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Effects of Exercise Snacks on Physical Health and Cognitive Function in Individuals With Intellectual Disabilities

6. august 2026 opdateret af: University of Macau
Intellectual disability (ID) is a neurodevelopmental disorder accompanied by sedentary lifestyles, which worsens cognitive function and physical health. Short-duration high-frequency exercise snacks (ES) may be a feasible intervention for adults with ID. This randomized controlled crossover study aims to explore the acute effects of exercise snacks, conventional HIIT and daily routine control on cognitive function, stereotyped behaviors and prefrontal cortex activation in adults with mild to moderate ID. All participants will receive three intervention conditions with a 1-week washout period between each trial. Neurophysiological indicators including EEG and heart rate variability will be measured to reveal the underlying mechanisms.

Studieoversigt

Status

Ikke rekrutterer endnu

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Background:

Adults with intellectual disability commonly maintain sedentary daily routines, resulting in progressive decline in physical fitness and cognitive performance. Traditional long-duration exercise interventions are difficult to implement for this population due to behavioral and cognitive limitations. Exercise snacks, consisting of repeated ultra-short exercise bursts, are easy to carry out and show promising benefits for cognition.

Methods:

A randomized controlled crossover design will be adopted. Twenty-four adults aged 18-35 years with mild to moderate ID will complete three conditions in random sequence: no-exercise control, high-intensity interval training (HIIT), and exercise snacks (ES). A 1-week washout interval separates different interventions.

Intervention protocols:

  1. Control: maintain habitual daily activities.
  2. HIIT: one afternoon session, 10 sets of 6-second high-knee exercise with 9 seconds rest.
  3. ES: morning and afternoon sessions every day; each session contains 5 sets of 6-second high-knee exercise with 9 seconds rest.

Main measurements include prefrontal cortex activation via EEG, cognitive function, stereotyped behaviors, and heart rate variability. Repeated-measures statistical models will be used for data analysis.

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

24

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiekontakt

Studiesteder

  • Kina
    • Zhejiang
      • Hangzhou, Zhejiang, Kina
        • Hangzhou First Social Welfare Institute
        • Kontakt:

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen

Tager imod sunde frivillige

Ingen

Beskrivelse

Inclusion Criteria:

  1. Aged 18-35 years old;
  2. Clinically diagnosed mild to moderate intellectual disability;
  3. Able to follow simple verbal instructions and complete exercise protocols;
  4. No contraindications for moderate physical activity confirmed by medical inquiry;
  5. Participants or legal guardians provide written informed consent;
  6. Maintain stable daily routine and do not participate in other structured exercise programs during the trial.

Exclusion Criteria:

  1. Severe physical disabilities, orthopedic injury or neurological disorders that restrict movement;
  2. History of cardiovascular disease, uncontrolled hypertension or other exercise contraindications;
  3. Current psychiatric medication that significantly affects motor or cognitive function;
  4. Inability to cooperate with EEG and physiological signal collection;
  5. Pregnancy;
  6. Participation in other interventional studies within the past 3 months.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Grundvidenskab
  • Tildeling: Randomiseret
  • Interventionel model: Crossover opgave
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Ingen indgriben: Arm 1
Participants maintain their usual daily activities without additional prescribed exercise. Daily physical activity will be recorded throughout the intervention period.
Eksperimentel: Arm 2（Exercise Snacks）
Twice-daily short-bout exercise snacks. Each session includes 5 sets of 6-second high-knee exercise with 9 seconds rest between sets.
Adfærdsmæssigt: Exercise Snacks
Twice-daily short-bout exercise snacks. Each session includes 5 sets of 6-second high-knee exercise with 9 seconds rest between sets.
Eksperimentel: Arm 3（High-Intensity Interval Training ）
One intervention session scheduled in the afternoon. The protocol consists of 10 sets of 6-second high-knee exercise, separated by 9 seconds of rest between sets.
Adfærdsmæssigt: High-Intensity Interval Training
Acute high-intensity interval training protocol: 10 × 6 s high-knee exercise with 9 s rest between sets, completed in a single afternoon session.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Changes in cognitive function assessed by cognitive test battery
Tidsramme: Baseline and immediately after the acute intervention
Changes in cognitive performance measured after each intervention condition, including attention and executive function.
Baseline and immediately after the acute intervention

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Prefrontal cortex activation measured by electroencephalography (EEG)
Tidsramme: Baseline and immediately after the acute intervention
Changes in prefrontal cortical brain activity indexed by EEG power spectrum during cognitive tasks.
Baseline and immediately after the acute intervention

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

University of Macau

Efterforskere

  • Ledende efterforsker: Zhaowei Kong, PhD, University of Macau

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Anslået)

16. november 2026

Primær færdiggørelse (Anslået)

18. januar 2027

Studieafslutning (Anslået)

8. februar 2027

Datoer for studieregistrering

Først indsendt

29. juli 2026

Først indsendt, der opfyldte QC-kriterier

6. august 2026

Først opslået (Faktiske)

12. august 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

12. august 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

6. august 2026

Sidst verificeret

1. juli 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • BSE-1553-2026

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

JA

IPD-planbeskrivelse

De-identified individual participant data will be available upon reasonable request to the corresponding investigator after study completion and main publication. Data sharing will be subject to a formal data use agreement.

IPD-delingstidsramme

Data and supporting materials will be available starting 6 months following the publication of primary study outcomes, and remain accessible for up to 5 years thereafter.

IPD-delingsadgangskriterier

Qualified researchers who submit a methodologically sound research proposal. Requests need to be sent to the corresponding investigator and a data use agreement must be signed.

IPD-deling Understøttende informationstype

  • STUDY_PROTOCOL
  • SAP
  • ICF
  • ANALYTIC_CODE

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