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LIVERAGE™: En undersøgelse for at teste, om Survodutide hjælper mennesker med en leversygdom kaldet NASH/MASH, som har moderat eller avanceret leverfibrose

27. oktober 2026 opdateret af: Boehringer Ingelheim

Et randomiseret, dobbeltblindt, placebokontrolleret, multicenter, fase III-forsøg, der evaluerer langsigtet effektivitet og sikkerhed af ugentlige Survodutide-injektioner hos voksne deltagere med ikke-cirrhotisk ikke-alkoholisk steatohepatitis/metabolisk associeret steatohepatitis (NASH/MASH) og (F2) (F3) Stadium af leverfibrose

This study is open to adults who are at least 18 years old living with obesity and have:

  • a confirmed liver disease called non-alcoholic steatohepatitis (NASH)/metabolic associated steatohepatitis (MASH) and
  • moderate or advanced liver fibrosis

People with a history of acute or chronic liver diseases other than MASH or chronic alcohol intake cannot take part in this study. The purpose of this study is to find out whether a medicine called survodutide helps people with MASH and moderate or advanced liver fibrosis improve their liver function.

This study has 2 parts. The purpose of the first part of this study is to find out the effect of survodutide on MASH and liver fibrosis. The purpose of the second part is to find out how safe and effective survodutide is in improving liver function. Participants are put into 2 groups randomly, which means by chance. 1 group gets survodutide and 1 group gets placebo. Placebo looks like survodutide but does not contain any medicine. Each participant has twice the chance of getting survodutide. Participants and doctors do not know who is in which group. Participants inject survodutide or placebo under their skin once a week. The survodutide doses are slowly increased until the target dose is reached. All participants receive counselling to make changes to their diet and to exercise regularly.

Participants are in the study for up to 7 years. During this time, they regularly visit the study site or have remote visits by video call. For about the first year of the study, participants have these visits every 2 weeks, increasing to every 4 weeks and then every 6 weeks. After being in the study for a little over a year participants will then alternate between visiting the study site or having a remote visit every 3 months until the end of the study.

The doctors check participants' health and take note of any unwanted effects. The participants' body weight and effects on the stomach and intestines are regularly measured. At some visits the liver is measured using different imaging methods. At 2 or 3 visits doctors take a small sample of liver tissue (biopsy). The participants also fill in questionnaires about their symptoms and quality of life. The results are compared between the groups to see whether the treatment works.

Studieoversigt

Status

Rekruttering

Betingelser

Intervention / Behandling

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

1800

Fase

  • Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiekontakt

Studiesteder

  • Argentina
      • Buenos Aires, Argentina, C1199ABB
        • Rekruttering
        • Hospital Italiano de Buenos Aires
        • Kontakt:
      • Buenos Aires, Argentina, 1061
      • Buenos Aires, Argentina, C1056ABJ
        • Rekruttering
        • Centro de Investigaciones Metabolicas (CINME)
        • Kontakt:
      • Buenos Aires, Argentina, C1012AAR
        • Rekruttering
        • IDIM - Instituto de Diagnostico e Investigaciones Metabolicas
        • Kontakt:
      • Buenos Aires, Argentina, C1430CKE
        • Rekruttering
        • Glenny Corp - Centro Medico Saavedra
        • Kontakt:
      • Buenos Aires, Argentina, C1061AAE
      • Buenos Aires, Argentina, C1128AAF
        • Rekruttering
        • Mautalen- Salud e Investigacion
        • Kontakt:
      • Ciudad Autonoma Buenos Aires, Argentina, C1221ADC
        • Rekruttering
        • Hospital General de Agudos Dr. J. M. Ramos Mejia
        • Kontakt:
      • Pilar, Argentina, B1629ODT
      • Ramos Mejía, Argentina, 1704
      • San Juan Bautista, Argentina, B1888
  • Australien
    • New South Wales
      • Concord, New South Wales, Australien, 2139
        • Afsluttet
        • Concord Repatriation General Hospital
      • Kingswood, New South Wales, Australien, 2747
      • Liverpool, New South Wales, Australien, 2170
      • Westmead, New South Wales, Australien, 2145
    • Queensland
      • Birtinya, Queensland, Australien, 4575
        • Rekruttering
        • Sunshine Coast University Hospital
        • Kontakt:
    • Victoria
      • Clayton, Victoria, Australien, 3168
      • Heidelberg, Victoria, Australien, 3084
      • Parkville, Victoria, Australien, 3050
    • Western Australia
      • Perth, Western Australia, Australien, 6000
  • Belgien
      • Brussels, Belgien, 1070
      • Brussels, Belgien, 1200
        • Ikke rekrutterer endnu
        • Cliniques Universitaires Saint-Luc
        • Kontakt:
      • Edegem, Belgien, 2650
        • Rekruttering
        • Universitair Ziekenhuis Antwerpen
        • Kontakt:
      • Genk, Belgien, 3600
      • Ghent, Belgien, 9000
      • Leuven, Belgien, 3000
        • Suspenderet
        • UZ Leuven
      • Liège, Belgien, 4000
        • Rekruttering
        • Centre Hospitalier Universitaire de Liège
        • Kontakt:
      • Namur, Belgien, 5004
      • Roeselare, Belgien, 8800
  • Brasilien
      • Barra, Brasilien, 21941-617
        • Ikke rekrutterer endnu
        • Universidade Federal do Rio de Janeiro
        • Kontakt:
      • Belo Horizonte, Brasilien, 30130-100
        • Ikke rekrutterer endnu
        • Hospital das Clinicas da Universidade Federal de Minas Gerais (HC-UFMG)
        • Kontakt:
      • Belém, Brasilien, 66073-005
        • Rekruttering
        • Hospital Universitário João de Barros Barreto
        • Kontakt:
      • Botucatu, Brasilien, 18618-970
        • Rekruttering
        • Universidade Estadual Paulista "Julio De Mesquita Filho"
        • Kontakt:
      • Cerqueira César, Brasilien, 05403-000
        • Rekruttering
        • Hospital das Clinicas da Faculdade de Medicina da USP
        • Kontakt:
      • Lago Sul, Brasilien, 71625-175
        • Ikke rekrutterer endnu
        • Centro de Pesquisa Clinica do Brasil
        • Kontakt:
      • Porto Alegre, Brasilien, 90035-903
        • Rekruttering
        • Universidade Federal do Rio Grande do Sul
        • Kontakt:
      • Porto Alegre, Brasilien, 90035-001
        • Rekruttering
        • Hospitalar Moinhos de Vento
        • Kontakt:
      • São José do Rio Preto, Brasilien, 15090-000
      • São Paulo, Brasilien, 04077-020
        • Rekruttering
        • Rocco E Nazato Servicos Medicos LTDA
        • Kontakt:
  • Bulgarien
      • Gorna Oryahovitsa, Bulgarien, 5100
      • Panagyurishte, Bulgarien, 4500
        • Rekruttering
        • Multi-profile Hospital For Active Treatment-Uni Hospital Ltd.
        • Kontakt:
      • Sofia, Bulgarien, 1606
        • Rekruttering
        • Medical Military Academy MHAT Sofia
        • Kontakt:
      • Sofia, Bulgarien, 1407
        • Rekruttering
        • Acibadem City Clinic Tokuda University Hospital EAD
        • Kontakt:
      • Sofia, Bulgarien, 1431
        • Rekruttering
        • Diagnostic Consultative Center Alexandrovska
        • Kontakt:
      • Sofia, Bulgarien, 1431
        • Rekruttering
        • University Multiprofile Hospital for Active Treatment St. Ivan Rilski EAD
        • Kontakt:
      • Stara Zagora, Bulgarien, 6001
        • Rekruttering
        • Medical Center New Rehabilitation Center EOOD
        • Kontakt:
  • Canada
      • Québec, Canada, G1V 4T3
        • Rekruttering
        • Diex Recherche Québec
        • Kontakt:
    • Alberta
      • Calgary, Alberta, Canada, T2N 4N1
        • Rekruttering
        • University of Calgary
        • Kontakt:
    • British Columbia
      • Vancouver, British Columbia, Canada, V5Z 1M9
        • Rekruttering
        • University of British Columbia
        • Kontakt:
      • Vancouver, British Columbia, Canada, V6Z 2K5
        • Rekruttering
        • Pacific Gastroenterology Associates
        • Kontakt:
    • Nova Scotia
      • Bridgewater, Nova Scotia, Canada, B4N 3N2
        • Rekruttering
        • Viable Clinical Research
        • Kontakt:
    • Ontario
      • Toronto, Ontario, Canada, M6H 3M1
        • Rekruttering
        • Toronto Liver Centre
        • Kontakt:
    • Quebec
      • Montreal, Quebec, Canada, H3H 2R9
        • Rekruttering
        • McGill University Health Centre (MUHC)
        • Kontakt:
      • Montreal, Quebec, Canada, H2X 1R9
        • Ikke rekrutterer endnu
        • Centre Hospitalier de l'Universite de Montreal (CHUM)
        • Kontakt:
      • Terrebonne, Quebec, Canada, J6X 4P7
        • Rekruttering
        • Centre de Médecine Métabolique de Lanaudière
        • Kontakt:
  • Chile
      • La Serena, Chile, 1710209
      • Santiago, Chile, 8330024
        • Rekruttering
        • Centro de Investigaciones Medicas UC
        • Kontakt:
      • Viña del Mar, Chile, 2540488
        • Rekruttering
        • Centro de Investigaciones Clinicas Viña del Mar
        • Kontakt:
  • Det Forenede Kongerige
      • Aberdeen, Det Forenede Kongerige, AB25 2ZN
      • Ashton in Makerfield, Det Forenede Kongerige, WN4 8LB
      • Bristol, Det Forenede Kongerige, BS82RA
      • Camberley, Det Forenede Kongerige, GU16 7UJ
      • Dagenham, Det Forenede Kongerige, RM9 5QP
      • Edgbaston, Birmingham, Det Forenede Kongerige, B15 2WB
      • Edgware, Det Forenede Kongerige, HA8 0AD
        • Rekruttering
        • Elpida Clinical Trials - Edgware Community Hospital
        • Kontakt:
      • Enfield, London, Det Forenede Kongerige, EN3 4GS
      • Exeter, Det Forenede Kongerige, EX2 5AX
      • Glasgow, Det Forenede Kongerige, G51 4TY
      • Hull, Det Forenede Kongerige, HU3 2JZ
      • London, Det Forenede Kongerige, SE5 9RS
      • London, Det Forenede Kongerige, SW10 9NH
      • London, Det Forenede Kongerige, NW3 2Qg
      • Newcastle upon Tyne, Det Forenede Kongerige, NE4 6BE
      • Northwood, Det Forenede Kongerige, HA6 2RN
      • Nottingham, Det Forenede Kongerige, NG7 2UH
      • Orpington, London, Det Forenede Kongerige, BR5 3QG
      • Preston, Det Forenede Kongerige, PR2 9RB
      • Rochdale, Det Forenede Kongerige, OL11 4AU
      • Sheffield, Det Forenede Kongerige, S2 5FX
      • Southampton, Det Forenede Kongerige, SO16 6YD
      • Tooting, London, Det Forenede Kongerige, SW17 0QT
      • York, Det Forenede Kongerige, YO24 4LJ
  • Forenede Stater
    • Alabama
      • Birmingham, Alabama, Forenede Stater, 35233
        • Ikke rekrutterer endnu
        • University of Alabama at Birmingham
        • Kontakt:
    • Arizona
      • Peoria, Arizona, Forenede Stater, 85381
        • Rekruttering
        • The Institute for Liver Health II DBA Arizona Clinical Trials
        • Kontakt:
      • Scottsdale, Arizona, Forenede Stater, 85258
      • Tucson, Arizona, Forenede Stater, 85712
      • Tucson, Arizona, Forenede Stater, 85715
      • Tucson, Arizona, Forenede Stater, 85712
    • California
      • Canoga Park, California, Forenede Stater, 91303
      • Chula Vista, California, Forenede Stater, 91911
      • Coronado, California, Forenede Stater, 92118
      • Fountain Valley, California, Forenede Stater, 92708
      • Fresno, California, Forenede Stater, 93720
      • Gardena, California, Forenede Stater, 90247
      • Huntington Park, California, Forenede Stater, 90255
        • Rekruttering
        • Velocity Clinical Research-Huntington Park
        • Kontakt:
      • Inglewood, California, Forenede Stater, 90301
      • La Mesa, California, Forenede Stater, 91942
      • Lancaster, California, Forenede Stater, 93534
      • Long Beach, California, Forenede Stater, 90815
      • Los Angeles, California, Forenede Stater, 90057
      • Montclair, California, Forenede Stater, 91763
      • Orange, California, Forenede Stater, 92868
      • Oxnard, California, Forenede Stater, 93030
      • Pasadena, California, Forenede Stater, 91105
      • Poway, California, Forenede Stater, 92064
      • Poway, California, Forenede Stater, 92064
      • Rialto, California, Forenede Stater, 92377
      • San Bernardino, California, Forenede Stater, 92404
      • San Diego, California, Forenede Stater, 92123
        • Ikke rekrutterer endnu
        • Medical Associates Research Group, Inc.
        • Kontakt:
      • San Diego, California, Forenede Stater, 92120
      • Santa Ana, California, Forenede Stater, 92704
        • Afsluttet
        • Velocity Clinical Research, Santa Ana
      • Van Nuys, California, Forenede Stater, 91405
      • Victorville, California, Forenede Stater, 92395
    • Colorado
      • Colorado Springs, Colorado, Forenede Stater, 80907
      • Englewood, Colorado, Forenede Stater, 80113
    • Connecticut
      • Bristol, Connecticut, Forenede Stater, 06010
        • Rekruttering
        • Connecticut Gastroenterology Clinical Research Foundation
        • Kontakt:
      • New Haven, Connecticut, Forenede Stater, 06520
    • Florida
      • Altamonte Springs, Florida, Forenede Stater, 32714
      • Bradenton, Florida, Forenede Stater, 34209
      • Brandon, Florida, Forenede Stater, 33511
      • Brooksville, Florida, Forenede Stater, 34613
      • Clearwater, Florida, Forenede Stater, 33761
      • Clermont, Florida, Forenede Stater, 34711
      • Coral Gables, Florida, Forenede Stater, 33134
      • Cutler Bay, Florida, Forenede Stater, 33189
      • Fort Myers, Florida, Forenede Stater, 33912
        • Rekruttering
        • Covenant Metabolic Specialists, LLC - Fort Myers
        • Kontakt:
      • Gainesville, Florida, Forenede Stater, 32610
      • Hialeah, Florida, Forenede Stater, 33016
      • Hialeah Gardens, Florida, Forenede Stater, 33016
      • Homestead, Florida, Forenede Stater, 33030
      • Lady Lake, Florida, Forenede Stater, 32159
      • Lakewood Rch, Florida, Forenede Stater, 34211
      • Maitland, Florida, Forenede Stater, 32751
      • Miami, Florida, Forenede Stater, 33176
      • Miami, Florida, Forenede Stater, 33134
      • Miami, Florida, Forenede Stater, 33135
      • Miami, Florida, Forenede Stater, 33176
      • Miami, Florida, Forenede Stater, 33156
      • Miami, Florida, Forenede Stater, 33136
      • Miami Lakes, Florida, Forenede Stater, 33016
      • Naples, Florida, Forenede Stater, 34102
      • Orlando, Florida, Forenede Stater, 32803
      • Orlando, Florida, Forenede Stater, 32828
      • Orlando, Florida, Forenede Stater, 32806
        • Afsluttet
        • K2 Medical Research
      • Palmetto Bay, Florida, Forenede Stater, 33157
      • Pembroke Pines, Florida, Forenede Stater, 33024
        • Rekruttering
        • MplusM - Best Choice Medical and Research Service
        • Kontakt:
      • Port Orange, Florida, Forenede Stater, 32127
      • Riverview, Florida, Forenede Stater, 33578
        • Rekruttering
        • Covenant Metabolic Specialist, LLC - Riverview
        • Kontakt:
      • St. Petersburg, Florida, Forenede Stater, 33714
      • Tampa, Florida, Forenede Stater, 33618
      • The Villages, Florida, Forenede Stater, 32162
      • University Park, Florida, Forenede Stater, 34201
        • Rekruttering
        • Covenant Metabolic Specialists, LLC - University Park
        • Kontakt:
      • Winter Park, Florida, Forenede Stater, 32789
      • Zephyrhills, Florida, Forenede Stater, 33542
    • Georgia
      • Macon, Georgia, Forenede Stater, 31201
        • Rekruttering
        • Gastroenterology Associates of Central Georgia
        • Kontakt:
      • Riverdale, Georgia, Forenede Stater, 30274
        • Rekruttering
        • EmVenio Research Center at Prime Healthcare - Riverdale
        • Kontakt:
    • Indiana
      • Hammond, Indiana, Forenede Stater, 46324
      • South Bend, Indiana, Forenede Stater, 46635
    • Iowa
      • Clive, Iowa, Forenede Stater, 50325
      • West Des Moines, Iowa, Forenede Stater, 50265
        • Rekruttering
        • Iowa Diabetes and Endocrinology Research Center
        • Kontakt:
    • Kansas
      • Kansas City, Kansas, Forenede Stater, 66160
        • Ikke rekrutterer endnu
        • University of Kansas Medical Center
        • Kontakt:
      • Topeka, Kansas, Forenede Stater, 66606
    • Louisiana
      • Bastrop, Louisiana, Forenede Stater, 71220
      • Marrero, Louisiana, Forenede Stater, 70072
      • Shreveport, Louisiana, Forenede Stater, 71105
    • Maryland
      • Baltimore, Maryland, Forenede Stater, 21202
    • Massachusetts
      • Boston, Massachusetts, Forenede Stater, 02118
    • Michigan
      • Clinton Township, Michigan, Forenede Stater, 48038
        • Rekruttering
        • Clinical Research Institute of Michigan, LLC
        • Kontakt:
      • Wyoming, Michigan, Forenede Stater, 49519
    • Minnesota
      • Minneapolis, Minnesota, Forenede Stater, 55413
    • Mississippi
      • Flowood, Mississippi, Forenede Stater, 39232
    • Missouri
      • Chesterfield, Missouri, Forenede Stater, 63005
      • Columbia, Missouri, Forenede Stater, 65201
      • Kansas City, Missouri, Forenede Stater, 64131
    • Nebraska
      • Omaha, Nebraska, Forenede Stater, 68198
    • Nevada
      • Las Vegas, Nevada, Forenede Stater, 89106
      • Las Vegas, Nevada, Forenede Stater, 89121
      • Las Vegas, Nevada, Forenede Stater, 89109
    • New Jersey
      • Warren Township, New Jersey, Forenede Stater, 07059
    • New York
      • Brooklyn, New York, Forenede Stater, 11215
        • Rekruttering
        • NewYork-Presbyterian Brooklyn Methodist Hospital
        • Kontakt:
      • Laurelton, New York, Forenede Stater, 11413
      • New York, New York, Forenede Stater, 10029
        • Ikke rekrutterer endnu
        • Icahn School of Medicine at Mount Sinai
        • Kontakt:
      • Rochester, New York, Forenede Stater, 14642
    • North Carolina
      • Durham, North Carolina, Forenede Stater, 27710
      • Fayetteville, North Carolina, Forenede Stater, 28304
      • Greenville, North Carolina, Forenede Stater, 27834
      • New Bern, North Carolina, Forenede Stater, 28562
      • Raleigh, North Carolina, Forenede Stater, 27612
    • Ohio
      • Columbus, Ohio, Forenede Stater, 43210
        • Rekruttering
        • The Ohio State University Wexner Medical Center
        • Kontakt:
      • Mentor, Ohio, Forenede Stater, 44060
      • Springboro, Ohio, Forenede Stater, 45066
        • Rekruttering
        • ObjectiveHealth-DSI Research - Springboro, LLC
        • Kontakt:
      • Westlake, Ohio, Forenede Stater, 44145
    • Oklahoma
      • Tulsa, Oklahoma, Forenede Stater, 74104
    • Pennsylvania
      • Flourtown, Pennsylvania, Forenede Stater, 19031
      • Hershey, Pennsylvania, Forenede Stater, 17033
        • Rekruttering
        • Penn State Milton S. Hershey Medical Center
        • Kontakt:
      • Lancaster, Pennsylvania, Forenede Stater, 17601
      • State College, Pennsylvania, Forenede Stater, 16801
      • Wyomissing, Pennsylvania, Forenede Stater, 19610
    • South Carolina
      • Charleston, South Carolina, Forenede Stater, 29425
      • Columbia, South Carolina, Forenede Stater, 29204
        • Rekruttering
        • ObjectiveHealth-Columbia Digestive Health Research
        • Kontakt:
      • Summerville, South Carolina, Forenede Stater, 29485
    • Tennessee
      • Chattanooga, Tennessee, Forenede Stater, 37421
      • Clarksville, Tennessee, Forenede Stater, 37040
      • Nashville, Tennessee, Forenede Stater, 37232
    • Texas
      • Arlington, Texas, Forenede Stater, 76012
      • Austin, Texas, Forenede Stater, 78757
      • Austin, Texas, Forenede Stater, 78759
      • Austin, Texas, Forenede Stater, 78745
      • Austin, Texas, Forenede Stater, 78757
      • Bellaire, Texas, Forenede Stater, 77401
      • Brownsville, Texas, Forenede Stater, 78520
        • Rekruttering
        • South Texas Research Institute - Brownsville
        • Kontakt:
      • Carrollton, Texas, Forenede Stater, 75006
      • Corpus Christi, Texas, Forenede Stater, 78404
        • Rekruttering
        • Pinnacle Clinical Research - Corpus Christi
        • Kontakt:
      • Dallas, Texas, Forenede Stater, 75230
      • Dallas, Texas, Forenede Stater, 75246
      • Dallas, Texas, Forenede Stater, 75230
      • Dallas, Texas, Forenede Stater, 75150
      • DeSoto, Texas, Forenede Stater, 75115
      • Denison, Texas, Forenede Stater, 75020
      • Edinburg, Texas, Forenede Stater, 78539
        • Rekruttering
        • South Texas Research Institute-Edinburg-67012
        • Kontakt:
      • Forney, Texas, Forenede Stater, 75126
      • Garden City, Texas, Forenede Stater, 48135
        • Rekruttering
        • EmVenio Research Center at Prime Healthcare - Farmers Branch
        • Kontakt:
      • Garland, Texas, Forenede Stater, 75043
      • Georgetown, Texas, Forenede Stater, 78626
      • Houston, Texas, Forenede Stater, 77084
        • Rekruttering
        • Biopharma Informatic, Inc. Research Center
        • Kontakt:
      • Houston, Texas, Forenede Stater, 77089
      • Houston, Texas, Forenede Stater, 77030-1608
      • Houston, Texas, Forenede Stater, 77004
      • Lewisville, Texas, Forenede Stater, 75057
      • Mansfield, Texas, Forenede Stater, 76063
      • McAllen, Texas, Forenede Stater, 78503
      • McAllen, Texas, Forenede Stater, 78504
      • Plano, Texas, Forenede Stater, 75093
      • San Antonio, Texas, Forenede Stater, 78215
        • Rekruttering
        • American Research Corporation at the Texas Liver Institute
        • Kontakt:
      • San Antonio, Texas, Forenede Stater, 78219
      • San Antonio, Texas, Forenede Stater, 78229
      • San Antonio, Texas, Forenede Stater, 78229
      • San Antonio, Texas, Forenede Stater, 78240
      • San Antonio, Texas, Forenede Stater, 78222
      • Waco, Texas, Forenede Stater, 76710
      • Waco, Texas, Forenede Stater, 76712
        • Rekruttering
        • Objective Health-Digestive Research of Central Texas
        • Kontakt:
      • Wichita Falls, Texas, Forenede Stater, 76301
        • Rekruttering
        • ObjectiveHealth-Digestive Health Research of North Texas
        • Kontakt:
    • Virginia
      • Newport News, Virginia, Forenede Stater, 23601
        • Ikke rekrutterer endnu
        • Liver Institute of Virginia-Bremo
        • Kontakt:
      • Richmond, Virginia, Forenede Stater, 23236
      • Richmond, Virginia, Forenede Stater, 23298
    • Washington
      • Seattle, Washington, Forenede Stater, 98105
      • Spokane, Washington, Forenede Stater, 99218
  • Frankrig
      • Amiens, Frankrig, 80054
        • Ikke rekrutterer endnu
        • CHU Amiens-Picardie
        • Kontakt:
      • Angers, Frankrig, 49100
        • Ikke rekrutterer endnu
        • Centre Hospitalier Universitaire D'Angers
        • Kontakt:
      • Clichy, Frankrig, 92110
        • Ikke rekrutterer endnu
        • Hopital Beaujon
        • Kontakt:
      • Créteil, Frankrig, 94000
        • Ikke rekrutterer endnu
        • Hopital Henri Mondor
        • Kontakt:
      • Dijon, Frankrig, 21000
        • Ikke rekrutterer endnu
        • HOP Dijon-Bourgogne
        • Kontakt:
      • Le Chesnay, Frankrig, 78150
        • Ikke rekrutterer endnu
        • Centre Hospitalier De Versailles
        • Kontakt:
      • Lille, Frankrig, 59000
        • Ikke rekrutterer endnu
        • Hôpital Claude Huriez
        • Kontakt:
      • Lyon, Frankrig, 69004
        • Ikke rekrutterer endnu
        • Hopital De La Croix-Rousse
        • Kontakt:
      • Nice, Frankrig, 06200
        • Ikke rekrutterer endnu
        • Hôpital de l'Archet
        • Kontakt:
      • Paris, Frankrig, 75014
        • Ikke rekrutterer endnu
        • Hôpital Cochin
        • Kontakt:
      • Paris, Frankrig, 75013
        • Ikke rekrutterer endnu
        • Hopitaux Universitaires Pitié-Salpétrière
        • Kontakt:
      • Pessac, Frankrig, 33600
        • Ikke rekrutterer endnu
        • Centre Hospitalier Universitaire De Bordeaux
        • Kontakt:
      • Pierre-Bénite, Frankrig, 69495
        • Ikke rekrutterer endnu
        • Centre Hospitalier Lyon Sud
        • Kontakt:
      • Toulouse, Frankrig, 31059
        • Ikke rekrutterer endnu
        • Hôpital Rangueil - CHU de Toulouse
        • Kontakt:
  • Georgien
      • Batumi, Georgien, 6010
      • Tbilisi, Georgien, 0112
        • Rekruttering
        • Israeli - Georgian Medical Research Clinic Healthycore LTD
        • Kontakt:
  • Holland
      • Amsterdam, Holland, 1081HV
      • Dordrecht, Holland, 3318 AT
      • Nijmegen, Holland, 6525 GA
        • Rekruttering
        • Radboud Universitair Medisch Centrum
        • Kontakt:
      • Rotterdam, Holland, 3015 GD
      • Schiedam, Holland, 3118 JH
      • Tilburg, Holland, 5042 AD
        • Rekruttering
        • Tweesteden Ziekenhuis, locatie Tilburg
        • Kontakt:
  • Hong Kong
      • Hong Kong, Hong Kong, 999077
  • Indien
      • Ahemdabad, Indien, 380060
        • Rekruttering
        • Aryav Superspeciality Hospital
        • Kontakt:
      • Chandigarh, Indien, 14209-1120
        • Rekruttering
        • Post Graduate Institute of Medical Education and Research
        • Kontakt:
      • Hyderabad, Afzalgunj, Indien, 500012
        • Rekruttering
        • Osmania Medical College & Hospital
        • Kontakt:
      • Jaipur, Indien, 302001
        • Rekruttering
        • SR Kalla Memorial Hospital
        • Kontakt:
      • Jaipur, Indien, 302020
        • Rekruttering
        • ManglamPlus Medicity Hospital
        • Kontakt:
      • Lucknow, Indien, 226003
        • Rekruttering
        • Atharva Multispecialty Hospital and research Centre
        • Kontakt:
      • Mohali, Indien, 160062
        • Rekruttering
        • Fortis Hospital, Mohali
        • Kontakt:
      • Nagpur, Indien, 440010
        • Rekruttering
        • Midas Multispeciality Hospital Pvt. Ltd.
        • Kontakt:
      • New Delhi, Indien, 110029
        • Rekruttering
        • All India Institute of Medical Sciences
        • Kontakt:
      • New Delhi, Indien, 110 070
        • Rekruttering
        • Insitute of Liver and Billiary Sciences
        • Kontakt:
      • Rohtak, Indien, 124001
        • Rekruttering
        • Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
        • Kontakt:
      • Secunderabad, Indien, 500003
        • Rekruttering
        • Yashoda Hospitals - Secunderabad
        • Kontakt:
      • Surat, Indien, 395002
        • Rekruttering
        • Surat Institute of Digestive Sciences
        • Kontakt:
      • Surat, Indien, 395009
        • Rekruttering
        • Gujarat Gastro and Vascular Hospital
        • Kontakt:
      • Surat, Indien, 395009
        • Rekruttering
        • BAPS Pramukh Swami Hospital
        • Kontakt:
  • Italien
      • Bologna, Italien, 40138
        • Rekruttering
        • Policlinico S. Orsola-Malpighi
        • Kontakt:
      • Foggia, Italien, 71122
        • Rekruttering
        • Az.Osp. Universitaria "Ospedali Riuniti"
        • Kontakt:
      • Milan, Italien, 20122
        • Rekruttering
        • Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico
        • Kontakt:
      • Modena, Italien, 41121
        • Rekruttering
        • Università di Modena e Reggio Emilia
        • Kontakt:
      • Novara, Italien, 28100
        • Ikke rekrutterer endnu
        • Ospedale Maggiore della Carità
        • Kontakt:
      • Palermo, Italien, 90127
        • Rekruttering
        • Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone
        • Kontakt:
      • Rome, Italien, 00168
        • Rekruttering
        • Fondazione Policlinico Universitario Agostino Gemelli IRCCS
        • Kontakt:
      • Rome, Italien, 00128
        • Rekruttering
        • Fondazione Policlinico Universitario Campus Bio-medico
        • Kontakt:
      • Rozzano, Italien, 20089
        • Rekruttering
        • Istituto Clinico Humanitas
        • Kontakt:
      • San Giovanni Rotondo, Italien, 71013
        • Rekruttering
        • IRCCS Ospedale "Casa Sollievo della Sofferenza"
        • Kontakt:
      • Torino, Italien, 10126
        • Rekruttering
        • Universita Degli Studi di Torino
        • Kontakt:
      • Verona, Italien, 37134
        • Rekruttering
        • Azienda Ospedaliera Universitaria Integrata Verona
        • Kontakt:
  • Japan
      • Bunkyō City, Japan, 113-8655
        • Rekruttering
        • The University of Tokyo Hospital
        • Kontakt:
      • Chiba, Japan, 260-8677
        • Rekruttering
        • Chiba University Hospital
        • Kontakt:
      • Chiba, Ichikawa, Japan, 272-8516
        • Rekruttering
        • Japan Institute for Health Security National Kohnodai Medical Center
        • Kontakt:
      • Ehime, Toon, Japan, 791-0295
        • Rekruttering
        • Ehime University Hospital
        • Kontakt:
      • Fukui-shi, Japan, 918-8503
        • Rekruttering
        • Fukuiken Saiseikai Hospital
        • Kontakt:
      • Fukuoka, Fukuoka, Japan, 810-8563
        • Rekruttering
        • National Hospital Organization Kyushu Medical Center
        • Kontakt:
      • Fukuoka, Kurume, Japan, 830-0011
        • Rekruttering
        • Kurume University Hospital
        • Kontakt:
      • Gifu, Gifu, Japan, 500-8513
        • Rekruttering
        • Gifu Municipal Hospital
        • Kontakt:
      • Hanishina-gun, Japan, 381-8551
        • Rekruttering
        • Nagano Municipal Hospital
        • Kontakt:
      • Hiroshima, Japan, 734-8551
        • Rekruttering
        • Hiroshima University Hospital
        • Kontakt:
      • Hiroshima, Japan, 730-8619
        • Rekruttering
        • Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital
        • Kontakt:
      • Hokkaido, Sapporo, Japan, 062-8618
        • Rekruttering
        • Japan Community Health Care Organization Hokkaido Hospital
        • Kontakt:
      • Hyogo, Nishinomiya, Japan, 663-8501
        • Rekruttering
        • Hyogo College of Medicine Hospital
        • Kontakt:
      • Ibaraki, Inashiki-gun, Japan, 300-0395
        • Rekruttering
        • Tokyo Medical University Ibaraki Medical Center
        • Kontakt:
      • Isehara-shi, Japan, 259-1193
        • Rekruttering
        • Tokai University Hospital
        • Kontakt:
      • Ishikawa, Kanazawa, Japan, 920-8641
        • Rekruttering
        • Kanazawa University Hospital
        • Kontakt:
      • Izumo, Japan, 693-8501
        • Rekruttering
        • Shimane University Hospital
        • Kontakt:
      • Kagoshima, Japan, 890-8520
        • Rekruttering
        • Kagoshima University Hospital
        • Kontakt:
      • Kanagawa, Kawasaki, Japan, 215-0026
        • Rekruttering
        • Shin-yurigaoka General Hospital
        • Kontakt:
      • Kawasaki-shi, Japan, 216-8511
        • Rekruttering
        • St. Marianna University Hospital
        • Kontakt:
      • Kita-gun, Japan, 761-0793
        • Rekruttering
        • Kagawa University Hospital
        • Kontakt:
      • Kobe, Japan, 650-0017
        • Rekruttering
        • Kobe University Hospital
        • Kontakt:
      • Kumamoto, Japan, 860-8556
        • Rekruttering
        • Kumamoto University Hospital
        • Kontakt:
      • Kumamoto, Japan, 862-8655
        • Rekruttering
        • Kumamoto Shinto General Hospital
        • Kontakt:
      • Kure, Japan, 737-0023
        • Rekruttering
        • National Hospital Organization Kure Medical Center and Chugoku Cancer Center
        • Kontakt:
      • Kyoto, Japan, 602-8566
        • Rekruttering
        • University Hospital Kyoto Prefectural University of Medicine
        • Kontakt:
      • Miyazaki, Japan, 889-1692
        • Rekruttering
        • University of Miyazaki Hospital
        • Kontakt:
      • Musashino, Japan, 186-8610
        • Rekruttering
        • Japanese Red Cross Musashino Hospital
        • Kontakt:
      • Nagano, Matsumoto, Japan, 390-8621
        • Rekruttering
        • Shinshu University Hospital
        • Kontakt:
      • Nagasaki, Omura, Japan, 856-8562
        • Rekruttering
        • Nagasaki Medical Center
        • Kontakt:
      • Nara, Kashihara, Japan, 634-8522
        • Rekruttering
        • Nara Medical University Hospital
        • Kontakt:
      • Narita, Japan, 286-0105
        • Rekruttering
        • International University of Health and Welfare Narita Hospital
        • Kontakt:
      • Niigata, Japan, 951-8520
        • Rekruttering
        • Niigata University Medical and Dental Hospital
        • Kontakt:
      • Okayama, Japan, 700-8558
        • Rekruttering
        • Okayama University Hospital
        • Kontakt:
      • Osaka, Japan, 545-0051
        • Rekruttering
        • Osaka City University Hospital
        • Kontakt:
      • Saga, Japan, 849-8501
        • Rekruttering
        • Saga University Hospital
        • Kontakt:
      • Sakai, Japan, 591-8025
        • Rekruttering
        • Osaka Rosai Hospital
        • Kontakt:
      • Sakai, Japan, 599-8247
        • Rekruttering
        • Seichokai Bell Land General Hospital
        • Kontakt:
      • Sapporo, Japan, 060-0033
        • Rekruttering
        • Sapporo Kosei General Hospital
        • Kontakt:
      • Sendai, Japan, 981-3116
        • Rekruttering
        • Sendai Tokushukai Hospital
        • Kontakt:
      • Shimonoseki, Japan, 750-0061
        • Rekruttering
        • JCHO Shimonoseki Medical Center
        • Kontakt:
      • Shiwa-gun, Japan, 028-3695
        • Ikke rekrutterer endnu
        • Iwate Medical University Hospital
        • Kontakt:
      • Shizuoka, Hamamatsu, Japan, 431-3192
        • Rekruttering
        • Hamamatsu University Hospital
        • Kontakt:
      • Shizuoka, Izunokuni, Japan, 410-2295
        • Rekruttering
        • Juntendo University Shizuoka Hospital
        • Kontakt:
      • Suita-Shi, Japan, 564-0013
      • Suita-shi, Japan, 565-0871
        • Rekruttering
        • The University of Osaka Hospital
        • Kontakt:
      • Takasaki-shi, Japan, 370-0829
        • Rekruttering
        • National Hospital Organization Takasaki General Medical Center
        • Kontakt:
      • Tokyo, Japan, 173-8610
        • Rekruttering
        • Nihon University Itabashi Hospital
        • Kontakt:
      • Tokyo, Japan, 160-0023
        • Rekruttering
        • Tokyo Medical University Hospital
        • Kontakt:
      • Tokyo, Japan, 113-8519
        • Rekruttering
        • Institute of Science Tokyo Hospital
        • Kontakt:
      • Tokyo, Bunkyo-ku, Japan, 113-8603
        • Rekruttering
        • Nippon Medical School Hospital
        • Kontakt:
      • Tokyo, Minato-ku, Japan, 105-8470
      • Toyoake-shi, Japan, 470-1192
        • Rekruttering
        • Fujita Health University Hospital
        • Kontakt:
      • Tsu, Japan, 514-8507
        • Rekruttering
        • Mie University Hospital
        • Kontakt:
      • Wakayama, Japan, 641-8509
        • Rekruttering
        • Wakayama Medical University Hospital
        • Kontakt:
      • Yokohama, Japan, 236-0004
        • Rekruttering
        • Yokohama City University Hospital
        • Kontakt:
      • Ōita, Japan, 870-0837
        • Rekruttering
        • Oita Cardiovascular Hospital
        • Kontakt:
  • Jordan
      • Amman, Jordan, 11194
        • Rekruttering
        • The Speciality Hospital (TSH)
        • Kontakt:
      • Irbid, Jordan, 21110
        • Rekruttering
        • Irbid Specialty Hospital
        • Kontakt:
      • Jordan, Jordan, 13046
        • Rekruttering
        • Jordan University Hospital
        • Kontakt:
  • Kasakhstan
      • Almaty, Kasakhstan, 050000
        • Rekruttering
        • Asfendiyarov Kazakh National Medical University
        • Kontakt:
      • Almaty, Kasakhstan, 050026
        • Rekruttering
        • Institute of Gastroenterology, Hepatology and Metabolism LLP
        • Kontakt:
  • Kina
      • Beijing, Kina, 100050
        • Rekruttering
        • Beijing Friendship Hospital
        • Kontakt:
      • Beijing, Kina, 100044
        • Rekruttering
        • Peking University People's Hospital
        • Kontakt:
      • Beijing, Kina, 102218
        • Rekruttering
        • Beijing Tsinghua Changgung Hospital
        • Kontakt:
      • Beijing, Kina, 100015
        • Rekruttering
        • Beijing Ditan Hospital Capital Medical University
        • Kontakt:
      • Beijing, Kina, 100069
        • Rekruttering
        • Beijing Youan Hospital, Capital Medical University
        • Kontakt:
      • Changchun, Kina, 130021
        • Rekruttering
        • The First Hospital of Jilin University
        • Kontakt:
      • Changsha, Kina, 410008
        • Rekruttering
        • Xiangya Hospital, Central South University
        • Kontakt:
      • Changsha, Kina, 410005
        • Rekruttering
        • Hunan Provincial People's Hospital
        • Kontakt:
      • Changzhou Shi, Kina, 214442
        • Rekruttering
        • Changzhou Third People's Hospital
        • Kontakt:
      • Chengdu, Kina, 610041
        • Rekruttering
        • West China Hospital, Sichuan University
        • Kontakt:
      • Chongqing, Kina, 404000
        • Rekruttering
        • Chongqing Three Gorges Central Hospital
        • Kontakt:
      • Foshan, Kina, 528000
        • Rekruttering
        • The First People's Hospital of Foshan
        • Kontakt:
      • Fuzhou, Kina, 350005
        • Rekruttering
        • The First Affiliated Hospital of Fujian Medical University
        • Kontakt:
      • Fuzhou, Kina, 350025
        • Rekruttering
        • Mengchao Hepatobiliary Hospital of Fujian Medical University
        • Kontakt:
      • Guangzhou, Kina, 510515
        • Rekruttering
        • NanFang Hosptial
        • Kontakt:
      • Guangzhou, Kina, 510630
        • Rekruttering
        • The third affiliated hospital of Sun Yat-Sen University
        • Kontakt:
      • Guangzhou, Kina, 510000
        • Rekruttering
        • Guangzhou Eighth People's Hospital,Guangzhou Medical University
        • Kontakt:
      • Guangzhou, Kina, 510013
        • Rekruttering
        • Guangzhou First People's Hospital
        • Kontakt:
      • Guangzhou, Kina, 510080
        • Rekruttering
        • The First Affiliated Hospital,Sun Yat-sen University
        • Kontakt:
      • Guiyang, Kina, 550002
        • Rekruttering
        • Guizhou Provincial People's Hospital
        • Kontakt:
      • Hangzhou, Kina, 310013
        • Rekruttering
        • Zhejiang Hospital
        • Kontakt:
      • Hangzhou, Kina, 310015
        • Rekruttering
        • The Affiliated Hospital of Hangzhou Normal University
        • Kontakt:
      • Hangzhou, Kina, 310003
        • Rekruttering
        • The First Affiliated Hospital, Zhejiang University
        • Kontakt:
      • Hangzhou, Kina, 310016
        • Rekruttering
        • Sir Run Run Shaw Hospital, Zhejiang University, School of Medicine
        • Kontakt:
      • Jiaxing, Kina, 314001
        • Rekruttering
        • The First Hospital of Jiaxing
        • Kontakt:
      • Liaocheng, Kina, 252000
        • Rekruttering
        • Liaocheng People's Hospital
        • Kontakt:
      • Luoyang, Kina, 471003
        • Rekruttering
        • The First Affiliated Hospital of Henan University of Science and Technology
        • Kontakt:
      • Nanchang, Kina, 330006
        • Rekruttering
        • The First Affiliated Hospital of Nanchang University
        • Kontakt:
      • Nanchang, Kina, 330006
        • Rekruttering
        • The Second Affiliated Hospital to Nanchang University
        • Kontakt:
      • Nanjing, Kina, 210008
        • Rekruttering
        • Nanjing Drum Tower Hospital
        • Kontakt:
      • Nanjing, Kina, 210003
        • Rekruttering
        • The Second Hospital of Nanjing
        • Kontakt:
      • Ningbo, Kina, 315010
        • Rekruttering
        • Ningbo Second Hospital
        • Kontakt:
      • Ningxia, Kina, 750004
        • Rekruttering
        • General Hospital of Ningxia Medical University
        • Kontakt:
      • Pingxiang, Kina, 337000
        • Rekruttering
        • Pingxiang People's Hospital
        • Kontakt:
      • Qingdao, Kina, 266001
        • Rekruttering
        • Qingdao Municipal Hospital
        • Kontakt:
      • Shanghai, Kina, 200120
        • Rekruttering
        • Shanghai East Hospital
        • Kontakt:
      • Shanghai, Kina, 201508
        • Rekruttering
        • Shanghai Public Health Clinical Center
        • Kontakt:
      • Shanghai, Kina, 200040
        • Rekruttering
        • Huashan Hospital, Fudan University
        • Kontakt:
      • Shanghai, Kina, 200080
        • Rekruttering
        • Shanghai General Hospital
        • Kontakt:
      • Shanghai, Kina, 200025
        • Rekruttering
        • Ruijin Hospital Shanghai Jiao Tong University School of Medicine
        • Kontakt:
      • Shanghai, Kina, 200127
        • Rekruttering
        • Renji Hospital Shanghai Jiaotong University School of Medicine
        • Kontakt:
      • Shenyang, Kina, 110006
        • Rekruttering
        • The Sixth People's Hospital of Shenyang
        • Kontakt:
      • Shenzhen, Kina, 518112
        • Rekruttering
        • The Third People's Hospital of Shenzhen
        • Kontakt:
      • Suzhou, Kina, 215007
        • Rekruttering
        • The Fifth People's Hospital of Suzhou
        • Kontakt:
      • Tianjin, Kina, 300192
        • Rekruttering
        • Tianjin Second People's Hospital
        • Kontakt:
      • Tianjin, Kina, 300170
        • Rekruttering
        • Tianjin Third Central Hospital
        • Kontakt:
      • Wenzhou, Kina, 325000
        • Rekruttering
        • The First Affiliated Hospital of Wenzhou Medical University
        • Kontakt:
      • Wuhan, Kina, 430060
        • Rekruttering
        • Renmin Hospital of Wuhan University
        • Kontakt:
      • Wuhan, Kina, 430022
        • Rekruttering
        • Union Hospital Tongji Medical College Huazhong University of Science and Technology
        • Kontakt:
      • Wuxi, Kina, 214005
        • Rekruttering
        • Wuxi No. 5 People's Hospital
        • Kontakt:
      • Xi'an, Kina, 710061
        • Rekruttering
        • First Affiliated Hospital of Xi'an JiaoTong University
        • Kontakt:
      • Xi'an, Kina, 710004
        • Rekruttering
        • Second Affiliated Hospital of medical college of Xi'an JiaoTong University
        • Kontakt:
      • Xuzhou, Kina, 221002
        • Rekruttering
        • The Affiliated Hospital of Xuzhou Medical College
        • Kontakt:
      • Yanji, Kina, 133000
        • Rekruttering
        • Yanbian University Hospital
        • Kontakt:
      • Yueyang, Kina, 414000
        • Rekruttering
        • Yueyang Central Hospital
        • Kontakt:
      • Yuncheng, Kina, 44099
        • Rekruttering
        • Yuncheng Center Hopsital
        • Kontakt:
      • Zhengzhou, Kina, 450005
        • Rekruttering
        • Sixth People's Hospital of Zhengzhou
        • Kontakt:
      • Zhenjiang, Kina, 212021
        • Rekruttering
        • The Third People's Hospital of Zhenjiang
        • Kontakt:
  • Malaysia
      • Ampang, Malaysia, 68000
      • Kota Bharu, Malaysia, 16150
        • Rekruttering
        • Hospital Universiti Sains Malaysia
        • Kontakt:
      • Kuala Lumpur, Malaysia, 59100
        • Rekruttering
        • University Malaya Medical Centre
        • Kontakt:
      • Putrajaya, Malaysia, 0000
  • Mexico
      • Acapulco de Juárez, Mexico, 39670
        • Rekruttering
        • Centro de Investigacion Clinica del Pacifico (CICPA)
        • Kontakt:
      • Col. Xoco, Mexico, 03339
        • Rekruttering
        • Centro de Investigación y Gastroenterología
        • Kontakt:
      • Cuernavaca, Mexico, 62250
        • Rekruttering
        • Instituto de Diabetes, Obesidad y Nutrición S.C.
        • Kontakt:
      • Mexico City, Mexico, 03300
        • Rekruttering
        • Clinicos Asociados BOCM SC
        • Kontakt:
      • Mexico City, Mexico, 06700
        • Rekruttering
        • Centro de Investigación y Gastroenterología
        • Kontakt:
      • Mérida, Mexico, 97070
        • Rekruttering
        • Medical Care and Research
        • Kontakt:
      • Veracruz, Mexico, 91910
        • Rekruttering
        • Practice Dr Rosa Isela Luna Ceballos
        • Kontakt:
      • Xalapa, Mexico, 91020
        • Rekruttering
        • Centro de Alta Especialidad del Estado de Veracruz
        • Kontakt:
  • New Zealand
    • Auckland
      • Grafton, Auckland, New Zealand, 1010
        • Rekruttering
        • New Zealand Clinical Research (NZCR)
        • Kontakt:
      • Papatoetoe, Auckland, New Zealand, 2025
    • Canterbury
      • Christchurch, Canterbury, New Zealand, 8140
    • Waikato Region
      • Hamilton, Waikato Region, New Zealand, 3240
  • Polen
      • Krakow, Polen, 31-501
        • Rekruttering
        • Medical Centre FutureMeds Krakow
        • Kontakt:
      • Lodz, Polen, 91-363
      • Lodz, Polen, 90-302
      • Lublin, Polen, 20-081
        • Rekruttering
        • Uniwersytecki Szpital Kliniczny Nr 1 W Lublinie
        • Kontakt:
      • Mysłowice, Polen, 41-400
      • Warsaw, Polen, 00-215
        • Rekruttering
        • FutureMeds Warszawa Centrum
        • Kontakt:
      • Warsaw, Polen, 03-712
        • Rekruttering
        • Bodyclinic sp. z o.o. sp.k.
        • Kontakt:
      • Wroclaw, Polen, 53-673
        • Rekruttering
        • FutureMeds Wroclaw
        • Kontakt:
      • Wroclaw, Polen, 54-144
        • Rekruttering
        • EMC Instytut Medyczny S.A. - Wroclaw
        • Kontakt:
  • Puerto Rico
      • San Juan, Puerto Rico, 00927
        • Rekruttering
        • FDI Clinical Research
        • Kontakt:
      • San Juan, Puerto Rico, 00909
        • Rekruttering
        • Latin Clinical Trial Center
        • Kontakt:
      • San Juan, Puerto Rico, 00909
        • Rekruttering
        • Klinical Investigations Group, LLC
        • Kontakt:
  • Rumænien
      • Bucharest, Rumænien, 011658
        • Ikke rekrutterer endnu
        • Arensia Clinics S.R.L.
        • Kontakt:
      • Cluj-Napoca, Rumænien, 400006
        • Rekruttering
        • Cluj Napoca Clinical County Hospital
        • Kontakt:
      • Cluj-Napoca, Rumænien, 400162
        • Rekruttering
        • Regional Institute of Gastroenterology Hepatology "Prof. Dr. O. Fodor"
        • Kontakt:
      • Craiova, Rumænien, 200642
        • Rekruttering
        • Spitalul Clinic Judetean De Urgenta Craiova
        • Kontakt:
      • Iași, Rumænien, 700506
      • Satu Mare, Rumænien, 440055
        • Rekruttering
        • Spital Judetean De Urgenta Satu Mare
        • Kontakt:
  • Saudi Arabien
      • Riyadh, Saudi Arabien, 11564
        • Rekruttering
        • King Faisal Specialist Hospital and Research Center
        • Kontakt:
      • Riyadh, Saudi Arabien, 14611
        • Rekruttering
        • King Abdulaziz Medical City, National Guard Health Affairs
        • Kontakt:
  • Schweiz
      • Arzo, Schweiz, 6900
        • Rekruttering
        • Fondazione Epatocentro Ticino
        • Kontakt:
      • Bern, Schweiz, 3010
        • Rekruttering
        • University Hospital Bern
        • Kontakt:
      • Geneva, Schweiz, 1205
        • Rekruttering
        • Hopitaux Universitaires de Geneve (HUG)
        • Kontakt:
      • Zurich, Schweiz, 8091
        • Rekruttering
        • University Hospital Zurich
        • Kontakt:
  • Singapore
      • Singapore, Singapore, 169608
      • Singapore, Singapore, 119074
      • Singapore, Singapore, 529889
  • Spanien
      • A Coruña, Spanien, 15006
        • Rekruttering
        • Complejo Hospitalario Universitario A Coruña
        • Kontakt:
      • Barcelona, Spanien, 08035
        • Rekruttering
        • Hospital Universitari Vall d'Hebron
        • Kontakt:
      • Córdoba, Spanien, 14004
        • Rekruttering
        • Hospital Universitario Reina Sofía
        • Kontakt:
      • Madrid, Spanien, 28041
        • Rekruttering
        • Hospital Universitario 12 de Octubre
        • Kontakt:
      • Majadahonda, Spanien, 28222
        • Rekruttering
        • Hospital Puerta de Hierro
        • Kontakt:
      • Pontevedra, Spanien, 36071
        • Rekruttering
        • Complexo Hospitalario Universitario de Pontevedra
        • Kontakt:
      • Santander, Spanien, 39008
        • Rekruttering
        • Hospital Universitario Marqués de Valdecilla
        • Kontakt:
      • Santiago de Compostela, Spanien, 15706
        • Rekruttering
        • Hospital Clínico de Santiago
        • Kontakt:
  • Sydafrika
      • Johannesburg, Sydafrika, 2000
        • Ikke rekrutterer endnu
        • Charlotte Maxeke Johannesburg Academic Hospital
        • Kontakt:
      • Johannesburg, Sydafrika, 1827
      • Plumstead, Sydafrika, 7800
  • Sydkorea
      • Bucheon-si, Sydkorea, 14584
        • Rekruttering
        • Soon Chun Hyang University Hospital Bucheon
        • Kontakt:
      • Busan, Sydkorea, 49241
        • Rekruttering
        • Pusan National University Hospital
        • Kontakt:
      • Deagu, Sydkorea, 42415
        • Rekruttering
        • Yeungnam University Medical Center
        • Kontakt:
      • Incheon, Sydkorea, 22332
        • Rekruttering
        • Inha University Hospital
        • Kontakt:
      • Seoul, Sydkorea, 05505
      • Seoul, Sydkorea, 03080
        • Rekruttering
        • Seoul National University Hospital
        • Kontakt:
      • Seoul, Sydkorea, 07061
        • Rekruttering
        • SMG-SNU Boramae Medical Center
        • Kontakt:
      • Seoul, Sydkorea, 6351
        • Rekruttering
        • Samsung Medical Center
        • Kontakt:
      • Seoul, Sydkorea, 08308
        • Rekruttering
        • Korea University Guro Hospital
        • Kontakt:
      • Seoul, Sydkorea, 6973
        • Rekruttering
        • Chung-Ang University Hospital
        • Kontakt:
      • Wŏnju, Sydkorea, 26426
        • Rekruttering
        • Yonsei University Wonju Severance Christian Hospital
        • Kontakt:
  • Taiwan
      • Changhua, Taiwan, 50006
        • Rekruttering
        • Changhua Christian Hospital
        • Kontakt:
      • Kaohsiung City, Taiwan, 824005
      • Kaohsuing City, Taiwan, 80756
        • Rekruttering
        • Kaohsiung Medical University Chung-Ho Memorial Hospital
        • Kontakt:
      • Taichung, Taiwan, 40705
        • Rekruttering
        • Taichung Veterans General Hospital
        • Kontakt:
      • Taichung, Taiwan, 40201
        • Rekruttering
        • Chung Shan Medical University Hospital
        • Kontakt:
      • Tainan, Taiwan, 70403
        • Rekruttering
        • National Cheng Kung University Hospital
        • Kontakt:
      • Tainan, Taiwan, 71004
        • Rekruttering
        • Chi Mei Medical Center
        • Kontakt:
      • Taipei, Taiwan, 110301
        • Rekruttering
        • Taipei Medical University Hospital
        • Kontakt:
      • Taipei, Taiwan, 10048
        • Rekruttering
        • National Taiwan University Hospital
        • Kontakt:
      • Taipei, Taiwan, 112201
        • Rekruttering
        • Taipei Veterans General Hospital
        • Kontakt:
      • Taoyuan, Taiwan, 33305
        • Rekruttering
        • Chang Gung Medical Foundation (CGMF) - Linkou Bran
        • Kontakt:
  • Tjekkiet
      • Liberec, Tjekkiet, 460 01
        • Rekruttering
        • Krajska nemocnice Liberec a.s.
        • Kontakt:
      • Pilsen, Tjekkiet, 301 00
        • Rekruttering
        • Research Site s.r.o.
        • Kontakt:
      • Prague, Tjekkiet, 128 00
        • Rekruttering
        • Vseobecna Fakultni Nemocnice V Praze
        • Kontakt:
  • Tyrkiet (Türkiye)
      • Ankara, Tyrkiet (Türkiye), 06230
        • Rekruttering
        • Ankara Üniversitesi Tıp Fakültesi Hastanesi
        • Kontakt:
      • Ankara, Tyrkiet (Türkiye), 06560
        • Rekruttering
        • Gazi Universitesi Tip Fakultesi
        • Kontakt:
      • Bursa, Tyrkiet (Türkiye), 16059
        • Rekruttering
        • Uludag Universitesi Tip Fakultesi
        • Kontakt:
      • Fatih, Tyrkiet (Türkiye), 34093
        • Rekruttering
        • Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi
        • Kontakt:
      • Istanbul, Tyrkiet (Türkiye), 34180
        • Rekruttering
        • Memorial Bahçelievler Hospital
        • Kontakt:
      • Istanbul, Tyrkiet (Türkiye), 34010
        • Rekruttering
        • Koc Universitesi Hastanesi
        • Kontakt:
      • Izmir, Tyrkiet (Türkiye), 35030
        • Rekruttering
        • Ege Universitesi Tip Fakultesi
        • Kontakt:
      • Rize, Tyrkiet (Türkiye), 53020
        • Rekruttering
        • Recep Tayyip Erdogan Universitesi Egitim ve Arastirma Hastanesi
        • Kontakt:
  • Tyskland
      • Berlin, Tyskland, 13353
      • Bochum, Tyskland, 44892
        • Rekruttering
        • Universitätsklinikum Knappschaftskrankenhaus Bochum GmbH
        • Kontakt:
      • Cologne, Tyskland, 50937
      • Dresden, Tyskland, 01307
      • Erlangen, Tyskland, 91054
      • Frankfurt, Tyskland, 69590
      • Heidelberg, Tyskland, 69120
      • Homburg, Tyskland, 66421
      • Landshut, Tyskland, 84034
        • Rekruttering
        • Klinikum Landshut AdöR der Stadt Landshut
        • Kontakt:
      • Leipzig, Tyskland, 04103
      • Lübeck, Tyskland, 23538
        • Rekruttering
        • Universitätsklinikum Schleswig-Holstein, Campus Lübeck
        • Kontakt:
      • Magdeburg, Tyskland, 39120
        • Rekruttering
        • Otto-von-Guericke-Universität Magdeburg
        • Kontakt:
      • Mainz, Tyskland, 55131
        • Rekruttering
        • Universitätsmedizin der Johannes Gutenberg-Universität Mainz
        • Kontakt:
      • Mannheim, Tyskland, 68167
      • Münster, Tyskland, 49129
      • Tübingen, Tyskland, 72076
      • Wiesbaden, Tyskland, 65189
      • Würzburg, Tyskland, 97080
  • Ungarn
      • Budapest, Ungarn, 1097
        • Rekruttering
        • Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet
        • Kontakt:
      • Budapest, Ungarn, 1036
      • Budapest, Ungarn, 1082
        • Rekruttering
        • Semmelweis Egyetem Sebeszeti, Transzplantacios es Gasztroenterologiai Klinika
        • Kontakt:
      • Békéscsaba, Ungarn, 5600
  • Østrig
      • Graz, Østrig, 8036
      • Linz, Østrig, 4010
      • Vienna, Østrig, 1090
      • Vienna, Østrig, 1130
      • Vienna, Østrig, 1030
      • Wels, Østrig, 4600

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inclusion criteria:

  1. Male or female participants ≥18 years (or who are of legal age in countries where that is greater than 18 years) of age at time of consent
  2. Diagnosis of MASH (non-alcoholic fatty liver disease (NAFLD)) activity score [NAS] ≥4
  3. Stable body weight defined as less than 5% self-reported change in body weight 3 months prior to the screening or during the period between the historical biopsy and randomisation, if a historical biopsy is used
  4. Be willing to maintain a stable diet and physical activity levels throughout the entire trial Further inclusion criteria apply

Exclusion criteria:

  1. Any of the following liver laboratory test abnormalities at screening:

    • Serum AST and/or alanine aminotransferase (ALT) elevation ≥5x upper limit of normal (ULN)

    • Platelet count <140 000/mm^3 (<140 GI/L)

    • Alkaline phosphatase >2x upper limit of normal (ULN)

    • Abnormal synthetic liver function as defined by screening central laboratory evaluation:

      • Albumin below <3.5 g/dL (35.0 g/L)
      • OR International normalised ratio (INR) of prothrombin time >1.3
      • OR total serum bilirubin concentration ≥1.5x ULN

  2. Any history or evidence of acute or chronic liver disease other than MASH

  3. Histologically documented liver cirrhosis (fibrosis stage F4), either at screening or in a historical biopsy

  4. History of or current diagnosis of hepatocellular carcinoma

  5. History of or planned liver transplant

  6. Inability or unwillingness to undergo a liver biopsy at screening (if a suitable historical biopsy is unavailable for central review), or during trial conduct.

  7. History of portal hypertension or presence of decompensated liver disease

  8. Model for end-stage liver disease (MELD) score ≥12 due to liver disease. Further exclusion criteria apply

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Dobbelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Placebo komparator: Placebo
Kombinationsprodukt: Placebo

Subcutaneous injection, prefilled syringe
Eksperimentel: Survodutide
Kombinationsprodukt: Survodutide

Subcutaneous injection, prefilled syringe

Andre navne:
  • BI 456906

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Del 1: Opløsning af MASH uden forværring af leverfibrose på MASH Clinical Research Network (CRN) fibrose-score
Tidsramme: Baseline og i uge 52.
Baseline og i uge 52.
Del 1: Mindst en 1-punkts forbedring i fibrosestadiet uden forværring af MASH
Tidsramme: Baseline og i uge 52.
Baseline og i uge 52.
Part 2: Time to first occurrence of any of components of the composite endpoint consisting of progression to cirrhosis, all-cause mortality, liver transplant, hepatic decompensation event(s), worsening of MELD score to ≥15, progression to CSPH
Tidsramme: Up to 7 years.

Progression to cirrhosis is defined as histological fibrosis score CRN F4. MELD = Model for End-stage Liver Disease CSPH =clinically significant portal hypertension
Up to 7 years.

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Nøgle sekundært endepunkt del 1: Absolut ændring fra baseline i forstærket leverfibrose (ELF) score
Tidsramme: Baseline og i uge 52.
Baseline og i uge 52.
Nøgle sekundært endepunkt del 1: Opnåelse af ingen progression af fibrose vurderet ved central patologi (ja/nej)
Tidsramme: Baseline og i uge 52.
Baseline og i uge 52.
Nøgle sekundært endepunkt del 2: Absolut ændring fra baseline i ELF-score
Tidsramme: Ved baseline og i uge 114.
Ved baseline og i uge 114.
Nøgle sekundært endepunkt del 2: Opnåelse af ingen progression af fibrose vurderet ved central patologi (ja/nej)
Tidsramme: Ved baseline og ved 7 år.
Ved baseline og ved 7 år.
Nøglesekundært endepunkt del 2: Forekomst af hospitalsindlæggelse af alle årsager (første og tilbagevendende)
Tidsramme: Op til 7 år.
Op til 7 år.
Nøgle sekundært endepunkt del 2: Tid til første forekomst af nogen af ​​de bedømte komponenter i det sammensatte endepunkt 5-punkts større uønskede hjertehændelser (5P-MACE)5-punkts større uønskede hjertehændelser (5P-MACE)
Tidsramme: Op til 7 år.
Op til 7 år.
Del 1: Absolut ændring fra baseline i alaninaminotransferase (ALT) [U/L]
Tidsramme: Ved baseline og i uge 52.
Ved baseline og i uge 52.
Del 2: Absolut ændring fra baseline i alaninaminotransferase (ALT) [U/L]
Tidsramme: Ved baseline og i uge 114.
Ved baseline og i uge 114.
Del 1: Absolut ændring fra baseline i aspartataminotransferase (AST) [U/L]
Tidsramme: Ved baseline og i uge 52.
Ved baseline og i uge 52.
Del 2: Absolut ændring fra baseline i aspartataminotransferase (AST) [U/L]
Tidsramme: Ved baseline og i uge 114.
Ved baseline og i uge 114.
Del 1: Absolut ændring fra baseline i systolisk blodtryk (SBP) [mmHg]
Tidsramme: Ved baseline og i uge 52.
Ved baseline og i uge 52.
Del 2: Absolut ændring fra baseline i systolisk blodtryk (SBP) [mmHg]
Tidsramme: Ved baseline og i uge 114.
Ved baseline og i uge 114.
Del 1: Absolut ændring fra baseline i diastolisk blodtryk (DBP) [mmHg]
Tidsramme: Ved baseline og i uge 52.
Ved baseline og i uge 52.
Del 2: Absolut ændring fra baseline i diastolisk blodtryk (DBP) [mmHg]
Tidsramme: Ved baseline og i uge 114.
Ved baseline og i uge 114.
Del 1: Absolut ændring fra baseline i frie fedtsyrer [mg/dL]
Tidsramme: Ved baseline og i uge 52.
Ved baseline og i uge 52.
Del 2: Absolut ændring fra baseline i frie fedtsyrer [mg/dL]
Tidsramme: Ved baseline og i uge 114.
Ved baseline og i uge 114.
Del 1: Progression til cirrhose (defineret som histologisk fibrose score CRN F4) (ja/nej)
Tidsramme: Ved baseline og i uge 52.
Ved baseline og i uge 52.
Key Secondary Endpoint Del 1: Procentdelændring fra baseline i kropsvægt [kg]
Tidsramme: Baseline og i uge 52.
Baseline og i uge 52.
Key Secondary Endpoint Del 1: Absolut ændring fra baseline i leverstivhed [KPA] vurderet ved vibrationsstyret forbigående elastografi (VCTE)
Tidsramme: Baseline og i uge 52.
Baseline og i uge 52.
Key Secondary Endpoint Del 2: Procentdelændring fra baseline i kropsvægt [kg]
Tidsramme: Ved baseline og i uge 114
Ved baseline og i uge 114
Key Secondary Endpoint Del 2: Absolut ændring fra baseline i leverstivhed [KPA] vurderet af VCTE
Tidsramme: Ved baseline og i uge 114.
Ved baseline og i uge 114.
Del 2: Absolutte ændringer fra baseline i lipider [mg/dl] (inklusive men ikke begrænset til: total kolesterol, LDL-kolesterol, lipoprotein med lav densitet [VLDL] kolesterol, lipoprotein med høj densitet [HDL] cholesterol, triglycerider)
Tidsramme: Ved baseline og i uge 114.
Ved baseline og i uge 114.
Key secondary endpoint part 1: Absolute change from baseline in glycosylated haemoglobin (HbA1c) [%]
Tidsramme: Baseline and at Week 52.

This endpoint is specified only for the participants with type 2 diabetes mellitus.
Baseline and at Week 52.
Key secondary endpoint part 2: Absolute change from baseline in HbA1c [%]
Tidsramme: At baseline and at Week 114

This endpoint is specified only for the participants with type 2 diabetes mellitus.
At baseline and at Week 114
Part 1: Improvement of liver fat content (LFC)
Tidsramme: At baseline and at Week 52.

Defined as at least 30% relative reduction in LFC compared with baseline assessed by Magnetic resonance imaging proton density fat fraction (MRI-PDFF).

This endpoint will be reported only for a subset of participants in the MRI sub-study.
At baseline and at Week 52.
Part 2: Improvement of LFC
Tidsramme: At baseline and at Week 114.

Defined as at least 30% relative reduction in LFC compared with baseline assessed by MRI-PDFF.

This endpoint will be reported only for a subset of participants in the MRI sub-study.
At baseline and at Week 114.
Part 1: Absolute change from baseline in LFC [%] in MRI-PDFF
Tidsramme: At baseline and at Week 52.

This endpoint will be reported only for a subset of participants in the MRI sub-study.
At baseline and at Week 52.
Part 2: Absolute change from baseline in LFC [%] in MRI-PDFF
Tidsramme: At baseline and at Week 114.

This endpoint will be reported only for a subset of participants in the MRI sub-study.
At baseline and at Week 114.
Part 1: Absolute changes from baseline in lipids [mg/dL] (including but not limited to: total cholesterol, LDL cholesterol, very low-density lipoprotein [VLDL] cholesterol, high-density lipoprotein [HDL] cholesterol, triglycerides)
Tidsramme: At baseline and at Week 52.

LDL=low-density lipoprotein
At baseline and at Week 52.

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Boehringer Ingelheim

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Hjælpsomme links

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

14. oktober 2024

Primær færdiggørelse (Anslået)

27. december 2031

Studieafslutning (Anslået)

27. december 2031

Datoer for studieregistrering

Først indsendt

8. oktober 2024

Først indsendt, der opfyldte QC-kriterier

8. oktober 2024

Først opslået (Faktiske)

9. oktober 2024

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

28. oktober 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

27. oktober 2026

Sidst verificeret

1. oktober 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • 1404-0044
  • 2024-513739-25-00 (Registry Identifier: CTIS)
  • U1111-1306-9071 (Registry Identifier: WHO International Clinical Trials Registry Platform (ICTRP))

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

JA

IPD-planbeskrivelse

Once the criteria in section 'time frame' are fulfilled, researchers can use the following link https:// www.mystudywindow.com/msw/datasharing to request access to the clinical study documents regarding this study, and upon a signed "Document Sharing Agreement". Furthermore, researchers can request access to the clinical study data, for this and other listed studies, after the submission of a research proposal and according to the terms outlined in the website.

IPD-delingstidsramme

One year after the approval has been granted by major Regulatory Authorities and after the primary manuscript has been accepted for publication, or after termination of the development program.

IPD-delingsadgangskriterier

For study documents -upon signing of a 'Document Sharing Agreement '. For study data -1. after the submission and approval of the research proposal (checks will be performed by the sponsor and/or the independent review panel, including checking that the planned analysis does not compete with sponsor's publication plan); 2. and upon signing of a legal agreement.

IPD-deling Understøttende informationstype

  • STUDY_PROTOCOL
  • SAP
  • CSR

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ja

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Abonner