Search clinical trials for: symptomatic heart failure

Total 80467 results

InnovHeart
MAXIS, LLC

Recruiting

Reduction of Mitral Regurgitation With the SATURN Trans-Septal Transcatheter Mitral Valve Replacement (TMVR) System in Patients With Severe Symptomatic Mitral Regurgitation (CASSINI-EU)

Heart Failure

Lithuania, Poland
Medstar Health Research Institute

Not yet recruiting

Randomized Evaluation for Failed TAVR (REVIVE-TAVR)

Prosthesis Failure | Prosthetic Valve Malfunction | Symptomatic Patients Who Have Had Transcatheter Heart Valve (THV) Failure
Colorado Prevention Center
Bayer; Saint Luke's Hospital of Kansas City

Not yet recruiting

A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists (FINALITY-HF)

Heart Failure
CVRx, Inc.

Recruiting

Symptomatic CRT Patients: Real-World Experience - Barostim™ Advancing the Level of Clinical Evidence

Heart Failure

United States
Cytokinetics

Recruiting

Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol Succinate in Adults With Symptomatic oHCM (MAPLE-HCM)

Obstructive Hypertrophic Cardiomyopathy (oHCM)

United States, Denmark, Spain, Netherlands, United Kingdom, France, China, Israel, Germany, Italy, Hungary, Canada
Bristol-Myers Squibb

Recruiting

A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive HCM) (DISCOVER-HCM)

Obstructive Hypertrophic Cardiomyopathy

United States, Puerto Rico
Impulse Dynamics

Recruiting

Assessment of CCM in HF With Higher Ejection Fraction (AIM HIGHer)

Heart Failure | Heart Failure With Preserved Ejection Fraction | Diastolic Heart Failure | Heart Failure With Mid Range Ejection Fraction | Heart Failure With Moderately Reduced Ejection Fraction

United States
Ancora Heart, Inc.

Recruiting

Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF): The CORCINCH-HF Study

Dilated Cardiomyopathy | Heart Failure With Reduced Ejection Fraction (HFrEF)

United States, France, Netherlands, Czechia, Belarus, Belgium, Serbia
Cytokinetics

Enrolling by invitation

Open-label Extension Study to Evaluate the Long-term Safety and Tolerability of Aficamten in Adults With HCM (FOREST-HCM)

Symptomatic Hypertrophic Cardiomyopathy (HCM)

United States, France, Israel, Spain, United Kingdom, Italy, Portugal, Poland, Hungary, Denmark, Netherlands, Germany, Czechia
University Medical Center Groningen

Withdrawn

Ablation in Patients With HF and Symptomatic AF: PULVERISE-AF-CRT

Heart Failure | Atrial Fibrillation

Netherlands
Organon and Co

Completed

Study to Evaluate Potential Decrease in Hospitalization Events, Time Between Events, and Increasing Longevity in Patients With Symptomatic Heart Failure (0954-948)

Heart Failure
AstraZeneca

Active, not recruiting

Study to Assess Efficacy and Safety of SZC for the Management of High Potassium in Patients With Symptomatic HFrEF Receiving Spironolactone (REALIZE-K)

Heart Failure With Reduced Ejection Fraction | Hyperkalaemia

United States, Spain, Canada, Brazil, Hungary, Czechia, Ukraine, Poland, United Kingdom
Medtronic Cardiovascular

Active, not recruiting

SMall Annuli Randomized To Evolut™ or SAPIEN™ Trial (SMART)

Aortic Valve Stenosis | Aortic Valve Replacement | Symptomatic Aortic Stenosis

United Kingdom, United States, Netherlands, Canada, Israel, Spain, Finland, Denmark, France, Germany, Switzerland, Italy, Portugal
St. Antonius Hospital
ZonMw: The Netherlands Organisation for Health Research and Development

Enrolling by invitation

Evaluating Edge-to-edge Transcatheter Tricuspid Valve Repair in Patients With Severe Symptomatic Tricuspid Regurgitation (TRACE-NL)

Cardiac Catheterization | Tricuspid Valve Regurgitation, Nonrheumatic | Heart Failure, Right Sided | Valve Regurgitation, Tricuspid

Netherlands
Chelsea Therapeutics

Completed

Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) (Droxi-304) (NOH304)

Neurogenic Orthostatic Hypotension | Primary Autonomic Failure | Dopamine Beta Hydroxylase Deficiency | Non-Diabetic Neuropathy
Pfizer

Terminated

A Study of ARRY-371797 (PF-07265803) in Patients With Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation (REALM-DCM)

Dilated Cardiomyopathy | Lamin A/C Gene Mutation

United States, Spain, Canada, Belgium, Italy, Argentina, Mexico, Netherlands, Norway, United Kingdom
Alere San Diego
Abbott Diagnostics Division; Alere, Inc.

Completed

Acute Kidney Injury Neutrophil Gelatinase-Associated Lipocalin Evaluation of Symptomatic Heart Failure Study (AKINESIS)

Acute Decompensated Heart Failure | Acute Kidney Injury

United States, Spain, Italy, Greece, Ireland, Netherlands, Switzerland
Abbott Medical Devices

Active, not recruiting

Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation (The COAPT Trial) and COAPT CAS (COAPT)

Heart Failure | Mitral Regurgitation | Mitral Valve Regurgitation | Treatment of Functional Mitral Regurgitation in Symptomatic Heart Failure Subjects

United States, Canada
H. Lundbeck A/S

Completed

Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension (RESTORE)

Symptomatic Neurogenic Orthostatic Hypotension

United States
Prairie Education and Research Cooperative
Boston Scientific Corporation; Medtronic; Philips Healthcare

Terminated

HFpEF and Symptomatic Obstructive Iliofemoral Venous Disease Study (PERSUADE)

Heart Failure With Preserved Ejection Fraction | Venous Disease

United States
Theravance Biopharma

Terminated

Phase 3 Clinical Effect Durability of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure (REDWOOD)

Parkinson's Disease (PD) | MSA | Symptomatic Neurogenic Orthostatic Hypotension | Pure Autonomic Failure (PAF)

United States, Spain, United Kingdom, Canada, France, Estonia, Australia, Israel, Denmark, Italy, Poland, New Zealand, Germany, Ukraine, Austria, Bulgaria, Portugal, Hungary, Russian Federation
Theravance Biopharma

Terminated

Phase 3 Open-Label Extension Study of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure (OAK)

Symptomatic Neurogenic Orthostatic Hypotension

United States, Spain, Portugal, United Kingdom, France, Denmark, Ukraine, Israel, Estonia, Poland, Italy, Russian Federation, Australia, Austria, Bulgaria, Canada, Germany, New Zealand
ARCA Biopharma, Inc.
Medtronic

Completed

Genetically Targeted Therapy for the Prevention of Symptomatic Atrial Fibrillation in Patients With Heart Failure (GENETIC-AF)

Current or Recent History of Atrial Fibrillation

United States, Canada, Hungary, Netherlands, Poland, Serbia
Theravance Biopharma

Completed

Clinical Effect of Ampreloxetine (TD-9855) for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure (SEQUOIA)

Symptomatic Neurogenic Orthostatic Hypotension

United States, Spain, Israel, Hungary, Portugal, Australia, Canada, Germany, Russian Federation, Estonia, France, Italy, United Kingdom, Denmark, Poland, New Zealand, Austria, Bulgaria, Ukraine
University of Alberta

Completed

The Need for FibEr Addition in SympTomatic Heart Failure (FEAST-HF)

Heart Failure

Canada
Bispebjerg Hospital
Rigshospitalet, Denmark

Enrolling by invitation

A Registry-based Cluster Randomized Trial to Compare the Effect of Spironolactone vs. Eplerenone on Clinical Outcomes in Patients With Symptomatic Systolic Heart Failure (CROWD-ASPECT)

Systolic Heart Failure

Denmark
Rigshospitalet, Denmark

Completed

Direct HIS-pacing as an Alternative to BiV-pacing in Symptomatic HFrEF Patients With True LBBB (HISalternative)

Left Bundle-Branch Block | Heart Failure With Reduced Ejection Fraction

Denmark
Abbott Medical Devices

Completed

AVJ-514 Japan Trial

Mitral Valve Regurgitation | Mitral Valve Incompetence | Mitral Insufficiency | Functional Mitral Regurgitation | Mitral Stenosis With Insufficiency

Japan
University of Aarhus

Completed

Exploring the Comorbidity Between Mental Disorders and General Medical Conditions (COMO-GMC)

Heart Failure | Stroke | Epilepsy | Pain | Multiple Sclerosis | Hypertension | Diabetes Mellitus | Cancer | Chronic Kidney Diseases | Schizophrenia | Parkinson Disease | Migraine | Inflammatory Bowel Diseases | Anemia | HIV/AIDS | Atrial Fibrillation | Dyslipidemias | Allergy | Osteoporosis | Ischemic Heart Disease | Hearing Disorders | Substance... and other conditions
Medtronic Cardiac Rhythm and Heart Failure
Medtronic Atrial Fibrillation Solutions

Completed

Catheter Cryoablation Versus Antiarrhythmic Drug as First-Line Therapy of Paroxysmal Atrial Fibrillation

Symptomatic Paroxysmal Atrial Fibrillation Without Clinically Significant Heart Diseases

Netherlands, Australia, France, Norway, Germany, Croatia, Italy, Argentina, Belgium
Elpen Pharmaceutical Co. Inc.

Withdrawn

Clinical Study to Evaluate the Predictive Value of the Heart Failure Questionnaire (HF-Q) for the Occurrence of Μajor Αdverse Cardiovascular Events (MACE) in Patients With Symptomatic Heart Failure (THETIS)

Heart Failure | Heart Failure NYHA Class II | Heart Failure NYHA Class III | Heart Failure NYHA Class IV
Columbia University

Completed

Study of the Effect of Intradialytic Vasopressin on Chronic Hypertension in Patients With End Stage Renal Disease

Hypertension | End Stage Renal Disease

United States
Martini Hospital Groningen
Baxter Healthcare Corporation; Roche BV Netherlands

Terminated

Peritoneal Dialysis in Congestive Heart Failure (PDinCHF)

Congestive Heart Failure

Netherlands
Abbott Medical Devices

Completed

Atrial Fibrillation Management in Congestive Heart Failure With Ablation (AMICA)

Heart Failure | Persistent Atrial Fibrillation | ICD

Germany, Hungary, Spain
Medtronic Atrial Fibrillation Solutions
Medtronic

Completed

FIRE AND ICE: Comparative Study of Two Ablation Procedures in Patients With Atrial Fibrillation

Symptomatic Paroxysmal Atrial Fibrillation (PAF)

Germany, Czechia, France, Hungary, Italy, Netherlands, Spain, Switzerland
Gilead Sciences

Terminated

Effect of Eleclazine (GS-6615) on Exercise Capacity in Subjects With Symptomatic Hypertrophic Cardiomyopathy (LIBERTY-HCM)

Hypertrophic Cardiomyopathy

Australia, United States, Netherlands, Israel, Italy, France, Germany, United Kingdom
University Hospital, Rouen

Unknown

Prospective Randomized Trial Comparing TRIPLE Site ventriculAr Stimulation Versus Conventional Pacing in CRT canDidates (TRIPLEAD)

Cardiac Resynchronization Therapy

France
Biosense Webster, Inc.

Completed

THERMOCOOL® SMARTTOUCH™ Catheter for the Treatment of Symptomatic Paroxysmal Atrial Fibrillation CONTINUED ACCESS

Drug Refractory Symptomatic Paroxysmal Atrial Fibrillation

United States
Amgen

Completed

Subcutaneous (SC) Darbepoetin Alfa in Subjects With Symptomatic Congestive Heart Failure (CHF) & Anemia

Anemia | Congestive Heart Failure
Novartis

Completed

Efficacy and Safety of Valsartan Versus Placebo on Exercise Tolerance in Patients With Heart Failure

Diastolic Dysfunction, Symptomatic Heart Failure

Switzerland, Germany
Medtronic Cardiac Rhythm and Heart Failure

Completed

Usability Study to Assess the Reveal LINQ Insertable Cardiac Monitor System

Syncope | Recurrent Symptomatic Atrial Fibrillation

Netherlands, Australia, United Kingdom, Belgium, Austria, Russian Federation, Slovakia
Chelsea Therapeutics

Terminated

A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy

Parkinson's Disease | Pure Autonomic Failure | Dopamine Beta Hydroxylase Deficiency | Symptomatic Neurogenic Orthostatic Hypotension | Multiple Systems Atrophy

United States
Gruppo di Ricerca GISSI

Completed

GISSI-HF- Effects of n-3 PUFA and Rosuvastatin on Mortality-Morbidity of Patients With Symptomatic CHF

Heart Failure

Italy, Switzerland
Meir Medical Center

Unknown

Bilevel Positive Pressure Ventilation (BIPAP)in Patients With Sleep Disorders Breathing (SDB)and Congestive Heart Failure (CHF):Comparison of Two Diagnostic Methods

Symptomatic Congestive Heart Failure

Israel
Biotronik AG

Completed

Self Expanding Nitinol Stent Versus Percutaneous Transluminal Arterial Angioplasty (PTA) With Optional Bailout Stenting in Case of PTA Failure in Patients With Symptomatic Critical Limb Ischemia or Severe Intermittent Claudication (EXPAND) (EXPAND)

Severe Intermittent Claudication | Patients With Symptomatic Critical Limb Ischemia

Germany
Medtronic Cardiac Rhythm and Heart Failure
Medtronic Bakken Research Center

Completed

Study of Continuous Cardiac Monitoring to Assess Atrial Fibrillation After Cryptogenic Stroke (CRYSTAL-AF)

Cryptogenic Symptomatic Transient Ischemic Attack | Cryptogenic Ischemic Stroke

Netherlands, United States, France, Belgium, Germany, Sweden, Italy, Austria, Canada, Denmark, Finland, Greece, Slovakia, Spain
Acorda Therapeutics

Completed

Single Ascending Doses of GGF2 in Patients With Left Ventricular Dysfunction and Symptomatic Heart Failure (GGF2-1101-1)

Heart Failure

United States
Chelsea Therapeutics
Chiltern International Inc.

Completed

Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) (NOH302)

Primary Autonomic Failure | Dopamine Beta Hydroxylase Deficiency | Symptomatic Neurogenic Orthostatic Hypotension (NOH) | Non-diabetic Neuropathy

United States, Australia, Canada, New Zealand
Chelsea Therapeutics
Chiltern International Inc.

Completed

A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using Droxidopa (NOH301)

Primary Autonomic Failure | Dopamine Beta Hydroxylase Deficiency | Symptomatic Neurogenic Orthostatic Hypotension (NOH) | Non-diabetic Neuropathy

United States, Canada
Cumberland Pharmaceuticals

Terminated

Safety and Efficacy of Conivaptan in Hyponatremic Patients With Symptomatic Acute Decompensated Heart Failure (ADHF) (CONVERT-H)

Acute Decompensated Heart Failure | Hyponatremia

India

Search clinical trials for: symptomatic heart failure

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