- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03981484
REPlaCE- Randomized Trial Evaluating the Use of Prothrombin Complex concEntrate to Improve Survival in Patients With Traumatic Coagulopathy (REPLaCE)
June 7, 2019 updated by: Bellal A. Joseph, MD, FACS
Uncontrolled hemorrhage continues to be a significant source of mortality for trauma patients.
Their condition is further complicated by Trauma Induced Coagulopathy (TIC), which makes it more difficult to control bleeding due to coagulation factor deficiency. Prothrombin Complex Concentrate (PCC) is thought to be a promising treatment option.
This phase II clinical trial evaluates the use of 4-Factor PCC in addition to standard resuscitation methods compared to standard resuscitation methods alone in patients with TIC.
Patients will be randomized at a 1:1 ratio.
The primary endpoint of this trial will be 30 day mortality.
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Anticipated)
280
Phase
- Phase 2
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Andrea Seach, BS
- Phone Number: 520-626-2876
- Email: aseach@surgery.arizona.edu
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
15 years and older (ADULT, OLDER_ADULT, CHILD)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- ≥15 years old
- anticipate giving 4+ units based on Revised Assessment of Bleeding and Transfusion score ≥ 2
Exclusion Criteria:
- Cardiopulmonary Resuscitation > 5 minutes
- Penetrating cranial injury or exposed brain matter
- Anticoagulation treatment
- Transfer patients
- Known pregnancy
- Prisoners
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: SINGLE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: PCC
single dose of 4-Factor PCC in addition to standard resuscitation methods
|
single dose of 25 IU/kg of 4-PCC at time of enrollment
|
ACTIVE_COMPARATOR: Standard of Care
standard resuscitation methods only
|
site's standard resuscitation protocol
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
24 Hour Mortality
Time Frame: 24 hours after enrollment
|
Assess if patient is alive at 24 hours post treatment
|
24 hours after enrollment
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ANTICIPATED)
January 1, 2020
Primary Completion (ANTICIPATED)
October 1, 2022
Study Completion (ANTICIPATED)
January 1, 2023
Study Registration Dates
First Submitted
June 6, 2019
First Submitted That Met QC Criteria
June 7, 2019
First Posted (ACTUAL)
June 10, 2019
Study Record Updates
Last Update Posted (ACTUAL)
June 10, 2019
Last Update Submitted That Met QC Criteria
June 7, 2019
Last Verified
June 1, 2019
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 00001
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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