Search clinical trials for: opioid tolerant

Total 7281 results

M.D. Anderson Cancer Center

Recruiting

A Phase II Randomized Controlled Trial to Determine the Efficacy of an auGmented reAlity gaMe in pediatrIc caNcer Patients Who Are Opioid Tolerant Users Undergoing Surgery to Reduce Post-operative Opioid Use

Cancer

United States
Azienda Ospedaliera Città della Salute e della...

Recruiting

Assessment of the Development of Postoperative Persistent Postoperative Pain

Chronic Pain | Opioid Use | Post Operative Pain

Italy
Massachusetts General Hospital

Not yet recruiting

Buprenorphine/Naloxone Micro-Dosing for Postoperative Pain Management in Opioid-Tolerant Patients

Post-operative Pain

United States
Washington University School of Medicine

Recruiting

Preeclampsia And Nonsteroidal Drugs for Analgesia: a Randomized Non Inferiority Trial (PANDA)

Preeclampsia Postpartum | Preeclampsia Severe

United States
Jacques E. Chelly

Terminated

Perioperative Ketamine in Opioid-Tolerant Patients Undergoing Lumbar Spine Surgery

Chronic Pain | Opioid Dependence

United States
Wake Forest University Health Sciences

Completed

Auricular Acupressure as a Non-Opioid Adjuvant in Opioid Tolerant Patients

Opioid Use Disorder

United States
Duke University
Massachusetts Institute of Technology; University of California, Irvine

Suspended

Optimal Management of Pain in Hospitalized Patients - Opioid Tolerant Populations.

Pain | Postoperative Pain | Acute Pain

United States
Assistance Publique - Hôpitaux de Paris

Completed

Retrospective Study on Prolonged Sedation Effects With Inhaled Agents in PICU (RESPIRE)

Mechanical Ventilation

France
MedVadis Research Corporation

Completed

Effect of Extended-release Oxymorphone Taken With or Without Food on Cognitive Functioning

Chronic Pain

United States
The Methodist Hospital Research Institute

Enrolling by invitation

Cryoablation of Intercostal Nerves for Post-Operative Pain Management in Opioid-Tolerant Patients

Pain | Pain, Postoperative

United States
Boston Medical Center
National Institute on Drug Abuse (NIDA)

Completed

Benzodiazepine Discontinuation in Opioid Agonist Therapy (BZD-OAT)

Substance Use Disorders

United States
The University of Texas Health Science Center,...

Completed

Impact of Daily, Digital and Behavioral Tele-health Tapering Program for Perioperative Surgical Patients Exposed to Opioids and Benzodiazepines.

Elective Spine Surgery Receiving Pre and/or Postoperative Pain Control With Opioids

United States
Endo Pharmaceuticals

Terminated

Open-Label Safety and Tolerability of Oxymorphone IR and ER in Opioid Tolerant Pediatric Subjects

Chronic Pain

United States
Mallinckrodt

Terminated

Open-Label Safety and PK Study of ER Hydromorphone Tablets in Opioid-Tolerant Pediatric Chronic Pain Patients

Chronic Pain

United States
Allina Health System

Completed

Perioperative Pain Management In Spine Surgery Patients: Part I

Pain

United States
University of Oklahoma

Completed

Diphenhydramine as an Adjunctive Sedative in Patients on Chronic Opioids

Colonoscopy | Adjunct Anesthesia Medication

United States
Dennis Jensen, Ph.D.

Unknown

Morphine to Maximize the Benefits of Exercise Training in COPD or ILD and Persistent Breathlessness (MorEx)

Chronic Obstructive Pulmonary Disease | Interstitial Lung Disease

Canada
Endo Pharmaceuticals

Completed

Open-Label Safety and Tolerability Study of Oxymorphone for Acute Postoperative Pain in Pediatric Subjects.

Postoperative Pain

United States
University of Pittsburgh

Terminated

Opioid Induced Loss of Local Anesthetic Potency in Patients Undergoing Total Knee Arthroplasty

Opioid Tolerance, Opioid Naive, Opioid Exposure

United States
University of Tennessee

Completed

Opioid Physiology Project (OPP)

Addiction | Tolerance | Epigenetic Changes | Withdrawal

United States
NYU Langone Health

Completed

A Comparison of Ketamine Infusion Versus Placebo in Opioid Tolerant and Opioid Naive Patients After Spinal Fusion

Spinal Fusion

United States
Stanford University

Completed

Study of Pain Processing in Subjects Suffering From Obstructive Sleep Apnea

Sleep Apnea, Obstructive

United States
Dalin Tzu Chi General Hospital

Completed

Meperidine for Patients Expected to Have Poor Tolerance During Diagnostic Esophagogastroduodenoscopy.

Patients Undergoing Diagnostic EGD

Taiwan
Alkermes, Inc.

Completed

ALK21-004: Single-dose Opiate Challenge of Medisorb® Naltrexone (VIVITROL®) in Adults Who Use Opioids

Opiate Dependence
University of Texas Southwestern Medical Center

Terminated

Pharmacokinetics of Low Dose Ketamine Infusion

Sedation | Opioid Tolerance

United States
Julia Finkel

Completed

Low Dose Ketamine Study on Opioid Tolerance and Hyperalgesia (KPSF)

Idiopathic Scoliosis | Spondylolisthesis

United States
Bassett Healthcare

Withdrawn

Post-Operative Pain Control in Opioid Tolerant Patients: Fentanyl Challenge Protocol Versus Standard of Care

Pain, Postoperative

United States
McGill University Health Centre/Research Institute...

Unknown

Morphine, Dyspnea, Exercise and COPD

Chronic Obstructive Pulmonary Disease

Canada
Butler Hospital

Completed

Distress Tolerance and Buprenorphine (TRUST)

Opioid Dependence

United States
University of Chicago
National Institute on Drug Abuse (NIDA)

Completed

Lack of Acute Tolerance Development to Effects of Nitrous Oxide - 4

Substance-Related Disorders | Opioid-Related Disorders

United States
University of Chicago
National Institute on Drug Abuse (NIDA)

Completed

Differential Acute Tolerance Development to Effects of Nitrous Oxide - 7

Substance-Related Disorders | Opioid-Related Disorders

United States
King Abdullah International Medical Research Center

Unknown

Effect of N-methyl D-aspartate (NMDA) Receptor Antagonist Dextromethorphan on Opiods Analgesia and Tolerance in Pediatric Intensive Care Unit Patients

Pain | Opioid Tolerance | Analgesia Tolerance

Saudi Arabia
Saint-Joseph University

Completed

Sedation During Bronchoscopy:Dexmedetomidine vs Alfentanil

Bronchoscopy | Conscious Sedation

Lebanon
Xian-Janssen Pharmaceutical Ltd.

Completed

A Pharmacokinetic and Safety Study of Osmotic Release Oral System (OROS) Hydromorphone in Non-Opioid Tolerant Chinese Participants With Cancer

Pain

China
Cephalon

Completed

Efficacy/Safety Study of ACTIQ® for Opioid-Tolerant Children and Adolescents With Breakthrough Pain (BTP)

Cancer | Breakthrough Pain

United States, Puerto Rico
Cephalon

Completed

Study to Evaluate the Efficacy and Safety of OraVescent Fentanyl Citrate Treatment for the Management of Breakthrough Pain in Opioid-Tolerant Patients With Noncancer-Related Chronic Pain

Pain

United States
Cephalon

Completed

Treatment of Breakthrough Pain in Opioid Tolerant Cancer Patients

Pain | Cancer

United States
Cephalon

Completed

Evaluating the Safety and Tolerability of OraVescent Fentanyl for Opioid Tolerant Patients With Noncancer Related Breakthrough Pain

Diabetic Neuropathies | Osteoarthritis | Low Back Pain | Migraine

United States
INSYS Therapeutics Inc

Completed

Fentanyl Sublingual Spray in Treating Opioid-tolerant Cancer Patients With or Without Oral Mucositis

Pain | Unspecified Adult Solid Tumor, Protocol Specific | Mucositis

United States
University of Adelaide

Unknown

An Assessment of Fentanyl Dose Requirements in Opioid-maintained Individuals (FEN001)

Opioid Dependence

Australia
Cephalon

Terminated

Study of Breakthrough Cancer Pain: Assessment of Fentanyl Buccal Tablets Titration and Treatment in Opioid-Tolerant Patients

Breakthrough Pain | Cancer Pain

Spain, Germany, France, Ireland, Italy, Poland, United Kingdom
Endo Pharmaceuticals

Withdrawn

Effectiveness, Safety, and Tolerability Study of Oxymorphone Immediate Release (IR) Oral Liquid in Opioid Tolerant Pediatric Subjects

Chronic Pain
Cephalon

Completed

OraVescent Fentanyl (OVF) for the Treatment of Breakthrough Pain in Opioid Tolerant Cancer Patients

Pain | Cancer

United States
Cephalon

Completed

Fentanyl Buccal Tablets Versus Immediate Release Oxycodone for Breakthrough Pain in Patients With Chronic Pain

Chronic Pain

United States
Cephalon

Completed

Efficacy and Safety of Fentanyl Buccal Tablets Compared With Oxycodone for the Management of Break Through Pain

Chronic Pain

United States
Tel-Aviv Sourasky Medical Center

Unknown

Oral Ketamine as an Adjuvant to Opioids for Pain Treatment in Cancer Patients

Pain | Cancer | Tolerance

Israel
Children's Mercy Hospital Kansas City

Completed

Safety and Efficacy of a Low Dose Naloxone Infusion in NICU Patients

Pain | Opioid Tolerance

United States
Ullevaal University Hospital
University of Oslo

Completed

Postoperative Pain After Orthopedic Surgery: Does it Help to Give Fentanyl Before Start of Remifentanil Based Anesthesia?

Pain, Postoperative

Norway
Alza Corporation, DE, USA

Completed

A Study to Evaluate the Safety of D-TRANS Fentanyl With Naltrexone in Adult Patients With Chronic Pain and Who Are Opioid Tolerant

Chronic Pain
Tel-Aviv Sourasky Medical Center

Completed

Pre- Versus Post-Incisional Epidural Morphine: Higher Postoperative Pain Perception and Extra Morphine Consumption

Pain

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