Search clinical trials for: prothrombin complex concentrate

Total 7535 results

Konkuk University Medical Center

Not yet recruiting

Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Liver Transplantation Surgery

Liver Diseases
Konkuk University Medical Center

Not yet recruiting

Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Cardiac Surgery

Cardiac Valve Disease
Konkuk University Medical Center

Not yet recruiting

Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Non-cardiac Surgery

Prostate Cancer | Hip Osteoarthritis | Knee Disease | Spine, Open
Second Affiliated Hospital, School of Medicine,...

Not yet recruiting

Evaluation of the Efficacy of Early Bunching of a FF-PCC in Patients With Severe Traumatic Hemorrhage

Trauma
Medical University of Vienna

Recruiting

Coagulation in Cirrhosis (COUCH)

Liver Cirrhosis

Austria
Octapharma

Recruiting

Active-control Randomised Trial Comparing 4-factor Prothrombin Complex Concentrate With Frozen Plasma in Cardiac Surgery (FARES-2)

Bleeding Cardiac Surgery Patients

Canada, United States
Emory University
Takeda Pharmaceuticals North America, Inc.

Recruiting

SAFE Study: Safety of aPCC Following Emicizumab Prophylaxis (SAFE)

Hemophilia A

United States
University Health Network, Toronto
Sunnybrook Health Sciences Centre; Canadian Institutes of Health Research (CIHR) and other collaborators

Recruiting

Factor In the Initial Resuscitation of Severe Trauma 2 Patients (FiiRST-2)

Coagulopathy | Traumatic Hemorrhage | Massive Hemorrhage

Canada
Chinese Academy of Medical Sciences, Fuwai Hospital
Peking Union Medical College Hospital; Guizhou Provincial People's Hospital; Beijing... and other collaborators

Not yet recruiting

Efficacy of Prothrombin Complex Concentrate Reducing Perioperative Blood Loss in Cardiac Surgery

Cardiac Surgical Procedures
Emory University
Octapharma

Recruiting

Treatment of Hemophilia A Patients With FVIII Inhibitors (MOTIVATE)

Hemophilia A

United States, Germany
Brigham and Women's Hospital
CSL Behring

Recruiting

Assessment of Coagulation Factor Levels in Left Ventricular Device (LVAD )Patients Following Temporary Warfarin Reversal With Four Factor Prothrombin Complex Concentrate (4F-PCC) (KVAD)

Anticoagulation | Anticoagulation Reversal

United States
Kathirvel Subramaniam
University of Maryland, Baltimore; CSL Behring

Recruiting

Administration of Prothrombin Complex Concentrate vs. Standard Transfusion During/After Heart Transplantation (OPSTAHT)

Heart Failure，Congestive | Heart Disease End Stage

United States
Fondation Ophtalmologique Adolphe de Rothschild

Completed

CPP Versus PFC to Correct Coagulation Disorders in Adult Neurosurgical Patients (CLOT-CRANE)

Intracranial Hemorrhages

France
Oregon Health and Science University

Active, not recruiting

Prehospital Kcentra for Hemorrhagic Shock

Trauma Injury

United States
HealthPartners Institute

Completed

Fixed Versus Variable Dosing of 4-factor Prothrombin Complex Concentrate for Emergent Warfarin Reversal (kcentra)

Hemorrhage | Acute Bleeding on Long-Term Anticoagulation Therapy | Significant Bleeding in Patients With a Coagulopathy (Prolonged Thrombin Time) | Urgent Reversal of Vitamin K Antagonist (VKA) Anticoagulation

United States
Janssen Research & Development, LLC

Completed

A Study to Assess the Reversal of the Anticoagulant Effects of Milvexian by 4-Factor Prothrombin Complex Concentrate (4F-PCC) (Part 1) and Recombinant Human Factor VIIa (rFVIIa) (Part 2) in Healthy Participants

Healthy

Netherlands
Baxalta now part of Shire
Baxalta Innovations GmbH, now part of Shire

Completed

FEIBA Reconstitution Volume Reduction and Faster Infusion Study (FEIBA STAR)

Hemophilia A or B With Inhibitors

Croatia, North Macedonia, Ukraine
Octapharma

Completed

Study of Octaplex (Human Prothrombin Complex Concentrate) and Fresh Frozen Plasma in Patients Under Vitamin K Therapy Antagonist Needing Urgent Surgery or Invasive Procedures

Reversal of Anticoagulant Treatment

United States
Mayo Clinic

Withdrawn

FEIBA to Optimize Postcardiopulmonary Bypass Hemostasis in Pediatric Cardiac Patients

Cardiac Disease
University Hospital, Grenoble

Completed

Early Administration of Prothrombin Concentrate Complex in Patients With Acute Hemorrhage Following Severe Trauma (PROCOAG)

Shock, Hemorrhagic

France
Mayo Clinic
CSL Behring

Completed

PCC vs. FFP for Post Cardiopulmonary Bypass Coagulopathy and Bleeding

Bleeding | Blood Loss, Surgical | Cardiovascular Surgical Procedures | Prothrombin Complex Concentrates | Fresh Frozen Plasma

United States
Octapharma

Completed

Study of Octaplex, a Four-factor Prothrombin Complex Concentrate (4F-PCC) and Beriplex® P/N (Kcentra) for the Reversal of Vitamin K Antagonist (VKA) Induced Anticoagulation in Patients Needing Urgent Surgery With Significant Bleeding Risk.

Significant Bleeding Risk

Russian Federation, United States, Romania, Ukraine, Belarus, Bulgaria, Georgia, Germany, Moldova, Republic of, Poland, Spain
IRCCS Policlinico S. Donato

Terminated

ZEPLAST- PED: ZEro_PLASma Trial in Small Infants Undergoing Cardiac Surgery (ZEPLAST-PED)

Bleeding | Surgery--Complications | Congenital Heart Disease | Transfusion-Related Acute Lung Injury | Cardiac Defect | Fibrinogenopenia; Acquired | Transfusion-Associated Circulatory Overload

Italy
Octapharma

Completed

Use of Prothrombin Complex Concentrate in Patients Admitted in Emergency Care Units for Severe Bleeding While Receiving Oral Anticoagulants

Emergency Care for Severe Bleeding While on Anticoagulants

France
Angel Augusto Perez Calatayud
Grupo Mexicano para el Estudio de la Medicina Intensiva

Completed

Patient Blood Management for Massive Obstetric Hemorrhage

Post Partum Hemorrhage | Transfusion Related Complication | Fibrinogenolysis; Hemorrhage | Fibrinogen; Deficiency, Acquired | Massive Hemorrhage

Mexico
CSL Behring
Kaiser Permanente

Completed

An Observational Cohort Study to Investigate the Risk of Thromboembolic Events in Patients Receiving Kcentra® or Plasma to Reverse Vitamin K Antagonist (VKA) Therapy in the Setting of Acute Major Bleeding

Hemorrhage

United States
Baxalta now part of Shire

Completed

Efficacy and Safety of Prothromplex Total (Prothrombin Complex Concentrate) in Oral Anticoagulant Reversal

Prothrombin Complex Factor Deficiency

Hungary, Austria
Queen Mary University of London
British Heart Foundation

Completed

Trial of PCC Versus FFP in Patients Undergoing Heart Surgery (PROPHESY)

Bleeding | Surgery | Transfusion

United Kingdom
University Health Network, Toronto

Unknown

Factor Replacement in Surgery (FARES)

Bleeding in Cardiac Surgery

Canada
Tulane University School of Medicine

Completed

Efficacy Study of Activated Prothrombin Complex for Prevention of Bleeds in Hemophilia A With Inhibitors (ProFEIBA)

Hemophilia A With Inhibitors

United States
Bellal A. Joseph, MD, FACS

Unknown

REPlaCE- Randomized Trial Evaluating the Use of Prothrombin Complex concEntrate to Improve Survival in Patients With Traumatic Coagulopathy (REPLaCE)

Hemorrhage | Coagulopathy
Daiichi Sankyo, Inc.

Completed

A Two-part Study in Edoxaban-treated Healthy Subjects to Establish a Punch Biopsy Bleeding Model and to Evaluate the Effect of a 4-factor Prothrombin Complex Concentrate on Anticoagulation

Bleeding

United States
Rush University Medical Center
Advocate Health Care

Completed

Fixed-dose Activated Versus Variable-dose Inactivated Prothrombin Complex Concentrate for Warfarin-associated Major Bleed

Hemorrhage
CSL Behring

Completed

Observational Study of Prophylaxis and Treatment of Acute Perioperative Bleeding With Beriplex® P/N (Probe Study)

Coagulation Protein Disorders | Perioperative Care | Blood Loss, Surgical

United Kingdom
Janssen Research & Development, LLC

Completed

A Study to Evaluate Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Pharmacodynamics of JNJ-64179375 in Healthy Male Subjects

Healthy

Belgium
Janssen Scientific Affairs, LLC
Bayer

Completed

A Study to Assess the Independent Effects of 4-Factor Prothrombin Complex Concentrate and Tranexamic Acid on Bleeding/Pharmacodynamics in Healthy Participants

Healthy

United States
Janssen Research & Development, LLC
Bayer

Completed

A Study to Assess the Effects of 2 Different Prothrombin Complex Concentrates on the Pharmacodynamics of Rivaroxaban in Healthy Adult Volunteers

Healthy

Belgium
University of Utah

Withdrawn

FFP Versus PCC in Intracranial Hemorrhage

Intracranial Hemorrhage, Traumatic | Intracranial Hemorrhage, Spontaneous

United States
University of Sao Paulo General Hospital

Completed

Strategy of Transfusion in Trauma Patients - STATA Trial (STATA)

Wounds and Injuries

Brazil
Heidelberg University

Completed

International Normalized Ratio (INR) Normalization in Coumadin Associated Intracerebral Haemorrhage (INCH)

Intracranial Hemorrhages

Germany
Thomas Jefferson University
Bristol-Myers Squibb; CSL Behring

Completed

Reversibility of Apixaban Anticoagulation With the Four Factor Prothrombin Complex Concentrate Kcentra (4PAR)

Thrombosis

United States
University Medical Center Groningen
Boehringer Ingelheim; CSL Behring

Unknown

Reversal of Dabigatran With Prothrombin Complex Concentrate

Drug Action Reversal

Netherlands
CSL Behring

Completed

Study of a Prothrombin Complex Concentrate for Rapid Reversal of Coagulopathy Induced by Vitamin K Antagonists in Japanese Subjects

Acute Major Bleeding | Reversal of Coagulopathy

Japan
Medical University Innsbruck

Terminated

RETIC Trial: Reversal of Trauma Induced Coagulopathy Using Coagulation Factor Concentrates or Fresh Frozen Plasma

Major Trauma

Austria
Bristol-Myers Squibb

Completed

A Study to Assess the Effects of 2 Prothrombin Complex Concentrates on the Pharmacodynamics of Apixaban in Healthy Adult Subjects

Anticoagulation
CSL Behring

Completed

An Open-label, Randomized, Multicenter Phase IIIb Study to Assess the Efficacy, Safety and Tolerance of BERIPLEX® P/N (Kcentra) Compared With Plasma for Rapid Reversal of Coagulopathy Induced by Vitamin K Antagonists in Subjects Requiring an Urgent Surgical Procedure (BE1116_3003)

Reversal of Coagulopathy

United States, Belarus, Bulgaria, Lebanon, Romania, Russian Federation
CSL Behring

Completed

Efficacy and Safety Study of BERIPLEX® P/N (Kcentra) Compared With Plasma in Patients With Acute Major Bleeding Caused by Anticoagulant Therapy

Blood Coagulation Disorders | Acute Major Bleeding

United States, Belarus, Bulgaria, Romania, Russian Federation, Ukraine
Emory University
Children's Research Oversight Committee Funds

Completed

Thrombin Generation in Neonatal Plasma After Cardiopulmonary Bypass

Cardiopulmonary Bypass

United States
University of L'Aquila
TRIB s.r.l.

Completed

Treatment of Inherited Factor VII Deficiency (STER)

Factor VII Deficiency

Italy
Ottawa Hospital Research Institute
Canadian Institutes of Health Research (CIHR); Canadian Blood Services

Completed

Appropriateness of Frozen Plasma Use in Canada

Blood Component Transfusion

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