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Study of Cognitive-Linguistic Profiles: The Role of Executive Control in Aphasia (P-CLAC)

10. august 2026 opdateret af: University Hospital, Toulouse

Study of Cognitive-linguistic Profiles in Brain-injured Adults: the Role of Executive Control in Mild Aphasia.

In France, stroke affects 150,000 people annually and is the leading cause of acquired disability in adults; 10-12% of patients exhibit mild post-stroke aphasia, a condition defined by language difficulties.

Few studies describe mild post-stroke aphasia, and none characterize the impairment of linguistic executive control in this population; consequently, its prevalence remains unknown. To date, the role of linguistic executive control in mild aphasia remains an open question.

The aim of this project is to investigate linguistic executive control impairment in stroke survivors with mild aphasia, provide an initial estimate of its prevalence, and demonstrate its interactions with other linguistic and communicative aspects, as well as with executive and attentional functions.

Studieoversigt

Status

Ikke rekrutterer endnu

Betingelser

Intervention / Behandling

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

30

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiekontakt

Studiesteder

  • Frankrig
      • Toulouse, Frankrig, 31300
        • Service de Médecine Physique et de Réadaptation Hôpital Raymonde Fournet Purpan
        • Kontakt:

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ingen

Beskrivelse

Inclusion Criteria:

  • Patient who has experienced a first ischemic stroke resulting in clinical symptoms within the last 3 months and is receiving care in the Physical Medicine and Rehabilitation department.
  • Score ≤ 31 on the conversational speech observation scale of the MEC test (Montreal Protocol for the Evaluation of Communication).
  • Patients with a BDAE score ≥ 3 (Boston Diagnostic Aphasia Examination - French version, Mazaux J.-M. [1990]); this score is the gold standard in aphasiology.
  • Native French-speaking patient capable of understanding oral or written instructions.

Exclusion Criteria:

  • Patients exhibiting behavior or a clinical condition incompatible with test administration, as assessed by the clinician.
  • Known major visual, auditory, or motor impairments incompatible with test performance.
  • Known neurodegenerative and/or neurodevelopmental disorders.
  • Known social cognition disorders (e.g., ASD).

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Forebyggelse
  • Tildeling: N/A
  • Interventionel model: Enkelt gruppeopgave
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: Patients whose neuropsychological and speech-language pathology tests will be randomized
Diagnostisk test: Neuropsychological tests
Patients undergo neuropsychological tests, the order of which will be randomized.
Diagnostisk test: Speech-language assessments
Patients will undergo speech-language assessments, with the order of the tests randomized.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
measure the proportion of patients with mild post-stroke aphasia exhibiting deficits in linguistic executive control within three months of a first stroke
Tidsramme: 7 days after the inclusion
CATEX score result (deficit score if below the mean value minus 1.65 times the standard deviation)
7 days after the inclusion

Sekundære resultatmål

Resultatmål
Tidsramme
Study of the correlation between executive control of language (CATEX score) and the score of the test evaluating access to the lexical stock
Tidsramme: 7 days after the inclusion
7 days after the inclusion
Study of the correlation between linguistic executive control (CATEX score) and the score of the test evaluating access to the semantic system
Tidsramme: 7 days after the inclusion
7 days after the inclusion
Study of the correlation between linguistic executive control (CATEX score) and the score of the test evaluating non-verbal executive control
Tidsramme: 7 days after the inclusion
7 days after the inclusion
Study of the correlation between linguistic executive control (CATEX score) and the score of the test evaluating gnosies
Tidsramme: 7 days after the inclusion
7 days after the inclusion
Identification of patients' cognitive-linguistic impairment profiles based on cognitive test scores
Tidsramme: 7 days after the inclusion
7 days after the inclusion
Identification of patients' cognitive-linguistic impairment profiles based on stroke location using factor analysis
Tidsramme: 7 days after the inclusion
7 days after the inclusion

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

University Hospital, Toulouse

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Anslået)

1. september 2026

Primær færdiggørelse (Anslået)

1. september 2028

Studieafslutning (Anslået)

8. september 2028

Datoer for studieregistrering

Først indsendt

20. juli 2026

Først indsendt, der opfyldte QC-kriterier

10. august 2026

Først opslået (Faktiske)

14. august 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

14. august 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

10. august 2026

Sidst verificeret

1. august 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • RC31/25/0614
  • ID-RCB (Anden identifikator: 2025-A00414-45)

Plan for individuelle deltagerdata (IPD)

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INGEN

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Ingen

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