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Pain Perception in Suicidal Behavior Vulnerability (DOCS)

20. december 2021 opdateret af: University Hospital, Montpellier

In France, almost 1 death on 50 is a suicide. The suicide occurs in unbearable psychic pain where mental trouble has a major influence. It is classified as preventable mortality. According to interpersonal psychological theory of suicide, the repeated exposition to stressful and painful events (as physical abuse) would facilitate suicide attempt through the increased pain tolerance. The social pain (or psychical pain on the broader sense) and physical pain are closely linked.

The investigators hypothesize that the measure of painful perception will be significantly superior on suicidals attempters compared to non-attempters. It will be the case for recent suicide attempters and former suicide attempters, suggesting a suicidal vulnerability trait. Moreover, the investigators expect that social distress induced by a social exclusion paradigm will be significantly superior on suicide attempters compared to non-attempters.

The aim of the study is to investigate the physical and psychic pain on depressed subjects with or without history of suicide attempts.

After a clinical evaluation (psychiatric symptomatology, personality trait, suicidal dimension), subjects will be submitted to a painful thermic stimulation and will participate at a computer test of social exclusion (named Cyberball).

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

242 depressed patients ( 81 recent suicide attempters, 81 former suicide attempters, 80 non-attempters)

First visit : clinical assessment Second visit : pain evaluation and blood sample (from one day to a week maximum after the first visit).

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

167

Fase

  • Ikke anvendelig

Kontakter og lokationer

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Studiesteder

  • Frankrig
      • Montpellier, Frankrig, 34295
        • Montpellier Hospital University

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inclusion criteria:

  • aged by 18 years old
  • came from West Europe, excepted Basque and Sardinian (because of genetics analysis)
  • main diagnosis of major depressive episode (DSM V criteria)
  • not having take antalgics in the 24 hours before assessment
  • received a minimal psychotrope treatment (clinician evaluation)
  • Able to understand nature, aims, methodology of the study
  • Agree to cooperate in clinical and biological assessment
  • Having signed informed consent

Specific inclusion criteria :

81 recent suicide attempters (being hospitalised for suicidal attempts and having realised a suicide attempts 8 days before inclusion) 81 former suicide attempters (having realised in his lifetime a suicide attempt, one month before inclusion)

Exclusion criteria:

  • Current diagnosis of manic, hypomanic or alcohol dependance or substance abuse in the last 6 months, or diagnosis of schizophrenia or schizoaffective disorder in his lifetime
  • Current algic and chronic neurologic disease
  • Current or actual treatment by tricyclic antidepressant and Serotonin and norepinephrine reuptake inhibitors(SNRIs)
  • Pregnancy
  • Patients on protective measure

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Andet
  • Tildeling: N/A
  • Interventionel model: Enkelt gruppeopgave
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Andet: Study participant

All the participants performed blood sample for genetic purpose, psychiatric assessment and pain investigation:

  • 81 depressed patients admitted after a recent suicidal act (<8 days)
  • 81 depressed subjects with a past history of suicidal act (>1month)
  • 80 depressed subjects without any personal history of suicidal behaviour
Andet: Blood sample for genetic purpose, psychiatric assessment and pain investigation

All the participant will performed the same evaluation and blood analysis:

  • A clinical assessment by psychiatrics assessing psychiatric disorder and suicidal behavior
  • Thermal stimulation for pain assessment
  • Computer game named Cyberball: test of social exclusion
  • Self report questionnaire for the assessment of reject sensitivity, relationship style, impulsivity, childhood trauma.
  • Routine blood sampling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Pain tolerance reported by the patient
Tidsramme: During thermal stimulation
temperature measured when the subject will perceive as intolerable the pain following a painful stimulation performed using a thermode
During thermal stimulation

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Pain intensity reported by the patient
Tidsramme: During thermal stimulation
comparison between the three groups of the pain intensity (assessed by likert scale) at constant temperature (43 ° C)
During thermal stimulation
Pain threshold reported by the patient
Tidsramme: During thermal stimulation
comparison between the three groups of the pain threshold (temperature perceived as painful)
During thermal stimulation
Temperature assessed at 4/10 on likert scale
Tidsramme: During thermal stimulation performed at the inclusion
comparison between the three groups of the temperature assessed at 4/10 on a visual analogic painful scale, kinetics of pain intensity by visual analog scale (VAS) scale.
During thermal stimulation performed at the inclusion
Kinetics of pain intensity
Tidsramme: During thermal stimulation performed at the inclusion
comparison between the three groups of kinetics of pain intensity by visual analog scale (VAS) scale.
During thermal stimulation performed at the inclusion
Social distress perception assessed by social distress questionnaire
Tidsramme: At V2 (one week maximum after the inclusion)
comparison between the three groups of the score of social distress scale after cyberball game
At V2 (one week maximum after the inclusion)
Social distress perception assessed by the Rejection Sensitivity Questionnaire (RSQ)
Tidsramme: At the inclusion
comparison between the three groups of the score of social distress scale after cyberball game
At the inclusion
Social rejection sensitivity assessed by the Rejection Sensitivity Questionnaire (RSQ)
Tidsramme: At the inclusion
comparison between the three groups of the score of social rejection sensitivity by RSQ
At the inclusion
Psychological pain intensity
Tidsramme: At V2 (one week maximum after the inclusion)
comparison between the three groups of the score of psychological pain intensity assessed by VAS scale.
At V2 (one week maximum after the inclusion)
Measure of cardiac frequency in response to thermal pain
Tidsramme: At V2 (one week maximum after the inclusion)
comparison between the three groups of the cardiac frequency.
At V2 (one week maximum after the inclusion)

Samarbejdspartnere og efterforskere

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Sponsor

University Hospital, Montpellier

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

17. juni 2015

Primær færdiggørelse (Faktiske)

6. maj 2021

Studieafslutning (Faktiske)

6. maj 2021

Datoer for studieregistrering

Først indsendt

1. august 2016

Først indsendt, der opfyldte QC-kriterier

23. september 2016

Først opslået (Skøn)

27. september 2016

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

11. januar 2022

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

20. december 2021

Sidst verificeret

1. december 2021

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Andre undersøgelses-id-numre

  • UF 9185
  • 2013-A01029-36 (Anden identifikator: Agence Nationale de Sécurité des Médicaments)

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