Search clinical trials for: investigate gene-environment interactions

Total 3088 results

Alexion Pharmaceuticals, Inc.

Completed

A Study to Investigate the Potential Drug Interactions Between ALXN2080 and Rosuvastatin and Metformin in Healthy Adult Participants

Healthy

United Kingdom
University of Nebraska
University of Colorado, Denver; National Institute of Arthritis and Musculoskeletal... and other collaborators

Completed

Gene-Environment Interactions in Rheumatoid Arthritis Autoimmunity Disease Severity

Rheumatoid Arthritis

United States
Jazz Pharmaceuticals

Completed

An Open-label Extension Trial to Investigate Possible Drug-drug Interactions Between Stiripentol or Valproate and Cannabidiol in Patients With Epilepsy

Epilepsy

Spain, Sweden, Netherlands
Jazz Pharmaceuticals

Completed

An Open-label Extension Study to Investigate Possible Drug-drug Interactions Between Clobazam and Cannabidiol

Epilepsy

Spain, United Kingdom
Jazz Pharmaceuticals

Completed

A Randomized Controlled Trial to Investigate Possible Drug-drug Interactions Between Clobazam and Cannabidiol

Epilepsy

Spain, United Kingdom
Aurinia Pharmaceuticals Inc.

Completed

Drug-Drug Interaction Study to Investigate Effects of Voclosporin on Pharmacokinetics of Simvastatin (Statin-DDI)

Drug-drug Interaction

United States
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.

Completed

A Study to Investigate the Drug-drug Interactions (DDIs) Between SKLB1028 and Midazolam in Healthy Subjects

Healthy Subjects

China
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.

Active, not recruiting

A Study to Investigate the Drug-drug Interactions (DDIs) of SKLB1028 With Itraconazole, Gemfibrozil or Rifampicin in Healthy Subjects

Healthy Subjects

China
Janssen Sciences Ireland UC

Completed

A Study to Investigate the Pharmacokinetic Interactions Between Simeprevir and Ledipasvir in a Treatment Regimen Consisting of Simeprevir, Sofosbuvir, and Ledipasvir in Treatment-naive Participants With Chronic Hepatitis C Virus Genotype 1 Infection

Hepatitis C, Chronic

Belgium
Idorsia Pharmaceuticals Ltd.

Completed

A Study to Investigate the Drug-drug Interactions Between ACT-541468 and Ethanol in Healthy Subjects

Healthy

Netherlands
UCB Pharma SA

Completed

A Study to Investigate the Drug-Drug Interactions of Brivaracetam and Ethanol in Healthy Male Subjects

Healthy Volunteers

Netherlands
Idorsia Pharmaceuticals Ltd.

Completed

A Clinical Study to Investigate the Potential Interactions Between Food and ACT-541468 and Between ACT-541468 and Midazolam

Healthy Subjects

Germany
Idorsia Pharmaceuticals Ltd.

Terminated

Clinical Study to Investigate Safety and Effects on Heart Rate, Blood Pressure, and Pharmacokinetic Interactions of ACT-334441

Healthy Subjects

France
Yuyu Pharma, Inc.

Completed

A Study to Investigate the Pharmacokinetic Drug Interactions Between Dutasteride and Tadalafil in Healthy Male Subjects

Benign Prostate Hyperplasia
West Virginia University
West Virginia Clinical and Translational Science Institute

Terminated

Pilot Study of Metformin in HNSCC to Investigate the Effects of MF, Tumor Genotype and MF-genotype Interactions, on Tumor Metabolism and Anoikis

Cancer of Head and Neck

United States
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study to Investigate Whether Pharmacokinetic and Pharmacodynamic Interactions Exist Between Metformin and Canagliflozin (JNJ-28431754) in Healthy Volunteers

Healthy

United States
NVP Healthcare

Completed

to Investigate the Pharmacokinetic Interactions and Safety Between Rosuvastatin and Ezetimibe in Healthy Male Volunteers (NVP-1205)

Healthy
Pfizer

Completed

A Drug-Drug Interaction Study To Investigate The Potential For Multiple Doses Of Palbociclib (PD-0332991) To Alter The Pharmacokinetics Of Oral Midazolam In Adult Healthy Women of Non-Childbearing Potential.

Healthy

United States
AstraZeneca

Completed

Study in Healthy Volunteers to Investigate the Effects of Ketoconazole on the Pharmacokinetics of NKTR-118

Healthy Volunteers | Bioavailability | Drug- Drug Interactions

United States
Janssen Infectious Diseases BVBA

Completed

A Study to Investigate the Potential Pharmacokinetic Interactions Between Phenytoin or Carbamazepine and Telaprevir

Healthy Participants

Netherlands
LG Life Sciences

Completed

Study for Investigate the Pharmacokinetic Drug Interactions Between Gemigliptin and Rosuvastatin

Healthy

Korea, Republic of
Far Eastern Memorial Hospital
National Taiwan University Hospital

Unknown

Environmental and Genetic Determinants of Nasopharyngeal Carcinoma (NPC)

Nasopharyngeal Carcinoma

Taiwan
Tibotec BVBA

Completed

VX-950-TiDP24-C124: A Phase I Trial to Investigate the Potential Pharmacokinetic Interactions Between Telaprevir and Darunavir/Ritonavir and Between Telaprevir and Fosamprenavir/Ritonavir at Steady-state.

Hepatitis C | HIV | Telaprevir
AstraZeneca

Not yet recruiting

Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Balcinrenone

Hepatic Impairment

United States
Cairo University

Recruiting

Drug-drug Interactions With Anti-tuberculous Drugs

Drug-drug Interaction

Egypt
AstraZeneca
Parexel

Recruiting

A Study to Investigate Safety, Tolerability, and Pharmacokinetics of Oral AZD0233 Compared With Placebo in Healthy Adult Participants.

Dilated Cardiomyopathy

United States
Apollo Therapeutics Ltd

Not yet recruiting

A Study to Investigate APL-4098 Alone and/or in Combination With Azacitidine in R/R AML and High-Risk MDS

Myelodysplastic Syndrome With Excess Blasts | Acute Myeloid Leukemia, in Relapse | Acute Myeloid Leukemia Refractory | Myelodysplastic Syndrome Acute Myeloid Leukemia
Sanofi

Recruiting

A Study to Investigate Long-term Safety and Tolerability of Tolebrutinib in Participants With Multiple Sclerosis.

Relapsing Multiple Sclerosis | Secondary Progressive Multiple Sclerosis | Progressive Relapsing Multiple Sclerosis

Belgium
ViiV Healthcare

Not yet recruiting

A Study to Investigate the Effect of Food on the Bioavailability of a Capsid Inhibitor (CAI) in Male and Female Healthy Participants

HIV Infections
AstraZeneca

Not yet recruiting

A Study to Investigate the Safety and Pharmacokinetics of AZD6793 in Healthy Japanese and Chinese Participants

Healthy Participants

United States
Sanofi Pasteur, a Sanofi Company

Recruiting

A Study to Investigate the Safety and Immunogenicity of the Quadrivalent Influenza mRNA Vaccines in Adults Aged 18 Years and Above

Influenza Immunization

United States, Puerto Rico
PMV Pharmaceuticals, Inc

Recruiting

A Study to Investigate the Effects of Itraconazole on the Pharmacokinetics of PC14586 in Healthy Participants

Healthy Volunteers

United States
Sanofi

Not yet recruiting

A Study to Investigate Subcutaneous Isatuximab in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma (SubQSA)

Plasma Cell Myeloma Refractory
AstraZeneca

Recruiting

A Study to Investigate the Pharmacokinetics of Baxdrostat When Given Alone and in Combination With Itraconazole in Healthy Participants

Healthy Participants

United States
GlaxoSmithKline

Not yet recruiting

A Study to Investigate the Pharmacokinetics of a Combined Oral Contraceptive When Given Alone and in Combination With GSK3036656 in Female Participants of Non-childbearing Potential Aged 18 to 65 Years of Age

Tuberculosis

Spain
University of Copenhagen
LEGO Foundation

Recruiting

The Playful Learning in Infancy Program (PLIP)

Parent-Child Relations | Infant Development

Denmark
ProPersona

Not yet recruiting

A Single-case Design to Investigate a Compensatory Brain Game Supporting Goal Management Training Intervention in a Psychiatric Brain Injury Population

Anxiety | Depressive Symptoms | Acquired Brain Injury | Executive Dysfunction

Netherlands
University of Parma
Foundation for Liver Research; Azienda Ospedaliero-Universitaria di Parma; National... and other collaborators

Not yet recruiting

Precision Nutrition to Improve Cardiometabolic Health With Dietary (Poly)Phenols (PRE-CARE-DIET)

Obesity | Cardiometabolic Health | Individual Variability in (Poly)Phenol Metabolism | Personalized Dietary Intervention

Italy
AstraZeneca

Not yet recruiting

A Phase III Study to Investigate the Efficacy and Safety of Baxdrostat in Asian Participants With Uncontrolled Hypertension on Two or More Medications Including Participants With Resistant Hypertension (BaxAsia)

Resistant Hypertension | Uncontrolled Hypertension

Vietnam, Korea, Republic of, Philippines, China, Hong Kong, Turkey, Japan, India, Russian Federation, Argentina
Aalborg University

Not yet recruiting

Investigate the Relationship Between Catastrophizing and the Perception of Itch Intensity in Healthy Individuals

Histamine | Cowhage
Insel Gruppe AG, University Hospital Bern
Paul Scherrer Institut, Center for Proton Therapy

Not yet recruiting

A Clinical Trial to Investigate 18F-AzaFol in the Diagnosis of Large Vessel Vasculitis (CRAFT)

Giant Cell Arteritis

Switzerland
Shouyao Holdings (Beijing) Co. LTD

Not yet recruiting

A Study to Evaluate the Effect of Itraconazole and Rifampicin on the Pharmacokinetics of SY-5007 in Healthy Subjects

Healthy Subjects

China
University Hospital Tuebingen
University Hospital Freiburg

Not yet recruiting

Imaging in Moyamoya Disease - Study to Investigate Different Imaging Technologies for a Better Understanding of Various Imaging Techniques to Evaluate Cerebral Hemodynamics, Disease-activity and Possibly the Etiology in Moyamoya Patients (IMAGINE)

Moyamoya Disease | Moyamoya
CMC Ambroise Paré

Not yet recruiting

Brain Heart InterActioNs in Cardiac Arrest. Ancillary Study of the HEAVENwARd Trial (BHIANCA)

Cardiac Arrest

France
Nested Therapeutics, Inc

Recruiting

A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors (NST-628)

Glioma | Melanoma | NSCLC | Oncology | Solid Tumor, Adult | MEK Mutation | RAF Gene Mutation | Ras (KRAS or NRAS) Gene Mutation | MAPK Pathway Gene Mutation

Australia
Rivus Pharmaceuticals, Inc.

Recruiting

A Study to Investigate the Absorption, Metabolism, and Excretion of [14C]-HU6

Healthy

United States
Horizon Therapeutics Ireland DAC

Recruiting

A Phase 2 Study to Investigate Efficacy and Safety of HZN-1116 in Participants With Sjogren's Syndrome

Sjogren's Syndrome

United States
ViiV Healthcare

Recruiting

A Study to Investigate the Potential Drug-Drug Interaction Between VH4524184 and Oral Contraceptive (Loestrin) in Healthy Adult Female Participants

HIV Infections

United States
Avistone Biotechnology Co., Ltd.

Not yet recruiting

A Study to Investigate ANS014004 in Participants With Locally Advanced or Metastatic Solid Tumors

Locally Advanced or Metastatic Solid Tumors

United States
Tubulis GmbH

Not yet recruiting

FiH Study to Investigate Safety, PK and Efficacy of the NaPi2b ADC TUB-040 in Patients With PROC or r/r Adenocarcinoma NSCLC (NAPISTAR1-01)

Ovarian Cancer | Non-small Cell Lung Cancer

United States

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