Search clinical trials for: renal impairment

Total 20986 results

Ottawa Hospital Research Institute
Canadian Institutes of Health Research (CIHR)

Unknown

Renal Hypothermia During Partial Nephrectomy

Kidney Cancer | Kidney Diseases | Urologic Diseases | Cancer | Renal Impairment | Hypothermia

Canada
GlaxoSmithKline

Completed

A Study To Investigate The Effects Of End Stage Renal Disease And Hemodialysis On The Pharmacokinetics Of Ropinirole

Restless Legs Syndrome

United States, United Kingdom
AstraZeneca
Bristol-Myers Squibb

Completed

Renal Impairment in Type 2 Diabetic Subjects

Diabetes Mellitus, Type 2

United States
Par Pharmaceutical, Inc.
Covance; SFBC Anapharm

Terminated

Effect of Renal Impairment on the Pharmacokinetics, and Safety of Megestrol Acetate Concentrated Suspension

Healthy

United States
AstraZeneca

Completed

Study to Assess the Blood Levels and Safety of Olaparib in Patients With Advanced Solid Tumours and Normal or Impaired Kidney Function

Solid Tumours

Belgium, France, Netherlands, United Kingdom, Denmark
University of Pittsburgh
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Hemophilia Adult Prophylaxis Study: Factor VIII in Severe Hemophilia A

Severe Hemophilia A

United States
University Hospital Birmingham NHS Foundation Trust

Active, not recruiting

What Are the Determinations of Adult Progressive CKD? The Renal Impairment In Secondary Care (RIISC) Study (RIISC)

Chronic Kidney Disease

United Kingdom
Massachusetts General Hospital

Completed

The CASABLANCA Study: Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA)

Atherosclerosis | Renal Impairment | Contrast Induced Nephropathy

United States
Wockhardt
Clinartis

Completed

A Single-dose Study to Investigate the Pharmacokinetics of Intravenous FEP-TAZ in Patients With Renal Impairment

Renal Impairment

United States
Hospital Clinic of Barcelona

Completed

Midodrine and Albumin for Cirrhotic Patients With Functional Renal Impairment (MAFRI)

Renal Failure | Cirrhosis

Spain
Jazz Pharmaceuticals

Withdrawn

A Study to Evaluate the Pharmacokinetics Of Sativex® in Subjects With Severe Renal Impairment or End Stage Renal Disease, Compared to Matched Subjects With Normal Renal Function.

Renal Insufficiency | Kidney Disease
Hoffmann-La Roche

Completed

A Study of Peginterferon Alfa-2a (Pegasys) and Ribavirin (Copegus) Combination Therapy in Participants With Chronic Hepatitis C (CHC) and Various Degrees of Renal Impairment

Hepatitis C, Chronic

Sweden, New Zealand, United States, France, Brazil
Cubist Pharmaceuticals LLC

Terminated

Daptomycin in the Treatment of Patients With Renal Insufficiency and Complicated Skin and Skin Structure Infections

Soft Tissue Infections

United States
Polyphor Ltd.

Completed

Pharmacokinetics and Safety of POL7080 in Patients With Renal Impairment

Renal Impairment

Germany
Intarcia Therapeutics

Completed

Study to Evaluate Pharmacokinetics of ITCA 650 in Subjects With Renal Impairment Compared to Normal Subjects

Renal Insufficiency

Germany, United States
Universitaire Ziekenhuizen KU Leuven

Completed

Prematurity as Predictor of Children's Cardiovascular-renal Health (PREMATCH)

Renal Impairment | Ventricular Dysfunction, Left | Endothelial Dysfunction | Visual Disturbances and Blindness | Sublingual Capillary Glycocalyx and Density

Belgium
Trius Therapeutics LLC

Completed

A Pharmacokinetics and Safety Study in Subjects With Renal Impairment

Renal Impairment

United States
Gilead Sciences

Completed

Cobicistat-containing Highly Active Antiretroviral Regimens in HIV-1 Infected Patients With Mild to Moderate Renal Impairment

HIV Infections | Acquired Immunodeficiency Syndrome

Puerto Rico, United States, United Kingdom, Canada, Germany, Austria, Australia, Dominican Republic, Mexico
LG Life Sciences

Completed

A Phase IIIb Study to Evaluate the Safety and Efficacy of Gemigliptin in Type 2 Diabetes Mellitus Patients With Moderate or Severe Renal Impairment(GUARD Study) (GUARD)

Type 2 DM Patients With Moderate or Severe Renal Impairment

Korea, Republic of
Pfizer

Completed

A Study To Investigate The Pharmacokinetics, Safety And Tolerability Of An Intravenous And Oral Form Of A Compound In Subjects With Varying Degrees Of Renal Impairment And Normal Renal Function

Pneumonia

Belgium, United States
Sahlgrenska University Hospital, Sweden

Completed

NAG-excretion During Cardiopulmonary Bypass (CPBNAG)

Renal Impairment

Sweden
AbbVie

Completed

Pharmacokinetics and Safety of ABT-493 and ABT-530 in Subjects With Normal and Impaired Renal Function

Renal Impairment

United States, New Zealand
Amgen

Completed

Multiple Dose Study to Evaluate the Safety of Multiple Doses of Denosumab 120 mg in Adults With Severe Chronic Kidney Disease (CKD) and CKD on Dialysis

Renal Impairment

United States
Bayer

Completed

Safety of Gadovist in Renally Impaired Patients (GRIP)

Fibrosis | Renal Impairment

Italy, Spain, Korea, Republic of, Germany, Canada, France, Austria, Thailand, Australia, Switzerland
Alkermes, Inc.

Completed

Pharmacokinetics and Safety of ALKS 5461 in Subjects With Renal Impairment and Normal Renal Function

Renal Impairment

United States
Conatus Pharmaceuticals Inc.

Completed

PK and PD Study of IDN-6556 in Subjects With Severe Renal Impairment and Matched Healthy Volunteers

Kidney Diseases | Renal Insufficiency | Renal Impairment | Kidney Disease

United States
Gilead Sciences

Completed

Pharmacokinetics of Eleclazine in Adults With Normal and Impaired Renal Function

Long QT Syndrome

United States, Romania, Moldova, Republic of
Pierre Fabre Medicament

Completed

JAVLOR Association Study in CDDP-unfit Patients With Advanced Transitional Cell Carcinoma: Gemcitabine Versus Carboplatin (JASINT1)

Bladder Transitional Cell Carcinoma Stage IV

France
Stealth BioTherapeutics Inc.

Completed

A Phase 1 Study Investigating the Safety and Pharmacokinetics of Repeat-dose Intravenous Infusion of MTP-131 in Subjects With Impaired Renal Function

Normal and Impaired Renal Function

United States
Bristol-Myers Squibb

Completed

Pharmacokinetic and Safety Study of Daclatasvir in Patients With Renal Impairment

Hepatitis C

United States
H. Lundbeck A/S

Completed

Pharmacokinetic Properties of Idalopirdine (Lu AE58054) in Subjects With and Without Impaired Kidney Function

Alzheimer Disease

Germany
Novartis Pharmaceuticals

Completed

Pharmacokinetics of LCZ696 in Subjects With Mild and Moderate Renal Impairment Compared to Healthy Subjects With Normal Renal Function

Mild and Moderate Renal Impairment

Russian Federation, Germany, Serbia
Novartis Pharmaceuticals

Completed

Study of Safety, Tolerability and Pharmacokinetics of Serelaxin in Japanese Acute Heart Failure (AHF) Patients

Acute Heart Failure

Japan
Novartis Pharmaceuticals

Completed

Multiple Dose Pharmacokinetics of LCZ696 and Its Metabolites in Subjects With Severe Renal Impairment vs. Matched Healthy Subjects With Normal Renal Function

Pharmacokinetics | Healthy Volunteer | Renal Impaired

Russian Federation, Germany, Serbia
Boehringer Ingelheim

Completed

Pradaxa (Dabigatran Etexilate) 150 mg/q.d. in Patients With Moderate Renal Impairment After Hip or Knee Replacement Surgery

Thromboembolism | Arthroplasty, Replacement

Austria, France, Germany, Italy, Spain, Sweden, United Kingdom
Massachusetts General Hospital

Withdrawn

Calcium, Phosphate, Renal Impairment and Coronary Artery Disease in the Cardio-renal Syndrome, The CAPRICORN-CRS Study (CAPRICORN)

Heart Failure

United States
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

Study of the Effect of Renal Impairment on the Pharmacokinetics of Isavuconazole.

Healthy Volunteers | Pharmacokinetics of Isavuconazole | Renal Impaired

United States
Dong-A ST Co., Ltd.

Completed

PK//PD/Tolerability Study of DA-1229(Evogliptin) in Renal Impaired Patients

Renal Impairment

Korea, Republic of
FORUM Pharmaceuticals Inc
PRA Health Sciences

Completed

EVP-6124 Renal Impairment Study

Renal Impairment

Czech Republic, Hungary
Merck Sharp & Dohme LLC

Completed

A Study to Compare the Efficacy and Safety of a Combination of Ketoconazole and Clindamycin Compared to Tetracycline/Amphotericin B Combination Cream for the Treatment of Bacterial Vaginosis and Vaginal Candidiasis (P08077)

Vaginosis, Bacterial | Candidiasis, Vulvovaginal
Boehringer Ingelheim

Completed

Pharmacokinetics and Safety of BI 201335 in Patients With Mild to Severe Renal Impairment

Hepatitis C

Germany
Cubist Pharmaceuticals LLC
Syneos Health

Terminated

Single Oral Dose of Bevenopran in Patients With Varying Degrees of Renal Impairment

Renal Impairment

United States
Janssen R&D Ireland

Withdrawn

An Efficacy, Safety, Tolerability and Pharmacokinetics Study of 12 Weeks Treatment With Simeprevir and Daclatasvir in Participants With Chronic Hepatitis C Virus Genotype 1b or 4 Infection and Either Severe Renal Impairment or End-stage Renal Disease on Hemodialysis.

Renal Impairment | End-stage Renal Disease

France, Spain
AstraZeneca

Completed

To Assess the Pharmacokinetics, Safety and Tolerability of Selumetinib in Renal Impaired Subjects and Healthy Subjects

Solid Tumours

United States
University Medical Centre Ljubljana

Completed

Liraglutide as Add on Therapy on Metformin in Women With Polycystic Ovary Syndrome

Obesity | PCOS

Slovenia
Sahlgrenska University Hospital, Sweden

Completed

Fluid Investigation Colloid vs Crystalloid Reg. Renal Hemodynamics and Function

Renal Impairment

Sweden
Sanofi

Completed

Open Label Pharmacokinetic Study of SAR302503 in Subjects With Renal Impairment

Renal Impairment

United States
Melbourne Health

Withdrawn

Frusemide Infusion for the Prevention of Deterioration in Renal Function Post Cardiac Surgery.

Renal Impairment After Cardiac Surgery

Australia
Eisai Inc.

Completed

A Phase 1, Open-Label, Single-Dose, Pharmacokinetic and Safety Study of E7080 (24 mg) Administered to Subjects With Mild, Moderate, and Severe Renal Impairment and to Healthy Subjects

Renal Impairment | Disease Severity

United States
Merck Sharp & Dohme LLC

Completed

Dialysis of Sugammadex in Participants With Severe Renal Impairment (Study 19.4.333) (P05773)

Neuromuscular Blockade

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