Search clinical trials for: valproic acid

Total 27858 results

Kafrelsheikh University

Recruiting

Valproate Versus Topiramate in Migraine

Migraine Disorders

Egypt
Haukeland University Hospital

Not yet recruiting

A Study to Investigate Treatment of HU and VPA, or 6-MP and VPA in Unfit AML/HR-MDS Patients (HUVAMER)

Acute Myeloid Leukemia, Adult | Myelodysplastic Syndromes, Adult

Norway
Tanta University

Recruiting

Zolmitriptane as Prophylaxis for Chilhood Migraine

Migraine

Egypt
University of North Carolina, Chapel Hill

Recruiting

Antiseizure Medication in Seizure Networks at Early Acute Brain Injury

Stroke | Brain Ischemia | Brain Injuries, Traumatic | Heart Arrest | Intracranial Hemorrhages | Brain Hypoxia | Coma | Hypoxia-Ischemia, Brain | Persistent Vegetative State | Brain Injuries, Acute

United States
RenJi Hospital

Recruiting

Sodium Valproate in Patients With Acute Ischemic Stroke

Acute Ischemic Stroke

China
Dr. Inge Winter
Universität Münster

Recruiting

The Effect of a Six Week Intensified Pharmacological Treatment for Bipolar Depression Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. (INTENSIFY BD)

Bipolar Depression

Austria, Germany, Italy, Spain, United Kingdom
Xue-chun Lu

Recruiting

Combination Regimen With Sodium Valproate for Severe Hemophilia: a Single-arm, Phase 1, Pilot Trial.

Hemophilia

China
Assiut University

Not yet recruiting

Effect of Adding Lamotrigine to Sodium Valproate in Childhood Epilepsy: Clinicolabratory Study

Epilepsy | Lamotrigine | Sodium Valproate Adverse Reaction
National Cancer Institute, Naples

Recruiting

Valproic Acid/Simvastatin Plus Gemcitabine/Nab-paclitaxel Based Regimens in Untreated Metastatic Pancreatic Adenocarcinoma Patients

Adenocarcinoma of the Pancreas

Italy, Spain
Dr Cipto Mangunkusumo General Hospital

Recruiting

The Benefit and Safety of Older Generation Anti-Epileptic Drugs (AEDs) in Drug-Resistant Epilepsy Children

Drug Resistant Epilepsy

Indonesia
Australasian Gastro-Intestinal Trials Group
Olivia Newton-John Cancer Research Institute

Recruiting

Combining Sodium Valproate With Standard-of-care EGFR (Epidermal Growth Factor Receptor) Monoclonal Antibody Treatment in Patients With Metastatic Colorectal Cancer

Metastatic Colorectal Cancer

Australia
Dr. Inge Winter
Universität Münster

Not yet recruiting

Intensified Pharmacological Treatment for Schizophrenia, Major Depressive Disorder and Bipolar Depression After a First-time Treatment Failure (INTENSIFY)

Bipolar Depression | Major Depressive Disorder | Schizophrenia and Related Disorders

Israel
Prof. Janet Dunn
King's College Hospital NHS Trust; University of Manchester; University of Birmingham and other collaborators

Recruiting

Repurposed Drugs to Improve Haematological Responses in Myelodysplastic Syndromes (REPAIR-MDS)

Myelodysplastic Syndromes (MDS)

United Kingdom
Centre d'Etude des Cellules Souches
Genethon

Recruiting

Efficacy Study of Daily Administration of VPA in Patients Affected by Wolfram Syndrome (AUDIOWOLF)

Wolfram Syndrome

France, Spain
Erasmus Medical Center
Ludwig Institute for Cancer Research; Dutch Cancer Society; Stichting Coolsingel... and other collaborators

Recruiting

MAGE-C2 TCR T Cell Trial to Treat Melanoma and Head and Neck Cancer (MC2TCR)

Melanoma | Head and Neck Cancer | Melanoma, Uveal

Netherlands
National Cancer Institute, Naples

Recruiting

Valproic Acid in Combination With Bevacizumab and Oxaliplatin/Fluoropyrimidine Regimens in Patients With Ras-mutated Metastatic Colorectal Cancer (REVOLUTION)

Ras-mutated Metastatic Colorectal Cancer

Italy
Johns Hopkins University

Recruiting

Ketogenic Diet for New-Onset Absence Epilepsy

Absence Epilepsy | Ketogenic Dieting | Epilepsy, Absence

United States
Virginia Commonwealth University
Puma Biotechnology, Inc.

Recruiting

Neratinib + Valproate in Advanced Solid Tumors, w/Expansion Cohort in Ras-Mutated Ca

Solid Tumor, Adult

United States
University of Leicester

Recruiting

The Val-CARD Trial (Val-CARD)

Coronary Artery Disease | Cardiac Valve Disease | Organ Failure, Multiple

United Kingdom
University of Göttingen
Hannover Medical School; Deutsche Kinderkrebsstiftung

Recruiting

International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013) (HIT-HGG-2013)

Diffuse Intrinsic Pontine Glioma | Gliomatosis Cerebri | Glioblastoma WHO Grade IV | Diffuse Midline Glioma Histone 3 K27M WHO Grade IV | Anaplastic Astrocytoma WHO Grade III

Germany
Assistance Publique - Hôpitaux de Paris

Recruiting

Population Pharmacokinetics of Antiepileptic in Pediatrics (EPIPOP)

Epilepsy

France
Leiden University Medical Center
Erasmus Medical Center; Amsterdam UMC, location VUmc; Medical Center Haaglanden

Recruiting

Seizure Treatment in Glioma (STING)

Glioma

Netherlands
Miller Children's & Women's Hospital Long Beach
Children's Hospital of Orange County

Recruiting

Metronomic Therapy for Pediatric Patients With Solid Tumors at High Risk of Recurrence (Metronomic)

Solid Tumor

United States
Centre Leon Berard

Recruiting

An International Clinical Program for the Diagnosis and Treatment of Children With Ependymoma (SIOP-EP-II)

Childhood Ependymoma

Italy, Denmark, France, Czechia, Sweden, Germany, Slovenia, United Kingdom, Austria, Belgium, Ireland, Netherlands, Norway, Spain, Switzerland
Patrick Stiff

Recruiting

Vidaza and Valproic Acid Post Allogeneic Transplant for High Risk AML and MDS

Myelodysplastic Syndrome MDS | Acute Myelogenous Leukemia AML

United States
National Cancer Institute, Naples

Recruiting

Preoperative Valproic Acid and Radiation Therapy for Rectal Cancer (V-shoRT-R3)

Colorectal Cancer

Italy
M.D. Anderson Cancer Center
Cancer Prevention Research Institute of Texas

Enrolling by invitation

Managing Agitated Delirium With Neuroleptics and Anti-Epileptics as a Neuroleptic Sparing Strategy

Delirium | Epileptics | Neuroleptics

United States
Universidad Autonoma de San Luis Potosí

Completed

Comparative Study Between Valproate and Memantine in the Prophylactic Management of Episodic Migraine.

Migraine Headache

Mexico
Mazandaran University of Medical Sciences

Completed

Levetiracetam Versus Valproate in Idiopathic Generalized Epilepsy (LEVAGE)

Treatment of Idiopathic Generalized Epilepsy

Iran, Islamic Republic of
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease

Castleman Disease | Lymphangioleiomyomatosis | Digestive System Carcinoma | Malignant Neoplasm | Recurrent Breast Carcinoma | Recurrent Thyroid Gland Carcinoma | Metastatic Urothelial Carcinoma | Malignant Female Reproductive System Neoplasm | Neurofibromatosis Type 2 | Recurrent Adult Soft Tissue Sarcoma and other conditions

United States
Sidney Kimmel Cancer Center at Thomas Jefferson...
Pfizer

Active, not recruiting

Sunitinib Malate or Valproic Acid in Preventing Metastasis in Patients With High-Risk Uveal Melanoma

Ciliary Body and Choroid Melanoma, Medium/Large Size | Ciliary Body and Choroid Melanoma, Small Size | Iris Melanoma | Stage IIIA Intraocular Melanoma | Stage IIIB Intraocular Melanoma | Stage IIIC Intraocular Melanoma | Stage I Intraocular Melanoma | Stage IIA Intraocular Melanoma | Stage IIB Intraocular... and other conditions

United States
Cerebral Therapeutics LLC

Terminated

Anti-Epilepsy Medication Valproate Administered Via ICV Route and Catheters and Pumps for CSF Infusion

Focal Epilepsy

Israel, Australia
University of New Mexico
Patient-Centered Outcomes Research Institute; Montana State University; National... and other collaborators

Terminated

Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies

Bipolar Disorder

United States
Mario Negri Institute for Pharmacological Research
Ministry of Health, Italy; Azienda Ospedaliera San Gerardo di Monza

Active, not recruiting

Low vs. Standard Daily Doses of Antiepileptic Drugs in Newly Diagnosed, Previously Untreated Epilepsy(STANDLOW) (STANDLOW)

Epilepsies, Partial

Italy
Children's Hospital Medical Center, Cincinnati
National Institute of Mental Health (NIMH)

Completed

Lithium Versus Divalproex for Treating Pediatric Bipolar Disorder (PBC)

Bipolar Disorder

United States
Desitin Arzneimittel GmbH
BioPharma Services, Inc

Completed

Bioavailability of Orfiril Long 500 mg Prolonged-Release Minitablets and Ergenyl Chrono 500 mg Prolonged-Release Tablets

Multiple Drug Use

Canada
Desitin Arzneimittel GmbH
BioPharma Services, Inc

Completed

Bioavailability and Food Effect of Sodium Valproate Minitablets in Healthy Subjects.

Food-drug Interaction

Canada
Kathmandu University
Asian Pharmaceuticals Pvt. Ltd.

Active, not recruiting

Bioequivalence Study of Sodium Valproate and Valproic Acid Tablets (BA-BE)

Epilepsy

Nepal
AHS Cancer Control Alberta
EMD Serono

Active, not recruiting

Avelumab With Valproic Acid in Virus-associated Cancer (LATENT)

Squamous Cell Carcinoma of the Cervix | Cancer That is Associated With a Chronic Viral Infection | p16 Positive SCCHN | p16 Positive Squamous Cell Carcinoma of the Vagina or Vulva | p16 Positive Squamous Cell Carcinoma of the Penis | p16 Positive Squamous Cell Carcinoma of the Anus or Anal... and other conditions

Canada
Mental Health Services in the Capital Region, Denmark

Completed

Lithium Versus Anticonvulsants and the Risk of Physical Disorders

Bipolar Disorder

Denmark
University of Birmingham

Active, not recruiting

Efficacy and Safety Trial of Sodium Valproate, in Paediatric and Adult Patients With Wolfram Syndrome

Wolfram Syndrome

France, United Kingdom, Poland, Spain
Damanhour University
Mansoura University

Completed

Valproic Acid Use in Patients With Neurological Disorders

Neurological Disorders
Kasr El Aini Hospital

Completed

Sodium Valproate-loaded Nanospanlastics in Patchy Alopecia Areata in Comparison to Topical Steroids

Alopecia Areata

Egypt
University of Utah
Abbott; Leadiant Biosciences, Inc.; Families of Spinal Muscular Atrophy

Completed

Study of Safety and Dosing Effect on SMN Levels of Valproic Acid (VPA) in Patients With Spinal Muscular Atrophy

Spinal Muscular Atrophy

United States
Otsuka Pharmaceutical Development & Commercialization...
Otsuka America Pharmaceutical

Completed

A Study of Aripiprazole (Abilify) in Patients With Bipolar Mania

Bipolar Disorder

United States, South Africa, Brazil, Russian Federation, France, Czechia, Croatia, India, Bulgaria
Virginia Commonwealth University
National Cancer Institute (NCI)

Active, not recruiting

Sorafenib, Valproic Acid, and Sildenafil in Treating Patients With Recurrent High-Grade Glioma

Glioblastoma | Malignant Glioma | WHO Grade III Glioma | Recurrent Adult Brain Neoplasm

United States
University of Miami

Withdrawn

Valproate Alone or in Combination With Quetiapine for Severe COVID-19 Pneumonia With Agitated Delirium

Pneumonia, Viral | Covid19 | Hyperactive Delirium

United States
National Cancer Institute, Naples

Active, not recruiting

Valproic Acid Plus Cisplatin and Cetuximab in Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck (V-CHANCE)

Squamous Cell Carcinoma of the Head and Neck

Italy
Cerebral Therapeutics LLC
Neuroscience Trials Australia

Completed

A Dose Ranging Pilot Study for Intracerebroventricular (ICV) Delivery of Valproate in Subjects With Temporal Seizures

Epilepsy

Australia
Jean-Pierre Routy
Canadian Foundation for AIDS Research (CANFAR); CIHR Canadian HIV Trials Network

Completed

Valproic Acid and Its Effects on HIV Latent Reservoirs

HIV Infections

Canada

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