Učení sociální bezpečnosti v mozkovém oxytocinovém systému
10. června 2026 aktualizováno: Angela Fang, University of Washington
Vyšetřovatelé provádějí tuto výzkumnou studii, aby prozkoumali, zda oxytocin zlepšuje učení sociální bezpečnosti (učení se bezpečnosti prostřednictvím zkušenosti jiného jedince) u lidí se sociální úzkostnou poruchou (SAD) ve srovnání se zdravými dobrovolníky.
Oxytocin je hormon, který může také fungovat jako chemický posel v mozku.
Oxytocin hraje roli v řadě funkcí, včetně reakce na strach a sociální interakce.
V této studii by vyšetřovatelé chtěli porovnat účinky oxytocinu a placebo nosních sprejů u dospělých se SAD a zdravých dospělých.
Tato výzkumná studie porovná oxytocinový nosní sprej s nosním sprejem s placebem.
Této výzkumné studie se zúčastní asi 120 lidí, všichni na University of Washington (UW).
Přehled studie
Detailní popis
Cílem této studie je prozkoumat potenciální roli oxytocinu při posilování sociálního učení u SAD.
Primární hypotéza výzkumníků je, že učení zástupného zániku přispěje k učení o bezpečnosti a že oxytocin zesílí učení zástupného zániku u pacientů se SAD ve srovnání se zdravými kontrolami (HC).
Výzkumníci budou přímo testovat účinek intranazálního oxytocinu a odpovídajícího placeba na mozkové mechanismy, které jsou základem učení zástupného vymírání pomocí nového úkolu.
60 dospělých s SAD a 60 zdravých účastníků kontroly provede úkol, který zahrnuje tři fáze: (i) standardní proceduru získávání sociálního strachu v simulovaném skeneru, po níž následuje (ii) zástupná extinkce a (iii) testovací procedura pro obnovení strachu, při skenování během funkční magnetické rezonance (fMRI).
Účastníci dostanou oxytocin nebo placebo před fází extinkce.
Vyšetřovatelé budou také měřit odezvy kožní vodivosti jako index učení v každé fázi.
Typ studie
Intervenční
Zápis (Aktuální)
121
Fáze
- Fáze 2
Kontakty a umístění
Tato část poskytuje kontaktní údaje pro ty, kteří studii provádějí, a informace o tom, kde se tato studie provádí.
Studijní místa
-
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Washington
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Seattle, Washington, Spojené státy, 98195
- University of Washington
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-
Kritéria účasti
Výzkumníci hledají lidi, kteří odpovídají určitému popisu, kterému se říká kritéria způsobilosti. Některé příklady těchto kritérií jsou celkový zdravotní stav osoby nebo předchozí léčba.
Kritéria způsobilosti
Věk způsobilý ke studiu
- Dospělý
Přijímá zdravé dobrovolníky
Ano
Popis
Kritéria pro zařazení:
Pro klinický vzorek
- Muži a ženy ve věku 18-45 let
- Ženy musí mít pravidelné menstruační cykly a nesmí užívat perorální antikoncepci
- Primární diagnóza sociální úzkostné poruchy
Pro zdravý vzorek
- Muži a ženy ve věku 18-45 let
- Ženy musí mít pravidelné menstruační cykly a nesmí užívat perorální antikoncepci
- Žádná současná nebo celoživotní anamnéza psychiatrických, neurologických nebo zdravotních poruch
Kritéria vyloučení:
Pro všechny skupiny
- Těhotenství nebo kojení
- Pozitivní výsledek screeningového testu na drogy v moči
- Historie nosní patologie
- Současné užívání jakýchkoli psychotropních léků nebo steroidů
- Porucha užívání účinných látek během posledních 6 měsíců
- Závažná onemocnění nebo neléčená endokrinní onemocnění v anamnéze
- Poranění hlavy, neurologická porucha nebo neurochirurgický zákrok v anamnéze
- Obrazovka s pozitivní magnetickou rezonancí (MR).
Pro klinický vzorek
- Celoživotní diagnózy mánie nebo psychotické poruchy založené na diagnostickém a statistickém manuálu (DSM-5th ed)
- Akutní sebevražedné myšlenky
Pro zdravý vzorek
- Doživotní diagnostika DSM-5 jakéhokoli lékařského, neurologického nebo psychiatrického onemocnění
Studijní plán
Tato část poskytuje podrobnosti o studijním plánu, včetně toho, jak je studie navržena a co studie měří.
Jak je studie koncipována?
Detaily designu
- Primární účel: Léčba
- Přidělení: Randomizované
- Intervenční model: Paralelní přiřazení
- Maskování: Dvojnásobek
Zbraně a zásahy
Skupina účastníků / Arm |
Intervence / Léčba |
|---|---|
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Experimentální: Klinický
Tuto skupinu tvoří jedinci s alespoň středně závažnými příznaky sociální úzkostné poruchy.
Této skupině bude podáván buď oxytocin nebo placebo (slepá randomizace).
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Single acute administration of 24 international units (IU) oxytocin or matching placebo
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Komparátor placeba: Řízení
Tuto skupinu tvoří zdravý vzorek jedinců (žádné celoživotní diagnózy mánie nebo psychotických poruch).
Této skupině bude podáván buď oxytocin nebo placebo (slepá randomizace).
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Single acute administration of 24 international units (IU) oxytocin or matching placebo
|
Co je měření studie?
Primární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
|
Neural Responses in the CS+R vs CS+S Contrast in the Insula During the Extinction Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the insula during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the insula region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS+S Contrast in the Hippocampus During the Extinction Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the hippocampus during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the hippocampus region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS+S Contrast in the Anterior Cingulate Cortex During the Extinction Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the anterior cingulate cortex during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the anterior cingulate cortex region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS+S Contrast in the Ventromedial Prefrontal Cortex During the Extinction Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the ventromedial prefrontal cortex during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal cortex region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS+S Contrast in the Anterior Cingulate Cortex During the Reinstatement Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the anterior cingulate cortex during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the anterior cingulate cortex region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS+S Contrast in the Insula During the Reinstatement Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the insula during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the insula region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS+S Contrast in the Hippocampus During the Reinstatement Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the hippocampus during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the hippocampus region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS+S Contrast in the Amygdala During the Reinstatement Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the amygdala during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the amygdala region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Skin Conductance Responses (SCR) to CS- During Extinction
Časové okno: immediately (45 minutes) after receiving drug
|
mean skin conductance responses (SCR) for CS- stimuli during Extinction
|
immediately (45 minutes) after receiving drug
|
|
Skin Conductance Responses (SCR) to CS+S During Extinction
Časové okno: immediately (45 minutes) after receiving drug
|
mean skin conductance responses (SCR) for CS+S stimuli during Extinction
|
immediately (45 minutes) after receiving drug
|
|
Skin Conductance Responses (SCR) to CS+R During Extinction
Časové okno: immediately (45 minutes) after receiving drug
|
mean skin conductance responses (SCR) for CS+R stimuli during Extinction
|
immediately (45 minutes) after receiving drug
|
|
Skin Conductance Responses (SCR) to CS- During Reinstatement
Časové okno: immediately (45 minutes) after receiving drug
|
mean skin conductance responses (SCR) for CS- stimuli during Reinstatement
|
immediately (45 minutes) after receiving drug
|
|
Skin Conductance Responses (SCR) to CS+S During Reinstatement
Časové okno: immediately (45 minutes) after receiving drug
|
mean skin conductance responses (SCR) for CS+S stimuli during Reinstatement
|
immediately (45 minutes) after receiving drug
|
|
Skin Conductance Responses (SCR) to CS+R During Reinstatement
Časové okno: immediately (45 minutes) after receiving drug
|
mean skin conductance responses (SCR) for CS+R stimuli during Reinstatement
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS- Contrast in the Insula During the Extinction Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the insula during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the insula region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS- Contrast in the Amygdala During the Extinction Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the amygdala during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the amygdala region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS+S Contrast in the Ventromedial Prefrontal Cortex During the Reinstatement Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the ventromedial prefrontal cortex during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS- Contrast in the Hippocampus During the Extinction Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the hippocampus during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the hippocampus region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS- Contrast in the Anterior Cingulate Cortex During the Extinction Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the anterior cingulate cortex during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the anterior cingulate cortex region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS- Contrast in the Ventromedial Prefrontal Cortex During the Extinction Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the ventromedial prefrontal cortex during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal cortex region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS- Contrast in the Amygdala During the Reinstatement Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the amygdala during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS- (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the amygdala region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS- Contrast in the Insula During the Reinstatement Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the insula during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS- (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the insula region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS- Contrast in the Hippocampus During the Reinstatement Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the hippocampus during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS- (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the hippocampus region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS- Contrast in the Anterior Cingulate Cortex During the Reinstatement Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the anterior cingulate cortex during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS- (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the anterior cingulate cortex region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+S vs CS- Contrast in the Hippocampus During the Extinction Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the hippocampus during vicarious extinction (specifically for CS+S versus CS- conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the hippocampus region of interest and estimated using a general linear model.
A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS- Contrast in the Ventromedial Prefrontal Cortex During the Reinstatement Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the ventromedial prefrontal cortex during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS- (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal cortex region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+S vs CS- Contrast in the Amygdala During the Extinction Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the amygdala during vicarious extinction (specifically for CS+S versus CS- conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the amygdala region of interest and estimated using a general linear model.
A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+S vs CS- Contrast in the Insula During the Extinction Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the insula during vicarious extinction (specifically for CS+S versus CS- conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the insula region of interest and estimated using a general linear model.
A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+S vs CS- Contrast in the Ventromedial Prefrontal Cortex During the Extinction Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the ventromedial prefrontal cortex during vicarious extinction (specifically for CS+S versus CS- conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal cortex region of interest and estimated using a general linear model.
A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+S vs CS- Contrast in the Anterior Cingulate Cortex During the Extinction Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the anterior cingulate cortex during vicarious extinction (specifically for CS+S versus CS- conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the anterior cingulate cortex region of interest and estimated using a general linear model.
A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+S vs CS- Contrast in the Amygdala During the Reinstatement Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the amygdala during fear reinstatement, which tests the return of fear (specifically for CS+S versus CS- conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the amygdala region of interest and estimated using a general linear model.
A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+S vs CS- Contrast in the Insula During the Reinstatement Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the insula during fear reinstatement, which tests the return of fear (specifically for CS+S versus CS- conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the insula region of interest and estimated using a general linear model.
A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+S vs CS- Contrast in the Hippocampus During the Reinstatement Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the hippocampus during fear reinstatement, which tests the return of fear (specifically for CS+S versus CS- conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the hippocampus region of interest and estimated using a general linear model.
A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+S vs CS- Contrast in the Anterior Cingulate Cortex During the Reinstatement Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the anterior cingulate cortex during fear reinstatement, which tests the return of fear (specifically for CS+S versus CS- conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the anterior cingulate cortex region of interest and estimated using a general linear model.
A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+S vs CS- Contrast in the Ventromedial Prefrontal Cortex During the Reinstatement Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the ventromedial prefrontal cortex during fear reinstatement, which tests the return of fear (specifically for CS+S versus CS- conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal cortex region of interest and estimated using a general linear model.
A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS+S Contrast in the Ventromedial Prefrontal Cortex During the Reinstatement Phase
Časové okno: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the amygdala during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal cortex region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
Sekundární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
|
kožní vodivostní reakce (SCR) na zprostředkovaně zhasnuté tágo versus zprostředkovaně zesílené tágo během obnovy
Časové okno: bezprostředně po zásahu
|
střední SCR pro CS- versus CS+
|
bezprostředně po zásahu
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Spolupracovníci a vyšetřovatelé
Zde najdete lidi a organizace zapojené do této studie.
Sponzor
Vyšetřovatelé
- Vrchní vyšetřovatel: Angela Fang, PhD, University of Washington
Termíny studijních záznamů
Tato data sledují průběh záznamů studie a předkládání souhrnných výsledků na ClinicalTrials.gov. Záznamy ze studií a hlášené výsledky jsou před zveřejněním na veřejné webové stránce přezkoumány Národní lékařskou knihovnou (NLM), aby se ujistily, že splňují specifické standardy kontroly kvality.
Hlavní termíny studia
Začátek studia (Aktuální)
26. června 2023
Primární dokončení (Aktuální)
30. září 2024
Dokončení studie (Aktuální)
30. září 2024
Termíny zápisu do studia
První předloženo
10. července 2023
První předloženo, které splnilo kritéria kontroly kvality
26. července 2023
První zveřejněno (Aktuální)
1. srpna 2023
Aktualizace studijních záznamů
Poslední zveřejněná aktualizace (Aktuální)
11. června 2026
Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality
10. června 2026
Naposledy ověřeno
1. března 2026
Více informací
Termíny související s touto studií
Klíčová slova
Další relevantní podmínky MeSH
Další identifikační čísla studie
- STUDY00013670
Informace o lécích a zařízeních, studijní dokumenty
Studuje lékový produkt regulovaný americkým FDA
Ano
Studuje produkt zařízení regulovaný americkým úřadem FDA
Ne
produkt vyrobený a vyvážený z USA
Ne
Tyto informace byly beze změn načteny přímo z webu clinicaltrials.gov. Máte-li jakékoli požadavky na změnu, odstranění nebo aktualizaci podrobností studie, kontaktujte prosím register@clinicaltrials.gov. Jakmile bude změna implementována na clinicaltrials.gov, bude automaticky aktualizována i na našem webu .