- ICH GCP
- US Clinical Trials Registry
- Klinisk utprøving NCT03871374
Factors Affecting Salt Intake in Young Adults
Studieoversikt
Status
Forhold
Detaljert beskrivelse
Hypertension is a major cause of cardiovascular disease (CVD) and overall mortality. High dietary salt intake is a major risk factor for hypertension estimated to be responsible for one in ten deaths from CVD events. Salt consumption worldwide and in the UK exceeds the recommendations. One of the main determinants of food intake, and potentially salt, is taste which may be genetically determined. Research exploring the associations between genetics, salt taste and salt intake is scarce. Better understanding of these associations would be of specific interest in younger populations as it has been shown that it is the young adults that have higher preference for salty taste and consequently salt intake. Therefore, the aim of this study is to explore the associations between genetics, salt taste perception and salt intake in young UK adults.
One hundred participants (18-35 years) will be recruited. Salt taste thresholds will be identified using the British Standards Institution sensory analysis method (BS ISO 3972:2011) and preference for salty taste by rating the pleasantness and bitterness of six tomato soups with differing salt concentrations. Salt intake will be measured using five step multiple pass 24-hour recall completed via online platform (Online surveys) for one day of the week and one weekend day. Participants will be genotyped for genetic variants in the SCNN1B and TRPV1 genes coding for ion channels expressed in taste cells.
Studietype
Registrering (Forventet)
Kontakter og plasseringer
Studiesteder
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London, Storbritannia, TW14SX
- St Mary's University
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Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
Tar imot friske frivillige
Kjønn som er kvalifisert for studier
Prøvetakingsmetode
Studiepopulasjon
Beskrivelse
Inclusion Criteria:
- Males or females, aged 18-35 years and healthy.
Exclusion Criteria:
- Current stage 1 or 2 hypertension
- Current or recent (less than one month prior to screening visit) use of antihypertensive medications or medications that affect BP
- Secondary hypertension
- History of cardiovascular disease, including myocardial infarction, congestive heart failure, stroke, and peripheral arterial disease
- Chronic kidney failure
- Peptic ulcer disease requiring treatment during the previous two years
- Currently pregnant women
- Underweight (BMI<18.5 kg/m2) and obese (BMI>30 kg/m2)
- Currently adhering to a low sodium diet
- Any illness that permanently alters taste
- Inability or unwillingness to participate or sign informed consent form
- Food allergy
Studieplan
Hvordan er studiet utformet?
Designdetaljer
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
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Salt intake
Tidsramme: 2 days observation
|
Dietary salt intake - two 24-hour recalls
|
2 days observation
|
Samarbeidspartnere og etterforskere
Sponsor
Studierekorddatoer
Studer hoveddatoer
Studiestart (Forventet)
Primær fullføring (Forventet)
Studiet fullført (Forventet)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Faktiske)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Andre studie-ID-numre
- SMEC_2018-19_007
Plan for individuelle deltakerdata (IPD)
Planlegger du å dele individuelle deltakerdata (IPD)?
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