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Sammenligning af to kombinationskemoterapiregimer til behandling af kvinder med brystkræft

10. august 2022 opdateret af: NSABP Foundation Inc

Et klinisk forsøg med adjuverende terapi, der sammenligner seks cyklusser af 5-fluorouracil, epirubicin og cyclophosphamid (FEC) med fire cyklusser af Adriamycin og cyclophosphamid (AC) hos patienter med node-negativ brystkræft

RATIONALE: Lægemidler, der bruges i kemoterapi, såsom fluorouracil, epirubicin, cyclophosphamid og doxorubicin, virker på forskellige måder for at forhindre tumorceller i at dele sig, så de holder op med at vokse eller dør. Det vides endnu ikke, hvilken kombination af kemoterapi, der er mere effektiv til behandling af brystkræft.

FORMÅL: Dette randomiserede fase III-forsøg studerer to kombinationskemoterapiregimer for at sammenligne, hvor godt de virker til at behandle kvinder, der er blevet opereret for brystkræft, der ikke har spredt sig til lymfeknuderne.

Studieoversigt

Status

Afsluttet

Betingelser

Brystkræft

Intervention / Behandling

Detaljeret beskrivelse

MÅL:

Primær

Sammenlign sygdomsfri overlevelse af kvinder med node-negativ brystkræft behandlet med adjuvans fluorouracil, epirubicin og cyclophosphamid vs doxorubicin og cyclophosphamid.

Sekundær

Sammenlign overlevelse, gentagelsesfrit interval og fjernt tilbagefaldsfrit interval hos patienter behandlet med disse regimer.
Sammenlign bivirkninger hos patienter behandlet med disse regimer.
Sammenlign livskvalitet med hensyn til fysisk funktion, vitalitet, symptomer og hyppighed af postkemoterapi amenoré hos præmenopausale patienter behandlet med disse regimer.
Bestem effekten af induktion af postkemoterapi amenoré på sygdomsfri overlevelse hos præmenopausale patienter behandlet med disse regimer.
Korrelér postkemoterapi amenoré og sygdomsfri overlevelse med hormonreceptorstatus hos præmenopausale patienter behandlet med disse regimer.
Korreler ændringer i venstre ventrikulær ejektionsfraktion (LVEF) med selvrapporteret fysisk funktion hos patienter behandlet med disse regimer.
Sammenlign effektiviteten af disse regimer hos patienter med human epidermal vækstfaktorreceptor 2 (HER2)/neu og/eller topoisomerase-2-alfa-genamplifikation.

OVERSIGT: Dette er en randomiseret, multicenter undersøgelse. Patienterne er stratificeret efter hormonreceptorstatus (østrogenreceptor [ER] positiv eller progesteronreceptor [PR] positiv vs ER negativ eller PR-negativ) og type tidligere operation (lumpektomi vs total mastektomi). Patienterne randomiseres til 1 ud af 2 behandlingsarme.

Arm 1: Patienterne får doxorubicin IV over 15 minutter efterfulgt af cyclophosphamid IV over 30 minutter på dag 1. Behandlingen gentages hver 21. dag i 4 forløb.
Arm 2: Patienterne får fluorouracil IV, epirubicin IV over 15 minutter og cyclophosphamid IV over 30 minutter på dag 1. Behandlingen gentages hver 21. dag i 6 forløb.

I begge arme fortsætter behandlingen i fravær af sygdomsprogression eller uacceptabel toksicitet.

Alle patienter med ER- eller PR-positive tumorer modtager daglig hormonbehandling, der begynder inden for 3-12 uger efter afslutning af kemoterapi og fortsætter i mindst 5 år.

Alle patienter, der har gennemgået tidligere lumpektomi, gennemgår strålebehandling af hele brystet, der begynder så hurtigt som muligt efter afslutningen af kemoterapien. Patienter, der tidligere har gennemgået total mastektomi, kan efter investigators skøn gennemgå strålebehandling af brystvæggen. Patienter, der er tildelt gruppen med partiel brystbestråling (PBI) i protokollen NSABP-B-39, gennemgår PBI i henhold til protokolspecifikke retningslinjer.

Livskvalitet vurderes ved baseline, på dag 1 af kursus 4 af kemoterapi, og derefter hver 6. måned i 3 år.

Patienterne følges hver 6. måned i op til 5 år og derefter årligt.

PROJEKTERET TILSLUTNING: I alt 2.700 patienter (1.350 pr. behandlingsarm) vil blive akkumuleret til denne undersøgelse inden for 3,75 år.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

2722

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Canada
- Alberta
  - Calgary, Alberta, Canada, T2N 4N2
    - Tom Baker Cancer Centre - Calgary
  - Edmonton, Alberta, Canada, T6G 1Z2
    - Cross Cancer Institute at University of Alberta
- Manitoba
  - Winnipeg, Manitoba, Canada, R3E 0V9
    - CancerCare Manitoba
- New Brunswick
  - Saint John, New Brunswick, Canada, E2L 4L2
    - Saint John Regional Hospital
- Ontario
  - Mississauga, Ontario, Canada, L5B 1B8
    - Trillium Health Centre - Mississauga Site
  - Mississauga, Ontario, Canada, L5M 2N1
    - Carlo Fidani Peel Regional Cancer Centre at Credit Valley Hospital
  - Ottawa, Ontario, Canada, K1Y 4K7
    - Ottawa Hospital Regional Cancer Centre - General Campus
  - Toronto, Ontario, Canada, M4N 3M5
    - Edmond Odette Cancer Centre at Sunnybrook
- Quebec
  - Montreal, Quebec, Canada, H1T 2M4
    - Maisonneuve-Rosemont Hospital
  - Montreal, Quebec, Canada, H3G 1A4
    - Montreal General Hospital
  - Montreal, Quebec, Canada, H3A 1A1
    - Royal Victoria Hospital - Montreal
  - Montreal, Quebec, Canada, H3T 1E2
    - Jewish General Hospital - Montreal
  - Montreal, Quebec, Canada, H2L 4M1
    - Hopital Notre-Dame du CHUM
  - Montreal, Quebec, Canada, H2W 1T8
    - CHUM - Hotel Dieu Hospital
  - Montreal, Quebec, Canada, H2X 3J4
    - CHUM - Hopital Saint-Luc
  - Quebec City, Quebec, Canada, G1S 4L8
    - Hopital du Saint-Sacrement - Quebec
Forenede Stater
- Alabama
  - Huntsville, Alabama, Forenede Stater, 35805
    - Clearview Cancer Institute
- Alaska
  - Anchorage, Alaska, Forenede Stater, 99508
    - Providence Cancer Center
- Arizona
  - Glendale, Arizona, Forenede Stater, 85306
    - Banner Thunderbird Medical Center
  - Phoenix, Arizona, Forenede Stater, 85006
    - Banner Good Samaritan Medical Center
  - Phoenix, Arizona, Forenede Stater, 85006
    - CCOP - Western Regional, Arizona
- Arkansas
  - Little Rock, Arkansas, Forenede Stater, 72205
    - Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
- California
  - Berkeley, California, Forenede Stater, 94704
    - Alta Bates Summit Comprehensive Cancer Center
  - Burlingame, California, Forenede Stater, 94010
    - Peninsula Medical Center
  - Castro Valley, California, Forenede Stater, 94546
    - East Bay Radiation Oncology Center
  - Castro Valley, California, Forenede Stater, 94546
    - Valley Medical Oncology Consultants - Castro Valley
  - Duarte, California, Forenede Stater, 91010-3000
    - City of Hope Comprehensive Cancer Center
  - Fairfield, California, Forenede Stater, 94533
    - North Bay Cancer Center
  - Fremont, California, Forenede Stater, 94538
    - Kaiser Permanente - Fremont
  - Fremont, California, Forenede Stater, 94538
    - Valley Medical Oncology
  - Glendale, California, Forenede Stater, 91204
    - Glendale Memorial Hospital Comprehensive Cancer Center
  - Greenbrae, California, Forenede Stater, 94904
    - Marin Cancer Institute at Marin General Hospital
  - Greenbrae, California, Forenede Stater, 94904
    - Sutter Health - Western Division Cancer Research Group
  - Greenbrae, California, Forenede Stater, 94904
    - California Cancer Care, Incorporated - Greenbrae
  - Hayward, California, Forenede Stater, 94545
    - Kaiser Permanente Medical Center - Hayward
  - La Jolla, California, Forenede Stater, 92037
    - Scripps Cancer Center - San Diego
  - Loma Linda, California, Forenede Stater, 92354
    - Loma Linda University Cancer Institute at Loma Linda University Medical Center
  - Long Beach, California, Forenede Stater, 90813
    - Pacific Shores Medical Group - Long Beach
  - Los Angeles, California, Forenede Stater, 90095-1781
    - Jonsson Comprehensive Cancer Center at UCLA
  - Oakland, California, Forenede Stater, 94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland, California, Forenede Stater, 94602
    - Highland General Hospital
  - Oakland, California, Forenede Stater, 94609
    - Larry G Strieff MD Medical Corporation
  - Oakland, California, Forenede Stater, 94609
    - CCOP - Bay Area Tumor Institute
  - Oakland, California, Forenede Stater, 94609
    - Bay Area Breast Surgeons, Incorporated
  - Oakland, California, Forenede Stater, 94609
    - Tom K Lee, Incorporated
  - Oakland, California, Forenede Stater, 94611
    - Kaiser Permanente Medical Center - Oakland
  - Orange, California, Forenede Stater, 92868
    - Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center
  - Pleasanton, California, Forenede Stater, 94588
    - Valley Care Medical Center
  - Pleasanton, California, Forenede Stater, 94588
    - Valley Medical Oncology Consultants - Pleasanton
  - Redding, California, Forenede Stater, 96001
    - North Valley Breast Clinic
  - Redwood City, California, Forenede Stater, 94063
    - Kaiser Permanente Medical Center - Redwood City
  - Richmond, California, Forenede Stater, 94801
    - Kaiser Permanente Medical Center - Richmond
  - Roseville, California, Forenede Stater, 95661
    - Kaiser Permanente Medical Center - Roseville
  - Roseville, California, Forenede Stater, 95661
    - Sutter Cancer Center at Roseville Medical Center
  - Sacramento, California, Forenede Stater, 95816
    - Sutter Cancer center
  - Sacramento, California, Forenede Stater, 95823
    - South Sacramento Kaiser-Permanente Medical Center
  - Sacramento, California, Forenede Stater, 95825
    - Kaiser Permanente Medical Center - Sacramento
  - San Diego, California, Forenede Stater, 92120
    - Kaiser Permanente Medical Office -Vandever Medical Office
  - San Francisco, California, Forenede Stater, 94115
    - Kaiser Permanente Medical Center - San Francisco Geary Campus
  - San Francisco, California, Forenede Stater, 94118
    - California Pacific Medical Center - California Campus
  - San Jose, California, Forenede Stater, 95119
    - Kaiser Permanente Medical Center - Santa Teresa
  - San Pablo, California, Forenede Stater, 94806
    - Doctors Medical Center - San Pablo Campus
  - San Rafael, California, Forenede Stater, 94903
    - Kaiser Foundation Hospital - San Rafael
  - Santa Barbara, California, Forenede Stater, 93105
    - Cancer Center of Santa Barbara
  - Santa Clara, California, Forenede Stater, 95051
    - Kaiser Permanente Medical Center - Santa Clara Kiely Campus
  - Santa Rosa, California, Forenede Stater, 95403
    - Kaiser Permanente Medical Center - Santa Rosa
  - Santa Rosa, California, Forenede Stater, 95405
    - CCOP - Santa Rosa Memorial Hospital
  - South San Francisco, California, Forenede Stater, 94080
    - Kaiser Permanente Medical Center - South San Francisco
  - Stanford, California, Forenede Stater, 94305-5824
    - Stanford Cancer Center
  - Stockton, California, Forenede Stater, 95210
    - Kaiser Permanente Medical Facility - Stockton
  - Vallejo, California, Forenede Stater, 94589
    - Sutter Solano Medical Center
  - Vallejo, California, Forenede Stater, 94589
    - Kaiser Permanente Medical Center - Vallejo
  - Walnut Creek, California, Forenede Stater, 94596
    - Kaiser Permanente Medical Center - Walnut Creek
- Colorado
  - Aurora, Colorado, Forenede Stater, 80012
    - Aurora Presbyterian Hospital
  - Boulder, Colorado, Forenede Stater, 80301-9019
    - Boulder Community Hospital
  - Colorado Springs, Colorado, Forenede Stater, 80933
    - Penrose Cancer Center at Penrose Hospital
  - Denver, Colorado, Forenede Stater, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, Forenede Stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - Presbyterian - St. Luke's Medical Center
  - Denver, Colorado, Forenede Stater, 80204
    - St. Anthony Central Hospital
  - Denver, Colorado, Forenede Stater, 80218
    - St. Joseph Hospital
  - Denver, Colorado, Forenede Stater, 80224-2522
    - CCOP - Colorado Cancer Research Program
  - Englewood, Colorado, Forenede Stater, 80110
    - Swedish Medical Center
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Poudre Valley Hospital
  - Fort Collins, Colorado, Forenede Stater, 80528
    - Front Range Cancer Specialists
  - Grand Junction, Colorado, Forenede Stater, 81502
    - St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
  - Greeley, Colorado, Forenede Stater, 80631
    - North Colorado Medical Center
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Sky Ridge Medical Center
  - Longmont, Colorado, Forenede Stater, 80502
    - Hope Cancer Care Center at Longmont United Hospital
  - Loveland, Colorado, Forenede Stater, 80539
    - McKee Medical Center
  - Pueblo, Colorado, Forenede Stater, 81004
    - St. Mary - Corwin Regional Medical Center
  - Thornton, Colorado, Forenede Stater, 80229
    - North Suburban Medical Center
  - Wheat Ridge, Colorado, Forenede Stater, 80033
    - Exempla Lutheran Medical Center
- Connecticut
  - Hartford, Connecticut, Forenede Stater, 06102-5037
    - Helen and Harry Gray Cancer Center at Hartford Hospital
  - Norwich, Connecticut, Forenede Stater, 06360
    - Eastern Connecticut Hematology and Oncology Associates
- Delaware
  - Dover, Delaware, Forenede Stater, 19901
    - Kent General Hospital
  - Lewes, Delaware, Forenede Stater, 19958
    - Tunnell Cancer Center at Beebe Medical Center
  - Newark, Delaware, Forenede Stater, 19713
    - CCOP - Christiana Care Health Services
- District of Columbia
  - Washington, District of Columbia, Forenede Stater, 20007
    - Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
  - Washington, District of Columbia, Forenede Stater, 20016
    - Sibley Memorial Hospital
  - Washington, District of Columbia, Forenede Stater, 20010
    - Washington Cancer Institute at Washington Hospital Center
- Florida
  - Clearwater, Florida, Forenede Stater, 33756
    - Morton Plant Hospital
  - Daytona Beach, Florida, Forenede Stater, 32115
    - Herbert D. Kerman Regional Oncology Center - Daytona Beach
  - Fort Lauderdale, Florida, Forenede Stater, 33316
    - Broward General Medical Center Cancer Center
  - Fort Lauderdale, Florida, Forenede Stater, 33308
    - Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
  - Hollywood, Florida, Forenede Stater, 33021
    - Memorial Cancer Institute at Memorial Regional Hospital
  - Jacksonville, Florida, Forenede Stater, 32207
    - Baptist Cancer Institute - Jacksonville
  - Jupiter, Florida, Forenede Stater, 33458
    - Ella Milbank Foshay Cancer Center at Jupiter Medical Center
  - Lakeland, Florida, Forenede Stater, 33805
    - Lakeland Regional Cancer Center at Lakeland Regional Medical Center
  - Lakeland, Florida, Forenede Stater, 33805
    - Center for Cancer Care and Research at Watson Clinic, LLP
  - Miami Beach, Florida, Forenede Stater, 33140
    - CCOP - Mount Sinai Medical Center
  - Orlando, Florida, Forenede Stater, 32806
    - M.D. Anderson Cancer Center at Orlando
  - Sarasota, Florida, Forenede Stater, 34236
    - Florida Cancer Specialists - Sarasota Downtown
- Georgia
  - Atlanta, Georgia, Forenede Stater, 30309
    - Piedmont Hospital
  - Atlanta, Georgia, Forenede Stater, 30342-1611
    - Northside Hospital Cancer Center
  - Atlanta, Georgia, Forenede Stater, 30342-1701
    - Saint Joseph's Hospital of Atlanta
  - Atlanta, Georgia, Forenede Stater, 30342
    - CCOP - Atlanta Regional
  - Augusta, Georgia, Forenede Stater, 30912
    - MBCCOP - Medical College of Georgia Cancer Center
  - Augusta, Georgia, Forenede Stater, 30901
    - Augusta Oncology Associates - Walton Way
  - Austell, Georgia, Forenede Stater, 30106
    - WellStar Cobb Hospital
  - Decatur, Georgia, Forenede Stater, 30033
    - Charles B. Eberhart Cancer Center at DeKalb Medical Center
  - Fort Gordon, Georgia, Forenede Stater, 30905-5650
    - Dwight David Eisenhower Army Medical Center
  - Gainesville, Georgia, Forenede Stater, 30501
    - Northeast Georgia Medical Center
  - Lawrenceville, Georgia, Forenede Stater, 30045
    - Gwinnett Medical Center
  - Marietta, Georgia, Forenede Stater, 30060
    - Kennestone Cancer Center at Wellstar Kennestone Hospital
  - Riverdale, Georgia, Forenede Stater, 30274-2600
    - Southern Regional Medical Center
  - Savannah, Georgia, Forenede Stater, 31403-3089
    - Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center
  - Savannah, Georgia, Forenede Stater, 31405
    - Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
- Hawaii
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Cancer Research Center of Hawaii
  - Honolulu, Hawaii, Forenede Stater, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Queen's Cancer Institute at Queen's Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Straub Clinic and Hospital, Incorporated
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Hawaii Medical Center - East
- Illinois
  - Alton, Illinois, Forenede Stater, 62002
    - Saint Anthony's Hospital at Saint Anthony's Health Center
  - Aurora, Illinois, Forenede Stater, 60504
    - Rush-Copley Cancer Care Center
  - Bloomington, Illinois, Forenede Stater, 61701
    - St. Joseph Medical Center
  - Canton, Illinois, Forenede Stater, 61520
    - Graham Hospital
  - Carthage, Illinois, Forenede Stater, 62321
    - Memorial Hospital
  - Chicago, Illinois, Forenede Stater, 60657
    - Creticos Cancer Center at Advocate Illinois Masonic Medical Center
  - Chicago, Illinois, Forenede Stater, 60612-3785
    - John H. Stroger, Jr. Hospital of Cook County
  - Decatur, Illinois, Forenede Stater, 62526
    - Decatur Memorial Hospital Cancer Care Institute
  - Elgin, Illinois, Forenede Stater, 60120
    - Sherman Hospital
  - Elk Grove Village, Illinois, Forenede Stater, 60007
    - Alexian Brothers Radiation Oncology
  - Eureka, Illinois, Forenede Stater, 61530
    - Eureka Community Hospital
  - Evanston, Illinois, Forenede Stater, 60201-1781
    - Evanston Northwestern Healthcare - Evanston Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Galesburg Cottage Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Galesburg Clinic, PC
  - Geneva, Illinois, Forenede Stater, 60134
    - Delnor Community Hospital - Geneva
  - Havana, Illinois, Forenede Stater, 62644
    - Mason District Hospital
  - Hinsdale, Illinois, Forenede Stater, 60521
    - Hinsdale Hematology Oncology Associates
  - Hopedale, Illinois, Forenede Stater, 61747
    - Hopedale Medical Complex
  - Joliet, Illinois, Forenede Stater, 60435
    - Joliet Oncology-Hematology Associates, Limited - West
  - Kankakee, Illinois, Forenede Stater, 60901
    - Provena St. Mary's Regional Cancer Center - Kankakee
  - La Grange, Illinois, Forenede Stater, 60525
    - La Grange Memorial Hospital
  - Macomb, Illinois, Forenede Stater, 61455
    - Mcdonough District Hospital
  - Mount Vernon, Illinois, Forenede Stater, 62864
    - Good Samaritan Regional Health Center
  - Normal, Illinois, Forenede Stater, 61761
    - Bromenn Regional Medical Center
  - Normal, Illinois, Forenede Stater, 61761
    - Community Cancer Center
  - Olympia Fields, Illinois, Forenede Stater, 60461
    - Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields
  - Ottawa, Illinois, Forenede Stater, 61350
    - Community Hospital of Ottawa
  - Ottawa, Illinois, Forenede Stater, 61350
    - Oncology Hematology Associates of Central Illinois, PC - Ottawa
  - Park Ridge, Illinois, Forenede Stater, 60068-1174
    - Advocate Lutheran General Cancer Care Center
  - Pekin, Illinois, Forenede Stater, 61554
    - Cancer Treatment Center at Pekin Hospital
  - Peoria, Illinois, Forenede Stater, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Forenede Stater, 61614
    - Proctor Hospital
  - Peoria, Illinois, Forenede Stater, 61637
    - OSF St. Francis Medical Center
  - Peoria, Illinois, Forenede Stater, 61615
    - CCOP - Illinois Oncology Research Association
  - Peoria, Illinois, Forenede Stater, 61615
    - Oncology Hematology Associates of Central Illinois, PC - Peoria
  - Peru, Illinois, Forenede Stater, 61354
    - Illinois Valley Community Hospital
  - Princeton, Illinois, Forenede Stater, 61356
    - Perry Memorial Hospital
  - Rockford, Illinois, Forenede Stater, 61104-2315
    - Swedish-American Regional Cancer Center
  - Rockford, Illinois, Forenede Stater, 61108
    - Center for Cancer Care at OSF Saint Anthony Medical Center
  - Spring Valley, Illinois, Forenede Stater, 61362
    - St. Margaret's Hospital
  - Springfield, Illinois, Forenede Stater, 62781-0001
    - Regional Cancer Center at Memorial Medical Center
  - Urbana, Illinois, Forenede Stater, 61801
    - Carle Cancer Center at Carle Foundation Hospital
  - Urbana, Illinois, Forenede Stater, 61801
    - CCOP - Carle Cancer Center
- Indiana
  - Beech Grove, Indiana, Forenede Stater, 46107
    - St. Francis Hospital and Health Centers - Beech Grove Campus
  - Elkhart, Indiana, Forenede Stater, 46515
    - Elkhart General Hospital
  - Fort Wayne, Indiana, Forenede Stater, 46815
    - Fort Wayne Medical Oncology and Hematology
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Methodist Cancer Center at Methodist Hospital
  - Kokomo, Indiana, Forenede Stater, 46904
    - Howard Community Hospital
  - La Porte, Indiana, Forenede Stater, 46350
    - Center for Cancer Therapy at LaPorte Hospital and Health Services
  - Lafayette, Indiana, Forenede Stater, 47904
    - Clarian Arnett Cancer Care
  - Michigan City, Indiana, Forenede Stater, 46360
    - Saint Anthony Memorial Health Centers
  - Munster, Indiana, Forenede Stater, 46321
    - Community Hospital
  - Richmond, Indiana, Forenede Stater, 47374
    - Reid Hospital & Health Care Services
  - South Bend, Indiana, Forenede Stater, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Forenede Stater, 46601
    - CCOP - Northern Indiana CR Consortium
  - South Bend, Indiana, Forenede Stater, 46617
    - Saint Joseph Regional Medical Center
- Iowa
  - Ames, Iowa, Forenede Stater, 50010
    - McFarland Clinic, PC
  - Bettendorf, Iowa, Forenede Stater, 52722
    - Hematology Oncology Associates of the Quad Cities
  - Davenport, Iowa, Forenede Stater, 52803
    - Genesis Regional Cancer Center at Genesis Medical Center
  - Des Moines, Iowa, Forenede Stater, 50309
    - CCOP - Iowa Oncology Research Association
  - Des Moines, Iowa, Forenede Stater, 50309
    - John Stoddard Cancer Center at Iowa Methodist Medical Center
  - Des Moines, Iowa, Forenede Stater, 50309
    - Medical Oncology and Hematology Associates at John Stoddard Cancer Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Medical Oncology and Hematology Associates at Mercy Cancer Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mercy Cancer Center at Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forenede Stater, 50316
    - John Stoddard Cancer Center at Iowa Lutheran Hospital
  - Des Moines, Iowa, Forenede Stater, 50307
    - Mercy Capitol Hospital
  - Iowa City, Iowa, Forenede Stater, 52242-1002
    - Holden Comprehensive Cancer Center at University of Iowa
  - Mason City, Iowa, Forenede Stater, 50401
    - Mercy Cancer Center at Mercy Medical Center - North Iowa
  - Sioux City, Iowa, Forenede Stater, 51101
    - Siouxland Hematology-Oncology Associates, LLP
  - Sioux City, Iowa, Forenede Stater, 51104
    - St. Luke's Regional Medical Center
  - Sioux City, Iowa, Forenede Stater, 51104
    - Mercy Medical Center - Sioux City
  - Waterloo, Iowa, Forenede Stater, 50702
    - Covenant Cancer Treatment Center
- Kansas
  - Chanute, Kansas, Forenede Stater, 66720
    - Cancer Center of Kansas, PA - Chanute
  - Dodge City, Kansas, Forenede Stater, 67801
    - Cancer Center of Kansas, PA - Dodge City
  - El Dorado, Kansas, Forenede Stater, 67042
    - Cancer Center of Kansas, PA - El Dorado
  - Independence, Kansas, Forenede Stater, 67301
    - Cancer Center of Kansas-Independence
  - Kansas City, Kansas, Forenede Stater, 66112
    - Providence Medical Center
  - Kingman, Kansas, Forenede Stater, 67068
    - Cancer Center of Kansas, PA - Kingman
  - Lawrence, Kansas, Forenede Stater, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, Forenede Stater, 67901
    - Southwest Medical Center
  - Newton, Kansas, Forenede Stater, 67114
    - Cancer Center of Kansas, PA - Newton
  - Overland Park, Kansas, Forenede Stater, 66209
    - Menorah Medical Center
  - Overland Park, Kansas, Forenede Stater, 66210
    - Johnson County Radiation Therapy
  - Parsons, Kansas, Forenede Stater, 67357
    - Cancer Center of Kansas, PA - Parsons
  - Pratt, Kansas, Forenede Stater, 67124
    - Cancer Center of Kansas, PA - Pratt
  - Salina, Kansas, Forenede Stater, 67042
    - Cancer Center of Kansas, PA - Salina
  - Shawnee Mission, Kansas, Forenede Stater, 66204
    - Shawnee Mission Medical Center
  - Wellington, Kansas, Forenede Stater, 67152
    - Cancer Center of Kansas, PA - Wellington
  - Wichita, Kansas, Forenede Stater, 67208
    - Cancer Center of Kansas, PA - Medical Arts Tower
  - Wichita, Kansas, Forenede Stater, 67214
    - Cancer Center of Kansas, PA - Wichita
  - Wichita, Kansas, Forenede Stater, 67214
    - CCOP - Wichita
  - Wichita, Kansas, Forenede Stater, 67214
    - Via Christi Cancer Center at Via Christi Regional Medical Center
  - Wichita, Kansas, Forenede Stater, 67208
    - Associates in Womens Health, PA - North Review
  - Winfield, Kansas, Forenede Stater, 67156
    - Cancer Center of Kansas, PA - Winfield
- Kentucky
  - Ashland, Kentucky, Forenede Stater, 41101-0151
    - Cancer Resource Center at King's Daughters Medical Center
  - Lexington, Kentucky, Forenede Stater, 40536-0093
    - Lucille P. Markey Cancer Center at University of Kentucky
  - Louisville, Kentucky, Forenede Stater, 40207
    - Baptist Hospital East - Louisville
  - Louisville, Kentucky, Forenede Stater, 40202
    - Louisville Oncology at Norton Cancer Institute - Louisville
- Louisiana
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Ochsner Health Center - Bluebonnet
  - Baton Rouge, Louisiana, Forenede Stater, 70806
    - Pennington Cancer Center at Baton Rouge General
  - Houma, Louisiana, Forenede Stater, 70360
    - Terrebonne General Medical Center
  - Metairie, Louisiana, Forenede Stater, 70006
    - Drs Gurtler Brinz and Russo APMC-Metairie Oncologists
  - New Orleans, Louisiana, Forenede Stater, 70121
    - CCOP - Ochsner
  - New Orleans, Louisiana, Forenede Stater, 70112
    - MBCCOP - LSU Health Sciences Center
  - New Orleans, Louisiana, Forenede Stater, 70121
    - Ochsner Cancer Institute at Ochsner Clinic Foundation
  - Shreveport, Louisiana, Forenede Stater, 71101
    - Christus Schumpert Cancer Treatment Center
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21202
    - Mercy Medical Center
  - Baltimore, Maryland, Forenede Stater, 21229
    - St. Agnes Hospital Cancer Center
  - Baltimore, Maryland, Forenede Stater, 21215
    - Alvin and Lois Lapidus Cancer Institute at Sinai Hospital
  - Baltimore, Maryland, Forenede Stater, 21204
    - Greater Baltimore Medical Center Cancer Center
  - Baltimore, Maryland, Forenede Stater, 21237
    - Harry & Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center
  - Baltimore, Maryland, Forenede Stater, 21225
    - Harbor View Cancer Center at Harbor Hospital
  - Bethesda, Maryland, Forenede Stater, 20814
    - Suburban Hospital
  - Elkton, Maryland, Forenede Stater, 21921
    - Union Hospital Cancer Program at Union Hospital
  - Largo, Maryland, Forenede Stater, 20774
    - Kaiser Permanente Mid-Atlantic Medical Group-Largo Medical Facility
  - Leonardtown, Maryland, Forenede Stater, 20650
    - St. Mary's Hospital
  - Lutherville, Maryland, Forenede Stater, 21093
    - Kaiser Permanente - Towson
  - Rockville, Maryland, Forenede Stater, 20850
    - Kaiser Permanente Capital Area Medical Group - Shady Grove Facility
  - Salisbury, Maryland, Forenede Stater, 21801
    - Peninsula Regional Medical Center
- Massachusetts
  - Boston, Massachusetts, Forenede Stater, 02118
    - Boston University Cancer Research Center
  - Boston, Massachusetts, Forenede Stater, 02111
    - Tufts-NEMC Cancer Center
  - Concord, Massachusetts, Forenede Stater, 01742
    - Commonwealth Hematology-Oncology, PC - Concord
  - Dorchester, Massachusetts, Forenede Stater, 02124
    - Commonwealth Hematology Oncology PC - Dorchester
  - Fall River, Massachusetts, Forenede Stater, 02721
    - Hudner Oncology Center at Saint Anne's Hospital - Fall River
  - Haverhill, Massachusetts, Forenede Stater, 01830
    - Commonwealth Hematology-Oncology, PC - Haverhill
  - Lawrence, Massachusetts, Forenede Stater, 01842
    - Commonwealth Hematology-Oncology, PC - Lawrence
  - Leominster, Massachusetts, Forenede Stater, 01453
    - Commonwealth Hematology Oncology PC - Leominster
  - Milton, Massachusetts, Forenede Stater, 02186
    - Commonwealth Hematology Oncology PC - Milton
  - Pittsfield, Massachusetts, Forenede Stater, 01201
    - Berkshire Hematology Oncology, PC
  - Plymouth, Massachusetts, Forenede Stater, 02360
    - Jordan Hospital Club Cancer Center
  - Quincy, Massachusetts, Forenede Stater, 02169
    - Commonwealth Hematology-Oncology, PC - Quincy
  - Stoneham, Massachusetts, Forenede Stater, 02180
    - Commonwealth Hematology-Oncology, PC - Stoneham
  - Weymouth, Massachusetts, Forenede Stater, 02190
    - Commonwealth Hematology-Oncology, PC - Weymouth
  - Worcester, Massachusetts, Forenede Stater, 01605
    - Commonwealth Hematology-Oncology, PC - Worcester
- Michigan
  - Ann Arbor, Michigan, Forenede Stater, 48106-0995
    - Saint Joseph Mercy Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - CCOP - Michigan Cancer Research Consortium
  - Battle Creek, Michigan, Forenede Stater, 49017
    - Battle Creek Health System Cancer Care Center
  - Bay City, Michigan, Forenede Stater, 48708
    - Bay Regional Medical Center
  - Big Rapids, Michigan, Forenede Stater, 49307
    - Mecosta County Medical Center
  - Dearborn, Michigan, Forenede Stater, 48123-2500
    - Oakwood Cancer Center at Oakwood Hospital and Medical Center
  - Detroit, Michigan, Forenede Stater, 48202
    - Josephine Ford Cancer Center at Henry Ford Hospital
  - Flint, Michigan, Forenede Stater, 48503
    - Hurley Medical Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesys Hurley Cancer Institute
  - Flint, Michigan, Forenede Stater, 48532
    - Great Lakes Cancer Institute at McLaren Regional Medical Center
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Butterworth Hospital at Spectrum Health
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - CCOP - Grand Rapids
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Lacks Cancer Center at Saint Mary's Health Care
  - Grand Rapids, Michigan, Forenede Stater, 49506
    - Metro Health Hospital
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Van Elslander Cancer Center at St. John Hospital and Medical Center
  - Holland, Michigan, Forenede Stater, 49423
    - Holland Community Hospital
  - Jackson, Michigan, Forenede Stater, 49201
    - Foote Memorial Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49001
    - Borgess Medical Center
  - Kalamazoo, Michigan, Forenede Stater, 49007-3731
    - West Michigan Cancer Center
  - Lansing, Michigan, Forenede Stater, 48912-1811
    - Sparrow Regional Cancer Center
  - Lansing, Michigan, Forenede Stater, 48910
    - Breslin Cancer Center at Ingham Regional Medical Center
  - Lapeer, Michigan, Forenede Stater, 48446
    - Lapeer Regional Hospital
  - Livonia, Michigan, Forenede Stater, 48154
    - St. Mary Mercy Hospital
  - Marquette, Michigan, Forenede Stater, 49855
    - Upper Michigan Cancer Center at Marquette General Hospital
  - Muskegon, Michigan, Forenede Stater, 49442
    - Hackley Hospital
  - Pontiac, Michigan, Forenede Stater, 48341-2985
    - St. Joseph Mercy Oakland
  - Port Huron, Michigan, Forenede Stater, 48060
    - Mercy Regional Cancer Center at Mercy Hospital
  - Royal Oak, Michigan, Forenede Stater, 48073
    - William Beaumont Hospital - Royal Oak Campus
  - Saginaw, Michigan, Forenede Stater, 48601
    - Seton Cancer Institute at Saint Mary's - Saginaw
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Lakeland Regional Cancer Care Center - St. Joseph
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Oncology Care Associates, PLLC
  - Southfield, Michigan, Forenede Stater, 48075
    - Providence Cancer Institute at Providence Hospital - Southfield Campus
  - Traverse City, Michigan, Forenede Stater, 49684
    - Munson Medical Center
  - Warren, Michigan, Forenede Stater, 48093
    - St. John Macomb Hospital
- Minnesota
  - Bemidji, Minnesota, Forenede Stater, 56601
    - MeritCare Bemidji
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - Mercy and Unity Cancer Center at Mercy Hospital
  - Duluth, Minnesota, Forenede Stater, 55805
    - St. Luke's Hospital Cancer Care Center
  - Edina, Minnesota, Forenede Stater, 55435
    - Fairview Southdale Hospital
  - Fergus Falls, Minnesota, Forenede Stater, 56537
  - Fridley, Minnesota, Forenede Stater, 55432
    - Mercy and Unity Cancer Center at Unity Hospital
  - Hutchinson, Minnesota, Forenede Stater, 55350
    - Hutchinson Area Health Care
  - Litchfield, Minnesota, Forenede Stater, 55355
    - Meeker County Memorial Hospital
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Minnesota Oncology Hematology, PA - Maplewood
  - Maplewood, Minnesota, Forenede Stater, 55109
    - HealthEast Cancer Care at St. John's Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55415
    - Hennepin County Medical Center - Minneapolis
  - Robbinsdale, Minnesota, Forenede Stater, 55422-2900
    - Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - CentraCare Clinic - River Campus
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - CCOP - Metro-Minnesota
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Cancer Center
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - United Hospital
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Regions Hospital Cancer Care Center
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - HealthEast Cancer Care at St. Joseph's Hospital
  - Shakopee, Minnesota, Forenede Stater, 55379
    - St. Francis Cancer Center at St. Francis Medical Center
  - Waconia, Minnesota, Forenede Stater, 55387
    - Ridgeview Medical Center
  - Woodbury, Minnesota, Forenede Stater, 55125
    - Minnesota Oncology Hematology, PA - Woodbury
  - Woodbury, Minnesota, Forenede Stater, 55125
    - HealthEast Cancer Care at Woodwinds Health Campus
- Mississippi
  - Hattiesburg, Mississippi, Forenede Stater, 39401
    - Hattiesburg Clinic, PA at Forrest General
  - Hattiesburg, Mississippi, Forenede Stater, 39402
    - Hematology & Oncology Clinic
  - Pascagoula, Mississippi, Forenede Stater, 39581
    - Regional Cancer Center at Singing River Hospital
- Missouri
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Forenede Stater, 63701
    - Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
  - Chesterfield, Missouri, Forenede Stater, 63017
    - Saint Luke's Hospital
  - Columbia, Missouri, Forenede Stater, 65203
    - Ellis Fischel Cancer Center at University of Missouri - Columbia
  - Independence, Missouri, Forenede Stater, 64050
    - Independence Regional Health Center
  - Joplin, Missouri, Forenede Stater, 64804
    - St. John's Regional Medical Center
  - Joplin, Missouri, Forenede Stater, 64804
    - Freeman Cancer Institute at Freeman Health System
  - Kansas City, Missouri, Forenede Stater, 64131
    - CCOP - Kansas City
  - Kansas City, Missouri, Forenede Stater, 64116
    - North Kansas City Hospital
  - Kansas City, Missouri, Forenede Stater, 64108
    - Truman Medical Center - Hospital Hill
  - Kansas City, Missouri, Forenede Stater, 64111
    - Saint Luke's Cancer Institute at Saint Luke's Hospital
  - Kansas City, Missouri, Forenede Stater, 64114
    - St. Joseph Medical Center
  - Kansas City, Missouri, Forenede Stater, 64116
    - Parvin Radiation Oncology
  - Kansas City, Missouri, Forenede Stater, 64114
    - Kansas City Cancer Center at St. Joseph's Medical Mall
  - Kansas City, Missouri, Forenede Stater, 64154
    - Radiation Oncology Associates of Kansas City at Northland Radiation Oncology Center
  - Saint Joseph, Missouri, Forenede Stater, 64506
    - Heartland Regional Medical Center
  - Saint Louis, Missouri, Forenede Stater, 63131
    - Missouri Baptist Cancer Center
  - Saint Louis, Missouri, Forenede Stater, 63141
    - CCOP - St. Louis-Cape Girardeau
  - Saint Louis, Missouri, Forenede Stater, 63141
    - Arch Medical Services, Incorporated at Center for Cancer Care and Research
  - Saint Louis, Missouri, Forenede Stater, 63110
    - Saint Louis University Cancer Center
  - Saint Louis, Missouri, Forenede Stater, 63109
    - Midwest Hematology Oncology Group, Incorporated
  - Saint Louis, Missouri, Forenede Stater, 63141
    - David C. Pratt Cancer Center at St. John's Mercy
  - Springfield, Missouri, Forenede Stater, 65802
    - CCOP - Cancer Research for the Ozarks
  - Springfield, Missouri, Forenede Stater, 65804
    - St. John's Regional Health Center
  - Springfield, Missouri, Forenede Stater, 65807
    - Hulston Cancer Center at Cox Medical Center South
- Montana
  - Billings, Montana, Forenede Stater, 59101
    - CCOP - Montana Cancer Consortium
  - Billings, Montana, Forenede Stater, 59101
    - Hematology-Oncology Centers of the Northern Rockies - Billings
  - Billings, Montana, Forenede Stater, 59101
    - Northern Rockies Radiation Oncology Center
  - Billings, Montana, Forenede Stater, 59101
    - St. Vincent Healthcare Cancer Care Services
  - Billings, Montana, Forenede Stater, 59107-7000
    - Billings Clinic - Downtown
  - Bozeman, Montana, Forenede Stater, 59715
    - Bozeman Deaconess Cancer Center
  - Butte, Montana, Forenede Stater, 59701
    - St. James Healthcare Cancer Care
  - Great Falls, Montana, Forenede Stater, 59405
    - Great Falls Clinic - Main Facility
  - Great Falls, Montana, Forenede Stater, 59405
  - Great Falls, Montana, Forenede Stater, 59405-5309
    - Big Sky Oncology
  - Great Falls, Montana, Forenede Stater, 59405
    - Sletten Cancer Institute at Benefis Healthcare
  - Helena, Montana, Forenede Stater, 59601
    - St. Peter's Hospital
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Regional Medical Center
  - Kalispell, Montana, Forenede Stater, 59901
    - Glacier Oncology, PLLC
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Medical Oncology at KRMC
  - Missoula, Montana, Forenede Stater, 59801
    - Community Medical Center
  - Missoula, Montana, Forenede Stater, 59804
    - Guardian Oncology and Center for Wellness
  - Missoula, Montana, Forenede Stater, 59807-7877
    - Montana Cancer Specialists at Montana Cancer Center
  - Missoula, Montana, Forenede Stater, 59807
    - Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
- Nebraska
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Cancer Resource Center - Lincoln
  - Omaha, Nebraska, Forenede Stater, 68106
    - CCOP - Missouri Valley Cancer Consortium
  - Omaha, Nebraska, Forenede Stater, 68122
    - Immanuel Medical Center
  - Omaha, Nebraska, Forenede Stater, 68124
    - Alegant Health Cancer Center at Bergan Mercy Medical Center
  - Omaha, Nebraska, Forenede Stater, 68131-2197
    - Creighton University Medical Center
  - Omaha, Nebraska, Forenede Stater, 68114
    - Methodist Estabrook Cancer Center
- Nevada
  - Las Vegas, Nevada, Forenede Stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forenede Stater, 89106
    - CCOP - Nevada Cancer Research Foundation
  - Reno, Nevada, Forenede Stater, 89502
    - Renown Institute for Cancer at Renown Regional Medical Center
- New Hampshire
  - Exeter, New Hampshire, Forenede Stater, 03833
    - Center for Cancer Care at Exeter Hospital
- New Jersey
  - Flemington, New Jersey, Forenede Stater, 08822
    - Hunterdon Regional Cancer Center at Hunterdon Medical Center
  - Hamilton, New Jersey, Forenede Stater, 08690
    - Cancer Institute of New Jersey at Hamilton
  - Marlton, New Jersey, Forenede Stater, 08053
    - Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
  - Montclair, New Jersey, Forenede Stater, 07042
    - Mountainside Hospital Cancer Center
  - New Brunswick, New Jersey, Forenede Stater, 08903
    - Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
  - New Brunswick, New Jersey, Forenede Stater, 08903
    - Saint Peter's University Hospital
  - Newark, New Jersey, Forenede Stater, 07112
    - Newark Beth Israel Medical Center
  - Phillipsburg, New Jersey, Forenede Stater, 08865
    - Warren Hospital
  - Vineland, New Jersey, Forenede Stater, 08360
    - Franklin & Edith Scarpa Regional Cancer Center at South Jersey Healthcare
  - Voorhees, New Jersey, Forenede Stater, 08043
    - Cancer Institute of New Jersey at Cooper - Voorhees
  - Voorhees, New Jersey, Forenede Stater, 08043
    - Fox Chase Virtua Health Cancer Program at Virtua West Jersey
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87131-5636
    - University of New Mexico Cancer Center
  - Albuquerque, New Mexico, Forenede Stater, 87106
    - Hematology Oncology Associates, PC
  - Albuquerque, New Mexico, Forenede Stater, 87108
    - Lovelace Medical Center - Gibson
  - Santa Fe, New Mexico, Forenede Stater, 87505
    - New Mexico Cancer Care Associates
- New York
  - Albany, New York, Forenede Stater, 12206
    - New York Oncology Hematology, PC at Albany Regional Cancer Care
  - Albany, New York, Forenede Stater, 12208
    - New York Oncology Hematology, PC at Albany Medical Center
  - Amsterdam, New York, Forenede Stater, 12010
    - Amsterdam Community Cancer Program
  - Bronx, New York, Forenede Stater, 10461
    - Albert Einstein Cancer Center at Albert Einstein College of Medicine
  - Bronx, New York, Forenede Stater, 10466
    - Our Lady of Mercy Medical Center Comprehensive Cancer Center
  - Clifton Springs, New York, Forenede Stater, 14432
    - Finger Lakes Hematology and Oncology
  - East Syracuse, New York, Forenede Stater, 13057
    - CCOP - Hematology-Oncology Associates of Central New York
  - Glens Falls, New York, Forenede Stater, 12801
    - Charles R. Wood Cancer Center at Glens Falls Hospital
  - Hudson, New York, Forenede Stater, 12534
    - New York Oncology Hematology, PC - Hudson
  - Jamaica, New York, Forenede Stater, 11432
    - Queens Cancer Center of Queens Hospital
  - Latham, New York, Forenede Stater, 12110
    - New York Oncology Hematology, PC - Latham
  - Manhasset, New York, Forenede Stater, 11030
    - CCOP - North Shore University Hospital
  - Manhasset, New York, Forenede Stater, 11030
    - Don Monti Comprehensive Cancer Center at North Shore University Hospital
  - New Hyde Park, New York, Forenede Stater, 11042
    - Long Island Jewish Medical Center
  - Rexford, New York, Forenede Stater, 12148
    - Riverview Cancer Care Medical Associates, PC
  - Troy, New York, Forenede Stater, 12180
    - Samaritan Hospital at Northeast Health
- North Carolina
  - Asheboro, North Carolina, Forenede Stater, 27203-5400
    - Randolph Hospital
  - Asheville, North Carolina, Forenede Stater, 28801
    - Mission Hospitals - Memorial Campus
  - Burlington, North Carolina, Forenede Stater, 27216
    - Alamance Cancer Center at Alamance Regional Medical Center
  - Charlotte, North Carolina, Forenede Stater, 28232-2861
    - Blumenthal Cancer Center at Carolinas Medical Center
  - Eden, North Carolina, Forenede Stater, 27288
    - John Smith, Jr. - Dalton McMichael Cancer Center at Morehead Memorial Hospital
  - Fayetteville, North Carolina, Forenede Stater, 28302-2000
    - Cape Fear Valley Medical Center Cancer Center
  - Gastonia, North Carolina, Forenede Stater, 28053
    - CaroMont Cancer Center at Gaston Memorial Hospital
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Wayne Memorial Hospital, Incorporated
  - Greensboro, North Carolina, Forenede Stater, 27403-1198
    - Moses Cone Regional Cancer Center at Wesley Long Community Hospital
  - Greenville, North Carolina, Forenede Stater, 27835-6028
    - Leo W. Jenkins Cancer Center at ECU Medical School
  - Reidsville, North Carolina, Forenede Stater, 27320
    - Annie Penn Cancer Center
  - Rutherfordton, North Carolina, Forenede Stater, 28139
    - Rutherford Hospital
  - Washington, North Carolina, Forenede Stater, 27889
    - Marion L. Shepard Cancer Center at Beaufort County Hospital
  - Winston-Salem, North Carolina, Forenede Stater, 27157-1096
    - Wake Forest University Comprehensive Cancer Center
- North Dakota
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Bismarck Cancer Center
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Medcenter One Hospital Cancer Care Center
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Mid Dakota Clinic, PC
  - Bismarck, North Dakota, Forenede Stater, 58502
    - St. Alexius Medical Center Cancer Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - CCOP - MeritCare Hospital
  - Fargo, North Dakota, Forenede Stater, 58122
    - MeritCare Broadway
- Ohio
  - Akron, Ohio, Forenede Stater, 44307
    - McDowell Cancer Center at Akron General Medical Center
  - Akron, Ohio, Forenede Stater, 44309-2090
    - Summa Center for Cancer Care at Akron City Hospital
  - Bellefontaine, Ohio, Forenede Stater, 43311
    - Mary Rutan Hospital
  - Canton, Ohio, Forenede Stater, 44710-1799
    - Aultman Cancer Center at Aultman Hospital
  - Chillicothe, Ohio, Forenede Stater, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Forenede Stater, 45267
    - Charles M. Barrett Cancer Center at University Hospital
  - Cincinnati, Ohio, Forenede Stater, 45219
    - Christ Hospital Cancer Center
  - Cincinnati, Ohio, Forenede Stater, 45242
    - Oncology Hematology Care, Incorporated - Blue Ash
  - Cleveland, Ohio, Forenede Stater, 44106-5065
    - Case Comprehensive Cancer Center
  - Columbus, Ohio, Forenede Stater, 43214-3998
    - Riverside Methodist Hospital Cancer Care
  - Columbus, Ohio, Forenede Stater, 43222
    - Mount Carmel Health - West Hospital
  - Columbus, Ohio, Forenede Stater, 43210-1240
    - Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center
  - Columbus, Ohio, Forenede Stater, 43215
    - CCOP - Columbus
  - Columbus, Ohio, Forenede Stater, 43215
    - Grant Medical Center Cancer Care
  - Columbus, Ohio, Forenede Stater, 43228
    - Doctors Hospital at Ohio Health
  - Dayton, Ohio, Forenede Stater, 45428
    - Veterans Affairs Medical Center - Dayton
  - Dayton, Ohio, Forenede Stater, 45405
    - Grandview Hospital
  - Dayton, Ohio, Forenede Stater, 45406
    - Good Samaritan Hospital
  - Dayton, Ohio, Forenede Stater, 45409
    - David L. Rike Cancer Center at Miami Valley Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Samaritan North Cancer Care Center
  - Dayton, Ohio, Forenede Stater, 45429
    - CCOP - Dayton
  - Delaware, Ohio, Forenede Stater, 43015
    - Grady Memorial Hospital
  - Franklin, Ohio, Forenede Stater, 45005-1066
    - Middletown Regional Hospital
  - Kettering, Ohio, Forenede Stater, 45429
    - Charles F. Kettering Memorial Hospital
  - Lancaster, Ohio, Forenede Stater, 43130
    - Fairfield Medical Center
  - Lima, Ohio, Forenede Stater, 45801
    - St. Rita's Medical Center
  - Marietta, Ohio, Forenede Stater, 45750
    - Strecker Cancer Center at Marietta Memorial Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Licking Memorial Cancer Care Program at Licking Memorial Hospital
  - Springfield, Ohio, Forenede Stater, 45505
    - Community Hospital of Springfield and Clark County
  - Springfield, Ohio, Forenede Stater, 45504
    - Mercy Medical Center
  - Troy, Ohio, Forenede Stater, 45373-1300
    - UVMC Cancer Care Center at Upper Valley Medical Center
  - Westerville, Ohio, Forenede Stater, 43081
    - Mount Carmel St. Ann's Cancer Center
  - Wilmington, Ohio, Forenede Stater, 45177
    - Clinton Memorial Hospital
  - Wooster, Ohio, Forenede Stater, 44691
    - Cancer Treatment Center
  - Wright-Patterson Air Force Base, Ohio, Forenede Stater, 45433-5529
    - United States Air Force Medical Center - Wright-Patterson
  - Xenia, Ohio, Forenede Stater, 45385
    - Ruth G. McMillan Cancer Center at Greene Memorial Hospital
  - Youngstown, Ohio, Forenede Stater, 44501
    - Tod Children's Hospital
  - Zanesville, Ohio, Forenede Stater, 43701
    - Genesis - Good Samaritan Hospital
- Oklahoma
  - Lawton, Oklahoma, Forenede Stater, 73505
    - Cleo Craig Cancer Research Clinic
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - Oklahoma University Cancer Institute
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Cancer Care Associates - Mercy Campus
  - Tulsa, Oklahoma, Forenede Stater, 74136
    - Natalie Warren Bryant Cancer Center at St. Francis Hospital
  - Tulsa, Oklahoma, Forenede Stater, 74104
    - LaFortune Cancer Center at St. John Medical Center
- Oregon
  - Gresham, Oregon, Forenede Stater, 97030
    - Legacy Mount Hood Medical Center
  - Milwaukie, Oregon, Forenede Stater, 97222
    - Providence Milwaukie Hospital
  - Portland, Oregon, Forenede Stater, 97216
    - Adventist Medical Center
  - Portland, Oregon, Forenede Stater, 97210
    - Legacy Good Samaritan Hospital & Comprehensive Cancer Center
  - Portland, Oregon, Forenede Stater, 97213-2967
    - Providence Cancer Center at Providence Portland Medical Center
  - Portland, Oregon, Forenede Stater, 97225
    - CCOP - Columbia River Oncology Program
  - Portland, Oregon, Forenede Stater, 97225
    - Providence St. Vincent Medical Center
  - Portland, Oregon, Forenede Stater, 97227
    - Legacy Emanuel Hospital and Health Center and Children's Hospital
  - Portland, Oregon, Forenede Stater, 97232
    - Kaiser Permanente Health Care - Portland
  - Tualatin, Oregon, Forenede Stater, 97062
    - Legacy Meridian Park Hospital
- Pennsylvania
  - Abington, Pennsylvania, Forenede Stater, 19001
    - Rosenfeld Cancer Center at Abington Memorial Hospital
  - Allentown, Pennsylvania, Forenede Stater, 18105
    - Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
  - DuBois, Pennsylvania, Forenede Stater, 15801
    - Oncology Hematology Associates of Northern Pennsylvania, PC at Hahne Regional Cancer Center
  - East Stroudsburg, Pennsylvania, Forenede Stater, 18301
    - Dale and Frances Hughes Cancer Center at Pocono Medical Center
  - Easton, Pennsylvania, Forenede Stater, 18042
    - Easton Regional Cancer Center at Easton Hospital
  - Ephrata, Pennsylvania, Forenede Stater, 17522
    - Ephrata Cancer Center at Ephrata Community Hospital
  - Erie, Pennsylvania, Forenede Stater, 16505
    - Regional Cancer Center - Erie
  - Erie, Pennsylvania, Forenede Stater, 16544
    - Saint Vincent Health Center
  - Harrisburg, Pennsylvania, Forenede Stater, 17110-2098
    - PinnacleHealth Regional Cancer Center at Polyclinic Hospital
  - Kittanning, Pennsylvania, Forenede Stater, 16201
    - Richard G. Laube Cancer Center at ACMH
  - Media, Pennsylvania, Forenede Stater, 19063
    - Riddle Memorial Hospital Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19104-4283
    - Abramson Cancer Center of the University of Pennsylvania
  - Philadelphia, Pennsylvania, Forenede Stater, 19141
    - Albert Einstein Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19107-5541
    - Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
  - Philadelphia, Pennsylvania, Forenede Stater, 19114
    - Frankford Hospital Cancer Center - Torresdale Campus
  - Pittsburgh, Pennsylvania, Forenede Stater, 15232
    - UPMC Cancer Centers
  - Pittsburgh, Pennsylvania, Forenede Stater, 15212
    - Allegheny Cancer Center at Allegheny General Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15224-1791
    - Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
  - Pottstown, Pennsylvania, Forenede Stater, 19464
    - Pottstown Memorial Regional Cancer Center
  - Reading, Pennsylvania, Forenede Stater, 19612-6052
    - McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center
  - Sayre, Pennsylvania, Forenede Stater, 18840
    - Guthrie Cancer Center at Guthrie Clinic Sayre
  - Scranton, Pennsylvania, Forenede Stater, 18501
    - Mercy Hospital Cancer Center - Scranton
  - Scranton, Pennsylvania, Forenede Stater, 18508
    - Hematology and Oncology Associates of Northeastern Pennsylvania
  - State College, Pennsylvania, Forenede Stater, 16803
    - Mount Nittany Medical Center
  - Upland, Pennsylvania, Forenede Stater, 19013
    - Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center
  - York, Pennsylvania, Forenede Stater, 17405
    - York Cancer Center at Apple Hill Medical Center
- Rhode Island
  - Cranston, Rhode Island, Forenede Stater, 02920
    - Hematology and Oncology Associates of Rhode Island
  - Providence, Rhode Island, Forenede Stater, 02905
    - Women and Infants Hospital of Rhode Island
  - Warwick, Rhode Island, Forenede Stater, 02886
    - Kent County Memorial Hospital
- South Carolina
  - Anderson, South Carolina, Forenede Stater, 29621
    - AnMed Cancer Center
  - Greenville, South Carolina, Forenede Stater, 29615
    - CCOP - Greenville
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - CCOP - Upstate Carolina
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
- South Dakota
  - Aberdeen, South Dakota, Forenede Stater, 57401
    - Oncology Services of Aberdeen
  - Rapid City, South Dakota, Forenede Stater, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Medical X-Ray Center, PC
  - Sioux Falls, South Dakota, Forenede Stater, 57117-5039
    - Sanford Cancer Center at Sanford USD Medical Center
- Tennessee
  - Knoxville, Tennessee, Forenede Stater, 37920-6999
    - U.T. Medical Center Cancer Institute
- Texas
  - Austin, Texas, Forenede Stater, 78705
    - Texas Oncology - Midtown Austin
  - Austin, Texas, Forenede Stater, 78731
    - Texas Oncology, PA at Texas Oncology Cancer Center - Central
  - Austin, Texas, Forenede Stater, 78745
    - Texas Oncology, PA at South Austin Cancer Center
  - Bryan, Texas, Forenede Stater, 77802
    - St. Joseph Regional Cancer Center
  - Houston, Texas, Forenede Stater, 77030
    - Baylor University Medical Center - Houston
  - Lubbock, Texas, Forenede Stater, 79410-1894
    - Joe Arrington Cancer Research and Treatment Center
  - Round Rock, Texas, Forenede Stater, 78681
    - Texas Oncology, PA at Texas Cancer Center Round Rock
  - San Antonio, Texas, Forenede Stater, 78229-3900
    - University of Texas Health Science Center at San Antonio
  - Temple, Texas, Forenede Stater, 76508
    - CCOP - Scott and White Hospital
- Utah
  - American Fork, Utah, Forenede Stater, 84003
    - American Fork Hospital
  - Cedar City, Utah, Forenede Stater, 84720
    - Sandra L. Maxwell Cancer Center
  - Murray, Utah, Forenede Stater, 84157
    - Jon and Karen Huntsman Cancer Center at Intermountain Medical Center
  - Ogden, Utah, Forenede Stater, 84403
    - Val and Ann Browning Cancer Center at McKay-Dee Hospital Center
  - Provo, Utah, Forenede Stater, 84604
    - Utah Valley Regional Medical Center - Provo
  - Saint George, Utah, Forenede Stater, 84770
    - Dixie Regional Medical Center - East Campus
  - Salt Lake City, Utah, Forenede Stater, 84143
    - LDS Hospital
  - Salt Lake City, Utah, Forenede Stater, 84112
    - Huntsman Cancer Institute at University of Utah
  - Salt Lake City, Utah, Forenede Stater, 84106
    - Utah Cancer Specialists at UCS Cancer Center
- Vermont
  - Bennington, Vermont, Forenede Stater, 05201
    - Green Mountain Oncology Group
- Virginia
  - Fairfax, Virginia, Forenede Stater, 22033
    - Kaiser Permanente Medical Center - Fair Oaks
  - Hampton, Virginia, Forenede Stater, 23666
    - Virginia Oncology Associates - Hampton
  - Lynchburg, Virginia, Forenede Stater, 24501
    - Lynchburg Hematology-Oncology Clinic
  - Richmond, Virginia, Forenede Stater, 23298-0037
    - Virginia Commonwealth University Massey Cancer Center
  - Richmond, Virginia, Forenede Stater, 23230
    - Virginia Cancer Institute - West End
  - Roanoke, Virginia, Forenede Stater, 24014
    - Carilion Cancer Center of Western Virginia
- Washington
  - Bellevue, Washington, Forenede Stater, 98004
    - Overlake Cancer Center at Overlake Hospital Medical Center
  - Bellingham, Washington, Forenede Stater, 98225
    - St. Joseph Cancer Center
  - Bremerton, Washington, Forenede Stater, 98310
    - Olympic Hematology and Oncology
  - Federal Way, Washington, Forenede Stater, 98003
    - St. Francis Hospital
  - Port Angeles, Washington, Forenede Stater, 98362
    - Olympic Medical Center
  - Puyallup, Washington, Forenede Stater, 98372
    - Good Samaritan Cancer Center
  - Seattle, Washington, Forenede Stater, 98101
    - CCOP - Virginia Mason Research Center
  - Seattle, Washington, Forenede Stater, 98104
    - Fred Hutchinson Cancer Research Center
  - Seattle, Washington, Forenede Stater, 98112
    - Group Health Central Hospital
  - Seattle, Washington, Forenede Stater, 98122-4307
    - Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
  - Spokane, Washington, Forenede Stater, 99204-2967
    - Rockwood Clinic Cancer Treatment Center
  - Spokane, Washington, Forenede Stater, 99204
    - Providence Cancer Center at Sacred Heart Medical Center
  - Spokane, Washington, Forenede Stater, 99207
    - Providence Cancer Center at Holy Family Hospital
  - Spokane, Washington, Forenede Stater, 99218
    - Cancer Care Northwest - North
  - Tacoma, Washington, Forenede Stater, 98405-3004
    - Franciscan Cancer Center at St. Joseph Medical Center
  - Tacoma, Washington, Forenede Stater, 98405
    - Allenmore Hospital
  - Tacoma, Washington, Forenede Stater, 98405
    - CCOP - Northwest
  - Tacoma, Washington, Forenede Stater, 98499
    - St. Clare Hospital
  - Vancouver, Washington, Forenede Stater, 98668
    - Southwest Washington Medical Center Cancer Center
  - Walla Walla, Washington, Forenede Stater, 99362
    - St. Mary Regional Cancer Center at St. Mary Medical Center
  - Wenatchee, Washington, Forenede Stater, 98801-2028
    - Wenatchee Valley Medical Center
- West Virginia
  - Huntington, West Virginia, Forenede Stater, 25701
    - Edwards Comprehensive Cancer Center at Cabell Huntington Hospital
  - Huntington, West Virginia, Forenede Stater, 25702
    - St. Mary's Regional Cancer Center at St. Mary's Medical Center
  - Morgantown, West Virginia, Forenede Stater, 26506
    - Mary Babb Randolph Cancer Center at West Virginia University Hospitals
  - Parkersburg, West Virginia, Forenede Stater, 26102
    - Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital
  - Princeton, West Virginia, Forenede Stater, 24740
    - Princeton Community Hospital
- Wisconsin
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Center for Cancer Treatment & Prevention at Sacred Heart Hospital
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Marshfield Clinic Cancer Care at Regional Cancer Center
  - Elkhorn, Wisconsin, Forenede Stater, 53121
    - Vince Lombardi Cancer Center at Aurora Lakeland Medical Center - Elkhorn
  - Fond Du Lac, Wisconsin, Forenede Stater, 54935
    - Central Wisconsin Cancer Program at Agnesian HealthCare
  - Glendale, Wisconsin, Forenede Stater, 53212-1038
    - Oncology Alliance, SC - Milwaukee - East
  - Green Bay, Wisconsin, Forenede Stater, 54307-3508
    - St. Vincent Hospital Regional Cancer Center
  - Green Bay, Wisconsin, Forenede Stater, 54301-3526
    - Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Green Bay Oncology, Limited at St. Mary's Hospital
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - St. Mary's Hospital Medical Center - Green Bay
  - Madison, Wisconsin, Forenede Stater, 53717
    - Dean Medical Center - Madison
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Bay Area Cancer Care Center at Bay Area Medical Center
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Saint Joseph's Hospital
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Clinic - Marshfield Center
  - Milwaukee, Wisconsin, Forenede Stater, 53226
    - Medical College of Wisconsin Cancer Center
  - Milwaukee, Wisconsin, Forenede Stater, 53201-0342
    - Aurora Sinai Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - Medical Consultants, Limited
  - Minocqua, Wisconsin, Forenede Stater, 54548
    - Marshfield Clinic - Lakeland Center
  - Rhinelander, Wisconsin, Forenede Stater, 54501
    - Ministry Medical Group at Saint Mary's Hospital
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Marshfield Clinic - Indianhead Center
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - Saint Michael's Hospital Cancer Center
  - Two Rivers, Wisconsin, Forenede Stater, 54241
    - Vince Lombardi Cancer Clinic - Two Rivers
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Marshfield Clinic - Wausau Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Marshfield Clinic - Weston Center
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
- Wyoming
  - Sheridan, Wyoming, Forenede Stater, 82801
    - Welch Cancer Center at Sheridan Memorial Hospital
Puerto Rico
- - Ponce, Puerto Rico, 00733
    - Andres Grillasca Hospital
  - San Juan, Puerto Rico, 00928
    - San Juan City Hospital
  - San Juan, Puerto Rico, 00917
    - Hato Rey Hematology/Oncology Group, PSC
  - San Juan, Puerto Rico, 00919
    - I. Gonzalez Martinez Oncologic Hospital

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Kvinde

Beskrivelse

Berettigelse

Patienter skal være ældre end eller lig med 18 år.
Patienten skal have en forventet levetid på mindst 10 år, eksklusive hendes diagnose brystkræft. (Komorbide tilstande og præstationsstatus bør tages i betragtning, men ikke diagnosen brystkræft.)
Intervallet mellem den sidste operation for brystkræftbehandling (lumpektomi, mastektomi, sentinel lymfeknudebiopsi, aksillær operation eller re-excision af lumpektomimarginer) og randomisering må ikke være mere end 84 dage.
Tumoren skal være invasivt adenocarcinom ved histologisk undersøgelse. (Patienter med tumorer, der er rene tubulære eller mucinøse adenokarcinomer, er ikke kvalificerede.)
Den primære tumor skal være T1-3 ved klinisk og patologisk evaluering.
Lymfeknuder opnået fra alle aksillære stadieprocedurer skal være pN0 i henhold til patologiske stadiekriterier i 6. udgave af American Joint Committee on Cancer (AJCC) Cancer Staging Manual.
Patienter skal have gennemgået aksillære nodal-stadieprocedurer, f.eks. sentinel node (SN) biopsi alene, SN biopsi efterfulgt af aksillær prøvetagning eller komplet dissektion, eller aksillær node dissektion for at opnå lymfeknuder til patologisk evaluering. Hvis patienten har palpable noder, kræves aksillær dissektion.
Patienter skal have en østrogenreceptor (ER) analyse udført på den primære tumor før randomisering. Hvis ER er negativ, skal der udføres progesteronreceptor (PgR) analyse. Hvis ER er positiv, ønskes PgR-analyse, men ikke obligatorisk. ("Marginale" eller "grænsende" resultater [dvs. resultater, der ikke er definitivt negative] vil blive betragtet som positive uanset den anvendte metode.)
Patienterne skal have foretaget enten en lumpektomi eller total mastektomi.
Patienter må ikke have nogen klinisk eller radiologisk tegn på metastatisk sygdom.
Patienter med skeletsmerter er berettiget til at blive inkluderet i undersøgelsen, hvis knoglescanning eller røntgenologisk undersøgelse ikke afslører metastatisk sygdom. Mistænkelige fund skal bekræftes som benigne ved røntgen, MR eller biopsi.
Patientens menopausale status skal bestemmes inden randomisering.
- Præ- og postmenopausale kvinder er berettigede. Følgende kriterier vil blive brugt til at definere postmenopausal:
- en tidligere dokumenteret bilateral ooforektomi, eller
- en historie på mindst 12 måneder uden spontan menstruationsblødning, eller
- alder 55 eller ældre med en tidligere hysterektomi eller
- alder 54 eller yngre med en tidligere hysterektomi uden oophorektomi (eller hvor æggestokkenes status er ukendt), med et dokumenteret follikelstimulerende hormon (FSH) niveau, der viser bekræftende stigning i laboratoriets postmenopausale område.
- Kvinder, der ikke opfylder et af disse kriterier, vil blive klassificeret som præmenopausale.
På randomiseringstidspunktet skal patienten have haft følgende: anamnese og fysisk undersøgelse, EKG og PA og lateral røntgen af thorax eller thorax CT inden for de seneste 3 måneder; bilateral mammografi inden for de seneste 6 måneder; og bækkenundersøgelse (for kvinder, der har en livmoder, og som vil få tamoxifen) inden for det seneste år.
Inden for 3 måneder før indrejsen skal patienten have en baseline LVEF målt ved Multi Gated Acquisition (MUGA) scanning eller ekkokardiogram, der er lig med eller større end den nedre normalgrænse for den facilitet, der udfører proceduren.
På tidspunktet for randomisering:
- Det postoperative absolutte granulocyttal (AGC) skal være større end eller lig med 1500/mm3 (eller større end eller lig med 1200/mm3, hvis dette efter investigators opfattelse repræsenterer en etnisk eller racemæssig variant af normalen).
- Postoperativt trombocyttal skal være større end eller lig med 100.000/mm3. Betydelige underliggende hæmatologiske lidelser skal udelukkes, når blodpladetallet er over ULN for laboratoriet.
- Der skal være postoperativ dokumentation for tilstrækkelig leverfunktion, dvs.
- total bilirubin skal være mindre end eller lig med ULN for laboratoriet, medmindre patienten har en kronisk grad 1 bilirubinstigning (større end ULN til 1,5 x ULN) på grund af Gilberts sygdom eller lignende syndrom på grund af langsom konjugering af bilirubin; og
- alkalisk fosfatase skal være mindre end 2,5 x ULN for laboratoriet; og
- aspartattransaminasen (AST) [serumglutamin-oxaloeddikesyretransaminase (SGOT)] skal være mindre end eller lig med 1,5 x ULN for laboratoriet.
- Der skal være postoperativ tegn på normal nyrefunktion (serumkreatinin mindre end eller lig med ULN).
Patienter med en anamnese med ikke-brystmaligniteter er berettigede, hvis de har været sygdomsfrie i 5 eller flere år før randomisering og af deres læge vurderes at have lav risiko for tilbagefald. Patienter med følgende kræftformer er kvalificerede, hvis de er diagnosticeret og behandlet inden for de seneste 5 år: carcinom in situ i livmoderhalsen, melanom in situ og basalcelle- og pladecellecarcinom i huden.
Særlige betingelser for berettigelse af lumpektomipatienter: strålebehandling og kirurgi Patienter, der behandles med lumpektomi efterfulgt af bryststrålebehandling, skal opfylde alle berettigelseskriterierne ud over følgende:
- Generelt bør lumpektomi være forbeholdt tumorer mindre end 5 cm. Efter investigators skøn er patienter behandlet med lumpektomi for tumorer større end eller lig med 5 cm dog kvalificerede, hvis kriterierne for lumpektomi er opfyldt.
- Randene af den resekerede prøve skal være histologisk fri for invasiv tumor og DCIS som bestemt af den lokale patolog. Hos patienter, hvor patologisk undersøgelse viser en tumor til stede ved resektionslinjen, kan der udføres yderligere operative procedurer for at opnå klare marginer. Dette er tilladt, selvom der er udført aksillær dissektion. Patienter, hvor tumor stadig er til stede ved den resekerede margin efter re-excision(er), skal gennemgå total mastektomi for at være berettiget.
- Dette er en node-negativ undersøgelse, derfor er bestråling af regionale lymfeknuder forbudt i dette forsøg.
- Helbrystbestråling er påkrævet, medmindre patienten er tildelt gruppen med delvis brystbestråling på NSABP B-39.
- Postmastektomi bestråling af brystvæggen efter investigatorens skøn er tilladt. Dette er dog en node-negativ undersøgelse; derfor er bestråling af regionale lymfeknuder forbudt i dette forsøg.

Udelukkelse

Mandlige patienter er ikke kvalificerede til denne undersøgelse.
Rene tubulære eller mucinøse adenokarcinomer.
Bilateral malignitet (inklusive DCIS) eller en masse eller mammografisk abnormitet i det modsatte bryst, der er mistænkelig for malignitet, medmindre der er biopsibevis for, at massen ikke er malign.
Primær tumor iscenesat som T4 uanset årsag.
Mistænkelige palpable noder i de ipsilaterale eller kontralaterale aksillen eller palpable supraclavikulære eller infraclavikulære noder. Patienter med disse tilstande anses for uegnede, medmindre der er biopsibevis på, at disse ikke er involveret med tumor.
Tidligere brystkræft, inklusive DCIS (patienter med en historie med lobular carcinoma in situ [LCIS] er berettiget).
Behandling inklusive strålebehandling, kemoterapi, bioterapi og/eller hormonbehandling administreret for den aktuelt diagnosticerede brystkræft før randomisering. De eneste undtagelser er:
- Hormonbehandling, som kan have været givet i op til i alt 28 dage når som helst efter diagnosen og før studiestart. I et sådant tilfælde skal hormonbehandling stoppe ved eller før randomisering og genoptages, hvis indiceret, efter kemoterapi.
- Hvis patienten er optaget i NSABP B-39 og randomiseret til gruppe 2, kan partiel brystbestråling (PBI) afsluttes før påbegyndelse af behandling med NSABP B-36.
Forudgående antracyklinbehandling for enhver malignitet.
Enhver kønshormonel terapi, f.eks. p-piller, hormonsubstitutionsterapi i æggestokkene osv. (Disse patienter er berettigede, hvis denne terapi afbrydes før randomisering.)
Terapi med hormonelle midler såsom raloxifen (Evista®), tamoxifen eller andre selektive østrogenreceptormodulatorer (SERM'er), enten til osteoporose eller forebyggelse af brystkræft. (Patienter er kun kvalificerede, hvis disse lægemidler seponeres før randomisering. Med undtagelse af tamoxifen er disse medikamenter ikke tilladt under undersøgelsen.)
Hjertesygdom, der ville udelukke brugen af antracykliner. Dette omfatter:
- ethvert dokumenteret myokardieinfarkt;
- angina pectoris, der kræver brug af anti-anginal medicin;
- enhver historie med dokumenteret kongestiv hjertesvigt;
- alvorlig hjertearytmi, der kræver medicin,
- alvorlig ledningsabnormitet;
- klapsygdom med dokumenteret nedsat hjertefunktion; og
- dårligt kontrolleret hypertension, dvs. diastolisk mere end 100 mm/Hg. (Patienter med hypertension, der er godt kontrolleret på medicin, er berettiget til adgang.)
Ikke-malign systemisk sygdom (kardiovaskulær, nyre, lever osv.), som ville udelukke en patient fra at blive udsat for nogen af behandlingsmulighederne eller ville forhindre forlænget opfølgning.
Graviditet eller amning på tidspunktet for foreslået randomisering. Kvinder med reproduktionspotentiale skal acceptere at bruge en effektiv ikke-hormonel præventionsmetode.
Samtidig behandling med forsøgsmidler.
Psykiatriske eller vanedannende lidelser eller andre tilstande, der efter undersøgerens opfattelse vil forhindre patienten i at opfylde undersøgelseskravene.
Særlige betingelser for udelukkelse af lumpektomipatienter: strålebehandling og kirurgi. For patienter behandlet med lumpektomi er brystbestråling påkrævet. Følgende patienter vil være udelukket:
- Patienter med diffuse tumorer (som vist på mammografi), som ikke ville blive betragtet som kirurgisk modtagelige for lumpektomi. (Disse patienter er kvalificerede, hvis de gennemgår mastektomi.)
- Patienter behandlet med lumpektomi, hvor der er en anden klinisk dominerende masse eller mammografisk mistænkelig abnormitet i den ipsilaterale brystrest. En sådan masse skal biopsieres og påvises at være histologisk godartet før randomisering eller, hvis den er malign, skal den fjernes kirurgisk med klare marginer.
- Patienter, hvor marginerne af den resekerede prøve er involveret med invasiv tumor eller ductal carcinoma in situ (DCIS). Yderligere kirurgiske resektioner for at opnå frie marginer er tilladt. Patienter, hvor tumor stadig er til stede efter den eller de yderligere resektion(er), skal gennemgå mastektomi for at være berettiget. (Patienter med marginer positive for LCIS er berettigede uden yderligere resektion.)

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Ingen (Åben etiket)

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Aktiv komparator: Arm 1: adriamycin + cyclophosphamid Patienterne får adriamycin IV over 15 minutter efterfulgt af cyclophosphamid IV over 30 minutter på dag 1. Behandlingen gentages hver 21. dag i 4 forløb.	Medicin: cyclophosphamid Arm 1: cyclophosphamid 600 mg/m2 IV hver 21. dag i 4 cyklusser; Arm 2: cyclophosphamid 500 mg/m2 IV hver 21. dag i 6 cyklusser Medicin: adriamycin adriamycin 60 mg/m2 IV hver 21. dag i 4 cyklusser Andre navne: doxorubicin doxorubicin hydrochlorid
Eksperimentel: Arm 2: fluorouracil + epirubicin + cyclophosphamid Patienterne får fluorouracil IV, epirubicin IV over 15 minutter og cyclophosphamid IV over 30 minutter på dag 1. Behandlingen gentages hver 21. dag i 6 forløb.	Medicin: cyclophosphamid Arm 1: cyclophosphamid 600 mg/m2 IV hver 21. dag i 4 cyklusser; Arm 2: cyclophosphamid 500 mg/m2 IV hver 21. dag i 6 cyklusser Medicin: epirubicin epirubicin 100 mg/m2 IV hver 21. dag i 6 cyklusser Andre navne: epirubicin hydrochlorid Medicin: fluorouracil fluorouracil 500 mg/m2 IV hver 21. dag i 6 cyklusser Andre navne: 5-FU 5-fluoruracil

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Sygdomsfri overlevelse Tidsramme: 9 år	Procentdel af patienter fri for DFS-hændelse. DFS-hændelser omfatter lokalt, regionalt eller fjernt recidiv, anden primær cancer eller død af en hvilken som helst årsag før recidiv eller anden primær cancer	9 år

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Overlevelse Tidsramme: 9 år	Procentdel af patienter i live	9 år
Uønskede hændelser Tidsramme: 9 år	Procentdel af patienter med mindst én grad 2 eller højere bivirkning rapporteret	9 år
Livskvalitet-Funktionel vurdering af kræftterapi Tidsramme: 12 måneder	Functional Assessment of Cancer Therapy (FACT-B) trial outcome index (TOI) score. FACT-B TOI-score varierer fra 0 til 92, med en højere score, der indikerer bedre QOL.	12 måneder
Amenoré efter kemoterapi Tidsramme: 18 måneder	Procent med amenoré efter kemoterapi	18 måneder
Ændring i venstre ventrikulær ejektionsfraktion (LVEF) ved 12-måneders evalueringen Tidsramme: 12 måneder	Ændring i LVEF fra randomisering til 12 måneder	12 måneder
HER-2 og Topo II genamplifikation Tidsramme: 6 år		6 år
Gentagelsesfrit interval Tidsramme: 9 år	Procentdel af patienter med lokalt-regionalt recidiv eller fjernt recidiv	9 år
Fjernt gentagelsesfrit interval Tidsramme: 9 år	Procentdel af patienter med fjernt tilbagefald	9 år

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

NSABP Foundation Inc

Samarbejdspartnere

National Cancer Institute (NCI)

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. maj 2004

Primær færdiggørelse (Faktiske)

1. marts 2014

Studieafslutning (Faktiske)

1. maj 2016

Datoer for studieregistrering

Først indsendt

8. juli 2004

Først indsendt, der opfyldte QC-kriterier

9. juli 2004

Først opslået (Skøn)

12. juli 2004

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

11. august 2022

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

10. august 2022

Sidst verificeret

1. august 2022

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

NSABP B-36
U10CA012027 (U.S. NIH-bevilling/kontrakt)

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Brystkræft

Cairo University

Ikke rekrutterer endnu

Gyldighed og pålidelighed af arabisk version af brystspørgeskema

BREAST-Q
The First Affiliated Hospital of Xiamen University

Ikke rekrutterer endnu

Pyrotinib maleat -tabletter i kombination med dalpiciclib isethionate tabletter og standard endokrin terapi

Locally Advanced Breast Cancer (LABC)
Abouqir General Hospital
Alexandria University

Rekruttering

Øjeblikkelig brystrekonstruktion med hybrid fedtoverførsel

Breast Udseende Rekonstruktion Disproportion

Egypten
Beijing Bio-Targeting Therapeutics Technology Co...

Trukket tilbage

En klinisk undersøgelse for at undersøge sikkerheden, tolerabiliteten og effektiviteten af rekombinant human NSIL12 Oncolytisk adenovirusinjektion (BIOTTT001) kombineret med neoadjuvansbehandling til lokalt avanceret brystkræft

Locally Advanced Breast Cancer (LABC)

Kina
Indonesia University

Ikke rekrutterer endnu

Præoperative skulderøvelser og postoperativ inflammation, smerte og funktion efter modificeret radikal mastektomi

Præhabilitering | Postoperativ inflammation | Locally Advanced Breast Cancer (LABC)

Indonesien
Tianjin Medical University Cancer Institute and...
Guangxi Medical University; Sun Yat-sen University; Chinese PLA General Hospital og andre samarbejdspartnere

Afsluttet

De tekniske operationer og standard klinisk anvendelsesprotokol for CBBCT i diagnostisk proces af brystkræft (CBBCT)

Den kliniske anvendelsesvejledning af Conebeam Breast CT

Kina
Atlas University

Ikke rekrutterer endnu

Patient-afledte organoider til funktionel karakterisering af kemoterapiresistens i brystkræft (BC-PDO)

Brystkræft | Locally Advanced Breast Cancer (LABC)

Tyrkiet (Türkiye)
ETOP IBCSG Partners Foundation

Afsluttet

Forsøg om den endokrine aktivitet af Neoadjuvant Degarelix (TREND)

Breast Cancer Invasive Nos

Italien
Spanish Breast Cancer Research Group
Hoffmann-La Roche; Roche Farma, S.A

Afsluttet

A Combined GWAS and miRNA for the Identification of Bevacizumab Response Predictors in Metastatic Breast Cancer

Breast Cancer Invasive Nos

Spanien
Second Affiliated Hospital, School of Medicine,...

Rekruttering

Neoadjuvant Toripalimab plus SBRT til kemoresistent triple-negativ brystkræft (NEOTRIO-2)

TNBC, Triple Negative Breast Cancer

Kina

Kliniske forsøg med cyclophosphamid

University of Colorado, Denver

Afsluttet

Arsentrioxid med cyclophosphamid hos patienter med recidiverende/refraktær akut myeloid leukæmi

Akut myeloid leukæmi | Recidiverende/Refraktær Akut Myeloid Leukæmi

Forenede Stater
Children's Hospital Los Angeles
Lucile Packard Children's Hospital

Afsluttet

Relateret hæmatopoietisk stamcelletransplantation (HSCT) for genetiske sygdomme i blodceller

Metaboliske sygdomme | Stamcelletransplantation | Kronisk granulomatøs sygdom | Knoglemarvstransplantation | Thalassæmi | Wiskott-Aldrich syndrom | Genetiske sygdomme | Perifer blodstamcelletransplantation | Pædiatri | Diamond-Blackfan Anæmi | Allogen Transplantation | Kombineret immundefekt | X-bundet lymfoproliferativ...
TCRCure Biopharma Ltd.

Rekruttering

Funktionelt Forbedrede ALPP-målrettede Konstruerede T-celler i Avancerede Solide Tumorer

Solid tumor

Kina
Medical College of Wisconsin
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute... og andre samarbejdspartnere

Afsluttet

Fludarabin-baseret konditionering til svær aplastisk anæmi (BMT CTN 0301)

Anæmi, aplastisk

Forenede Stater
Second Affiliated Hospital, School of Medicine,...

Ikke rekrutterer endnu

Benmelstobart i kombination med Anlotinib og oral metronomisk cyclophosphamid i behandlingen af recidiverende epitelial ovarie-, æggeleder- eller primær peritonealcancer (BACON)

Livmoderhalskræft | Primær peritoneal kræft | Æggelederkræft
European Organisation for Research and Treatment...
Pfizer; ETOP IBCSG Partners Foundation; UNICANCER; Breast International Group; SOLTI Breast Cancer Research Group og andre samarbejdspartnere

Aktiv, ikke rekrutterende

Adjuverende Palbociclib hos ældre patienter med brystkræft (Appalaches)

Brystkræft fase II | Brystkræft fase III

Spanien, Frankrig, Italien, Belgien, Jordan, Polen, Tyskland, Det Forenede Kongerige, Portugal
Institut Bergonié
Merck Sharp & Dohme LLC; National Cancer Institute, France; Transgene; Fondation...

Rekruttering

En undersøgelse af metronomisk CP og JX-594 hos patienter med avanceret brystkræft og avanceret bløddelssarkom (METROmaJX) (METROmaJX)

Brystkræft | Blødt væv sarkom | Faste tumorer

Frankrig
Shandong Cancer Hospital and Institute

Ukendt

Undersøgelse af brystkræftsvindtilstande efter neoadjuverende kemoterapi med helmonterede seriesnit og tredimensionel patologisk og MR-rekonstruktion (BCSMANC)

Brystkræft

Kina
Mahidol University

Afsluttet

Lavdosis VS Højdosis IV cyclophosphamid til proliferativ LN hos børn (Low/highIVCY)

Nyreinsufficiens | Infektion

Thailand
National Cancer Institute, Naples
Immatics Biotechnologies GmbH; CureVac; European Commission -FP7-Health-2013-Innovation-1

Afsluttet

IMA970A Plus CV8102 hos patienter med meget tidligt, tidligt og mellemstadie af hepatocellulært karcinom

Hepatocellulært karcinom

Belgien, Tyskland, Italien, Spanien, Det Forenede Kongerige

Sammenligning af to kombinationskemoterapiregimer til behandling af kvinder med brystkræft

Et klinisk forsøg med adjuverende terapi, der sammenligner seks cyklusser af 5-fluorouracil, epirubicin og cyclophosphamid (FEC) med fire cyklusser af Adriamycin og cyclophosphamid (AC) hos patienter med node-negativ brystkræft

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Køn, der er berettiget til at studere

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Publikationer og nyttige links

Generelle publikationer

Datoer for undersøgelser

Studer store datoer

Studiestart

Primær færdiggørelse (Faktiske)

Studieafslutning (Faktiske)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Skøn)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Kliniske forsøg med Brystkræft

Kliniske forsøg med cyclophosphamid

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Armenia

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer