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Leren over sociale veiligheid in het oxytocinesysteem van de hersenen

10 juni 2026 bijgewerkt door: Angela Fang, University of Washington
De onderzoekers voeren dit onderzoek uit om te onderzoeken of oxytocine het leren van sociale veiligheid (leerveiligheid door de ervaring van een ander individu) verbetert bij mensen met een sociale angststoornis (SAD) in vergelijking met gezonde vrijwilligers. Oxytocine is een hormoon dat ook kan fungeren als een chemische boodschapper in de hersenen. Oxytocine speelt een rol in een aantal functies, waaronder het reageren op angst en sociale interacties. In deze studie willen de onderzoekers de effecten van oxytocine en placebo-neussprays bij volwassenen met SAD vergelijken met gezonde volwassenen. In dit onderzoek wordt een oxytocine-neusspray vergeleken met een placebo-neusspray. Aan dit onderzoek zullen ongeveer 120 mensen deelnemen, allemaal aan de Universiteit van Washington (UW).

Studie Overzicht

Toestand

Voltooid

Conditie

Interventie / Behandeling

Gedetailleerde beschrijving

Het doel van de huidige studie is om de potentiële rol van oxytocine bij het verbeteren van sociaal leren bij SAD te onderzoeken. De primaire hypothese van de onderzoekers is dat plaatsvervangend extinctieleren zal bijdragen aan veiligheidsleren en dat oxytocine plaatsvervangend extinctieleren zal versterken bij patiënten met SAD, in vergelijking met gezonde controles (HC). De onderzoekers zullen direct het effect testen van intranasale oxytocine en bijpassende placebo op de hersenmechanismen die ten grondslag liggen aan plaatsvervangend uitsterven leren met behulp van een nieuwe taak. 60 volwassenen met SAD en 60 gezonde controledeelnemers zullen een taak uitvoeren die uit drie fasen bestaat: (i) een standaardprocedure voor het verwerven van sociale angst in een nepscanner, gevolgd door (ii) een plaatsvervangende extinctie en (iii) testprocedure voor het herstellen van angst, terwijl ze worden gescand tijdens functionele magnetische resonantiebeeldvorming (fMRI). Voorafgaand aan de extinctiefase krijgen deelnemers oxytocine of placebo toegediend. De onderzoekers zullen ook huidgeleidingsreacties meten als een leerindex in elke fase.

Studietype

Ingrijpend

Inschrijving (Werkelijk)

121

Fase

  • Fase 2

Contacten en locaties

In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.

Studie Locaties

  • Verenigde Staten
    • Washington
      • Seattle, Washington, Verenigde Staten, 98195
        • University of Washington

Deelname Criteria

Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.

Geschiktheidscriteria

Leeftijden die in aanmerking komen voor studie

  • Volwassen

Accepteert gezonde vrijwilligers

Ja

Beschrijving

Inclusiecriteria:

Voor klinische steekproef

  • Mannen en vrouwen van 18-45 jaar
  • Vrouwen moeten een regelmatige menstruatiecyclus hebben en geen orale anticonceptie gebruiken
  • Hoofddiagnose sociale angststoornis

Voor een gezonde steekproef

  • Mannen en vrouwen van 18-45 jaar
  • Vrouwen moeten een regelmatige menstruatiecyclus hebben en geen orale anticonceptie gebruiken
  • Geen huidige of levenslange geschiedenis van psychiatrische, neurologische of medische aandoeningen

Uitsluitingscriteria:

Voor alle groepen

  • Zwangerschap of borstvoeding
  • Positief resultaat van de urinedrugscreening
  • Geschiedenis van nasale pathologie
  • Huidig ​​​​gebruik van psychotrope medicatie of steroïden
  • Stoornis in het gebruik van werkzame stoffen in de afgelopen 6 maanden
  • Geschiedenis van ernstige medische ziekten of onbehandelde endocriene ziekten
  • Geschiedenis van hoofdletsel, neurologische aandoening of neurochirurgische procedure
  • Scherm met positieve magnetische resonantie (MR).

Voor klinische steekproef

  • Levenslange diagnoses van manie of psychotische stoornis op basis van de Diagnostic and Statistical Manual (DSM-5th ed)
  • Acute zelfmoordgedachten

Voor een gezonde steekproef

  • Levenslange DSM-5-diagnose van een medische, neurologische of psychiatrische aandoening

Studie plan

Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.

Hoe is de studie opgezet?

Ontwerpdetails

  • Primair doel: Behandeling
  • Toewijzing: Gerandomiseerd
  • Interventioneel model: Parallelle opdracht
  • Masker: Dubbele

Wapens en interventies

Deelnemersgroep / Arm
Interventie / Behandeling
Experimenteel: Klinisch
Deze groep bestaat uit personen met minimaal matige symptomen van een sociale angststoornis. Deze groep krijgt een oxytocine- of placebotoediening (blinde randomisatie).
Geneesmiddel: Oxytocin nasal spray or placebo
Single acute administration of 24 international units (IU) oxytocin or matching placebo
Placebo-vergelijker: Controles
Deze groep bestaat uit een gezonde steekproef van individuen (geen levenslange diagnose van manie of psychotische stoornissen). Deze groep krijgt een oxytocine- of placebotoediening (blinde randomisatie).
Geneesmiddel: Oxytocin nasal spray or placebo
Single acute administration of 24 international units (IU) oxytocin or matching placebo

Wat meet het onderzoek?

Primaire uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
Neural Responses in the CS+R vs CS+S Contrast in the Insula During the Extinction Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the insula during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the insula region of interest and estimated using a general linear model. Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+R vs CS+S Contrast in the Hippocampus During the Extinction Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the hippocampus during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the hippocampus region of interest and estimated using a general linear model. Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+R vs CS+S Contrast in the Anterior Cingulate Cortex During the Extinction Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the anterior cingulate cortex during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the anterior cingulate cortex region of interest and estimated using a general linear model. Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+R vs CS+S Contrast in the Ventromedial Prefrontal Cortex During the Extinction Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the ventromedial prefrontal cortex during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal cortex region of interest and estimated using a general linear model. Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+R vs CS+S Contrast in the Anterior Cingulate Cortex During the Reinstatement Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the anterior cingulate cortex during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the anterior cingulate cortex region of interest and estimated using a general linear model. Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+R vs CS+S Contrast in the Insula During the Reinstatement Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the insula during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the insula region of interest and estimated using a general linear model. Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+R vs CS+S Contrast in the Hippocampus During the Reinstatement Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the hippocampus during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the hippocampus region of interest and estimated using a general linear model. Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+R vs CS+S Contrast in the Amygdala During the Reinstatement Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the amygdala during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the amygdala region of interest and estimated using a general linear model. Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
immediately (45 minutes) after receiving drug
Skin Conductance Responses (SCR) to CS- During Extinction
Tijdsspanne: immediately (45 minutes) after receiving drug
mean skin conductance responses (SCR) for CS- stimuli during Extinction
immediately (45 minutes) after receiving drug
Skin Conductance Responses (SCR) to CS+S During Extinction
Tijdsspanne: immediately (45 minutes) after receiving drug
mean skin conductance responses (SCR) for CS+S stimuli during Extinction
immediately (45 minutes) after receiving drug
Skin Conductance Responses (SCR) to CS+R During Extinction
Tijdsspanne: immediately (45 minutes) after receiving drug
mean skin conductance responses (SCR) for CS+R stimuli during Extinction
immediately (45 minutes) after receiving drug
Skin Conductance Responses (SCR) to CS- During Reinstatement
Tijdsspanne: immediately (45 minutes) after receiving drug
mean skin conductance responses (SCR) for CS- stimuli during Reinstatement
immediately (45 minutes) after receiving drug
Skin Conductance Responses (SCR) to CS+S During Reinstatement
Tijdsspanne: immediately (45 minutes) after receiving drug
mean skin conductance responses (SCR) for CS+S stimuli during Reinstatement
immediately (45 minutes) after receiving drug
Skin Conductance Responses (SCR) to CS+R During Reinstatement
Tijdsspanne: immediately (45 minutes) after receiving drug
mean skin conductance responses (SCR) for CS+R stimuli during Reinstatement
immediately (45 minutes) after receiving drug
Neural Responses in the CS+R vs CS- Contrast in the Insula During the Extinction Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the insula during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the insula region of interest and estimated using a general linear model. Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+R vs CS- Contrast in the Amygdala During the Extinction Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the amygdala during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the amygdala region of interest and estimated using a general linear model. Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+R vs CS+S Contrast in the Ventromedial Prefrontal Cortex During the Reinstatement Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the ventromedial prefrontal cortex during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal region of interest and estimated using a general linear model. Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+R vs CS- Contrast in the Hippocampus During the Extinction Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the hippocampus during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the hippocampus region of interest and estimated using a general linear model. Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+R vs CS- Contrast in the Anterior Cingulate Cortex During the Extinction Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the anterior cingulate cortex during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the anterior cingulate cortex region of interest and estimated using a general linear model. Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+R vs CS- Contrast in the Ventromedial Prefrontal Cortex During the Extinction Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the ventromedial prefrontal cortex during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal cortex region of interest and estimated using a general linear model. Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+R vs CS- Contrast in the Amygdala During the Reinstatement Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the amygdala during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS- (non-reinforced) conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the amygdala region of interest and estimated using a general linear model. Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+R vs CS- Contrast in the Insula During the Reinstatement Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the insula during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS- (non-reinforced) conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the insula region of interest and estimated using a general linear model. Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+R vs CS- Contrast in the Hippocampus During the Reinstatement Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the hippocampus during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS- (non-reinforced) conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the hippocampus region of interest and estimated using a general linear model. Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+R vs CS- Contrast in the Anterior Cingulate Cortex During the Reinstatement Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the anterior cingulate cortex during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS- (non-reinforced) conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the anterior cingulate cortex region of interest and estimated using a general linear model. Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+S vs CS- Contrast in the Hippocampus During the Extinction Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the hippocampus during vicarious extinction (specifically for CS+S versus CS- conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the hippocampus region of interest and estimated using a general linear model. A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+R vs CS- Contrast in the Ventromedial Prefrontal Cortex During the Reinstatement Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the ventromedial prefrontal cortex during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS- (non-reinforced) conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal cortex region of interest and estimated using a general linear model. Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+S vs CS- Contrast in the Amygdala During the Extinction Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the amygdala during vicarious extinction (specifically for CS+S versus CS- conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the amygdala region of interest and estimated using a general linear model. A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+S vs CS- Contrast in the Insula During the Extinction Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the insula during vicarious extinction (specifically for CS+S versus CS- conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the insula region of interest and estimated using a general linear model. A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+S vs CS- Contrast in the Ventromedial Prefrontal Cortex During the Extinction Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the ventromedial prefrontal cortex during vicarious extinction (specifically for CS+S versus CS- conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal cortex region of interest and estimated using a general linear model. A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+S vs CS- Contrast in the Anterior Cingulate Cortex During the Extinction Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the anterior cingulate cortex during vicarious extinction (specifically for CS+S versus CS- conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the anterior cingulate cortex region of interest and estimated using a general linear model. A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+S vs CS- Contrast in the Amygdala During the Reinstatement Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the amygdala during fear reinstatement, which tests the return of fear (specifically for CS+S versus CS- conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the amygdala region of interest and estimated using a general linear model. A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+S vs CS- Contrast in the Insula During the Reinstatement Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the insula during fear reinstatement, which tests the return of fear (specifically for CS+S versus CS- conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the insula region of interest and estimated using a general linear model. A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+S vs CS- Contrast in the Hippocampus During the Reinstatement Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the hippocampus during fear reinstatement, which tests the return of fear (specifically for CS+S versus CS- conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the hippocampus region of interest and estimated using a general linear model. A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+S vs CS- Contrast in the Anterior Cingulate Cortex During the Reinstatement Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the anterior cingulate cortex during fear reinstatement, which tests the return of fear (specifically for CS+S versus CS- conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the anterior cingulate cortex region of interest and estimated using a general linear model. A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+S vs CS- Contrast in the Ventromedial Prefrontal Cortex During the Reinstatement Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the ventromedial prefrontal cortex during fear reinstatement, which tests the return of fear (specifically for CS+S versus CS- conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal cortex region of interest and estimated using a general linear model. A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
immediately (45 minutes) after receiving drug
Neural Responses in the CS+R vs CS+S Contrast in the Ventromedial Prefrontal Cortex During the Reinstatement Phase
Tijdsspanne: immediately (45 minutes) after receiving drug
Change in task-related blood oxygen level dependent (BOLD) responses in the amygdala during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions). Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal cortex region of interest and estimated using a general linear model. Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
immediately (45 minutes) after receiving drug

Secundaire uitkomstmaten

Uitkomstmaat
Maatregel Beschrijving
Tijdsspanne
huidgeleidingsreacties (SCR) op plaatsvervangend gedoofde cue versus plaatsvervangend versterkte cue tijdens herstel
Tijdsspanne: direct na de ingreep
gemiddelde SCR voor CS- versus CS+
direct na de ingreep

Medewerkers en onderzoekers

Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.

Sponsor

University of Washington

Onderzoekers

  • Hoofdonderzoeker: Angela Fang, PhD, University of Washington

Studie record data

Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.

Bestudeer belangrijke data

Studie start (Werkelijk)

26 juni 2023

Primaire voltooiing (Werkelijk)

30 september 2024

Studie voltooiing (Werkelijk)

30 september 2024

Studieregistratiedata

Eerst ingediend

10 juli 2023

Eerst ingediend dat voldeed aan de QC-criteria

26 juli 2023

Eerst geplaatst (Werkelijk)

1 augustus 2023

Updates van studierecords

Laatste update geplaatst (Werkelijk)

11 juni 2026

Laatste update ingediend die voldeed aan QC-criteria

10 juni 2026

Laatst geverifieerd

1 maart 2026

Meer informatie

Termen gerelateerd aan deze studie

Trefwoorden

Aanvullende relevante MeSH-voorwaarden

Andere studie-ID-nummers

  • STUDY00013670

Informatie over medicijnen en apparaten, studiedocumenten

Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel

Ja

Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct

Nee

product vervaardigd in en geëxporteerd uit de V.S.

Nee

Deze informatie is zonder wijzigingen rechtstreeks van de website clinicaltrials.gov gehaald. Als u verzoeken heeft om uw onderzoeksgegevens te wijzigen, te verwijderen of bij te werken, neem dan contact op met register@clinicaltrials.gov. Zodra er een wijziging wordt doorgevoerd op clinicaltrials.gov, wordt deze ook automatisch bijgewerkt op onze website .

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