Search clinical trials for: lofexidine

Total 41 results

USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Recruiting

Pharmacokinetic and Safety Study of Oral Lofexidine in Neonates Experiencing Opioid Withdrawal Due to Intrauterine Exposure to Opioids

Opioid Withdrawal (Disorder)

United States
University of Pennsylvania

Recruiting

Pregabalin Plus Lofexidine for the Outpatient Treatment of Opioid Withdrawal (UH3)

Opioid Use | Opiate Withdrawal Syndrome

United States
The First Affiliated Hospital of Guangzhou Medical...

Not yet recruiting

Nivolumab Combined With Chemotherapy in the Treatment of Primary Tracheal Squamous Cell Carcinoma (GALAXY-1)

Neoplasms | Antineoplastic Agents | Carcinoma, Squamous
New York State Psychiatric Institute
National Institute on Drug Abuse (NIDA); Yale University; Clinilabs, Inc.; BioXcel...

Recruiting

Sublingual Dexmedetomidine for Treating Opioid Withdrawal

Opioid Use Disorder | Opioid Withdrawal

United States
Johns Hopkins University

Recruiting

Evaluating Buspirone to Treat Opioid Withdrawal

Anxiety | Opioid Use Disorder | Opioid Withdrawal | Opioid Craving

United States
Spark Biomedical, Inc.
Hazelden Betty Ford Foundation; Gaudenzia, Inc.

Recruiting

Delivering Transcutaneous Auricular Neurostimulation to Improve Relapse Prevention in Opioid Use Disorder (RESTORE)

Opioid-use Disorder | Opioid Withdrawal

United States
Johns Hopkins University
National Institute on Drug Abuse (NIDA)

Recruiting

Assessing a Clinically-meaningful Opioid Withdrawal Phenotype

Opioid Use Disorder | Opioid Withdrawal | Opioid Craving

United States
Pharmacotherapies for Alcohol and Substance Use...
United States Department of Defense; Michael E. DeBakey VA Medical Center; RTI... and other collaborators

Recruiting

Lofexidine Combined With Buprenorphine for Reducing Symptoms of PTSD and OU Relapse in Veterans

Post Traumatic Stress Disorder | Opioid-use Disorder

United States
Johns Hopkins University
National Institute on Drug Abuse (NIDA)

Recruiting

An Innovative Intervention for OUD Treatment (Bridge)

Opioid-Related Disorders | Opioid Dependence | Opioid Withdrawal | Opioid Addiction

United States
Medical University of South Carolina
National Institute on Drug Abuse (NIDA); National Institutes of Health (NIH)

Completed

Impact of Lofexidine on Stress, Craving and Opioid Use

Opioid-use Disorder | Opiate Dependence

United States
University of Pennsylvania

Completed

Combining Pregabalin (LYRICA®) With Lofexidine (LUCEMYRATM) to Treat OPIOID Withdrawal (PGB-LOF)

Opioid Withdrawal

United States
Zagazig University

Completed

Treatment of Withdrawal Symptoms and Prevention of Relapse in Patients With Tramadol Abuse

Opiate Withdrawal Syndrome

Egypt
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

A Study Evaluating the Relative Bioavailability of Lofexidine Granules for Reconstitution Compared to LUCEMYRA (Lofexidine) Tablets and the Effect of Food on the Bioavailability of the Lofexidine Granules for Reconstitution

Normal Healthy Volunteers

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Efficacy, Safety and Dose-Response Study Followed by Open-Label Study of Lofexidine Treatment of Opioid Withdrawal

Opioid Dependence | Acute Opioid Withdrawal Syndrome

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Open-Label, Safety Study of Lofexidine (NU LEAF)

Opioid Withdrawal

United States
USWM, LLC (dba US WorldMeds)

Suspended

Randomized, Double-Blind, Placebo-Controlled Pilot Study on the Safety and Effectiveness of LUCEMYRA During an Opioid Taper in Treatment of Withdrawal (TAPER)

Opioid Withdrawal (Disorder)

United States
Mayo Clinic
USWM, LLC (dba US WorldMeds)

Completed

Lofexidine for Adults Undergoing Lumbar Spine Surgery

Opioid Withdrawal

United States
New York State Psychiatric Institute
USWM, LLC (dba US WorldMeds)

Completed

Lofexidine for Management of Opioid Withdrawal With XR-NTX Treatment

Opioid-use Disorder

United States
New York State Psychiatric Institute
National Institute on Drug Abuse (NIDA)

Completed

Combined Pharmacotherapy for Cannabis Dependency (D-LUCS)

Cannabis Dependence | Marijuana Dependence

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Lofexidine Food Effect Study in Healthy Volunteers

Healthy

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Lofexidine Pharmacokinetics in the Presence of Paroxetine in Healthy Volunteers

Healthy

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Pharmacokinetic & Pharmacodynamic Interaction of Lofexidine and Buprenorphine in Buprenorphine Maintained Patients

Opioid Dependence | Buprenorphine Withdrawal Syndrome

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Single-Dose Pharmacokinetics and Safety of Oral Lofexidine in Hepatically-Impaired Subjects

Liver Failure

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Pilot Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients

Opioid Dependence | Methadone Withdrawal Syndrome

United States
USWM, LLC (dba US WorldMeds)

Completed

Study to Evaluate the Exposures of Lofexidine and Its Major Metabolites in Subjects Seeking Buprenorphine Dose Reduction

Substance Withdrawal Syndrome | Opiate Dependence | Opiate Addiction

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Single-dose Pharmacokinetics and Safety of Oral Lofexidine in Renally-Impaired Subjects

Renally Impaired Subjects

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Main Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained Patients

Opioid Dependence | Methadone Withdrawal Syndrome

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Lofexidine ADME & Mass Balance in Volunteers

Normal Healthy Volunteers Will be Treated With Lofexidine to Understand the Absolute Bioavailability and Mass Balance Recovery of the Product

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Assessment of the Effect of Naltrexone on Lofexidine Single Dose Pharmacokinetics in Healthy Subjects

Healthy

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Lofexidine Mass Balance in Volunteers

Normal Healthy Volunteers

United States
GlaxoSmithKline

Completed

Safety, Tolerability, Pharmacokinetic (PK), and Pharmacodynamic Study of GSK2881078 and Study to Evaluate the Effect of CYP3A4 Inhibition on PK of GSK2881078

Cachexia

United States
National Institute on Drug Abuse (NIDA)

Completed

Effectiveness of Naltrexone and Lofexidine in Treating Detoxified Heroin Addicts - 1

Heroin Dependence

United States
National Institute on Drug Abuse (NIDA)
University of Pennsylvania

Completed

Evaluation of Lofexidine for Treatment of Opioid Withdrawal - 3

Substance-Related Disorders | Opioid-Related Disorders

United States
National Institute on Drug Abuse (NIDA)
University of Pennsylvania

Completed

Evaluation of Lofexidine for Treatment of Opioid Withdrawal - 7

Substance-Related Disorders | Opioid-Related Disorders

United States
National Institute on Drug Abuse (NIDA)
Britannia Pharmaceuticals Ltd.

Completed

Lofexidine for Opiate Withdrawal - 1

Opioid-Related Disorders

United States
National Institute on Drug Abuse (NIDA)

Completed

Evaluation of Lofexidine for Treatment of Opiate Withdrawal - 10

Opioid-Related Disorders

United States
National Institute on Drug Abuse (NIDA)

Terminated

Interactions Between Intravenous (IV) Cocaine and Lofexidine

Cocaine Related Disorders

United States
Institute of Mental Health, Singapore
Singapore Clinical Research Institute

Completed

Lofexidine for Inpatient Opiate Detox in Singapore

Opiate Dependent Patients Who Are Undergoing Inpatient Detoxification in Singapore

Singapore
Yale University
National Institute on Drug Abuse (NIDA)

Completed

Effectiveness of Lofexidine to Prevent Stress-Related Opiate Relapse During Naltrexone Treatment - 1

Opioid-Related Disorders

United States
New York State Psychiatric Institute
National Institute on Drug Abuse (NIDA)

Completed

Effect of Lofexidine and Oral THC on Marijuana Withdrawal and Relapse

Marijuana Dependence

United States
US Department of Veterans Affairs
National Institute on Drug Abuse (NIDA); USWM, LLC (dba US WorldMeds)

Completed

Lofexidine for Inpatient Opiate Detox

Opiate Addiction

United States

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