Sosiaalisen turvallisuuden oppiminen aivojen oksitosiinijärjestelmässä
keskiviikko 10. kesäkuuta 2026 päivittänyt: Angela Fang, University of Washington
Tutkijat tekevät tätä tutkimusta selvittääkseen, parantaako oksitosiini sosiaalisen turvallisuuden oppimista (oppimisen turvallisuutta toisen henkilön kokemuksen kautta) ihmisillä, joilla on sosiaalinen ahdistuneisuushäiriö (SAD) verrattuna terveisiin vapaaehtoisiin.
Oksitosiini on hormoni, joka voi myös toimia kemiallisena sanansaattajana aivoissa.
Oksitosiinilla on rooli useissa toiminnoissa, mukaan lukien pelko ja sosiaalinen vuorovaikutus.
Tässä tutkimuksessa tutkijat haluaisivat verrata oksitosiinin ja lumelääkettä sisältävien nenäsumutteiden vaikutuksia SAD-potilailla ja terveillä aikuisilla.
Tässä tutkimuksessa verrataan oksitosiini-nenäsumutetta lumelääkkeeseen.
Noin 120 henkilöä osallistuu tähän tutkimukseen, kaikki Washingtonin yliopistossa (UW).
Tutkimuksen yleiskatsaus
Tila
Valmis
Interventio / Hoito
Yksityiskohtainen kuvaus
Tämän tutkimuksen tavoitteena on tutkia oksitosiinin mahdollista roolia sosiaalisen oppimisen edistämisessä SAD:ssa.
Tutkijoiden ensisijainen hypoteesi on, että sijaisummettumisoppiminen edistää turvallisuusoppimista ja että oksitosiini tehostaa sijaissuupistumisoppimista SAD-potilailla verrattuna terveisiin kontrolleihin (HC).
Tutkijat testaavat suoraan intranasaalisen oksitosiinin ja vastaavan lumelääkkeen vaikutusta aivomekanismeihin, jotka ovat sijaissukupuutiooppimisen taustalla uuden tehtävän avulla.
60 aikuista, joilla on SAD, ja 60 tervettä kontrollin osallistujaa suorittavat tehtävän, joka sisältää kolme vaihetta: (i) tavallinen sosiaalisen pelon hankintamenettely valeskannerissa, jota seuraa (ii) sijaissukupuutio ja (iii) pelon palautumistesti, skannattaessa toiminnallisen magneettikuvauksen (fMRI) aikana.
Osallistujat saavat oksitosiinia tai lumelääkettä ennen ekstinktiovaihetta.
Tutkijat mittaavat myös ihon johtavuusvasteita oppimisindeksinä kussakin vaiheessa.
Opintotyyppi
Interventio
Ilmoittautuminen (Todellinen)
121
Vaihe
- Vaihe 2
Yhteystiedot ja paikat
Tässä osiossa on tutkimuksen suorittajien yhteystiedot ja tiedot siitä, missä tämä tutkimus suoritetaan.
Opiskelupaikat
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Washington
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Seattle, Washington, Yhdysvallat, 98195
- University of Washington
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Osallistumiskriteerit
Tutkijat etsivät ihmisiä, jotka sopivat tiettyyn kuvaukseen, jota kutsutaan kelpoisuuskriteereiksi. Joitakin esimerkkejä näistä kriteereistä ovat henkilön yleinen terveydentila tai aiemmat hoidot.
Kelpoisuusvaatimukset
Opintokelpoiset iät
- Aikuinen
Hyväksyy terveitä vapaaehtoisia
Joo
Kuvaus
Sisällyttämiskriteerit:
Kliiniselle näytteelle
- 18-45-vuotiaat miehet ja naiset
- Naisilla on oltava säännölliset kuukautiskierrot, eivätkä he saa käyttää oraalista ehkäisyä
- Sosiaalisen ahdistuneisuushäiriön ensisijainen diagnoosi
Terveelliseen näytteeseen
- 18-45-vuotiaat miehet ja naiset
- Naisilla on oltava säännölliset kuukautiskierrot, eivätkä he saa käyttää oraalista ehkäisyä
- Ei nykyistä tai elinikäistä psykiatrisia, neurologisia tai lääketieteellisiä häiriöitä
Poissulkemiskriteerit:
Kaikille ryhmille
- Raskaus tai imetys
- Positiivinen virtsan lääkeseulontatestitulos
- Nenän patologian historia
- Kaikkien psykotrooppisten lääkkeiden tai steroidien nykyinen käyttö
- Vaikuttavien aineiden käytön häiriö viimeisen 6 kuukauden aikana
- Vakavien lääketieteellisten sairauksien tai hoitamattomien hormonaalisten sairauksien historia
- Aiempi päävamma, neurologinen häiriö tai neurokirurginen toimenpide
- Positiivinen magneettiresonanssi (MR) -näyttö
Kliiniselle näytteelle
- Manian tai psykoottisen häiriön elinikäiset diagnoosit Diagnostic and Statistical Manualin (DSM-5. painos) perusteella
- Akuutit itsemurha-ajatukset
Terveelliseen näytteeseen
- Elinikäinen DSM-5-diagnoosi kaikista lääketieteellisistä, neurologisista tai psykiatrisista sairauksista
Opintosuunnitelma
Tässä osiossa on tietoja tutkimussuunnitelmasta, mukaan lukien kuinka tutkimus on suunniteltu ja mitä tutkimuksella mitataan.
Miten tutkimus on suunniteltu?
Suunnittelun yksityiskohdat
- Ensisijainen käyttötarkoitus: Hoito
- Jako: Satunnaistettu
- Inventiomalli: Rinnakkaistehtävä
- Naamiointi: Kaksinkertainen
Aseet ja interventiot
Osallistujaryhmä / Arm |
Interventio / Hoito |
|---|---|
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Kokeellinen: Kliininen
Tämä ryhmä koostuu henkilöistä, joilla on vähintään kohtalaisia sosiaalisen ahdistuneisuushäiriön oireita.
Tämä ryhmä saa joko oksitosiinia tai lumelääkettä (sokko satunnaistaminen).
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Single acute administration of 24 international units (IU) oxytocin or matching placebo
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Placebo Comparator: Säätimet
Tämä ryhmä koostuu terveistä yksilöistä (ei elinikäisiä maniadiagnooseja tai psykoottisia häiriöitä).
Tämä ryhmä saa joko oksitosiinia tai lumelääkettä (sokko satunnaistaminen).
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Single acute administration of 24 international units (IU) oxytocin or matching placebo
|
Mitä tutkimuksessa mitataan?
Ensisijaiset tulostoimenpiteet
Tulosmittaus |
Toimenpiteen kuvaus |
Aikaikkuna |
|---|---|---|
|
Neural Responses in the CS+R vs CS+S Contrast in the Insula During the Extinction Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the insula during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the insula region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS+S Contrast in the Hippocampus During the Extinction Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the hippocampus during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the hippocampus region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS+S Contrast in the Anterior Cingulate Cortex During the Extinction Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the anterior cingulate cortex during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the anterior cingulate cortex region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS+S Contrast in the Ventromedial Prefrontal Cortex During the Extinction Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the ventromedial prefrontal cortex during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal cortex region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS+S Contrast in the Anterior Cingulate Cortex During the Reinstatement Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the anterior cingulate cortex during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the anterior cingulate cortex region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS+S Contrast in the Insula During the Reinstatement Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the insula during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the insula region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS+S Contrast in the Hippocampus During the Reinstatement Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the hippocampus during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the hippocampus region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS+S Contrast in the Amygdala During the Reinstatement Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the amygdala during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the amygdala region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Skin Conductance Responses (SCR) to CS- During Extinction
Aikaikkuna: immediately (45 minutes) after receiving drug
|
mean skin conductance responses (SCR) for CS- stimuli during Extinction
|
immediately (45 minutes) after receiving drug
|
|
Skin Conductance Responses (SCR) to CS+S During Extinction
Aikaikkuna: immediately (45 minutes) after receiving drug
|
mean skin conductance responses (SCR) for CS+S stimuli during Extinction
|
immediately (45 minutes) after receiving drug
|
|
Skin Conductance Responses (SCR) to CS+R During Extinction
Aikaikkuna: immediately (45 minutes) after receiving drug
|
mean skin conductance responses (SCR) for CS+R stimuli during Extinction
|
immediately (45 minutes) after receiving drug
|
|
Skin Conductance Responses (SCR) to CS- During Reinstatement
Aikaikkuna: immediately (45 minutes) after receiving drug
|
mean skin conductance responses (SCR) for CS- stimuli during Reinstatement
|
immediately (45 minutes) after receiving drug
|
|
Skin Conductance Responses (SCR) to CS+S During Reinstatement
Aikaikkuna: immediately (45 minutes) after receiving drug
|
mean skin conductance responses (SCR) for CS+S stimuli during Reinstatement
|
immediately (45 minutes) after receiving drug
|
|
Skin Conductance Responses (SCR) to CS+R During Reinstatement
Aikaikkuna: immediately (45 minutes) after receiving drug
|
mean skin conductance responses (SCR) for CS+R stimuli during Reinstatement
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS- Contrast in the Insula During the Extinction Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the insula during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the insula region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS- Contrast in the Amygdala During the Extinction Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the amygdala during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the amygdala region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS+S Contrast in the Ventromedial Prefrontal Cortex During the Reinstatement Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the ventromedial prefrontal cortex during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS- Contrast in the Hippocampus During the Extinction Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the hippocampus during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the hippocampus region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS- Contrast in the Anterior Cingulate Cortex During the Extinction Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the anterior cingulate cortex during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the anterior cingulate cortex region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS- Contrast in the Ventromedial Prefrontal Cortex During the Extinction Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the ventromedial prefrontal cortex during vicarious extinction (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal cortex region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS- Contrast in the Amygdala During the Reinstatement Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the amygdala during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS- (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the amygdala region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS- Contrast in the Insula During the Reinstatement Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the insula during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS- (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the insula region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS- Contrast in the Hippocampus During the Reinstatement Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the hippocampus during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS- (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the hippocampus region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS- Contrast in the Anterior Cingulate Cortex During the Reinstatement Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the anterior cingulate cortex during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS- (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the anterior cingulate cortex region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+S vs CS- Contrast in the Hippocampus During the Extinction Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the hippocampus during vicarious extinction (specifically for CS+S versus CS- conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the hippocampus region of interest and estimated using a general linear model.
A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS- Contrast in the Ventromedial Prefrontal Cortex During the Reinstatement Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the ventromedial prefrontal cortex during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS- (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal cortex region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+S vs CS- Contrast in the Amygdala During the Extinction Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the amygdala during vicarious extinction (specifically for CS+S versus CS- conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the amygdala region of interest and estimated using a general linear model.
A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+S vs CS- Contrast in the Insula During the Extinction Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the insula during vicarious extinction (specifically for CS+S versus CS- conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the insula region of interest and estimated using a general linear model.
A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+S vs CS- Contrast in the Ventromedial Prefrontal Cortex During the Extinction Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the ventromedial prefrontal cortex during vicarious extinction (specifically for CS+S versus CS- conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal cortex region of interest and estimated using a general linear model.
A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+S vs CS- Contrast in the Anterior Cingulate Cortex During the Extinction Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the anterior cingulate cortex during vicarious extinction (specifically for CS+S versus CS- conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the anterior cingulate cortex region of interest and estimated using a general linear model.
A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+S vs CS- Contrast in the Amygdala During the Reinstatement Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the amygdala during fear reinstatement, which tests the return of fear (specifically for CS+S versus CS- conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the amygdala region of interest and estimated using a general linear model.
A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+S vs CS- Contrast in the Insula During the Reinstatement Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the insula during fear reinstatement, which tests the return of fear (specifically for CS+S versus CS- conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the insula region of interest and estimated using a general linear model.
A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+S vs CS- Contrast in the Hippocampus During the Reinstatement Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the hippocampus during fear reinstatement, which tests the return of fear (specifically for CS+S versus CS- conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the hippocampus region of interest and estimated using a general linear model.
A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+S vs CS- Contrast in the Anterior Cingulate Cortex During the Reinstatement Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the anterior cingulate cortex during fear reinstatement, which tests the return of fear (specifically for CS+S versus CS- conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the anterior cingulate cortex region of interest and estimated using a general linear model.
A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+S vs CS- Contrast in the Ventromedial Prefrontal Cortex During the Reinstatement Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the ventromedial prefrontal cortex during fear reinstatement, which tests the return of fear (specifically for CS+S versus CS- conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal cortex region of interest and estimated using a general linear model.
A lack of difference between these two task conditions is desirable, indicating processing both task conditions as safety cues.
|
immediately (45 minutes) after receiving drug
|
|
Neural Responses in the CS+R vs CS+S Contrast in the Ventromedial Prefrontal Cortex During the Reinstatement Phase
Aikaikkuna: immediately (45 minutes) after receiving drug
|
Change in task-related blood oxygen level dependent (BOLD) responses in the amygdala during fear reinstatement, which tests for the return of fear (specifically for CS+R (reinforced) versus CS+S (non-reinforced) conditions).
Changes in BOLD responses refer to differences in neural responses between these two task conditions, which were extracted from the ventromedial prefrontal cortex region of interest and estimated using a general linear model.
Higher mean responses reflect greater discrimination (better able to distinguish between threat and safety cues) between the task conditions.
|
immediately (45 minutes) after receiving drug
|
Toissijaiset tulostoimenpiteet
Tulosmittaus |
Toimenpiteen kuvaus |
Aikaikkuna |
|---|---|---|
|
ihon konduktanssireaktiot (SCR) tilapäisesti sammuneeseen vihjeeseen verrattuna sijaisvahvistettuun vihjeeseen palautuksen aikana
Aikaikkuna: heti toimenpiteen jälkeen
|
keskimääräinen SCR CS- vs. CS+
|
heti toimenpiteen jälkeen
|
Yhteistyökumppanit ja tutkijat
Täältä löydät tähän tutkimukseen osallistuvat ihmiset ja organisaatiot.
Sponsori
Tutkijat
- Päätutkija: Angela Fang, PhD, University of Washington
Opintojen ennätyspäivät
Nämä päivämäärät seuraavat ClinicalTrials.gov-sivustolle lähetettyjen tutkimustietueiden ja yhteenvetojen edistymistä. National Library of Medicine (NLM) tarkistaa tutkimustiedot ja raportoidut tulokset varmistaakseen, että ne täyttävät tietyt laadunvalvontastandardit, ennen kuin ne julkaistaan julkisella verkkosivustolla.
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Nämä tiedot haettiin suoraan verkkosivustolta clinicaltrials.gov ilman muutoksia. Jos sinulla on pyyntöjä muuttaa, poistaa tai päivittää tutkimustietojasi, ota yhteyttä register@clinicaltrials.gov. Heti kun muutos on otettu käyttöön osoitteessa clinicaltrials.gov, se päivitetään automaattisesti myös verkkosivustollemme .