Search clinical trials for: sonic hedgehog pathway
Total 1572 results
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University Hospital, LilleSun Pharmaceutical Industries LimitedNot yet recruitingBasal Cell Carcinoma | Radiotherapy; Complications
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St. Jude Children's Research HospitalNovartis PharmaceuticalsActive, not recruitingGlioma | Neoplasms | Glioblastoma | Neoplasms, Neuroepithelial | Central Nervous System Neoplasms | Brain Cancer | Brain Tumor | Ependymoma | Medulloblastoma | Anaplastic Astrocytoma | Anaplastic Ganglioglioma | Anaplastic Ependymoma | Anaplastic Oligodendroglioma | Pineoblastoma | Recurrent Medulloblastoma | CNS Tumor | Pediatric... and other conditionsUnited States
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St. Jude Children's Research HospitalNational Cancer Institute (NCI); Genentech, Inc.Active, not recruitingMedulloblastomaUnited States, Canada, Australia, New Zealand
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Centre Leon BerardMinistry of Health, FranceTerminatedHistologically Confirmed Medulloblastoma | Activation of the Sonic Hedgehog (SHH) PathwayFrance, Italy, Switzerland, United Kingdom
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Third Affiliated Hospital, Sun Yat-Sen UniversityNational Natural Science Foundation of ChinaUnknownArthritis, Rheumatoid | Neovascularization, Pathologic | Synovitis
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St. Jude Children's Research HospitalRecruitingMedulloblastomaUnited States
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Hangzhou Cancer HospitalRecruitingEsophageal Diseases | Esophageal Squamous Cell Carcinoma | Esophageal NeoplasmChina
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Regeneron PharmaceuticalsSanofiCompletedCarcinoma, Basal CellUnited States, Canada, France, Italy, Spain, Germany, Belgium, Austria, Greece, Switzerland
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Ascend Biopharmaceuticals LtdCompletedBasal Cell Nevus Syndrome | Basal Cell CarcinomaAustralia
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Pediatric Brain Tumor ConsortiumNational Cancer Institute (NCI); American Lebanese Syrian Associated Charities...SuspendedMedulloblastoma, ChildhoodUnited States
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St. Jude Children's Research HospitalEli Lilly and CompanyActive, not recruitingBrain Cancer | Brain Tumor | Medulloblastoma | Brain Tumor, Recurrent | CNS Tumor | Medulloblastoma Recurrent | CNS Cancer | Medulloblastoma, Non-WNT/Non-SHH | Brain Tumor, Pediatric | CNS Neoplasm | Brain Tumor, Refractory | Medulloblastoma, Non-WNT/Non-SHH, Group 3 | Medulloblastoma, Non-WNT/Non-SHH, Group 4United States
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Dallas VA Medical CenterActive, not recruitingEsophageal CancerUnited States
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Novartis PharmaceuticalsCompletedAdvanced Solid TumorUnited States
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Novartis PharmaceuticalsCompletedMetastatic Colorectal Cancer | Gastric Cancer | Advanced Solid Tumors | Metastatic Breast Cancer | Gastroesophageal Junction Cancer | Recurrent Glioblastoma Multiforme | Advanced Pancreatic Adenocarcinoma | Safety | Triple Negative Metastatic Breast Cancer | Dose Escalation | Preliminary Efficacy | Hormone Receptor...Canada, United Kingdom, Spain, Germany, Italy, Belgium, Australia, United States
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Novartis PharmaceuticalsCompletedAdvanced Solid Tumors | Recurrent or Refractory Medulloblastoma | Locally Advanced or Metastatic Basal Cell CarcinomaUnited States, United Kingdom, Switzerland, Netherlands
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Novartis PharmaceuticalsCompletedBone Marrow Diseases | Hematologic Diseases | Blood Coagulation Disorders | Hemorrhagic Disorders | Primary Myelofibrosis | Myeloproliferative Disorders | Polycythemia Vera | Thrombocytosis | Essential Thrombocythemia | Blood Platelet DisordersUnited Kingdom, Belgium, Canada, France, Australia, Netherlands, Spain, Denmark, Ireland, Italy, Germany
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Hospital de Clinicas de Porto AlegreUnknownBasal Cell Carcinoma | Hedgehog PathwayBrazil
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Medical University of WarsawUnknownBacterial Infections | Varicocele | Viral Infection | Sonic Hedgehog Expression | VEGF ExpressionPoland
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University of MiamiTerminatedEsophageal CancerUnited States
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National Cancer Institute (NCI)CompletedRecurrent Uterine Corpus Sarcoma | Chondrosarcoma | Recurrent Osteosarcoma | Gastrointestinal Stromal Tumor | Clear Cell Sarcoma of the Kidney | Metastatic Osteosarcoma | Ovarian Sarcoma | Recurrent Adult Soft Tissue Sarcoma | Stage III Adult Soft Tissue Sarcoma | Stage III Uterine Sarcoma | Stage IV Adult... and other conditionsUnited States
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Clinica Universidad de Navarra, Universidad de...Unknown
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Genentech, Inc.Completed
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Genentech, Inc.Completed
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Genentech, Inc.Completed
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Novartis PharmaceuticalsWithdrawnBasal Cell CarcinomaGreece, Switzerland, Germany, United Kingdom, Belgium, Canada, Czechia, Finland, Italy, Spain
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Novartis PharmaceuticalsCompletedGlioma | Astrocytoma | Medulloblastoma | Neuroblastoma | Rhabdomyosarcoma | HepatoblastomaFrance, Canada, Italy, Australia, United Kingdom, United States
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Infinity Pharmaceuticals, Inc.CompletedMetastatic Pancreatic CancerUnited States, Canada
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Novartis PharmaceuticalsCompletedNevoid Basal Cell Carcinoma Syndrome | Basal Cell Carcinoma | Gorlin SyndromeBelgium, Austria, Germany, Canada
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Genentech, Inc.National Cancer Institute (NCI); Sidney Kimmel Comprehensive Cancer Center...CompletedUnspecified Adult Solid Tumor, Protocol Specific
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Genentech, Inc.Completed
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Genentech, Inc.CompletedBasal Cell CarcinomaAustralia, France, United States, Germany, Belgium, United Kingdom
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Genentech, Inc.CompletedMetastatic Colorectal Cancer | Ovarian Cancer | Basal Cell CarcinomaUnited States
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Rutgers, The State University of New JerseyNational Cancer Institute (NCI); Novartis Pharmaceuticals; Rutgers Cancer Institute...WithdrawnResectable Pancreatic CancerUnited States
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Bristol-Myers SquibbExelixisCompletedBasal Cell Carcinoma (BCC) | Hedgehog Pathway | Smoothened | Basal Cell Nevoid Syndrome (BCNS)United States, Canada
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Infinity Pharmaceuticals, Inc.CompletedPrimary Myelofibrosis | Fibrosis, Bone MarrowUnited States
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Infinity Pharmaceuticals, Inc.CompletedNeoplasmsUnited States, Canada
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Xie KangjieRecruitingDiabetes | Postoperative DeliriumChina
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Mayo ClinicNot yet recruitingStage III Intrahepatic Cholangiocarcinoma AJCC v8 | Metastatic Cholangiocarcinoma | Refractory Cholangiocarcinoma | Stage III Hilar Cholangiocarcinoma AJCC v8 | Stage IV Hilar Cholangiocarcinoma AJCC v8 | Stage IV Intrahepatic Cholangiocarcinoma AJCC v8 | Advanced CholangiocarcinomaUnited States
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Hitit UniversityRecruiting
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University of AlbertaNot yet recruitingCardiovascular Disease | Diabetes | Dyslipidemia | Blood Pressure | Cardiovascular Risk Factors
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Assistance Publique Hopitaux De MarseilleRecruitingLung Cancer | Smoking-related Pathology | Atheroma | Non-progressive Cancer > 5 YearsFrance
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The Cleveland ClinicNot yet recruitingPrenatal DisorderUnited States
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Mayo ClinicNot yet recruitingRecurrent Prostate Cancer | Castration-resistant Prostate Cancer | Stage IVB Prostate Cancer AJCC v8 | Recurrent Castration-Sensitive Prostate CarcinomaUnited States
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University of AlbertaAlberta Innovates Health SolutionsNot yet recruiting
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Stony Brook UniversityMassachusetts General Hospital; Mclean HospitalRecruitingBipolar Disorder | Bipolar Disorder Type 1United States
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University Hospital, ToulouseJanssen, LP; Ligue contre le cancer, FranceNot yet recruiting
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Medical College of WisconsinNot yet recruiting
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University of Alabama at BirminghamNot yet recruitingConvulsion, Non-Epileptic | Functional Neurological Disorder | Functional SeizureUnited States
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Tianjin Medical University Cancer Institute and...RecruitingNon-small Cell Lung Cancer | EGFR Activating Mutation | EGFR-TKI Resistant Mutation | Cell Cycle DeregulationChina