Search clinical trials for: telomerase

Total 70 results

Centre Hospitalier Universitaire de Besancon
GERCOR - Multidisciplinary Oncology Cooperative Group; PRODIGE

Recruiting

Evaluation of the Interest to Combine a CD4 Th1-inducer Cancer Vaccine Derived From Telomerase and Atezolizumab Plus Bevacizumab in Unresectable Hepatocellular Carcinoma (TERTIO)

Hepatocellular Carcinoma

France
NRG Oncology
National Cancer Institute (NCI)

Recruiting

Testing the Addition of the Anti-cancer Viral Therapy Telomelysin™ to Chemoradiation for Patients With Advanced Esophageal Cancer and Are Not Candidates for Surgery

Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Unresectable Gastroesophageal Junction Adenocarcinoma | Postneoadjuvant Therapy Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Postneoadjuvant Therapy Stage IIIA Gastroesophageal Junction Adenocarcinoma... and other conditions

United States
Hillel Yaffe Medical Center

Recruiting

The Impact of Lifestyle on Sperm Telomere Length and Telomerase Activity in Men Undergoing IVF Treatments

Male Infertility

Israel
Centre Hospitalier Universitaire de Besancon

Recruiting

Interest of Anti-telomerase T CD4 Immune Responses for Predicting the Effectiveness of Immunotherapies Targeting PD1 / PDL1 (ITHER)

Cancer

France
Cumhuriyet University

Completed

Measuring Various Variables in Obstructive Sleep Apnea (OUAS)

Obstructive Sleep Apnea-hypopnea Syndrome

Turkey
Centre Hospitalier Universitaire de Besancon

Active, not recruiting

Anticancer Therapeutic Vaccination Using Telomerase-derived Universal Cancer Peptides in Glioblastoma (UCPVax-Glio)

Glioblastoma

France
Centre Hospitalier Universitaire de Besancon

Completed

Study of Anti-telomerase T CD4 Immunity in Metastatic Lung Cancer (Telocap02)

Lung Cancer

France
Centre Hospitalier Universitaire de Besancon
Invectys

Active, not recruiting

Universal Cancer Peptide-based Vaccination in Metastatic NSCLC (UCPVax)

Metastatic Non-small Cell Lung Cancer

France
Centre Hospitalier Universitaire de Besancon
Roche Pharma AG; National Cancer Institute, France

Active, not recruiting

Combination of UCPVax Vaccine and Atezolizumab for the Treatment of Human Papillomavirus Positive Cancers (VolATIL) (VolATIL)

Cervical Cancer | Squamous Cell Carcinoma of the Head and Neck | Anal Canal Cancer

France
Peking University

Completed

Targeting Aging and Promoting Longevity With Exogenous Nucleotides (TALENTs)

Aging

China
SF Research Institute, Inc.
Ixoreal Biomed Inc.

Active, not recruiting

Prospective, Multi Centric, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of KSM-66 Ashwagandha (Withania Somnifera) in Adults Experiencing High Stress and/or Anxiety

Stress | Anxiety

United States
IVI Madrid

Completed

Effects of Telomerase Reactivation With Danazol in Ovarian Function.

Ovarian Reserve

Spain
University of California, San Francisco

Completed

Fitness, Cellular Aging, and Caregiver Stress Study (FAST)

Stress | Aging | Disease Risk

United States
University Hospital, Strasbourg, France

Completed

Mindfulness-based Stress Reduction (MBSR) Program Combined With Endurance Exercise Training: a Help in Treatment for Breast Cancer (MBSR)

Breast Cancer

France
Abinopharm, Inc
ProRelix Services LLP

Completed

To Evaluate the Efficacy and Safety of NMN as an Anti-ageing Supplement in Middle Aged and Older (40-65 Years) Adults

Aging

India
National Research Center for Preventive Medicine

Completed

Comparative Effects of Moxonidine on Bone Metabolism, Vascular and Cellular Aging in Hypertensive Postmenopausal Women (COMPASS)

Osteopenia | Arterial Hypertension

Russian Federation
University of California, San Francisco

Completed

Health Enhancement And Resilience Training (HEART)

Stress | Aging | Well-being

United States
Abramson Cancer Center of the University of Pennsylvania

Completed

Initial Evaluation of a Telomerase-based Circulating Tumor Cell Assay in Bladder Cancer Cohorts

Urothelial Carcinoma of the Bladder

United States
Ohio University

Completed

Impact of Lifestyle Changes on Telomeric Activity in Patients With Chronic Pain

Chronic Pain

United States
University Hospitals, Leicester

Terminated

Genetic and Telomere Characteristics of High of Grade Soft Tissue Sarcomas

Soft Tissue Sarcoma

United Kingdom
Laboratoires Leurquin Mediolanum
Universita degli Studi di Genova

Completed

A Phase II Randomised Trial of Three Regimens of GX301 Vaccination in Castration-resistant Prostate Cancer

Prostate Cancer

Spain, Italy
Invectys
M.D. Anderson Cancer Center

Terminated

DNA Plasmid Encoding a Modified Human Telomerase Reverse Transcriptase (hTERT), Invac-1 in Chronic Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic, B-Cell

United States
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Telomere Repair Gene Mutation in Inflammatory Bowel Disease

Inflammatory Bowel Disease

United States
Guangzhou First People's Hospital

Unknown

To Explore the Effect of GH on Outcomes of IVF and Telomerase Activity of Granulosa Cells in Women With POR

GH | Poor Ovarian Reserve Based on POSEIDON
Abramson Cancer Center of the University of Pennsylvania
National Cancer Institute (NCI)

Completed

Vaccine Plus Montanide ISA-51 and Sargramostim in Treating Patients With Stage IV Breast Cancer

Breast Cancer

United States
Libella Gene Therapeutics

Unknown

Evaluation of Safety and Tolerability of Libella Gene Therapy for the Treatment of Aging: AAV- hTERT

Aging

Colombia
Mansoura University

Completed

The Potential Role Of MicroRNA-155 And Telomerase Reverse Transcriptase In Diagnosis Of Non-Muscle Invasive Bladder Cancer And Their Pathological Correlation

Bladder Cancer | Bladder Disease | Bladder Neoplasm | Micro-RNA

Egypt
Libella Gene Therapeutics

Unknown

Evaluation of Safety and Tolerability of Libella Gene Therapy for Alzheimer's Disease: AAV- hTERT

Alzheimer Disease

Colombia
Libella Gene Therapeutics

Unknown

Evaluation of Safety and Tolerability of Libella Gene Therapy for Critical Limb Ischemia: AAV- hTERT

Critical Limb Ischemia

Colombia
Chippewa Valley Eye Clinic
TA-Sciences

Completed

Telomerase Activator and Retinal Amyloid

Alzheimer Disease

United States
Syneos Health
Oncolys BioPharma Inc

Unknown

Evaluate Efficacy, Immunological Response of Intratumoral/Intralesional Oncolytic Virus (OBP-301) in Metastatic Melanoma

Melanoma Stage Iv | Melanoma Stage III

United States
Inovio Pharmaceuticals
Mayo Clinic; University of Pennsylvania; University of Pittsburgh; Thomas Jefferson... and other collaborators

Completed

hTERT Immunotherapy Alone or in Combination With IL-12 DNA Followed by Electroporation in Adults With Solid Tumors at High Risk of Relapse (TRT-001)

Breast Cancer | Head and Neck Cancer | Gastric Cancer | Pancreatic Cancer | Esophageal Cancer | Ovarian Cancer | Lung Cancer | ColoRectal Cancer | HepatoCellular Carcinoma

United States
University of Connecticut

Completed

Effects of TA-65, a Telomerase Activator on Metabolic Syndrome

Metabolic Syndrome X

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Terminated

Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors

Glioblastoma | Gliosarcoma | Ependymoma | Anaplastic Astrocytoma | Oligodendroglioma | Anaplastic Ependymoma | Giant Cell Glioblastoma | Astrocytoma, Grade II | Brainstem Tumors

United States
Providence Health & Services
Providence Cancer Center, Earle A. Chiles Research Institute; Robert W. Franz...

Completed

Immunochemoradiotherapy in Patients With Pancreatic Cancer

Locally Advanced Pancreatic Adenocarcinoma

United States
Groupe d'Etudes et de Recherche sur les Maladies...
Bichat Hospital

Completed

Pulmonary Fibrosis and Telomerase Mutation Study

Pulmonary Fibrosis

France
Queen Mary University of London
Barts & The London NHS Trust

Completed

Telomere Biology and AKI in Cardiac Surgery

Coronary Artery Disease | Heart Valve Diseases | Acute Kidney Injury

United Kingdom
Linkoeping University
Karolinska Institutet; Uppsala University; Umeå University; Stockholm University

Unknown

Brain Plasticity and Cellular Aging After Internet-delivered CBT for Social Anxiety Disorder (UMEII)

Anxiety Disorders | Social Anxiety Disorder

Sweden
University of Kansas Medical Center

Withdrawn

Telomere and Telomerase

Acute Myeloid Leukemia

United States
Istanbul University

Completed

Assessment of Telomerase Activity in Endometrial Tissue and Serum in Endometriosis Patients

Infertility, Female | Endometriosis Ovaries

Turkey
University of Pennsylvania

Completed

Multipeptide Vaccine for Advanced Breast Cancer

Breast Cancer | Breast Neoplasm | Carcinoma, Ductal | Cancer of the Breast

United States
Third Military Medical University

Unknown

Par-4 and Telomere-telomerase System in Type 2 Diabetes Patients Who Received GLP-1 or Metformin Treatment (Par-4；GLP-1)

GLP-1；Metformin；Telomere-telomerase System；Par-4

China
Centre Hospitalier Universitaire de Besancon

Unknown

Study of Anti-telomerase T CD4 Immunity in Melanoma (LyTéloMel)

Melanoma

France
Telomerase Activation Sciences, Inc

Unknown

Effect of TA-65MD on Healthy Volunteers (TA-65MD)

Healthy

United States
The University of Hong Kong

Completed

Qigong Intervention Program for Abused Chinese Women

Abused Women

China
Geron Corporation

Completed

Open Label Study With Imetelstat to Determine Effect of Imetelstat in Patients w/ Previously Treated Multiple Myeloma

Multiple Myeloma

United States
Geron Corporation

Completed

Open Label Study to Evaluate the Activity of Imetelstat in Patients With Essential Thrombocythemia or Polycythemia Vera (ET/PV)

Polycythemia Vera | Essential Thrombocythemia

United States, Germany, Switzerland
Geron Corporation

Completed

Imetelstat as Maintenance Therapy After Initial Induction Chemotherapy in Non-small Cell Lung Cancer (NSCLC)

Non-small Cell Lung Cancer

United States, Canada, Germany
Geron Corporation

Completed

Imetelstat in Combination With Paclitaxel (With or Without Bevacizumab) in Patients With Locally Recurrent or Metastatic Breast Cancer

Locally Recurrent or Metastatic Breast Cancer

United States, Canada
Medivation, Inc.

Completed

Safety, Tolerability and Efficacy Study of the Monoclonal Antibody, CT-011, in Patients With Metastatic Melanoma

Melanoma | Malignant Melanoma

United States, Israel

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