prior to merger with Pacira Pharmaceuticals)

Completed

Cryoanalgesia to Prevent Acute and Chronic Pain Following Surgery: A Randomized, Double-Masked, Sham-Controlled Study

Rotator Cuff Repair | Shoulder Arthroplasty | Mastectomy | Knee Arthropathy | Upper Limb Amputation Below Elbow | Upper Limb Amputation Above Elbow | Lower Limb Amputation Below Knee | Lower Limb Amputation Above Knee | Video-Assisted Thoracoscopic Surgery (VATS) | Skin Grafting

United States
Indiana University
National Institute of Mental Health (NIMH); University of Florida; Eskenazi Health

Completed

Goal Elicitation, Treatment Prioritization, & Electronically-Practiced Discussion for Psychiatry (GET-PrEPD)

Mental Illness | Shared Decision Making

United States
AbbVie

Enrolling by invitation

Long-term Extension Study to Assess Safety and Tolerability of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Pediatric Participants (Ages 6-17)

Migraine

United States, Puerto Rico
Fred Hutchinson Cancer Center
ADC Therapeutics

Withdrawn

Loncastuximab Tesirine in Combination With Chemotherapy Prior to Stem Cell Transplant for the Treatment of Recurrent or Refractory Diffuse Large B-Cell Lymphoma

Recurrent Diffuse Large B-Cell Lymphoma | Recurrent Primary Mediastinal (Thymic) Large B-Cell Lymphoma | Refractory Diffuse Large B-Cell Lymphoma | Refractory Primary Mediastinal (Thymic) Large B-Cell Lymphoma | Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified | Recurrent High... and other conditions

United States
University of Aarhus
Aarhus University Hospital

Completed

TReatment Strategy In Acute Ischemic larGE Vessel STROKE: Prioritize Thrombolysis or Endovascular Treatment (TRIAGE)

Stroke

Denmark
Bristol-Myers Squibb
PPD

Completed

An Open-Label, Multicenter Clinical Trial With Nivolumab (BMS-936558) Monotherapy in Subjects With Advanced or Metastatic Squamous Cell (Sq) Non-Small Cell Lung Cancer (NSCLC) Who Have Received at Least One Prior Systemic Regimen for the Treatment of Stage IIIb/IV SqNSCLC (Checkmate 171)

Non-Small Cell Lung Cancer

Poland, Spain, Austria, Denmark, Finland, Greece, Hungary, Ireland, Portugal, Romania, Russian Federation, Sweden, United Kingdom
Amgen

Completed

AMG 531 Treatment of Thrombocytopenic Subjects With Immune (Idiopathic) Thrombocytopenic Purpura (ITP) Prior to Splenectomy

Thrombocytopenia | Idiopathic Thrombocytopenic Purpura
Bristol-Myers Squibb

Completed

A Safety Trial of Nivolumab in Patients With Advanced or Metastatic Non-Small Cell Lung Cancer Who Have Progressed During or After Receiving At Least One Prior Chemotherapy Regimen (CheckMate153)

Non Small Cell Lung Cancer (NSCLC)

United States, Canada
AbbVie

Completed

The Objective of This Study is to Evaluate the Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD) Who Have Had an Inadequate Response to Antidepressants Alone

Major Depressive Disorder

United States, Canada, Czechia, Finland, Poland, Puerto Rico, Serbia, Slovakia
AstraZeneca
Merck Sharp & Dohme LLC; Myriad Genetic Laboratories, Inc.

Completed

Olaparib Treatment in Relapsed Germline Breast Cancer Susceptibility Gene (BRCA) Mutated Ovarian Cancer Patients Who Have Progressed at Least 6 Months After Last Platinum Treatment and Have Received at Least 2 Prior Platinum Treatments (SOLO3)

Relapsed Ovarian Cancer, BRCA Mutation, Platinum Sensitivity

United States, Italy, Spain, Belgium, Poland, Canada, Korea, Republic of, Brazil, Czechia, Hungary, Israel, Argentina, Mexico
GlaxoSmithKline

Active, not recruiting

A Long-term Treatment Extension Study of Niraparib in Participants Who Completed a Prior GlaxoSmithKline/TESARO-sponsored Niraparib Study

Breast Neoplasms | Ovarian Neoplasms

United States, Austria, Denmark, Spain, Canada, France, Israel, Italy
National Cancer Institute (NCI)

Terminated

Combining CRLX101, a Nanoparticle Camptothecin, With Enzalutamide in People With Progressive Metastatic Castration Resistant Prostate Cancer Following Prior Enzalutamide Treatment

Prostate Neoplasms | Metastatic Castration Resistant Prostate Cancer

United States
University of Malaya

Active, not recruiting

The Effects of Oral Hygiene Interventions Prior Orthodontic Treatment in Adults

Oral Hygiene | Adult

Malaysia
Samsung Medical Center

Completed

Study of Pembrolizumab in Metastatic Biliary Tract Cancer as Second-line Treatment After Failing to at Least One Cytotoxic Chemotherapy Regimen: Integration of Genomic Analysis to Identify Predictive Molecular Subtypes

Biliary Tract Cancer

Korea, Republic of
AbbVie

Completed

A Study to Assess the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Crohn's Disease Who Failed Prior Biologic Treatment

Crohn's Disease

United States, Argentina, Australia, Austria, Belarus, Belgium, Bosnia and Herzegovina, Bulgaria, Canada, Chile, China, Colombia, Croatia, Czechia, Denmark, Egypt, Estonia, France, Germany, Greece, Ireland, Israel, Italy, Korea, Republic... and more
Zai Lab (Shanghai) Co., Ltd.

Terminated

A Study of Niraparib Combined With MGD013 in Patients With Advanced or Metastatic Solid Tumor Who Failed Prior Treatment

Gastric Cancer | Triple Negative Breast Cancer | Endometrial Carcinoma | Biliary Tract Carcinoma

China
SPP Pharmaclon Ltd.

Completed

Study of the Use of the Drug Ingaron in Patients With COVID-19

COVID-19 Respiratory Infection | Viral Pneumonia

Russian Federation
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Withdrawn

Sapanisertib and Nivolumab for the Treatment of Stage I-IV Non-small Cell Lung Cancer in Patients Who Have Progressed on Prior PD-1/PD-L1 Inhibitor Therapy, I-OVERCOME Study

Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Lung Non-Small Cell Carcinoma | Stage III Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Stage II Lung Cancer AJCC v8 | Stage IIA Lung Cancer AJCC v8 | Stage IIB Lung Cancer AJCC v8 | Stage IIIA Lung Cancer AJCC v8 | Stage IIIB Lung... and other conditions
SPP Pharmaclon Ltd.

Completed

Efficiency and Safety of the Drug Ingaron (Interferon-gamma Human Recombinant) in the Treatment of Chronic Prostatitis (ING-HP-1)

Chronic Prostatitis
Thomas Stauffer Larsen

Completed

A Study of Low Dose Interferon Alpha Versus Hydroxyurea in Treatment of Chronic Myeloid Neoplasms (DALIAH)

Primary Myelofibrosis | Polycythemia Vera | Essential Thrombocythemia

Denmark
University of Missouri-Columbia

Terminated

Treatment Prior to Injection and Biopsy of the Vulva

Anesthesia, Local | Vulvar Diseases | Anesthesia

United States
Hoffmann-La Roche

Completed

A Study of Trastuzumab Emtansine in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer Who Have Received Prior Anti-HER2 And Chemotherapy-based Treatment

Breast Cancer

Italy, Belgium, Canada, United Kingdom, Argentina, Australia, Austria, Brazil, Bulgaria, China, Croatia, Denmark, Dominican Republic, Ecuador, Estonia, Finland, France, Germany, Greece, Guatemala, Hong Kong, Hungary, Iceland, Indonesia, Irelan... and more
Methodist Health System

Active, not recruiting

Quantifying Gram-negative Resistance to Empiric Therapy in the Intensive Care Unit (RESTART)

Gram-Negative Bacterial Infections

United States
National Institute of Allergy and Infectious Diseases...

Completed

Adaptive COVID-19 Treatment Trial 3 (ACTT-3)

COVID-19

United States, Japan, Mexico, Singapore, Korea, Republic of
Dartmouth-Hitchcock Medical Center

Completed

A Proof-of-principle Study of HBO-SRS for Brain Metastases

Brain Metastases

United States

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