Search clinical trials for: risk adapted therapy

Total 65647 results

Daniel George, MD
Merck Sharp & Dohme LLC

Not yet recruiting

Trimodality Approach of Low Dose iOnizing Radiation With or Without Neoadjuvant Pembrolizumab and Prostatectomy for Men With Intermediate/High Risk Prostate Cancer (TALON) (TALON)

Prostate Cancer

United States
Criterium, Inc.

Recruiting

DNA-Guided Second Line Adjuvant Therapy For High Residual Risk, Stage II-III, Hormone Receptor Positive, HER2 Negative Breast Cancer (DARE)

Breast Cancer

United States
West German Study Group
Eli Lilly and Company; Genomic Health®, Inc.

Recruiting

Adjuvant Therapy With Abemaciclib + SOC ET vs. SOC ET in Clinical or Genomic High Risk, HR+/HER2- EBC (ADAPTlate)

Breast Cancer Female

Germany
Children's Hospital of Philadelphia
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Locomotor Learning in Infants at High Risk for Cerebral Palsy

Cerebral Palsy

United States
Assistance Publique - Hôpitaux de Paris

Recruiting

Evaluation of the Impact of the Repositioning Schedule Adapted to the Risk of Pressure Ulcer of Patients in Intensive Care Unit (PROMESREA)

Pressure Ulcer | Ischemic | Ischemic Ulcer

France
St. Jude Children's Research Hospital
Incyte Corporation; North American Consortium for Histiocytosis; Cures Within...

Recruiting

Use Of A Response-Adapted Ruxolitinib-Containing Regimen For The Treatment Of Hemophagocytic Lymphohistiocytosis

Hemophagocytic Lymphohistiocytosis

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI); Genentech, Inc.

Recruiting

Venetoclax and Azacitidine for the Treatment of Relapsed or Refractory High-Risk Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia

Recurrent Chronic Myelomonocytic Leukemia | Recurrent Myelodysplastic Syndrome | Refractory Chronic Myelomonocytic Leukemia | Refractory Myelodysplastic Syndrome | Therapy-Related Myelodysplastic Syndrome

United States
The University of Hong Kong

Recruiting

Stress Cardiac Magnetic Resonance of Asymptomatic Type 2 Diabetics With Cardiovascular High Risk to Measure Empagliflozin Impact on Myocardial Blood Flow (CATCH-EM) (CATCH-EM)

Type 2 Diabetes | Microvascular Coronary Artery Disease

Hong Kong
Leipzig Heart Institute GmbH

Not yet recruiting

Personalised Risk scOre For Implantation of Defibrillators in Patients With Reduced LVEF≤35% and a Low Risk for Sudden Cardiac Death (PROFID-Reduced)

Myocardial Infarction | Heart Failure | Sudden Cardiac Death
Leipzig Heart Institute GmbH

Not yet recruiting

Personalised Risk scOre For Implantation of Defibrillators in Patients With Preserved LVEF>35% and a High Risk for Sudden Cardiac Death

Myocardial Infarction | Sudden Cardiac Death
Alexander Valdman

Recruiting

Preoperative Short-Course Radiation Therapy With PROtons Compared to Photons In High-Risk RECTal Cancer (PRORECT) (PRORECT)

Rectal Cancer

Sweden
Eastern Hepatobiliary Surgery Hospital

Not yet recruiting

Neoadjuvant Therapy for Resectable Intrahepatic Cholangiocarcinoma With High Predict Risk of Lymph Node Metastasis

Intrahepatic Cholangiocarcinoma Recurrent
Scientific Institute San Raffaele

Recruiting

Role of Endomyocardial Biopsy and Aetiology-based Treatment in Patients With Inflammatory Heart Disease in Arrhythmic and Non-arrhythmic Clinical Presentations: an Integrated Approach for the Optimal Diagnostic and Therapeutic Management (MYOCAR)

Arrhythmia | Myocarditis | Cardiomyopathies | Ventricular Arrythmia | Immunosuppression | Genetic Predisposition | Inflammatory Cardiomyopathy | Catheter Ablation | Autoimmunity

Italy
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

White Button Mushroom Sup for the Reduction of PSA in Pts With Biochemically Rec or Therapy Naive Fav Risk Prostate CA

Prostate Adenocarcinoma | Recurrent Prostate Carcinoma | Stage I Prostate Cancer AJCC v8 | Stage IIIA Prostate Cancer AJCC v8 | Stage IIC Prostate Cancer AJCC v8 | Stage IIIC Prostate Cancer AJCC v8 | PSA Failure | PSA Progression | Stage IIA Prostate Cancer AJCC v8 | Stage IIB Prostate Cancer AJCC v8

United States
NRG Oncology
National Cancer Institute (NCI)

Recruiting

Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial

Prostate Adenocarcinoma | Metastatic Malignant Neoplasm in the Bone | Stage IIIA Prostate Cancer AJCC v8 | Stage IIIB Prostate Cancer AJCC v8 | Stage III Prostate Cancer AJCC v8 | Stage IIIC Prostate Cancer AJCC v8 | Stage IVA Prostate Cancer AJCC v8

United States, Canada
Duke University

Recruiting

An Evaluation of Insomnia Treatment to Reduce Cardiovascular Risk in Patients With Posttraumatic Stress Disorder

Insomnia | Posttraumatic Stress Disorder | Cardiovascular Risk Factor

United States
Ralf Hofheinz
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest; Deutsche... and other collaborators

Recruiting

Preoperative FOLFOX Versus Postoperative Risk-adapted Chemotherapy in Patients With Locally Advanced Rectal Cancer

Rectal Cancer

Germany
University Hospital, Toulouse

Recruiting

Efficacy of Pre-exposure Treatment With Hydroxy-Chloroquine on the Risk and Severity of COVID-19 Infection (PREPCOV)

COVID-19

France
Shengjing Hospital

Recruiting

Sj-subway, a Predictor for the Recurrence of High-risk Hormone Receptor-positive Breast That is Sensitive to Extended Endocrine Therapy

Breast Cancer

China
University of Virginia

Recruiting

EBRT and HDR Brachytherapy for Unfavorable-intermediate, High, and Very High-risk Prostate Cancer (Prostate005)

Prostate Cancer | Prostate Adenocarcinoma

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI); Seagen Inc.

Recruiting

T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial

Anatomic Stage IA Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage IIA Breast Cancer AJCC v8 | Anatomic Stage IIB Breast Cancer AJCC v8 | Anatomic Stage III Breast Cancer AJCC v8 | Anatomic Stage IIIA Breast Cancer AJCC v8 | Anatomic Stage IIIB Breast Cancer AJCC... and other conditions

United States, Canada, Puerto Rico
McMaster University

Recruiting

Negative Pressure Incisional Wound Therapy for High-risk Ventral Hernia Repair (N-PITH)

Ventral Hernia

Canada
Sun Yat-sen University
Wuzhou Red Cross Hospital; Fifth Affiliated Hospital, Sun Yat-Sen University; Affiliated Cancer Hospital & Institute of Guangzhou Medical University and other collaborators

Recruiting

Concurrent and Adjuvant PD1 Treatment Combined With Chemo-radiotherapy for High-risk Nasopharyngeal Carcinoma

Nasopharyngeal Cancer | Chemotherapy | Radiotherapy | PD-1 Therapy

China
First Affiliated Hospital Xi'an Jiaotong University

Recruiting

Precision Therapy in Complex High-risk Coronary Artery Disease (PTCA)

Coronary Artery Disease

China
Institut Curie

Recruiting

Follow-up of Patients With Uveal Melanoma Adapted to the Risk of Relapse (SALOME) (SALOME)

Uveal Melanoma

France
Emory University
National Cancer Institute (NCI)

Recruiting

Cemiplimab Before and After Surgery for the Treatment of High Risk Cutaneous Squamous Cell Cancer

Metastatic Skin Squamous Cell Carcinoma | Recurrent Skin Squamous Cell Carcinoma

United States
Zhejiang University

Recruiting

Study on the Safety and Efficacy of Donafinib Combined With Anti-PD-1 Antibody as Adjuvant Therapy for HCC Patients (CISLD-8)

Hepatocellular Carcinoma

China
Duk-Woo Park, MD

Recruiting

Potassium-Competitive Acid Blocker Versus pROton-Pump Inhibitor for GastroproTECTion Strategies In Patients at High Gastro-Intestinal Bleeding Risk Receiving Antithrombotic Therapy (PROTECT-HBR)

Myocardial Infarction | Coronary Artery Disease | Acute Coronary Syndrome | Percutaneous Coronary Intervention

Korea, Republic of
Peking University Cancer Hospital & Institute

Recruiting

Total Neoadjuvant Therapy Followed by 'Watch and Wait' Approach or Organ Preservation for Low-risk Rectal Cancer (BJCC-R01)

Rectum Cancer

China
Weill Medical College of Cornell University
National Cancer Institute (NCI)

Recruiting

Study of PSMA PET/MR Guided Stereotactic Body Radiation Therapy With Simultaneous Integrated Boost (SBRT-SIB) for High-Intermediate and High Risk Prostate Cancer (PSMA SBRT-SIB)

Prostate Cancer

United States
Toronto Metropolitan University
University of British Columbia; Unity Health Toronto

Recruiting

Sexual Confidence: CBT for Social Anxiety Disorder With HIV Risk Reduction Counselling for HIV-negative gbMSM (SC-RCT)

HIV | Social Anxiety | Sexual Risk

Canada
Ohio State University Comprehensive Cancer Center
National Cancer Institute (NCI)

Recruiting

Effectiveness of a Multi-Level Smoking Cessation Program for High-Risk Women in Rural Communities

Tobacco-Related Carcinoma

United States
University of California, Los Angeles
National Institute of Mental Health (NIMH)

Recruiting

Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy Trial

Psychotic Disorders | Psychosis | Prodromal Schizophrenia | Prodromal Symptoms | Family

United States, Canada
Israeli Medical Association

Recruiting

Pediatric-type Therapy With Pre-transplant Blinatumomab for HR Patients - Phase II Study

High-Risk Cancer | Philadelphia-Negative ALL

Israel
Oslo University Hospital
Vestre Viken Hospital Trust; University of Oslo; St. Olavs Hospital; Nordlandssykehuset... and other collaborators

Recruiting

Predictors of Clinical Course and Treatment Response in DBT Programmes

Borderline Personality Disorder | Self Harm

Norway
West China Hospital

Recruiting

Radiotherapy Versus Radiotherapy Combined With Temozolomide in High-risk Low-grade Gliomas After Surgery

Low-grade Glioma

China
David Garcia Cinca
Fundacion Clinic per a la Recerca Biomédica

Not yet recruiting

Omission of Surgery and Sentinel Lymph Node Dissection in Clinically Low-risk HER2positive Breast Cancer With High HER2 Addiction and a Complete Response Following Standard Anti- HER2-based Neoadjuvant Therapy (ELPIS Trial) (ELPIS)

Mammary Cancer

Spain
National Cancer Institute (NCI)

Recruiting

Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

Chronic Lymphocytic Leukemia | Small Lymphocytic Lymphoma

United States, Canada
Istituto Clinico Humanitas

Recruiting

BRAIN-targeted Goal-directed Therapy in High-risk Patients undeRgOing Major electIve SurgEry: the BRAIN-PROMISE Study (BRAINPROMISE)

Surgery | Perioperative Complication

Italy
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Total Marrow and Lymphoid Irradiation as Conditioning Regimen Before Hematopoietic Cell Transplantation in Patients With Myelodysplastic Syndrome or Acute Leukemia

Acute Myeloid Leukemia | Acute Lymphoblastic Leukemia | Myelodysplastic Syndrome | High Risk Myelodysplastic Syndrome

United States
Medical University of Graz

Recruiting

Predominant Sensitizations to Single Bee Venom Allergens as a Risk Factor for Therapy Failure (PREDICT)

Bee Venom Allergy

Austria
Ottawa Hospital Research Institute
Canadian Institutes of Health Research (CIHR); Stem Cell Network; Ontario Institute...

Recruiting

Cellular Therapy for Extreme Preterm Infants at Risk of Developing Bronchopulmonary Dysplasia

Bronchopulmonary Dysplasia

Canada
Samsung Medical Center
Korean Cancer Study Group

Recruiting

High Risk ER+HER2- T1-2N0-1 Early Breast Cancer With Palbociclib Plus Endocrine Therapy(HIPEx)

Breast Cancer

Korea, Republic of
Palo Alto University
National Institute of Mental Health (NIMH); Stanford University; York University and other collaborators

Recruiting

Cognitive Processing Therapy (CPT) for Posttraumatic Stress Disorder and Borderline Personality Disorder (PTSD-BPD)

Borderline Personality Disorder | Posttraumatic Stress Disorder

United States
Case Comprehensive Cancer Center

Recruiting

Transplant Wellness Clinic for Elderly or High Risk Patients Undergoing BMT

Lymphoma | Myeloma | Stem Cell Transplant Complications | Allogeneic and Autologous Stem Cell Transplant

United States
University Health Network, Toronto
Bayer; Prostate Cancer Canada

Not yet recruiting

Study of Radiation Therapy in Combination With Darolutamide + Degarelix in Intermediate Risk Prostate Cancer (SChLAP/IDC)

Prostate Cancer

Canada
National Medical Research Center for Children's...

Recruiting

Results of the Aortic Valve Reconstruction in Children

Aortic Valve Insufficiency

Russian Federation
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Venetoclax and Azacitidine for the Treatment of High-Risk Recurrent or Refractory Myelodysplastic Syndrome

Chronic Myelomonocytic Leukemia | Myelodysplastic Syndrome | Recurrent Myelodysplastic Syndrome | Refractory Myelodysplastic Syndrome | Therapy-Related Myelodysplastic Syndrome

United States
Neuromed IRCCS

Recruiting

Role of ADA SNPs in Subjects With Relapsing Multiple Sclerosis (RMS)

Relapsing Multiple Sclerosis

Italy
University of Birmingham
Novartis; National Cancer Institute, France; MPN Voice

Recruiting

MITHRIDATE: Ruxolitinib Versus Hydroxycarbamide or Interferon as First Line Therapy in High Risk Polycythemia Vera (MITHRIDATE)

Polycythemia Vera

United Kingdom

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