Search clinical trials for: unfit for intensive chemotherapy

Total 366280 results

Centre Leon Berard
NETRIS Pharma

Recruiting

Acute Myeloid Leukemia Treated With With NETrin Abs in Combination With [AZACITIDINE + VENETOCLAX] (AML-NET)

Acute Myeloid Leukemia Refractory

France
Shanghai Jiao Tong University School of Medicine

Not yet recruiting

A Phase 2 Study of Venetoclax in Combination With Low-dose HHT, G-CSF, and AZA as First-line Treatment for Newly Diagnosed Elderly AML Patients Unfit for Intensive Chemotherapy

Leukemia, Myeloid, Acute
Gruppo Italiano Malattie EMatologiche dell'Adulto

Recruiting

Trial in AML Secondary to MPNs Patients, Unfit for Intensive Chemotherapy, Investigating a Treatment Combination Including Decitabine and Venetoclax (ENABLE)

Acute Myeloid Leukemia

Italy
Chinese PLA General Hospital

Unknown

Combined Inhibition of PD-1 and DNA Hypomethylating Agent +/- Chemotherapy in High-risk AML or Elderly Patients With AML Who Are Unfit for Intensive Chemotherapy

Acute Myeloid Leukemia, in Relapsed or Refractory | Acute Myeloid Leukemia, Elderly, Unfit | Acute Myeloid Leukemia With Positive Minimal Residual Disease

China
Milton S. Hershey Medical Center
Pfizer

Terminated

Avelumab With Decitabine as First Line for AML Treatment of Patients With AML, Who Are Unfit for Intensive Chemotherapy

Acute Myeloid Leukemia

United States
University of Ulm
German Federal Ministry of Education and Research

Completed

Study of Low-Dose Cytarabine and Etoposide With or Without All-Trans Retinoic Acid in Older Patients Not Eligible for Intensive Chemotherapy With Acute Myeloid Leukemia and NPM1 Mutation

Acute Myeloid Leukemia (AML)

Germany
Ulsan University Hospital
The Korean Society of Hematology, AML/MDS Working Party

Unknown

Decitabine for Chemotherapy Unfit Korean AML Patients in Real Practice (PURPLE-D)

Acute Myeloid Leukemia | Elderly | Intensive Chemotherapy Unfit

Korea, Republic of
Stemline Therapeutics, Inc.

Not yet recruiting

A Study of Tagraxofusp in Combination With Venetoclax and Azacitidine in Adults With Untreated CD123+ Acute Myeloid Leukemia Who Cannot Undergo Intensive Chemotherapy

Acute Myeloid Leukemia

United States
University of Leeds
The Leeds Teaching Hospitals NHS Trust

Not yet recruiting

PROSpECT-PRIOR-2-CHEMO: PRIOR Dental Intervention Before Chemo to Reduce Chemotherapy Complications

Periodontitis | Febrile Neutropenia | Oncology | Myeloma | Oral Mucositis

United Kingdom
Peking University Cancer Hospital & Institute

Not yet recruiting

Neoadjuvant Fruquintinib Plus Tislelizumab Combined With mCapeOX Versus CapeOX for Mid-high pMMR/MSS Locally Advanced Rectal Cancer (PKUCH-R09)

Rectal Cancer

China
Nantes University Hospital
Institut National de la Santé Et de la Recherche Médicale, France

Not yet recruiting

Biological, Prospective Study Evaluating the Dosage of Plasma Cytokines Including the FLT3 Ligand and IL6 of Patients Treated With Non-intensive Chemotherapy (CYTOK-AZA)

Acute Myeloid Leukemia | Myelodysplastic Syndromes | Chronic Myelomonocytic Leukemia

France
Institute of Hematology & Blood Diseases Hospital...

Not yet recruiting

Efficacy and Safety of Low-dose Chemotherapy Plus Immuno-targeted Drugs in Newly Diagnosed Elderly/Unfit Ph- B-ALL

Precursor Cell Lymphoblastic Leukemia-Lymphoma
French Innovative Leukemia Organisation
Acute Leukemia French Association

Not yet recruiting

Results From a French Temporary Utilization Authorization of First-line Acute Myeloid Leukemia (AML) Patients Ineligible for Intensive Chemotherapy (IC), Treated With Venetoclax Azacitidine (VENAZA)

AML, Adult

France
Syndax Pharmaceuticals

Recruiting

A Study of SNDX-5613 in Combination With Intensive Chemotherapy in Participants With Acute Myeloid Leukemias

Acute Myeloid Leukemias

United States
AbbVie

Recruiting

A Study to Asses Effectiveness and Treatment Management of Oral Venetoclax Tablets + Subcutaneously Injected Azacitidine in Adult Participants Ineligible for Intensive Chemotherapy With de Novo Acute Myeloid Leukemia (AML) in Italy (VERO)

Acute Myeloid Leukemia

Italy
Servier Affaires Médicales

Recruiting

An Open-label Phase 3b Study of Ivosidenib in Combination With Azacitidine in Adult Patients Newly Diagnosed With IDH1m Acute Myeloid Leukemia (AML) Ineligible for Intensive Induction Chemotherapy.

Acute Myeloid Leukemia (AML)

Netherlands, Italy, Austria, France
Technische Universität Dresden
AbbVie; University Hospital Heidelberg

Not yet recruiting

Venetoclax Plus Azacitidine Versus Intensive Chemotherapy for Fit Patients With Newly Diagnosed NPM1 Mutated AML (VINCENT)

Acute Myeloid Leukemia

Germany
University of Florida

Not yet recruiting

Trial of Cladribine and Low-Dose Cytarabine (LoDAC) Alternating With Decitabine vs. Hypomethylating Agents (HMA) Plus Venetoclax as Frontline Therapy for AML or High-Grade MDS in Patients Unfit for Intensive Induction

Acute Myeloid Leukemia | Myelodysplastic Syndromes
European Institute of Oncology

Recruiting

Metronomic Temozolomide in Unfit NENs Patients Metronomic Temozolomide in Unfit Patients With Advanced Neuroendocrine Neoplasms (NENs): MeTe Study (MeTe)

Frailty | Neuroendocrine Tumors | Chemotherapy Effect

Italy
Seoul National University Hospital

Recruiting

Platform Study of Circulating Tumor DNA Directed Adjuvant Chemotherapy in Colon Cancer (KCSG CO22-12) (CLAUDIA)

Colon Cancer

Korea, Republic of
AbbVie

Recruiting

A Study to Assess Change in Disease State in Adult Participants With Acute Myeloid Leukemia (AML) Ineligible for Intensive Chemotherapy Receiving Oral Venetoclax Tablets in Canada (LIVEN)

Acute Myeloid Leukemia

Canada
Institute of Hematology & Blood Diseases Hospital

Not yet recruiting

Intensive Therapy Combined With Venetoclax for Adult Acute Myeloid Leukemia

Acute Myeloid Leukemia
Ioannis Mantzaris
AbbVie

Recruiting

Venetoclax Plus Intensive Chemotherapy in AML and Advanced MDS

Acute Myeloid Leukemia | Myelodysplastic Syndromes

United States
Dr. Frank Behrens
Johann Wolfgang Goethe University Hospital

Recruiting

Prevention of Paclitaxel-induced Neuropathic Pain in Patients With Planned Paclitaxel Chemotherapy (PrevTel) (PrevTel)

Neuropathic Pain | Chemotherapy Effect

Germany
AbbVie

Recruiting

A Study to Assess Change in Disease State in Adult Participants With Acute Myeloid Leukemia (AML) Ineligible for Intensive Chemotherapy Receiving Oral Venetoclax Tablets in Greece (SURVIVE)

Acute Myeloid Leukemia

Greece
Centre Hospitalier Universitaire de Nice
Jazz Pharmaceuticals; Acute Leukemia French Association

Recruiting

CPX-351 vs Intensive Chemotherapy in Patients With de Novo Intermediate or Adverse Risk AML Stratified by Genomics (ALFA2101)

Acute Myeloid Leukemia

France
Centre Hospitalier Universitaire de Saint Etienne
Institut de Cancérologie de la Loire

Recruiting

Administration of Fibrinogen Concentrate for Refractory Bleeding (FORMAT)

Bleeding | Platelet Refractoriness | Hematological Patients

France
First Affiliated Hospital Xi'an Jiaotong University

Recruiting

A Study of Dasatinib Plus Reduced Intensive Consolidation Chemotherapy in Ph+ Adult ALL

Precursor Cell Lymphoblastic Leukemia-Lymphoma | ALL, Adult | Philadelphia-Positive Acute Lymphoblastic Leukemia

China
University of Chicago

Not yet recruiting

Study Comparing Standard of Care Chemotherapy With/ Without Sequential Cytoreductive Surgery for Patients With Metastatic Foregut Cancer and Undetectable Circulating Tumor-Deoxyribose Nucleic Acid Levels

Lung Cancer | Gastric Adenocarcinoma | Metastatic Cancer | Liver Cancer | GI Cancer | Foregut Carcinoid Tumor | Gallbladder Adenocarcinoma | GI Carcinoma
University Hospital, Angers

Recruiting

Physical Fitness Impact of Early Physiotherapy Intervention With a Standardized Exercise Therapy Program in Adult Patients Receiving Intensive Induction Chemotherapy for Treatment of Acute Leukemia During Extended Hospitalization. (KinHémo)

Acute Leukemia

France
Ruijin Hospital

Recruiting

Azacitidine Combined With Chidamide in the Treatment of Newly Diagnosed PTCL Unfit for Conventional Chemotherapy

Peripheral T-cell Lymphoma

China
University of Missouri-Columbia

Recruiting

Testing Less Intensive Radiation With Chemotherapy to Treat Low-risk Patients With HPV-positive Oropharyngeal Cancer (ENID)

Oropharynx Cancer | HPV Positive Oropharyngeal Squamous Cell Carcinoma | Cancer of the Head and Neck | Throat Carcinoma

United States
Institut für Klinische Krebsforschung IKF GmbH...
AstraZeneca; Thoraxklinik-Heidelberg gGmbH

Recruiting

Thoracic Radiotherapy Plus Durvalumab in Elderly and/or Frail NSCLC Stage III Patients Unfit for Chemotherapy (TRADE-hypo)

NSCLC, Stage III

Germany
National Cancer Institute (NCI)

Recruiting

BLAST MRD AML-1: BLockade of PD-1 Added to Standard Therapy to Target Measurable Residual Disease in Acute Myeloid Leukemia 1- A Randomized Phase 2 Study of Anti-PD-1 Pembrolizumab in Combination With Intensive Chemotherapy as Frontline Therapy in Patients With Acute Myeloid Leukemia

Acute Myeloid Leukemia | Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Secondary Acute Myeloid Leukemia | Acute Myeloid Leukemia Post Cytotoxic Therapy

United States
Centre hospitalier de l'Université de Montréal...
M.D. Anderson Cancer Center; Lawson Health Research Institute; Jewish General...

Recruiting

Stereotactic Boost and Short-course Radiation Therapy for Oropharynx Cancer (SHORT-OPC)

Head and Neck Cancer | Oropharynx Cancer | Human Papilloma Virus

Canada
Rambam Health Care Campus

Not yet recruiting

Study to Assess Length of Remission With Intensive Chemotherapy in Rapidly Responding AML Patients. (AML)

Acute Myeloid Leukemia
University of Ulm
Jazz Pharmaceuticals

Recruiting

Study of Standard Intensive Chemotherapy Versus Intensive Chemotherapy With CPX-351 in Adult Patients With Newly Diagnosed AML and Intermediate- or Adverse Genetics

Acute Myeloid Leukemia

Austria, Germany
Stichting Hemato-Oncologie voor Volwassenen Nederland
Deutsch-Österreichische Studiengruppe Akute Myeloische Leukämie (AMLSG)

Recruiting

A Study of Ivosidenib or Enasidenib in Combination With Induction Therapy and Consolidation Therapy, Followed by Maintenance Therapy in Patients With Newly Diagnosed Acute Myeloid Leukemia or Myedysplastic Syndrome EB2, With an IDH1 or IDH2 Mutation, Respectively, Eligible for Intensive Chemotherapy (HOVON150AML)

Acute Myeloid Leukemia | Myelodysplastic Syndrome With Excess Blasts-2

Australia, Austria, Belgium, Estonia, Finland, France, Germany, Ireland, Lithuania, Luxembourg, Netherlands, Norway, Spain, Sweden, Switzerland
Karen-Lise Garm Spindler

Recruiting

IMPROVE Intervention Trial Implementing Non-invasive Circulating Tumor DNA Analysis to Optimize the Operative and Postoperative Treatment for Patients With Colorectal Cancer (IMPROVE-IT)

Colorectal Cancer | Adjuvant Chemotherapy | Circulating Tumor DNA | Progression Free Survival

Denmark
Dana-Farber Cancer Institute
AbbVie; Genentech, Inc.

Recruiting

Venetoclax in Combination With Intensive Induction and Consolidation Chemotherapy in Treatment Naïve AML

Acute Myeloid Leukemia

United States
Technische Universität Dresden
German Cancer Research Center; National Center for Tumor Diseases, Heidelberg; Radiation Oncology Working Group of the German Cancer Society and other collaborators

Recruiting

De-escalation of Adjuvant Radio (Chemo) Therapy for HPV-positive Head-neck Squamous Cell Carcinomas (DELPHI)

Head-and-neck Squamous Cell Carcinoma

Germany
University Health Network, Toronto

Recruiting

A Study of Avelumab in Penile Cancer Who Are Unfit for or Have Progressed After Platinum-Based Chemotherapy

Metastatic Cancer | Advanced Cancer | Penile Cancer

Canada
Tao OUYANG

Recruiting

Research of Intensive Treatment in Hormone Receptor<10% and Human Epidermal Growth Factor Receptor-2 Negative Breast Cancer Patients With Positive Lymph Node Residual Disease After Neoadjuvant Chemotherapy

Primary Breast Cancer

China
AbbVie
Genentech, Inc.

Active, not recruiting

Study to Assess Adverse Events and Change in Disease State of Oral Venetoclax in Combination With Subcutaneous (SC) Azacitidine in Newly Diagnosed Adult Participants With Acute Myeloid Leukemia (AML) Who Are Ineligible for Intensive Chemotherapy in China

Acute Myeloid Leukemia (AML)

China
National Cancer Institute (NCI)

Suspended

Daunorubicin and Cytarabine With or Without Uproleselan in Treating Older Adult Patients With Acute Myeloid Leukemia Receiving Intensive Induction Chemotherapy

Acute Myeloid Leukemia

United States
Rush University Medical Center

Completed

Aprepitant- and Olanzapine- Containing Anti-emetic Regimens With High Dose Melphalan

Nausea | Vomiting

United States
Parth Patel
Children's of Alabama

Active, not recruiting

HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors

Medulloblastoma | Central Nervous System Embryonal Tumors

United States, New Zealand, Canada
Pfizer
Biomedical Advanced Research and Development Authority; Innovative Medicines...

Completed

A Study to Determine the Efficacy, Safety and Tolerability of Aztreonam-Avibactam (ATM-AVI) ± Metronidazole (MTZ) Versus Meropenem (MER) ± Colistin (COL) for the Treatment of Serious Infections Due to Gram Negative Bacteria. (REVISIT)

Ventilator Associated Pneumonia | Complicated Intra-abdominal Infection | Hosptial Acquired Pneumonia

Spain, China, Korea, Republic of, Philippines, United States, Romania, Taiwan, Italy, Malaysia, Mexico, India, Israel, Turkey, Greece, Thailand, Czechia, Croatia, Argentina, Russian Federation, Bulgaria, Ukraine
Novartis Pharmaceuticals

Active, not recruiting

A Study of MBG453 in Combination With Azacitidine and Venetoclax in AML Patients Unfit for Chemotherapy (STIMULUS-AML1)

Acute Myeloid Leukemia

Italy, Spain, Canada, Germany, Korea, Republic of, Japan, Australia, France, United States, Taiwan
Novartis Pharmaceuticals

Active, not recruiting

A Study of Siremadlin in Combination With Venetoclax Plus Azacitidine in Adult Participants With Acute Myeloid Leukemia (AML) Who Are Ineligible for Chemotherapy.

Acute Myeloid Leukemia

Italy, Hong Kong, Israel, Hungary, Turkey, Malaysia, United States

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