Mindfulness-based Stress Reduction (MBSR) Program Combined With Endurance Exercise Training: a Help in Treatment for Breast Cancer (MBSR)
December 12, 2025 updated by: University Hospital, Strasbourg, France
Effect of a Mindfulness-based Stress Reduction (MBSR) Program Combined With Endurance Exercise Training: a Help to Improve Exercise Capacity and Quality of Life in Breast Cancer
Integrative approaches to promote wellness and reduce the distress associated with cancer are considered as essential components of cancer care.
In case, exercise training has been shown to produce many positive physiological and psychological benefits.
Mindfulness-based stress reduction program shows similar beneficial effects, and especially in emotional distress management.
The aim of the study is to examine the cumulative effect of an 8 week-exercise-training program combined with an MBSR program on cardio-respiratory fitness and quality of life in women with breast cancer.
These effects are thought to be mediated in part through changes in underlying brain processes, that investigators will be put in light.
Through telomerase activity, oxidative stress, mitochondrial respiration and blood cytokine level measurements, investigators could expect to better understand the effect of these combined training in breast cancer.
Study Overview
Status
Completed
Conditions
Study Type
Interventional
Enrollment (Actual)
100
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
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Strasbourg, France, 67091
- Physiologie et EFR/ EA 3072 mitochondrie, stress oxydant et protection musculaire
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 65 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Description
Inclusion Criteria:
- Breast cancer
- Having completed the chemotherapy period
- Undergoing radiotherapy and/or hormono therapy
Exclusion Criteria:
- Regular physical activity higher than 4 hours per week.
- Any disease cardiac, respiratory, neurological or articular disease, which counteract the muscular training )
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Supportive Care
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Placebo Comparator: Control patients with no intervention
group without intervention
|
|
|
Experimental: Endurance training program (8 weeks) group
only physical training group
|
In each group, there will be a comparison of aerobic capacity, quality of life (with questionnaires), functional cerebral measurements (fRMI), and telomerase activity between before and after the 8 weeks program
|
|
Experimental: MBSR group (mindfulness-based-stress-reduction)
only mental training group (8 weeks)
|
|
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Experimental: Endurance training program combined with MBSR sessions
Endurance training program combined with MBSR sessions, during 8 weeks (mindfulness-based-stress-reduction)
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Evolution of V02 max between inclusion and 8 weeks
Time Frame: 8 weeks
|
effect of physical training associated with mental work on physical abilities of patients
|
8 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Investigators
- Principal Investigator: LONSDORFER Evelyne, Hôpitaux universitaires de Strasbourg
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
May 12, 2015
Primary Completion (Actual)
May 12, 2015
Study Completion (Actual)
March 30, 2021
Study Registration Dates
First Submitted
June 16, 2015
First Submitted That Met QC Criteria
September 13, 2016
First Posted (Estimated)
September 14, 2016
Study Record Updates
Last Update Posted (Estimated)
December 19, 2025
Last Update Submitted That Met QC Criteria
December 12, 2025
Last Verified
December 1, 2025
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Neoplasms by Site
- Neoplasms
- Skin Diseases
- Breast Diseases
- Skin and Connective Tissue Diseases
- Breast Neoplasms
- Health Care Quality, Access, and Evaluation
- Investigative Techniques
- Epidemiologic Methods
- Data Collection
- Health Care Evaluation Mechanisms
- Quality of Health Care
- Public Health
- Environment and Public Health
- Behavior Therapy
- Psychotherapy
- Behavioral Disciplines and Activities
- Cognitive Behavioral Therapy
- Health Status
- Demography
- Epidemiologic Measurements
- Surveys and Questionnaires
- Quality of Life
- Mindfulness
Other Study ID Numbers
- 5970
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.