Search clinical trials for: severe hepatic injury

Total 25154 results

Centre hospitalier de l'Université de Montréal...
Sunnybrook Health Sciences Centre; University of Alberta; Unity Health Toronto; University of Kentucky and other collaborators

Completed

Ultrasound Markers of Organ Congestion in Severe Acute Kidney Injury (ECHO-AKI)

Acute Kidney Injury | Ultrasonography | Fluid Overload

Canada, United States
University of Texas Southwestern Medical Center
Medical University of South Carolina; National Institute of Diabetes and Digestive... and other collaborators

Completed

13C-Methacetin Breath Test for the Prediction of Outcome in in ALI or ALF (ALFSG-MBT)

Acute Liver Failure

United States
William Lee
Medical University of South Carolina; National Institute of Diabetes and Digestive... and other collaborators

Completed

Safety Study of Ornithine Phenylacetate to Treat Patients With Acute Liver Failure/Severe Acute Liver Injury (STOP-ALF)

Acute Liver Failure | Acute Liver Injury

United States
Pfizer

Terminated

Risk Of Severe Hepatic Injury In Patients With Invasive Candidiasis Treated With Echinocandins

Candidemia | Invasive Candidiasis
Bristol-Myers Squibb

Not yet recruiting

Study to Assess Drug Levels and Safety of BMS-986278 in Healthy Participants and Participants With Different Degrees of Hepatic Impairment

Hepatic Impairment | Healthy Participants
Rigshospitalet, Denmark

Not yet recruiting

Microdialysis and Jugular Bulb Glucose Profiles During Hyperglycaemic Clamping in Patients With Severe Acute Brain Injury (CLAMP)

Acute Brain Injury

Denmark
Uppsala University Hospital

Not yet recruiting

Mechanisms of Acute Kidney Injury in Severe Infections (PET-AKI)

Sepsis | AKI - Acute Kidney Injury | Positron Emission Tomography (PET)
Seventh Medical Center of PLA General Hospital
Guangdong Provincial People's Hospital; Henan Provincial People's Hospital; People... and other collaborators

Not yet recruiting

Prone Position During ECMO in Pediatric Patients With Severe ARDS (PEPAD)

Extracorporeal Membrane Oxygenation | Pediatric Acute Respiratory Distress Syndrome

China
University of Health Sciences Lahore

Not yet recruiting

Cisternostomy Vs Decompressive Craniectomy for Severe Traumatic Brain Injury

Severe Traumatic Brain Injury
Bristol-Myers Squibb

Recruiting

A Study to Assess the Drug Levels of Repotrectinib in Healthy Participants and Participants With Moderate and Severe Hepatic Impairment

Healthy Volunteers | Hepatic Impairment

United States
Miromatrix Medical Inc.

Not yet recruiting

miroliverELAP® for the Treatment of Acute Liver Failure: A Phase 1 Trial

Acute Liver Failure | Acute Liver Injury, Drug Induced

United States
University of Arizona
United States Department of Defense

Not yet recruiting

Safety and Efficacy of Angiotensin (1-7) in Persons With Moderate to Severe Traumatic Brain Injury (ANGel T)

Traumatic Brain Injury
Academisch Medisch Centrum - Universiteit van Amsterdam...

Recruiting

Improving Diagnosis and Prediction of Outcome in Patients With Severe Disorders of Consciousness (IMPROVE-DOC)

Stroke | Encephalitis | Traumatic Brain Injury | Meningitis | Intracranial Hemorrhages | Subarachnoid Hemorrhage

Netherlands
Zhejiang University
Beijing YouAn Hospital; Beijing Ditan Hospital; Huashan Hospital; Qilu Hospital...

Not yet recruiting

A Multicenter Prospective Clinical Cohort Study on the Pathogen Spectrum of Severe Hepatitis (Liver Failure) Complicated With Infection

Liver Failure
Cedars-Sinai Medical Center
Jarrow Formulas Inc

Not yet recruiting

SAMe in Prevention of Oxaliplatin-associated Liver Injury

Colorectal Cancer | Liver Metastases | Liver Metastasis Colon Cancer | Liver Injury | Sinusoidal Obstruction Syndrome | 5-Fluorouracil Toxicity | Liver Toxicity, Chemically-Induced

United States
Noorik Biopharmaceuticals AG

Recruiting

Endothelin Receptor Antagonism With Ambrisentan to Treat Hepatorenal Syndrome

Liver Cirrhosis | Acute Kidney Injury | Hepatorenal Syndrome | Ascites Hepatic

India
SHINKEI Therapeutics, Inc
Duke Clinical Research Institute

Not yet recruiting

Study to Assess the Safety of Amantadine Hydrochloride (HCl) Intravenous (IV) Solution (MR-301) in Patients With Severe Traumatic Brain Injury (TBI).

Traumatic Brain Injury
University Hospital, Grenoble

Recruiting

Description of Lactulose Administration by Balloon Rectal Tube in Severe Hepatic Encephalopathy (ALPACA)

Hepatic Encephalopathy

France
Shanghai 6th People's Hospital

Not yet recruiting

Safety and Efficacy of Enhanced Recovery After Surgery in Neurocritical Care

Traumatic Brain Injury | Cerebrovascular Disease | Neurocritical Care | Moderate or Severe Coma

China
Azienda Ospedaliero-Universitaria di Modena

Recruiting

Impact of Graft Reconditioning With Hypothermic Machine Perfusion on HCC Recurrence After Liver Transplantation

Hepatocellular Carcinoma | Liver Transplant; Complications

Italy
Assistance Publique Hopitaux De Marseille

Not yet recruiting

Effects on Biotrauma of NMBAs and PP Association During ARDS (CURA-PRONE)

Moderate to Severe Acute Respiratory Distress Syndrome

France
Xuanwu Hospital, Beijing

Not yet recruiting

Chinese Severe Brain Injury Trial (CSBIT)

Severe Brain Injury
Nanfang Hospital, Southern Medical University

Recruiting

SSM Predicts Outcomes of CLD Inpatients With Acute Liver Injury

End Stage Liver Disease | Portal Hypertension | Jaundice | Liver Dysfunction

China
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Metabolic Reprogramming in Renal Tubular Cells in Acute Kidney Injury Following Severe Trauma (METAKIT)

Multi-organ Failure After Severe Trauma

France
London North West Healthcare NHS Trust

Recruiting

CArE for OAsI Study: Care Pathways and Anorectal Evaluation for OASI Associated Incontinence (CArE for OAsI)

Anal Incontinence | Faecal Incontinence | Follow-up | Biofeedback | Obstetric Anal Sphincter Injury | Urogynaecology | Urgency | Severe Perineal Trauma | Grade 3 Perineal Tear | Grade 4 Perineal Tear | Deferral Time | Pathways | Review | Endo-anal Ultrasound

United Kingdom
Nanfang Hospital, Southern Medical University

Recruiting

Cardioprotective Effects of Cardiopeptides for Injection in Patients With Non-severe Cardiac Disease: a Single-center Randomized Controlled Trial

Myocardial Injury | ICU

China
Beijing Tiantan Hospital

Recruiting

Correlation Patterns of Brain Temperature-Pressure in Acute Brain Injury (MERCURY)

Brain Injuries, Traumatic | Subarachnoid Hemorrhage | Cerebral Hemorrhage | Intracranial Pressure

China
Abalonex, LLC

Not yet recruiting

Safety and Efficacy of ABX-101 in Participants Aged 18 to 50 Years of Age With Moderate to Severe Traumatic Brain Injury

Traumatic Brain Injury | Cerebral Edema
Merz Therapeutics GmbH

Recruiting

A Clinical Trial to Investigate Efficacy and Safety of NT 201 Injections Compared With Placebo Injections in Participants Aged 18 Years and Older With Chronic Nerve Pain After Shingles or Nerve Injury (PaiNT)

Moderate to Severe Chronic Peripheral Neuropathic Pain (PNP) Due to Postherpetic Neuralgia (PHN) or Peripheral Nerve Injury

Bulgaria, Germany, Poland, France, Hungary, Spain
Qin Zhang

Recruiting

Liver Ischemia-reperfusion Injury and Clinical Data Analysis

Liver Injury

China
Tang-Du Hospital

Not yet recruiting

Baricitinib for Moderate and Severe Traumatic Intracerebral Hemorrhage/Contusions

Traumatic Brain Injury

China
Beijing Chao Yang Hospital

Recruiting

Effect of Transpulmonary MP on Prognosis of Patients With Severe ARDS Treated With VV-ECMO

Extracorporeal Membrane Oxygenation | Acute Respiratory Distress Syndrome | Mechanical Power | Transpulmonary Mechanical Power

China
University of Texas Southwestern Medical Center

Recruiting

Ketamine in Severe Traumatic Brain Injury

Traumatic Brain Injury | Traumatic Encephalopathy

United States
Northwestern University
University of Alabama at Birmingham; University of Southern California; Medical... and other collaborators

Not yet recruiting

FFP In Traumatic BRAin INjury (FIT-BRAIN) Trial

Moderate to Severe Traumatic Brain Injury
Erasmus Medical Center
Maasstad Hospital

Recruiting

FCV vs PCV in Moderate to Severe ARDS

Acute Respiratory Distress Syndrome | Ventilator Lung

Netherlands
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

IHD Versus CRRT for Severe Acute Kidney Injury in Critically Ill Patients (ICRAKI)

Acute Kidney Injury
D'Or Institute for Research and Education
Oswaldo Cruz Foundation; Rio de Janeiro State Research Supporting Foundation... and other collaborators

Not yet recruiting

Extracellular Vesicles From Mesenchymal Cells in the Treatment of Acute Respiratory Failure

Pneumonia | Acute Respiratory Distress Syndrome (ARDS) | Severe Acute Respiratory Syndrome (SARS)

Brazil
Hope Biosciences
The University of Texas Health Science Center, Houston

Recruiting

Autologous Adipose Derived Mesenchymal Stem Cells for Chronic Traumatic Brain Injury

Traumatic Brain Injury

United States
BioAegis Therapeutics Inc.

Not yet recruiting

Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)

Infections | Acute Respiratory Distress Syndrome
Aqualung Therapeutics Corp.

Not yet recruiting

Study of Safety and Efficacy of ALT-100mAb in Participants With Moderate/Severe ARDS

Acute Respiratory Distress Syndrome (ARDS)
AstraZeneca

Recruiting

A Phase I Study to Investigate the Effect of Hepatic Impairment on the PK, Safety, and Tolerability of AZD2693

Hepatic Impairment

United States
Brain Trauma Foundation
The Cleveland Clinic; Weill Medical College of Cornell University; Uniformed... and other collaborators

Not yet recruiting

External Lumbar Drainage to Reduce ICP in Severe TBI: a Phase 1 Clinical Trial (ELASTIC)

Intracranial Hypertension | Severe Traumatic Brain Injury

United States
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Recruiting

Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

Metastatic Malignant Neoplasm in the Liver | Metastatic Colorectal Carcinoma | Stage IV Colorectal Cancer AJCC v8 | Unresectable Colorectal Carcinoma

United States
Australian and New Zealand Intensive Care Research...

Recruiting

PRECISION-TBI - An Observational Study of Patients With Moderate to Severe Traumatic Brain Injury

Trauma, Brain

Australia
Consorcio Centro de Investigación Biomédica en...
Instituto de Salud Carlos III; European Commission

Not yet recruiting

Metoprolol in Acute Respiratory Distress Syndrome (MAIDEN) (MAIDEN)

Acute Respiratory Distress Syndrome (ARDS)

Spain
Centre Integre Universitaire de Sante et Services...
McGill University Health Centre/Research Institute of the McGill University...

Not yet recruiting

Five-day 20-minute 10-Hz tACS in Patients With a Disorder of Consciousness

Brain Injuries | Disorder of Consciousness | Brain Injury Traumatic Severe
University Hospital, Angers
Rennes University Hospital; University Hospital, Tours; Hospital, Laval, France; Hospital, Le Mans, France and other collaborators

Not yet recruiting

External Validation of the Clinical Pre-hospital "Red- Flag" Alert for Activation of Intra-hospital Hemorrhage Control Response in Blunt Trauma. (RED-FLAG 2)

Trauma Injury
RenJi Hospital

Recruiting

Multiomic Analysis of Traumatic Brain Injury and Hypertension Intracranial Hemorrhage Lesion Tissue (MOSS-THINK)

Intracranial Hemorrhage, Hypertensive | Brain Injury Traumatic Severe

China
HealthPartners Institute

Recruiting

Comparison of ICG Microangiography and Conventional Angiography in Severe Frostbite

Frostbite

United States
ReAlta Life Sciences, Inc.
Premier Research Group plc

Recruiting

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of RLS-0071 in Newborns With Moderate or Severe Hypoxic-Ischemic Encephalopathy Undergoing Therapeutic Hypothermia (STAR)

Hypoxic-Ischemic Encephalopathy

United States

Search clinical trials for: severe hepatic injury

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