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Pain Perception in Suicidal Behavior Vulnerability (DOCS)

20. desember 2021 oppdatert av: University Hospital, Montpellier

In France, almost 1 death on 50 is a suicide. The suicide occurs in unbearable psychic pain where mental trouble has a major influence. It is classified as preventable mortality. According to interpersonal psychological theory of suicide, the repeated exposition to stressful and painful events (as physical abuse) would facilitate suicide attempt through the increased pain tolerance. The social pain (or psychical pain on the broader sense) and physical pain are closely linked.

The investigators hypothesize that the measure of painful perception will be significantly superior on suicidals attempters compared to non-attempters. It will be the case for recent suicide attempters and former suicide attempters, suggesting a suicidal vulnerability trait. Moreover, the investigators expect that social distress induced by a social exclusion paradigm will be significantly superior on suicide attempters compared to non-attempters.

The aim of the study is to investigate the physical and psychic pain on depressed subjects with or without history of suicide attempts.

After a clinical evaluation (psychiatric symptomatology, personality trait, suicidal dimension), subjects will be submitted to a painful thermic stimulation and will participate at a computer test of social exclusion (named Cyberball).

Studieoversikt

Status

Avsluttet

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

242 depressed patients ( 81 recent suicide attempters, 81 former suicide attempters, 80 non-attempters)

First visit : clinical assessment Second visit : pain evaluation and blood sample (from one day to a week maximum after the first visit).

Studietype

Intervensjonell

Registrering (Faktiske)

167

Fase

  • Ikke aktuelt

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

  • Frankrike
      • Montpellier, Frankrike, 34295
        • Montpellier Hospital University

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

18 år og eldre (Voksen, Eldre voksen)

Tar imot friske frivillige

Nei

Kjønn som er kvalifisert for studier

Alle

Beskrivelse

Inclusion criteria:

  • aged by 18 years old
  • came from West Europe, excepted Basque and Sardinian (because of genetics analysis)
  • main diagnosis of major depressive episode (DSM V criteria)
  • not having take antalgics in the 24 hours before assessment
  • received a minimal psychotrope treatment (clinician evaluation)
  • Able to understand nature, aims, methodology of the study
  • Agree to cooperate in clinical and biological assessment
  • Having signed informed consent

Specific inclusion criteria :

81 recent suicide attempters (being hospitalised for suicidal attempts and having realised a suicide attempts 8 days before inclusion) 81 former suicide attempters (having realised in his lifetime a suicide attempt, one month before inclusion)

Exclusion criteria:

  • Current diagnosis of manic, hypomanic or alcohol dependance or substance abuse in the last 6 months, or diagnosis of schizophrenia or schizoaffective disorder in his lifetime
  • Current algic and chronic neurologic disease
  • Current or actual treatment by tricyclic antidepressant and Serotonin and norepinephrine reuptake inhibitors(SNRIs)
  • Pregnancy
  • Patients on protective measure

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

  • Primært formål: Annen
  • Tildeling: N/A
  • Intervensjonsmodell: Enkeltgruppeoppdrag
  • Masking: Ingen (Open Label)

Våpen og intervensjoner

Deltakergruppe / Arm
Intervensjon / Behandling
Annen: Study participant

All the participants performed blood sample for genetic purpose, psychiatric assessment and pain investigation:

  • 81 depressed patients admitted after a recent suicidal act (<8 days)
  • 81 depressed subjects with a past history of suicidal act (>1month)
  • 80 depressed subjects without any personal history of suicidal behaviour
Annen: Blood sample for genetic purpose, psychiatric assessment and pain investigation

All the participant will performed the same evaluation and blood analysis:

  • A clinical assessment by psychiatrics assessing psychiatric disorder and suicidal behavior
  • Thermal stimulation for pain assessment
  • Computer game named Cyberball: test of social exclusion
  • Self report questionnaire for the assessment of reject sensitivity, relationship style, impulsivity, childhood trauma.
  • Routine blood sampling

Hva måler studien?

Primære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Pain tolerance reported by the patient
Tidsramme: During thermal stimulation
temperature measured when the subject will perceive as intolerable the pain following a painful stimulation performed using a thermode
During thermal stimulation

Sekundære resultatmål

Resultatmål
Tiltaksbeskrivelse
Tidsramme
Pain intensity reported by the patient
Tidsramme: During thermal stimulation
comparison between the three groups of the pain intensity (assessed by likert scale) at constant temperature (43 ° C)
During thermal stimulation
Pain threshold reported by the patient
Tidsramme: During thermal stimulation
comparison between the three groups of the pain threshold (temperature perceived as painful)
During thermal stimulation
Temperature assessed at 4/10 on likert scale
Tidsramme: During thermal stimulation performed at the inclusion
comparison between the three groups of the temperature assessed at 4/10 on a visual analogic painful scale, kinetics of pain intensity by visual analog scale (VAS) scale.
During thermal stimulation performed at the inclusion
Kinetics of pain intensity
Tidsramme: During thermal stimulation performed at the inclusion
comparison between the three groups of kinetics of pain intensity by visual analog scale (VAS) scale.
During thermal stimulation performed at the inclusion
Social distress perception assessed by social distress questionnaire
Tidsramme: At V2 (one week maximum after the inclusion)
comparison between the three groups of the score of social distress scale after cyberball game
At V2 (one week maximum after the inclusion)
Social distress perception assessed by the Rejection Sensitivity Questionnaire (RSQ)
Tidsramme: At the inclusion
comparison between the three groups of the score of social distress scale after cyberball game
At the inclusion
Social rejection sensitivity assessed by the Rejection Sensitivity Questionnaire (RSQ)
Tidsramme: At the inclusion
comparison between the three groups of the score of social rejection sensitivity by RSQ
At the inclusion
Psychological pain intensity
Tidsramme: At V2 (one week maximum after the inclusion)
comparison between the three groups of the score of psychological pain intensity assessed by VAS scale.
At V2 (one week maximum after the inclusion)
Measure of cardiac frequency in response to thermal pain
Tidsramme: At V2 (one week maximum after the inclusion)
comparison between the three groups of the cardiac frequency.
At V2 (one week maximum after the inclusion)

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

University Hospital, Montpellier

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart

17. juni 2015

Primær fullføring (Faktiske)

6. mai 2021

Studiet fullført (Faktiske)

6. mai 2021

Datoer for studieregistrering

Først innsendt

1. august 2016

Først innsendt som oppfylte QC-kriteriene

23. september 2016

Først lagt ut (Anslag)

27. september 2016

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

11. januar 2022

Siste oppdatering sendt inn som oppfylte QC-kriteriene

20. desember 2021

Sist bekreftet

1. desember 2021

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Andre studie-ID-numre

  • UF 9185
  • 2013-A01029-36 (Annen identifikator: Agence Nationale de Sécurité des Médicaments)

Plan for individuelle deltakerdata (IPD)

Planlegger du å dele individuelle deltakerdata (IPD)?

Nei

Legemiddel- og utstyrsinformasjon, studiedokumenter

Studerer et amerikansk FDA-regulert medikamentprodukt

Nei

Studerer et amerikansk FDA-regulert enhetsprodukt

Nei

produkt produsert i og eksportert fra USA

Nei

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

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