Pain Perception in Suicidal Behavior Vulnerability (DOCS)
In France, almost 1 death on 50 is a suicide. The suicide occurs in unbearable psychic pain where mental trouble has a major influence. It is classified as preventable mortality. According to interpersonal psychological theory of suicide, the repeated exposition to stressful and painful events (as physical abuse) would facilitate suicide attempt through the increased pain tolerance. The social pain (or psychical pain on the broader sense) and physical pain are closely linked.
The investigators hypothesize that the measure of painful perception will be significantly superior on suicidals attempters compared to non-attempters. It will be the case for recent suicide attempters and former suicide attempters, suggesting a suicidal vulnerability trait. Moreover, the investigators expect that social distress induced by a social exclusion paradigm will be significantly superior on suicide attempters compared to non-attempters.
The aim of the study is to investigate the physical and psychic pain on depressed subjects with or without history of suicide attempts.
After a clinical evaluation (psychiatric symptomatology, personality trait, suicidal dimension), subjects will be submitted to a painful thermic stimulation and will participate at a computer test of social exclusion (named Cyberball).
Descripción general del estudio
Estado
Condiciones
Intervención / Tratamiento
Descripción detallada
242 depressed patients ( 81 recent suicide attempters, 81 former suicide attempters, 80 non-attempters)
First visit : clinical assessment Second visit : pain evaluation and blood sample (from one day to a week maximum after the first visit).
Tipo de estudio
Inscripción (Actual)
Fase
- No aplica
Contactos y Ubicaciones
Ubicaciones de estudio
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Montpellier, Francia, 34295
- Montpellier Hospital University
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Criterios de participación
Criterio de elegibilidad
Edades elegibles para estudiar
Acepta Voluntarios Saludables
Géneros elegibles para el estudio
Descripción
Inclusion criteria:
- aged by 18 years old
- came from West Europe, excepted Basque and Sardinian (because of genetics analysis)
- main diagnosis of major depressive episode (DSM V criteria)
- not having take antalgics in the 24 hours before assessment
- received a minimal psychotrope treatment (clinician evaluation)
- Able to understand nature, aims, methodology of the study
- Agree to cooperate in clinical and biological assessment
- Having signed informed consent
Specific inclusion criteria :
81 recent suicide attempters (being hospitalised for suicidal attempts and having realised a suicide attempts 8 days before inclusion) 81 former suicide attempters (having realised in his lifetime a suicide attempt, one month before inclusion)
Exclusion criteria:
- Current diagnosis of manic, hypomanic or alcohol dependance or substance abuse in the last 6 months, or diagnosis of schizophrenia or schizoaffective disorder in his lifetime
- Current algic and chronic neurologic disease
- Current or actual treatment by tricyclic antidepressant and Serotonin and norepinephrine reuptake inhibitors(SNRIs)
- Pregnancy
- Patients on protective measure
Plan de estudios
¿Cómo está diseñado el estudio?
Detalles de diseño
- Propósito principal: Otro
- Asignación: N / A
- Modelo Intervencionista: Asignación de un solo grupo
- Enmascaramiento: Ninguno (etiqueta abierta)
Armas e Intervenciones
Grupo de participantes/brazo |
Intervención / Tratamiento |
|---|---|
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Otro: Study participant
All the participants performed blood sample for genetic purpose, psychiatric assessment and pain investigation:
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All the participant will performed the same evaluation and blood analysis:
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¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
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Pain tolerance reported by the patient
Periodo de tiempo: During thermal stimulation
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temperature measured when the subject will perceive as intolerable the pain following a painful stimulation performed using a thermode
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During thermal stimulation
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Medidas de resultado secundarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
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Pain intensity reported by the patient
Periodo de tiempo: During thermal stimulation
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comparison between the three groups of the pain intensity (assessed by likert scale) at constant temperature (43 ° C)
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During thermal stimulation
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Pain threshold reported by the patient
Periodo de tiempo: During thermal stimulation
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comparison between the three groups of the pain threshold (temperature perceived as painful)
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During thermal stimulation
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Temperature assessed at 4/10 on likert scale
Periodo de tiempo: During thermal stimulation performed at the inclusion
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comparison between the three groups of the temperature assessed at 4/10 on a visual analogic painful scale, kinetics of pain intensity by visual analog scale (VAS) scale.
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During thermal stimulation performed at the inclusion
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Kinetics of pain intensity
Periodo de tiempo: During thermal stimulation performed at the inclusion
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comparison between the three groups of kinetics of pain intensity by visual analog scale (VAS) scale.
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During thermal stimulation performed at the inclusion
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Social distress perception assessed by social distress questionnaire
Periodo de tiempo: At V2 (one week maximum after the inclusion)
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comparison between the three groups of the score of social distress scale after cyberball game
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At V2 (one week maximum after the inclusion)
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Social distress perception assessed by the Rejection Sensitivity Questionnaire (RSQ)
Periodo de tiempo: At the inclusion
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comparison between the three groups of the score of social distress scale after cyberball game
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At the inclusion
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Social rejection sensitivity assessed by the Rejection Sensitivity Questionnaire (RSQ)
Periodo de tiempo: At the inclusion
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comparison between the three groups of the score of social rejection sensitivity by RSQ
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At the inclusion
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Psychological pain intensity
Periodo de tiempo: At V2 (one week maximum after the inclusion)
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comparison between the three groups of the score of psychological pain intensity assessed by VAS scale.
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At V2 (one week maximum after the inclusion)
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Measure of cardiac frequency in response to thermal pain
Periodo de tiempo: At V2 (one week maximum after the inclusion)
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comparison between the three groups of the cardiac frequency.
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At V2 (one week maximum after the inclusion)
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Colaboradores e Investigadores
Patrocinador
Fechas de registro del estudio
Fechas importantes del estudio
Inicio del estudio
Finalización primaria (Actual)
Finalización del estudio (Actual)
Fechas de registro del estudio
Enviado por primera vez
Primero enviado que cumplió con los criterios de control de calidad
Publicado por primera vez (Estimar)
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
Última actualización enviada que cumplió con los criterios de control de calidad
Última verificación
Más información
Términos relacionados con este estudio
Palabras clave
Otros números de identificación del estudio
- UF 9185
- 2013-A01029-36 (Otro identificador: Agence Nationale de Sécurité des Médicaments)
Plan de datos de participantes individuales (IPD)
¿Planea compartir datos de participantes individuales (IPD)?
Información sobre medicamentos y dispositivos, documentos del estudio
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