- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT03871374
Factors Affecting Salt Intake in Young Adults
Studieoversigt
Status
Betingelser
Detaljeret beskrivelse
Hypertension is a major cause of cardiovascular disease (CVD) and overall mortality. High dietary salt intake is a major risk factor for hypertension estimated to be responsible for one in ten deaths from CVD events. Salt consumption worldwide and in the UK exceeds the recommendations. One of the main determinants of food intake, and potentially salt, is taste which may be genetically determined. Research exploring the associations between genetics, salt taste and salt intake is scarce. Better understanding of these associations would be of specific interest in younger populations as it has been shown that it is the young adults that have higher preference for salty taste and consequently salt intake. Therefore, the aim of this study is to explore the associations between genetics, salt taste perception and salt intake in young UK adults.
One hundred participants (18-35 years) will be recruited. Salt taste thresholds will be identified using the British Standards Institution sensory analysis method (BS ISO 3972:2011) and preference for salty taste by rating the pleasantness and bitterness of six tomato soups with differing salt concentrations. Salt intake will be measured using five step multiple pass 24-hour recall completed via online platform (Online surveys) for one day of the week and one weekend day. Participants will be genotyped for genetic variants in the SCNN1B and TRPV1 genes coding for ion channels expressed in taste cells.
Undersøgelsestype
Tilmelding (Forventet)
Kontakter og lokationer
Studiesteder
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London, Det Forenede Kongerige, TW14SX
- St Mary's University
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Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Prøveudtagningsmetode
Studiebefolkning
Beskrivelse
Inclusion Criteria:
- Males or females, aged 18-35 years and healthy.
Exclusion Criteria:
- Current stage 1 or 2 hypertension
- Current or recent (less than one month prior to screening visit) use of antihypertensive medications or medications that affect BP
- Secondary hypertension
- History of cardiovascular disease, including myocardial infarction, congestive heart failure, stroke, and peripheral arterial disease
- Chronic kidney failure
- Peptic ulcer disease requiring treatment during the previous two years
- Currently pregnant women
- Underweight (BMI<18.5 kg/m2) and obese (BMI>30 kg/m2)
- Currently adhering to a low sodium diet
- Any illness that permanently alters taste
- Inability or unwillingness to participate or sign informed consent form
- Food allergy
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Salt intake
Tidsramme: 2 days observation
|
Dietary salt intake - two 24-hour recalls
|
2 days observation
|
Samarbejdspartnere og efterforskere
Sponsor
Datoer for undersøgelser
Studer store datoer
Studiestart (Forventet)
Primær færdiggørelse (Forventet)
Studieafslutning (Forventet)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Andre undersøgelses-id-numre
- SMEC_2018-19_007
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
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