Search clinical trials for: mutational burden

Total 1211 results

Hoffmann-La Roche

Recruiting

A Study of Adjuvant Atezolizumab or Atezolizumab Plus Tiragolumab in Solid Tumors With Resectable Disease With Intermediate-High Risk of Recurrence and High Tumor Mutational Burden (TMB-H) or Microsatellite Instability (MSI-H) (IMperator)

Solid Tumors

Spain
Cancer Research UK
Royal Marsden NHS Foundation Trust; Hoffmann-La Roche; University of Manchester; University of Birmingham

Recruiting

DETERMINE Trial Treatment Arm 02: Atezolizumab in Adult, Teenage/Young Adults and Paediatric Patients With Cancers With High Tumour Mutational Burden (TMB) or Microsatellite Instability-high (MSI-high) or Proven Constitutional Mismatch Repair Deficiency (CMMRD) Disposition (DETERMINE)

Melanoma | Neoplasms by Histologic Type | Lymphoproliferative Disorders | Neoplasms by Site | Cancer | Colorectal Neoplasms | Endometrial Neoplasms | Malignant Neoplasm | Malignancy

United Kingdom
Dermatologic Cooperative Oncology Group

Recruiting

Multicenter Tissue Registry in Melanoma (TRIM)

Metastatic Melanoma

Germany
Marengo Therapeutics, Inc.

Recruiting

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors (START-001)

Neoplasms | Urogenital Neoplasms | Neoplasms by Site | Carcinoma | Epstein-Barr Virus Infections | Advanced Solid Tumors | Vulvar Neoplasms | Vulvar Diseases | Abdominal Neoplasm | Lung Neoplasm | Papillomavirus Infection | Genital Neoplasm, Female

United States, Canada
Medicenna Therapeutics, Inc.
Merck Sharp & Dohme LLC

Recruiting

A Beta-only IL-2 ImmunoTherapY Study (ABILITY-1)

Clear Cell Renal Cell Carcinoma | Cervical Cancer | Gastric Cancer | Esophageal Cancer | Ovarian Cancer | Fallopian Tube Cancer | Solid Tumor | Squamous Cell Carcinoma of Head and Neck | Bladder Cancer | Skin Cancer | Triple Negative Breast Cancer | Advanced Solid Tumor | Primary Peritoneal Cancer | Endometrial Carcinoma and other conditions

United States, Australia, Korea, Republic of, Canada
The Belgian Society of Medical Oncology
Illumina, Inc.; OncoDNA; PierianDx

Recruiting

A Study to Examine the Clinical Value of Comprehensive Genomic Profiling Performed by Belgian NGS Laboratories: a Belgian Precision Study of the BSMO in Collaboration With the Cancer Centre (BALLETT)

Solid Tumor | Metastatic Cancer

Belgium
Josep Carreras Leukaemia Research Institute
Celgene

Recruiting

Monitoring Mutational Burden in Low Risk MDS Patients Using Sequential Peripheral Blood Samples

Myelodysplastic Syndromes

Spain
Yonsei University

Not yet recruiting

Pembrolizumab in Combination With Paclitaxel in the Hormone Receptor-positive Metastatic Breast Cancer With High Tumor Mutational Burden Selected by Whole Exome Sequencing: Korean Cancer Study Group Trial (KCSG BR20-16)

Metastatic Breast Cancer

Korea, Republic of
National Cancer Institute (NCI)

Suspended

A Study Testing the Effect of Immunotherapy (Ipilimumab and Nivolumab) in Patients With Recurrent Glioma With Elevated Mutational Burden

Diffuse Glioma | Secondary Glioblastoma | Glioblastoma, IDH-Wildtype | Astrocytoma, IDH-Mutant, Grade 4

United States, Puerto Rico
23andMe, Inc.

Active, not recruiting

A Phase 1/2a Study of 23ME-00610 in Patients With Advanced Solid Malignancies

Clear Cell Renal Cell Carcinoma | Fallopian Tube Cancer | Solid Tumor | Neuroendocrine Tumors | Epithelial Ovarian Cancer | Primary Peritoneal Carcinoma | Extensive-stage Small-cell Lung Cancer | MSI-H Cancer | Cancer With A High Tumor Mutational Burden

United States, Canada
John L. Villano, MD, PhD

Active, not recruiting

Durvalumab and Tremelimumab Combination in Somatically Hypermutated Recurrent Solid Tumors

Tumor, Solid

United States
ppharmaand GmbH
Bristol-Myers Squibb; Gynecologic Oncology Group; European Network of Gynaecological... and other collaborators

Active, not recruiting

A Study in Ovarian Cancer Patients Evaluating Rucaparib and Nivolumab as Maintenance Treatment Following Response to Front-Line Platinum-Based Chemotherapy (ATHENA)

Fallopian Tube Cancer | Epithelial Ovarian Cancer | Primary Peritoneal | Newly Diagnosed | FIGO Stage III-IV | Partial Response | Complete Response

United States, United Kingdom, Korea, Republic of, Russian Federation, Canada, Denmark, Taiwan, New Zealand, Ireland, Japan, Spain, Australia, Israel, Italy, Greece, Sweden, Czechia, Finland, Poland, Belgium, Germany, Romania, Singa... and more
Bristol-Myers Squibb

Completed

A Study of Nivolumab Combined With Ipilimumab and Nivolumab Alone in Patients With Advanced or Metastatic Solid Tumors of High Tumor Mutational Burden (TMB-H) (CheckMate 848)

Pan Tumor

United States, Puerto Rico, Italy, Argentina, Australia, Belgium, Canada, Chile, Denmark, France, Germany, Netherlands, Poland, Romania, Singapore, Spain, United Kingdom
Vincerx Pharma, Inc.

Active, not recruiting

Phase I Dose Escalation Study for VIP152 in Patients With Advanced Cancer

Neoplasms

United States, Chile, Spain
Assistance Publique - Hôpitaux de Paris
Bristol-Myers Squibb

Terminated

Tumor Mutational Burden in Lung Cancer Patients (MUBULUC)

Non Small Cell Lung Cancer | Non-small Cell Lung Cancer Stage IV | Non Small Cell Lung Cancer Stage III | Non-Small Cell Carcinoma of Lung

France
Uppsala University Hospital

Unknown

A MolEcularly Guided Anti-Cancer Drug Off-Label Trial (MEGALiT)

Solid Tumor

Sweden
Centre Hospitalier Intercommunal de Toulon La Seyne...
Assistance Publique Hopitaux De Marseille; F-CRIN INNOVTE Research Network

Not yet recruiting

DVT Burden and the Risk of Post-thrombotic Syndrome (DVT-Burden)

Postthrombotic Syndrome

France
University Health Network, Toronto
The Hospital for Sick Children; Canadian Institutes of Health Research (CIHR)

Not yet recruiting

Emotion and Symptom-Focused Engagement (EASE) for Caregivers (EASE)

Trauma and Stressor Related Disorders | Caregiver Burden | Pediatric Cancer
University of British Columbia
The Craig H. Neilsen Foundation

Not yet recruiting

Co-developing a Novel Intervention to Promote Wellbeing of Family Caregivers of Individuals With Spinal Cord Injury

Caregiver Burden | Spinal Cord Injuries
Supergene, LLC

Not yet recruiting

Non-immunogenic Recombinant Staphylokinase vs Placebo in Patients With Intermediate High-risk Pulmonary Embolism

Pulmonary Embolism

Russian Federation
Elin Tragardh
Lund University

Recruiting

AI-based Measurements of Tumour Burden in PSMA PET-CT

Prostate Cancer

Sweden
University of Aarhus
Aarhus University Hospital

Recruiting

Circulating Tumor DNA in Peripheral T-cell Lymphomas (CIRCULATE)

Peripheral T-cell Lymphoma | NK/T-Cell Lymphoma

Denmark
The University of Hong Kong

Not yet recruiting

Intervention for Emotions in Caregivers of Dementia

Depressive Symptoms | BPSD | Expressed Emotion
Barretos Cancer Hospital
Fundação de Amparo à Pesquisa do Estado de São Paulo; Farmoquimica S.A.; Hospital...

Not yet recruiting

Clinical Outcome and Biomarkers for Predicting Immunological Response in Patients Treated With Imiquimod

Biomarkers | HSIL, High-Grade Squamous Intraepithelial Lesions | Vaginal Microbiome
Color Health, Inc.

Recruiting

Building Empowerment and Coping Outcomes for caNcer Patients, Survivors and Their Caregivers (BEACON)

Cancer | Survivorship | Caregiver Burnout | Caregiving Stress

United States
Chinese PLA General Hospital

Recruiting

Status of Disease Burden of Lower Urinary Tract Symptoms in Chinese Male Community

Lower Urinary Tract Symptoms

China
Ankara City Hospital Bilkent

Recruiting

The Effect of the Anticholinergic Burden Following Elective Coronary Artery Surgery

Postoperative Complications | Mortality

Turkey
IRCCS Eugenio Medea

Recruiting

Eye Movement Desensitization and Reprocessing Group Treatment for Caregivers of Pediatric Brain Tumor Patients

Caregiver Burden

Italy
National Cancer Institute (NCI)

Not yet recruiting

Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

Classic Follicular Lymphoma | Follicular Lymphoma With Unusual Cytological Features
Centro Cardiologico Monzino
Politecnico di Milano; Azienda Ospedaliero-Universitaria Consorziale Policlinico...

Recruiting

Computational mOdelliNg of myoCardial pERfusion to Improve ouTcome Prediction Based on cOronary Artery Stenosis and Atherosclerotic Plaque Burden Assessment by Computed Tomography (CONCERTO)

Chronic Coronary Syndrome

Italy
Vanderbilt University Medical Center

Not yet recruiting

Voice and Swallowing Disorders in Adults With and Without Alzheimer's Disease

Alzheimer Disease | Caregiver Burden | Dysphagia | Healthy Aging | Dysphonia
Helwan University

Not yet recruiting

Efficacy of Using 50 ml Syringe Manual Thrombectomy Catheter in Primary PCI With Heavy Thrombus Burden

STEMI - ST Elevation Myocardial Infarction | Thrombosis Cardiac

Egypt
Pole Sante Grace de Dieu

Not yet recruiting

Improving the Well-being of Caregivers of Cystic Fibrosis Patients During Physiotherapy Treatment (MucoZar)

Cystic Fibrosis

France
Hamad Medical Corporation
Qatar University; Winchester District Memorial Hospital

Recruiting

Deprescribing Intervention for Patients With Chronic Kidney Disease

Chronic Kidney Diseases

Qatar
Atrial Fibrillation Network

Not yet recruiting

Early Atrial Fibrillation Ablation for Stroke Prevention in Patients With High Comorbidity Burden (EASThigh-AFNET 11)

Atrial Fibrillation

Germany, Australia, Canada, Netherlands, United Kingdom
Daynamica, Inc.
Masonic Cancer Center, University of Minnesota

Not yet recruiting

App-Assisted Day Reconstruction to Reduce Treatment Burden and Logistic Toxicity in Cancer Patients - Aim 3

Cancer
Lawson Health Research Institute

Not yet recruiting

Optimizing a Wellbeing Program for Care-partners of Those With SCI

Depression | Anxiety | Spinal Cord Injuries | Caregiver Burnout | Internet-Delivered Cognitive Behavioural Therapy
UMC Utrecht
Janssen-Cilag B.V.

Recruiting

Respiratory Syncytial Virus (RSV) Burden in Older Adults in Primary Care in The Netherlands (RAPID)

RSV Infection

Netherlands
Universidad de la Sabana
Universidad de Caldas

Not yet recruiting

Effect of the PLAN CUIDARTE on the Caregiving Competence of People With Heart Failure (PLANCUIDARTE)

Heart Failure | Caregiver Burden | Nursing | Care Transitions | Discharge Plan

Colombia
Memorial Sloan Kettering Cancer Center

Recruiting

A Study of Meaning-Centered Psychotherapy for Caregivers to People With Cancer

Caregiver Burden | Caregiver Stress Syndrome | Caregiver Burnout

United States
Istituto Nazionale di Ricovero e Cura per Anziani

Recruiting

HAAL: HeAlthy Ageing Eco-system for peopLe With Dementia (HAAL)

Dementia | Caregiver Burden | Artificial Intelligence | Older People | Devices

Italy
Uppsala University
The Swedish Research Council; Umeå University; Sahlgrenska University Hospital... and other collaborators

Not yet recruiting

Internet-based Support for Informal Caregivers of Patients With Head and Neck Cancer - Carer eSupport

Head and Neck Cancer

Sweden
Massachusetts General Hospital
Patient-Centered Outcomes Research Institute; Children's Hospital of Philadelphia and other collaborators

Not yet recruiting

Boosting Resources for Tracheostomy Care at Home (BREATHE)

Tracheostomy | Caregiver Burden

United States
Materia Medica Holding

Recruiting

Clinical Trial of the Efficacy and Safety of Raphamin in Prevention of Recurrences of Chronic Bacterial Cystitis

Cystitis Chronic | Cystitis Bacterial | Recurrence of Chronic Bacterial Cystitis

Russian Federation
University Medical Center Goettingen

Recruiting

Efficacy of Structured SOcial COnsultation and Support in Reducing the FINancial Burden of Radiotherapy (SOCOFIN-1)

Financial Toxicity

Germany
University of North Carolina, Chapel Hill

Recruiting

Self-Compassion to Enhance the Well-Being of Caregivers of Children With Physical Disabilities

Stress | Anxiety | Caregiver Burden | Depressive Symptoms

United States
Aydin Adnan Menderes University

Recruiting

Recovery Levels of Depression Patients and Caregiver Psychoeducation

Psychoeducation

Turkey
University of Manchester

Not yet recruiting

The 8x5 Diet for Bile Acid Diarrhoea: A Feasibility Randomised Controlled Trial

Bile Acid Diarrhea

United Kingdom
Technische Universität Dresden
Universitätsmedizin Mannheim; SOS Desmoid e.V.

Recruiting

Burden of Disease and Living Situation in Desmoid Patients (PROSa Desmoid)

Quality of Life | Desmoid Tumor

Germany
David Blum

Not yet recruiting

Does Virtual Reality Improve Symptom Burden in Dialysis Patients?

Virtual Reality | Dialysis

Switzerland

Search clinical trials for: mutational burden

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Thailand

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations