Search clinical trials for: phase II randomized controlled trial

Total 82725 results

Biocomposites Ltd
MCRA

Not yet recruiting

A Randomized Controlled Phase II Trial of STIMULAN VG vs Standard of Care (SoC) for the Treatment of Osteomyelitis Associated With Stage IV Pressure Ulcers. (BLADE OPU2)

Osteomyelitis | Pressure Ulcer, Stage IV
Nanjing Zenshine Pharmaceuticals

Not yet recruiting

A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Trial of ZX-7101A Tablets to Evaluate the Efficacy and Safety in the Treatment of Uncomplicated Influenza in Adolescents (ZX-7101A-207)

Respiratory Viral Infection

China
Ottawa Hospital Research Institute
Canadian Institutes of Health Research (CIHR); Technische Universität Dresden; Canadian Critical Care Trials Group and other collaborators

Recruiting

Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock (UC-CISSII)

Pathologic Processes | Infections | Sepsis | Systemic Inflammatory Response Syndrome | Inflammation | Shock | Septic Shock

Canada
VA Office of Research and Development

Not yet recruiting

Investigating Novel Interventions for Low Back Pain in US Military Veterans: A Randomized Controlled Adaptive Phase II Trial

Chronic Low Back Pain

United States
Genuine Research Center, Egypt
Adwia Pharma, Egypt

Not yet recruiting

A Randomized, Double-Blinded, Placebo-Controlled, Phase III Clinical Trial to Investigate the Efficacy and Safety of Ondansetron (Danset - Adwia) Versus Placebo Plus the Standard of Care in the Treatment of Nausea and Vomiting in Adult Patients With Acute Gastroenteritis

Gastroenteritis
National Human Genome Research Institute (NHGRI)

Recruiting

Development of Virtual Reality-based Interventions to Strengthen Cognitive Skillsets Related to Attention Deficit Hyperactivity Disorder (ADHD): A Pilot Phase I and Randomized Controlled Phase II Trial

Attention Deficit Hyperactivity Disorder

United States
Xeolas Pharmaceuticals Limited

Recruiting

A Randomized Control Trial Phase (IIIa) Unicentric, Placebo Controlled, Double-Blinded Efficacy and Safety of Topical Alendronic Acid on Alveolar Bone Remodeling After Tooth Extraction (XEOLAS)

Bone Loss, Alveolar

Spain
M.D. Anderson Cancer Center

Recruiting

A Phase II Randomized Controlled Trial to Determine the Efficacy of an auGmented reAlity gaMe in pediatrIc caNcer Patients Who Are Opioid Tolerant Users Undergoing Surgery to Reduce Post-operative Opioid Use

Cancer

United States
University of Washington
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

Benchmark Evidence Led by Latin America: Trial of Intracranial Pressure - Pediatrics (BELA TRIPP)

Severe Traumatic Brain Injury

Peru, United States, El Salvador, Guatemala, Honduras
M.D. Anderson Cancer Center
National Institutes of Health (NIH)

Recruiting

A Phase II Randomized Controlled Trial to Determine the Efficacy of an auGmented reAlity gaMe in pediatrIc caNcer Patients Who Are Opioid Naïve Undergoing Surgery to Reduce Postoperative Opioid Use (GAMING-ON Study)

Cancer | Pediatric ALL

United States
wang shusen

Recruiting

Tucidinostat and Metronomic Capecitabine for Metastatic Triple-negative Breast Cancer:a Multicenter,Open-label, Randomized Controlled, Phase II Clinical Trial

Triple Negative Breast Cancer

China
Code Pharma

Recruiting

Phase IIa Randomized Placebo Controlled Clinical Study of Codivir in Hospitalized Patients With Moderate COVID-19

COVID-19

South Africa
University Hospital, Montpellier

Recruiting

Neoadjuvant Atezo, Adjuvant Atezo + Beva Combined With RF Ablation of Small HCC: a Multicenter Randomized Phase II Trial (AB-LATE02)

Hepatocellular Carcinoma

France
Helse Fonna
Helse-Bergen HF; Klinbeforsk

Recruiting

Ambroxol in New and Early DLB, A Phase IIa Multicentre Randomized Controlled Double Blind Clinical Trial (ANeED)

Dementia With Lewy Bodies

Norway
A.J.M. van den Eertwegh
Idera Pharmaceuticals, Inc.

Recruiting

A Randomized Controlled Phase II Trial With Intradermal IMO-2125 in Pathological Tumor Stage (p) T3-4 cN0M0 Melanoma (INTRIM)

Malignant Melanoma

Netherlands
Centre Hospitalier Universitaire de Besancon
GERCOR - Multidisciplinary Oncology Cooperative Group

Recruiting

Adapted Physical Activity in Patients With Resected Pancreatic Cancer (APACaPOp PRODIGE-56 Study): a National Multicenter Randomized Controlled Phase II Trial (APACaPOp)

Quality of Life | Pancreas Cancer

France
SyneuRx International (Taiwan) Corp
Amarex Clinical Research

Recruiting

An Adaptive Phase II/III, Two-Part, Double-Blind, Randomized, Placebo-controlled, Dose-Finding, Multi-center Study of the Safety and Efficacy of NaBen®, as an Add-on Therapy With Clozapine, for Residual Symptoms of Refractory Schizophrenia in Adults

Refractory Schizophrenia

United States
Sun Yat-sen University

Recruiting

A Prospective Multi-center Phase III Randomized Controlled Trial (NACA)

Carcinoma，Non-Small-Cell Lung

China
James J. Irrgang
Brooke Army Medical Center; Wake Forest University

Terminated

Phase 1/2 Prospective Double-Blind Placebo-Controlled Randomized Clinical Trial of Losartan to Treat Grade II & III Hamstring Strains

Hamstring Injury

United States
Rennes University Hospital

Active, not recruiting

Prospective, Multicentric, Phase II Randomized Controlled Trial on Two Parallel Groups Comparing the Efficacy of Two Immunosuppressive Drugs (Methotrexate, Cyclophosphamide) in Large Granular Lymphocytes Leukemia (LGL)

Large Granular Lymphocytes Leukemia

France
Institut Curie
Paul Hartmann

Completed

Hydrosorb® Versus Control in the Management of Radio-induced Skin Toxicity: Multicentre Controlled Phase III Randomized Trial (HYDROSORB)

Breast Cancer | Radiation Dermatitis

France
The University of Texas Health Science Center,...
Michael J. Fox Foundation for Parkinson's Research

Completed

Phase IIa Randomized Placebo Controlled Trial: Mesenchymal Stem Cells as a Disease-modifying Therapy for iPD

Parkinson's Disease

United States
Eastern Cooperative Oncology Group
National Cancer Institute (NCI)

Completed

Phase II Study of Concurrent C225, Cisplatin and Radiation in Stage IV Squamous Cell Carcinoma of the Head and Neck

Head and Neck Cancer
Philogen S.p.A.

Terminated

A Randomized, Placebo-controlled Phase II Clinical Trial to Evaluate the Safety and Efficacy of F8IL10 (Dekavil) in Patients With Active RA Receiving MTX

Rheumatoid Arthritis

Switzerland, Germany, Italy
Federal University of São Paulo
University of Sao Paulo

No longer available

CLINICAL TRIAL PHASE II, MULTICENTRIC, NATIONAL, DOUBLE-BLIND, PARALLEL, RANDOMIZED, AND PLACEBO-CONTROLLED FOR EVALUATION OF THE IMPROVEMENT OF SLEEP QUALITY IN PARTICIPANTS OF RESEARCH WITH INSOMNIA DISORDER

Sleep Initiation and Maintenance Disorders
Pfizer

Completed

A PHASE 2B PLACEBO-CONTROLLED, RANDOMIZED STUDY OF A RESPIRATORY SYNCYTIAL VIRUS (RSV) VACCINE IN PREGNANT WOMEN

Respiratory Tract Infection

United States, New Zealand, Chile, Argentina, South Africa
Ludwig Institute for Cancer Research
Institute of Cancer Research, United Kingdom

Completed

Study of NY-ESO-1 ISCOMATRIX® in Patients With High-risk, Resected Melanoma

Melanoma

United Kingdom, Australia, New Zealand
National Institute of Allergy and Infectious Diseases...

Completed

Sanaria PfSPZ Challenge With Pyrimethamine or Chloroquine Chemoprophylaxis Vaccination (PfSPZ-CVac Approach): A Randomized Double Blind Placebo Controlled Phase I/II Trial to Determine Safety and Protective Efficacy Against Natural Plasmodium Falcipa...

Malaria

Mali
Romark Laboratories L.C.

Completed

A Phase III, Randomized, Double-Blind, Placebo Controlled Trial to Evaluate the Efficacy and Safety of Nitazoxanide in the Treatment of Uncomplicated Influenza

Influenza

United States, Australia, Puerto Rico
SK Life Science, Inc.

Completed

A Double-Blind, Randomized, Placebo-Controlled, Phase 2 Trial of YKP3089 as Adjunctive Therapy in Subjects With Partial Onset Seizures

Partial Epilepsy

Australia, United States, Korea, Republic of, Germany, Hungary, Serbia, Bulgaria, Czechia, France, Israel, Poland, Romania, Spain, Thailand, Ukraine
Prof. Dr. Matthias Preusser

Completed

A Single-blinded, Randomized, Placebo Controlled Phase II Trial of Prophylactic Treatment With Oral Azithromycin Versus Placebo in Cancer Patients Undergoing Antineoplastic Treatment During the Corona Virus Disease 19 (COVID-19) Pandemic

COVID

Austria
Organon and Co

Terminated

A Phase 2 Trial to Evaluate if Corifollitropin Alfa (Org 36286), Followed by a Low Daily Dose of hCG or Recombinant FSH Can Induce Monofollicular Growth in Women With WHO Group II Anovulatory Infertility (P05693)

Ovulation Induction
National Institute of Allergy and Infectious Diseases...
Upjohn

Completed

A Phase II Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Efficacy of Prednisone Therapy in HIV-Associated Nephropathy (HIVAN)

HIV Infections | AIDS-Associated Nephropathy

United States
Children's Hospital of Eastern Ontario

Completed

Rapid Normalization of Vitamin D in Critically Ill Children: A Phase II Dose Evaluation Randomized Controlled Trial (VITdAL-PICU)

Hypovitaminosis D

Canada, Austria, Chile
Asociacion Instituto Biodonostia

Active, not recruiting

Randomized, Unicentric, Open, Controlled Clinical Trial, in Phase Iii, to Demonstrate the Effectiveness of Tocilizumab

COVID-19 Pneumonia

Spain
Eli Sprecher, MD
OBCTCD24 Ltd

Active, not recruiting

A Phase II Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Exosomes Overexpressing CD24 to Prevent Clinical Deterioration in Patients With Moderate or Severe COVID-19 Infection

COVID-19 Disease

Israel
University of Oxford
Wellcome Trust; Department of Health, United Kingdom; 180 Therapeutics LP

Completed

Repurposing Anti-TNF for Treating Dupuytren's Disease (RIDD)

Dupuytren's Disease

United Kingdom, Netherlands
Novartis Pharmaceuticals

Completed

A Randomized, Blinded, Placebo-controlled, Phase II Trial of LEE011 in Patients With Relapsed, Refractory, Incurable Teratoma With Recent Progression

Teratoma

Spain, Netherlands, United States, France
National Cancer Institute (NCI)

Completed

Erlotinib Hydrochloride With or Without Carboplatin and Paclitaxel in Treating Patients With Stage III-IV Non-small Cell Lung Cancer

Lung Adenocarcinoma | Minimally Invasive Lung Adenocarcinoma | Malignant Pleural Effusion | Stage IIIB Lung Non-Small Cell Cancer AJCC v7 | Stage IV Lung Non-Small Cell Cancer AJCC v7 | Malignant Pericardial Effusion | Lung Adenosquamous Carcinoma

United States
Children's Hospital of Eastern Ontario
McGill University; Ottawa Hospital Research Institute; The Ottawa Hospital; Children...

Completed

Prevention of Vitamin D Deficiency Following Pediatric CHD Surgery: a Phase II Dose Evaluation Randomized Controlled Trial Comparing Usual Care With a High Dose Pre-operative Supplementation Regimen Based on the Institute of Medicine Daily Upper Tolerable Intake Level (HICCUPS 2)

Vitamin D Deficiency | Heart Defects, Congenital | Thoracic Surgery | Pediatric Disorders

Canada
Yonsei University

Completed

An Effect of an Individualized Physical Activity Intervention for Gastric Cancer Patient Undergoing Minimally Invasive Gastrectomy: a Phase III, Prospective Randomized Controlled Trial (Gastric cancer)

Gastric Cancer

Korea, Republic of
University of Miami
Massachusetts General Hospital

Completed

Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis

United States
Federal University of São Paulo

Completed

Oral Isotretinoin for Photoaging: Results of a Randomized Controlled Phase II Trial

Photoaging | Epidermal p53 Expression

Brazil
Gorm Greisen

Completed

SafeBoosC - a Phase II Trial (SafeBoosC)

Brain Injuries | Infant, Premature

Denmark
National Cancer Center, Korea

Completed

A Randomized, Controlled Phase III Trial of Sorafenib With or Without cTACE in Patients With Advanced HCC

Advanced Adult Hepatocellular Carcinoma

Korea, Republic of
Medical University of Warsaw

Completed

Lactobacillus Reuteri DSM 17938 in the Prevention of Antibiotic-associated Diarrhea in Children: Protocol of a Randomized Controlled Trial

Diarrhea | Antibiotic Associated Diarrhea

Poland
Maastricht University Medical Center

Completed

Randomized Controlled Phase II Trial of Pre-operative Celecoxib Treatment in Breast Cancer

Breast Cancer | Breast Neoplasms

Netherlands
Ottawa Hospital Research Institute
Canadian Institutes of Health Research (CIHR); Stem Cell Network; Ontario Institute...

Unknown

Cellular Immunotherapy for Septic Shock (CISS2)

Pathologic Processes | Sepsis | Systemic Inflammatory Response Syndrome | Inflammation | Shock | Septic Shock | Infection
Pharnext SA

Completed

Phase II, Randomized, Placebo-controlled Trial in Patients With Charcot-marie-tooth Disease Type 1A

Charcot-Marie-Tooth Disease | Hereditary Neuropathy With Liability to Pressure Palsies | Genetic Disorders

France
Kyowa Kirin Co., Ltd.

Completed

A Randomized Double-blind, Placebo-controlled Japanese Phase III Trial of ARQ 197 in Hepatocellular Carcinoma (HCC) (JET-HCC)

Liver Cancer

Japan

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